2o7k - Revision history

OCA at 09:22, 6 November 2024

2024-11-06T09:22:48Z

← Older revision		Revision as of 09:22, 6 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/2o7k_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/2o7k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 00:15, 28 December 2023

2023-12-28T00:15:19Z

← Older revision		Revision as of 00:15, 28 December 2023
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	<StructureSection load='2o7k' size='340' side='right'caption='[[2o7k]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2o7k' size='340' side='right'caption='[[2o7k]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2o7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O7K FirstGlance]. <br>		<table><tr><td colspan='2'>[[2o7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O7K FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2o85\|2o85]], [[2o87\|2o87]], [[2o89\|2o89]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">trxA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax~~.~~cgi?mode=Info~~&~~srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [https://pdbe.org/2o7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [https://www.ebi.ac.uk/pdbsum/2o7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o7k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [https://pdbe.org/2o7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [https://www.ebi.ac.uk/pdbsum/2o7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o7k ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/THIO_STAAU THIO_STAAU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Belle, K Van~~]]		[[Category: Staphylococcus aureus]]
	[[Category: Brosens, E]]		[[Category: Brosens E]]
	[[Category: Garcia-Pino, A]]		[[Category: Garcia-Pino A]]
	[[Category: Loris, R]]		[[Category: Loris R]]
	[[Category: Messens, J]]		[[Category: Messens J]]
	[[Category: Roos, G]]		[[Category: Roos G]]
	[[Category: ~~Vandenbussche, G]]~~		[[Category: Van Belle K]]
	~~[[Category: Wahni,~~ K]]		[[Category: Vandenbussche G]]
	[[Category: ~~Wyns, L~~]]		[[Category: Wahni K]]
	[[Category: ~~Electron transport~~]]		[[Category: Wyns L]]
	[[Category: ~~Oxidoreductase]]~~
	~~[[Category: Redox enzymology]]~~
	~~[[Category: Thioredoxin~~]]

OCA at 16:02, 8 June 2021

2021-06-08T16:02:14Z

← Older revision		Revision as of 16:02, 8 June 2021
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	==S. aureus thioredoxin==		==S. aureus thioredoxin==
	<StructureSection load='2o7k' size='340' side='right' caption='[[2o7k]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2o7k' size='340' side='right'caption='[[2o7k]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2o7k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2O7K FirstGlance]. <br>		<table><tr><td colspan='2'>[[2o7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O7K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o85\|2o85]], [[2o87\|2o87]], [[2o89\|2o89]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2o85\|2o85]], [[2o87\|2o87]], [[2o89\|2o89]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [~~http~~://pdbe.org/2o7k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2o7k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2o7k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [https://pdbe.org/2o7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [https://www.ebi.ac.uk/pdbsum/2o7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o7k ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/2o7k_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/2o7k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2o7k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2o7k" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Thioredoxin 3D structures\|Thioredoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Belle, K Van]]		[[Category: Belle, K Van]]
	[[Category: Brosens, E]]		[[Category: Brosens, E]]

OCA at 08:53, 18 October 2017

2017-10-18T08:53:25Z

← Older revision		Revision as of 08:53, 18 October 2017
Line 1:		Line 1:

	==S. aureus thioredoxin==		==S. aureus thioredoxin==
	<StructureSection load='2o7k' size='340' side='right' caption='[[2o7k]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2o7k' size='340' side='right' caption='[[2o7k]], [[Resolution\|resolution]] 2.20Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o85\|2o85]], [[2o87\|2o87]], [[2o89\|2o89]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o85\|2o85]], [[2o87\|2o87]], [[2o89\|2o89]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [http://pdbe.org/2o7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [http://www.ebi.ac.uk/pdbsum/2o7k PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [http://pdbe.org/2o7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [http://www.ebi.ac.uk/pdbsum/2o7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o7k ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2o7k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2o7k" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Thioredoxin\|Thioredoxin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:46, 8 February 2016

2016-02-08T16:46:40Z

← Older revision		Revision as of 16:46, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o7k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:32, 10 September 2015

2015-09-10T13:32:17Z

← Older revision		Revision as of 13:32, 10 September 2015
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	<StructureSection load='2o7k' size='340' side='right' caption='[[2o7k]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2o7k' size='340' side='right' caption='[[2o7k]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2o7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O7K FirstGlance]. <br>		<table><tr><td colspan='2'>[[2o7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O7K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o85\|2o85]], [[2o87\|2o87]], [[2o89\|2o89]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o85\|2o85]], [[2o87\|2o87]], [[2o89\|2o89]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 ~~Staphylococcus~~ aureus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [http://www.ebi.ac.uk/pdbsum/2o7k PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [http://pdbe.org/2o7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [http://www.ebi.ac.uk/pdbsum/2o7k PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2o7k" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Staphylococcus aureus]]~~
	[[Category: Belle, K Van]]		[[Category: Belle, K Van]]
	[[Category: Brosens, E]]		[[Category: Brosens, E]]

