2npy - Revision history

OCA at 10:18, 30 August 2023

2023-08-30T10:18:07Z

← Older revision		Revision as of 10:18, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2npy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2npy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPY FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>~~, ~~<scene name='pdbligand=S9L:2-~~[2~~-(2-HYDROXYETHOXY)ETHOXY]ETHYL+DIHYDROGEN+PHOSPHATE'>S9L</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=S9L:2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL+DIHYDROGEN+PHOSPHATE'>S9L</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1zfr\|1zfr]], [[2npz\|2npz]]~~</~~div~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [https://pdbe.org/2npy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [https://www.ebi.ac.uk/pdbsum/2npy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2npy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [https://pdbe.org/2npy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [https://www.ebi.ac.uk/pdbsum/2npy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2npy ProSAT]</span></td></tr>
	</table>		</table>
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	==See Also==		==See Also==
	*[[Ribozyme\|Ribozyme]]		*[[Ribozyme 3D structures\|Ribozyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Krucinska, J]]		[[Category: Krucinska J]]
	[[Category: MacElrevey, C]]		[[Category: MacElrevey C]]
	[[Category: Wedekind~~, J E]]~~		[[Category: Wedekind JE]]
	~~[[Category: 2'-deoxy 2'-amino]]~~
	~~[[Category: 9s linker]]~~
	~~[[Category: Catalytic rna]]~~
	~~[[Category: E-loop]]~~
	~~[[Category: Hairpin ribozyme]]~~
	~~[[Category: Mutation]]~~
	~~[[Category: Ribose zipper]]~~
	~~[[Category: Rna]]~~
	~~[[Category: S-turn~~]]

OCA at 09:06, 23 February 2022

2022-02-23T09:06:59Z

← Older revision		Revision as of 09:06, 23 February 2022
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	<StructureSection load='2npy' size='340' side='right'caption='[[2npy]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2npy' size='340' side='right'caption='[[2npy]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2npy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2NPY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2npy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=S9L:2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL+DIHYDROGEN+PHOSPHATE'>S9L</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=S9L:2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL+DIHYDROGEN+PHOSPHATE'>S9L</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[2npz\|2npz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zfr\|1zfr]], [[2npz\|2npz]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [~~http~~://pdbe.org/2npy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2npy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2npy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [https://pdbe.org/2npy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [https://www.ebi.ac.uk/pdbsum/2npy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2npy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:34, 20 May 2020

2020-05-20T06:34:10Z

← Older revision		Revision as of 06:34, 20 May 2020
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	==Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1==		==Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1==
	<StructureSection load='2npy' size='340' side='right' caption='[[2npy]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2npy' size='340' side='right'caption='[[2npy]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2npy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NPY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2npy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2NPY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=S9L:2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL+DIHYDROGEN+PHOSPHATE'>S9L</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=S9L:2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL+DIHYDROGEN+PHOSPHATE'>S9L</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[2npz\|2npz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[2npz\|2npz]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [http://pdbe.org/2npy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [http://www.ebi.ac.uk/pdbsum/2npy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2npy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [http://pdbe.org/2npy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [http://www.ebi.ac.uk/pdbsum/2npy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2npy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Krucinska, J]]		[[Category: Krucinska, J]]
	[[Category: MacElrevey, C]]		[[Category: MacElrevey, C]]

OCA at 16:54, 15 August 2018

2018-08-15T16:54:24Z

← Older revision		Revision as of 16:54, 15 August 2018
Line 1:		Line 1:

	==Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1==		==Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1==
	<StructureSection load='2npy' size='340' side='right' caption='[[2npy]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2npy' size='340' side='right' caption='[[2npy]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[2npz\|2npz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[2npz\|2npz]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [http://pdbe.org/2npy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [http://www.ebi.ac.uk/pdbsum/2npy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [http://pdbe.org/2npy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [http://www.ebi.ac.uk/pdbsum/2npy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2npy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:35, 11 September 2015

2015-09-11T16:35:02Z

← Older revision		Revision as of 16:35, 11 September 2015
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[2npz\|2npz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[2npz\|2npz]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [http://www.ebi.ac.uk/pdbsum/2npy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [http://pdbe.org/2npy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [http://www.ebi.ac.uk/pdbsum/2npy PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2npy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:20, 19 January 2015

