2ntd - Revision history

OCA at 10:20, 30 August 2023

2023-08-30T10:20:14Z

← Older revision		Revision as of 10:20, 30 August 2023
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	<StructureSection load='2ntd' size='340' side='right'caption='[[2ntd]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2ntd' size='340' side='right'caption='[[2ntd]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ntd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ntd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTD FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.52Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1jy0\|1jy0]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~FGF1, FGFA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [https://pdbe.org/2ntd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [https://www.ebi.ac.uk/pdbsum/2ntd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [https://pdbe.org/2ntd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [https://www.ebi.ac.uk/pdbsum/2ntd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>		[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blaber, M]]		[[Category: Blaber M]]
	[[Category: Dubey~~, V K]]~~		[[Category: Dubey VK]]
	~~[[Category: Beta-trefoil]]~~
	~~[[Category: Hormone-growth factor complex~~]]

OCA at 15:50, 8 June 2021

2021-06-08T15:50:34Z

← Older revision		Revision as of 15:50, 8 June 2021
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	==Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations==		==Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations==
	<StructureSection load='2ntd' size='340' side='right' caption='[[2ntd]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2ntd' size='340' side='right'caption='[[2ntd]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ntd]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NTD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ntd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy0\|1jy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jy0\|1jy0]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [~~http~~://pdbe.org/2ntd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ntd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [https://pdbe.org/2ntd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [https://www.ebi.ac.uk/pdbsum/2ntd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>		[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Fibroblast growth factor\|Fibroblast growth factor]]		*[[Fibroblast growth factor 3D structures\|Fibroblast growth factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Dubey, V K]]		[[Category: Dubey, V K]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]

OCA at 17:23, 15 August 2018

2018-08-15T17:23:34Z

← Older revision		Revision as of 17:23, 15 August 2018
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	==Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations==		==Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations==
	<StructureSection load='2ntd' size='340' side='right' caption='[[2ntd]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2ntd' size='340' side='right' caption='[[2ntd]], [[Resolution\|resolution]] 2.52Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy0\|1jy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy0\|1jy0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [http://pdbe.org/2ntd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [http://www.ebi.ac.uk/pdbsum/2ntd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [http://pdbe.org/2ntd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [http://www.ebi.ac.uk/pdbsum/2ntd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2ntd_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2ntd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ntd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:26, 11 September 2015

2015-09-11T22:26:04Z

← Older revision		Revision as of 22:26, 11 September 2015
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	<StructureSection load='2ntd' size='340' side='right' caption='[[2ntd]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2ntd' size='340' side='right' caption='[[2ntd]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ntd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ntd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy0\|1jy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy0\|1jy0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [http://www.ebi.ac.uk/pdbsum/2ntd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [http://pdbe.org/2ntd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [http://www.ebi.ac.uk/pdbsum/2ntd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ntd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Dubey, V K]]		[[Category: Dubey, V K]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]

OCA at 20:17, 25 December 2014

2014-12-25T20:17:09Z

← Older revision		Revision as of 20:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ntd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ntd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTD FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy0\|1jy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy0\|1jy0]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [http://www.ebi.ac.uk/pdbsum/2ntd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [http://www.ebi.ac.uk/pdbsum/2ntd PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M]]
	[[Category: Dubey, V K.]]		[[Category: Dubey, V K]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]

OCA at 19:33, 30 September 2014

2014-09-30T19:33:24Z

← Older revision		Revision as of 19:33, 30 September 2014
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	[[Image:~~2ntd~~.~~png~~\|~~left~~\|~~200px~~]]		==Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations==
			<StructureSection load='2ntd' size='340' side='right' caption='[[2ntd]], [[Resolution\|resolution]] 2.52Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ntd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTD FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy0\|1jy0]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ntd RCSB], [http://www.ebi.ac.uk/pdbsum/2ntd PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2ntd_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The beta-trefoil protein human fibroblast growth factor-1 (FGF-1) is made up of a six-stranded antiparallel beta-barrel closed off on one end by three beta-hairpins, thus exhibiting a 3-fold axis of structural symmetry. The N and C terminus beta-strands hydrogen bond to each other and their interaction is postulated from both NMR and X-ray structure data to be important in folding and stability. Specific mutations within the adjacent N and C terminus beta-strands of FGF-1 are shown to provide a substantial increase in stability. This increase is largely correlated with an increased folding rate constant, and with a smaller but significant decrease in the unfolding rate constant. A series of stabilizing mutations are subsequently combined and result in a doubling of the DeltaG value of unfolding. When taken in the context of previous studies of stabilizing mutations, the results indicate that although FGF-1 is known for generally poor thermal stability, the beta-trefoil architecture appears capable of substantial thermal stability. Targeting stabilizing mutations within the N and C terminus beta-strand interactions of a beta-barrel architecture may be a generally useful approach to increase protein stability. Such stabilized mutations of FGF-1 are shown to exhibit significant increases in effective mitogenic potency, and may prove useful as "second generation" forms of FGF-1 for application in angiogenic therapy.