OCA at 00:46, 25 December 2014

2014-12-25T00:46:24Z

← Older revision		Revision as of 00:46, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2o7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O7K FirstGlance]. <br>		<table><tr><td colspan='2'>[[2o7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O7K FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o85\|2o85]], [[2o87\|2o87]], [[2o89\|2o89]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o85\|2o85]], [[2o87\|2o87]], [[2o89\|2o89]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [http://www.ebi.ac.uk/pdbsum/2o7k PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [http://www.ebi.ac.uk/pdbsum/2o7k PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Belle, K Van.]]		[[Category: Belle, K Van]]
	[[Category: Brosens, E.]]		[[Category: Brosens, E]]
	[[Category: Garcia-Pino, A.]]		[[Category: Garcia-Pino, A]]
	[[Category: Loris, R.]]		[[Category: Loris, R]]
	[[Category: Messens, J.]]		[[Category: Messens, J]]
	[[Category: Roos, G.]]		[[Category: Roos, G]]
	[[Category: Vandenbussche, G.]]		[[Category: Vandenbussche, G]]
	[[Category: Wahni, K.]]		[[Category: Wahni, K]]
	[[Category: Wyns, L.]]		[[Category: Wyns, L]]
	[[Category: Electron transport]]		[[Category: Electron transport]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Redox enzymology]]		[[Category: Redox enzymology]]
	[[Category: Thioredoxin]]		[[Category: Thioredoxin]]

OCA at 04:38, 29 September 2014

2014-09-29T04:38:27Z

← Older revision		Revision as of 04:38, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2o7k~~.~~png~~\|~~left~~\|~~200px~~]]		==S. aureus thioredoxin==
			<StructureSection load='2o7k' size='340' side='right' caption='[[2o7k]], [[Resolution\|resolution]] 2.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2o7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O7K FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o85\|2o85]], [[2o87\|2o87]], [[2o89\|2o89]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o7k RCSB], [http://www.ebi.ac.uk/pdbsum/2o7k PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/2o7k_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Nature uses thioredoxin-like folds in several disulfide bond oxidoreductases. Each of them has a typical active site Cys-X-X-Cys sequence motif, the hallmark of thioredoxin being Trp-Cys-Gly-Pro-Cys. The intriguing role of the highly conserved proline in the ubiquitous reducing agent thioredoxin was studied by site-specific mutagenesis of Staphylococcus aureus thioredoxin (Sa_Trx). We present X-ray structures, redox potential, pK(a), steady-state kinetic parameters, and thermodynamic stabilities. By replacing the central proline to a threonine/serine, no extra hydrogen bonds with the sulphur of the nucleophilic cysteine are introduced. The only structural difference is that the immediate chemical surrounding of the nucleophilic cysteine becomes more hydrophilic. The pK(a) value of the nucleophilic cysteine decreases with approximately one pH unit and its redox potential increases with 30 mV. Thioredoxin becomes more oxidizing and the efficiency to catalyse substrate reduction (k(cat)/K(M)) decreases sevenfold relative to wild-type Sa_Trx. The oxidized form of wild-type Sa_Trx is far more stable than the reduced form over the whole temperature range. The driving force to reduce substrate proteins is the relative stability of the oxidized versus the reduced form Delta(T(1/2))(ox/red). This driving force is decreased in the Sa_Trx P31T mutant. Delta(T(1/2))(ox/red) drops from 15.5 degrees C (wild-type) to 5.8 degrees C (P31T mutant). In conclusion, the active site proline in thioredoxin determines the driving potential for substrate reduction.

	~~{{STRUCTURE_2o7k\| PDB=2o7k \| SCENE= }}~~		The conserved active site proline determines the reducing power of Staphylococcus aureus thioredoxin.,Roos G, Garcia-Pino A, Van Belle K, Brosens E, Wahni K, Vandenbussche G, Wyns L, Loris R, Messens J J Mol Biol. 2007 May 4;368(3):800-11. Epub 2007 Feb 22. PMID:17368484<ref>PMID:17368484</ref>

	~~===S. aureus thioredoxin===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17368484}}~~

	~~==About this Structure==~~
	~~[[2o7k]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2O7K OCA].~~

	==See Also==		==See Also==
	*[[Thioredoxin\|Thioredoxin]]		*[[Thioredoxin\|Thioredoxin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017368484<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Belle, K Van.]]		[[Category: Belle, K Van.]]

OCA at 10:47, 20 October 2012

2012-10-20T10:47:57Z

← Older revision		Revision as of 10:47, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2o7k]] is a 1 chain structure ~~of [[Thioredoxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA].		[[2o7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O7K OCA].

	==See Also==		==See Also==

OCA at 03:18, 26 July 2012

2012-07-26T03:18:01Z

← Older revision		Revision as of 03:18, 26 July 2012
Line 1:		Line 1:
	[[Image:2o7k.png\|left\|200px]]		[[Image:2o7k.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2o7k", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2o7k\| PDB=2o7k \| SCENE= }}		{{STRUCTURE_2o7k\| PDB=2o7k \| SCENE= }}

	===S. aureus thioredoxin===		===S. aureus thioredoxin===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17368484}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17368484 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17368484}}		{{ABSTRACT_PUBMED_17368484}}

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	==See Also==		==See Also==
	*[[Thioredoxin]]		*[[Thioredoxin\|Thioredoxin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17368484~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017368484</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Belle, K Van.]]		[[Category: Belle, K Van.]]