2015-01-19T13:20:02Z

← Older revision		Revision as of 13:20, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2npy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NPY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2npy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NPY FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=S9L:2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL+DIHYDROGEN+PHOSPHATE'>S9L</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=S9L:2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL+DIHYDROGEN+PHOSPHATE'>S9L</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[2npz\|2npz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[2npz\|2npz]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [http://www.ebi.ac.uk/pdbsum/2npy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [http://www.ebi.ac.uk/pdbsum/2npy PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Krucinska, J.]]		[[Category: Krucinska, J]]
	[[Category: MacElrevey, C.]]		[[Category: MacElrevey, C]]
	[[Category: Wedekind, J E.]]		[[Category: Wedekind, J E]]
	[[Category: 2'-deoxy 2'-amino]]		[[Category: 2'-deoxy 2'-amino]]
	[[Category: 9s linker]]		[[Category: 9s linker]]

OCA at 02:11, 29 September 2014

2014-09-29T02:11:16Z

← Older revision		Revision as of 02:11, 29 September 2014
Line 1:		Line 1:
	[[~~Image~~:~~2npy~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1==
			<StructureSection load='2npy' size='340' side='right' caption='[[2npy]], [[Resolution\|resolution]] 2.65Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2npy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NPY FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=S9L:2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL+DIHYDROGEN+PHOSPHATE'>S9L</scene><br>
			<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AU:2-AMINOURIDINE'>2AU</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[2npz\|2npz]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2npy RCSB], [http://www.ebi.ac.uk/pdbsum/2npy PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The hairpin ribozyme is a small catalytic RNA comprising two helix-loop-helix domains linked by a four-way helical junction (4WJ). In its most basic form, each domain can be formed independently and reconstituted without a 4WJ to yield an active enzyme. The production of such minimal junctionless hairpin ribozymes is achievable by chemical synthesis, which has allowed structures to be determined for numerous nucleotide variants. However, abasic and other destabilizing core modifications hinder crystallization. This investigation describes the use of a dangling 5'-U to form an intermolecular U.U mismatch, as well as the use of synthetic linkers to tether the loop A and B domains, including (i) a three-carbon propyl linker (C3L) and (ii) a nine-atom triethylene glycol linker (S9L). Both linker constructs demonstrated similar enzymatic activity, but S9L constructs yielded crystals that diffracted to 2.65 A resolution or better. In contrast, C3L variants diffracted to 3.35 A and exhibited a 15 A expansion of the c axis. Crystal packing of the C3L construct showed a paucity of 6(1) contacts, which comprise numerous backbone to 2'-OH hydrogen bonds in junctionless and S9L complexes. Significantly, the crystal packing in minimal structures mimics stabilizing features observed in the 4WJ hairpin ribozyme structure. The results demonstrate how knowledge-based design can be used to improve diffraction and overcome otherwise destabilizing defects.

	~~{{STRUCTURE_2npy\| PDB=2npy \| SCENE= }}~~		A posteriori design of crystal contacts to improve the X-ray diffraction properties of a small RNA enzyme.,MacElrevey C, Spitale RC, Krucinska J, Wedekind JE Acta Crystallogr D Biol Crystallogr. 2007 Jul;63(Pt 7):812-25. Epub 2007, Jun 15. PMID:17582172<ref>PMID:17582172</ref>

	~~===Crystal Structure~~ of ~~a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino~~ U ~~at A-1===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17582172}}~~

	~~==About this Structure==~~
	~~[[2npy]] is a 4 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il/oca-bin~~/~~ocashort?id=2NPY OCA].~~

	==See Also==		==See Also==
	*[[Ribozyme\|Ribozyme]]		*[[Ribozyme\|Ribozyme]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017582172<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Krucinska, J.]]		[[Category: Krucinska, J.]]
	[[Category: MacElrevey, C.]]		[[Category: MacElrevey, C.]]

OCA at 20:19, 20 October 2012

2012-10-20T20:19:56Z

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	==About this Structure==		==About this Structure==
	[[2npy]] is a 4 chain structure ~~of [[Ribozyme]]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA].		[[2npy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPY OCA].

	==See Also==		==See Also==

OCA at 10:07, 27 July 2012

2012-07-27T10:07:13Z

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	[[Image:2npy.png\|left\|200px]]		[[Image:2npy.png\|left\|200px]]

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	{{STRUCTURE_2npy\| PDB=2npy \| SCENE= }}		{{STRUCTURE_2npy\| PDB=2npy \| SCENE= }}

	===Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1===		===Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1===


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	==See Also==		==See Also==
	*[[Ribozyme]]		*[[Ribozyme\|Ribozyme]]

	==Reference==		==Reference==

OCA: Protected "2npy" [edit=sysop:move=sysop]

2011-08-17T06:38:28Z

Protected "2npy" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:38, 17 August 2011
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