	~~{{STRUCTURE_2ntd\| PDB=2ntd \| SCENE= }}~~		Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions.,Dubey VK, Lee J, Somasundaram T, Blaber S, Blaber M J Mol Biol. 2007 Aug 3;371(1):256-68. Epub 2007 May 31. PMID:17570396<ref>PMID:17570396</ref>

	~~===Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val~~/~~Pro134Cys mutations===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_17570396}}~~		==See Also==
			*[[Fibroblast growth factor\|Fibroblast growth factor]]
	==~~About this Structure~~==		== References ==
	[[~~2ntd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:017570396<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]

OCA: Protected "2ntd" [edit=sysop:move=sysop]

2013-01-07T11:55:17Z

Protected "2ntd" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:55, 7 January 2013
(No difference)

OCA at 11:55, 7 January 2013

2013-01-07T11:55:15Z

← Older revision		Revision as of 11:55, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2ntd.png\|left\|200px]]		[[Image:2ntd.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ntd", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ntd\| PDB=2ntd \| SCENE= }}		{{STRUCTURE_2ntd\| PDB=2ntd \| SCENE= }}

	===Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations===		===Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17570396}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17570396 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17570396}}		{{ABSTRACT_PUBMED_17570396}}

	==About this Structure==		==About this Structure==
	~~2NTD~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA].		[[2ntd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17570396~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017570396</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]
	[[Category: Dubey, V K.]]		[[Category: Dubey, V K.]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
			[[Category: Hormone-growth factor complex]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 05:54:50 2009''~~

OCA at 03:54, 18 February 2009

2009-02-18T03:54:52Z

← Older revision		Revision as of 03:54, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2NTD is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA].		2NTD is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTD OCA].

	==Reference==		==Reference==
	Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions., Dubey VK, Lee J, Somasundaram T, Blaber S, Blaber M, J Mol Biol. 2007 Aug 3;371(1):256-68. Epub 2007 May 31. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~17570396 17570396]~~		<ref group="xtra">PMID:17570396</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]
	[[Category: Dubey, V K.]]		[[Category: Dubey, V K.]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 12~~:39:~~09 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:54:50 2009''

OCA at 09:39, 29 July 2008

2008-07-29T09:39:11Z

← Older revision		Revision as of 09:39, 29 July 2008
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	[[Image:2ntd.~~jpg~~\|left\|200px]]		{{Seed}}
			[[Image:2ntd.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2ntd\| PDB=2ntd \| SCENE= }}		{{STRUCTURE_2ntd\| PDB=2ntd \| SCENE= }}

	~~'''~~Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations~~'''~~		===Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations===


	~~==Overview==~~		<!--
	The ~~beta-trefoil protein human fibroblast growth factor-1 (FGF-1) is made up of a six-stranded antiparallel beta-barrel closed off on one end by three beta-hairpins~~, thus exhibiting a 3-fold axis of structural symmetry. The N and C terminus beta-strands hydrogen bond to each other and their interaction is postulated from both NMR and X-ray structure data to be important in folding and stability. Specific mutations within the ~~adjacent N and C terminus beta-strands of FGF-1 are shown~~ to ~~provide a substantial increase in stability. This increase is largely correlated with an increased folding rate constant, and with a smaller but significant decrease in~~ the ~~unfolding rate constant~~. ~~A series of stabilizing mutations are subsequently combined and result in a doubling of the DeltaG value of unfolding~~. ~~When taken in the context of previous studies of stabilizing mutations~~, ~~the results indicate that although FGF-1~~ is ~~known for generally poor thermal stability,~~ the ~~beta-trefoil architecture appears capable of substantial thermal stability~~. ~~Targeting stabilizing mutations within the N and C terminus beta~~-~~strand interactions of a beta~~-barrel architecture may be a generally useful approach to increase protein stability. Such stabilized mutations of FGF-1 are shown to exhibit significant increases in effective mitogenic potency, and may prove useful as "second generation" forms of FGF-1 for application in angiogenic therapy.		The line below this paragraph, {{ABSTRACT_PUBMED_17570396}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 17570396 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_17570396}}

	==About this Structure==		==About this Structure==
Line 25:		Line 29:
	[[Category: Dubey, V K.]]		[[Category: Dubey, V K.]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 09~~:53:21 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:39:09 2008''