2oho - Revision history

OCA at 08:57, 25 October 2023

2023-10-25T08:57:31Z

← Older revision		Revision as of 08:57, 25 October 2023
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	<StructureSection load='2oho' size='340' side='right'caption='[[2oho]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2oho' size='340' side='right'caption='[[2oho]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oho]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Streptococcus_pyogenes_(serotype_1_/_m1_gas)~~ Streptococcus pyogenes ~~(serotype 1 / m1 gas)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OHO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oho]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_M1_GAS Streptococcus pyogenes M1 GAS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OHO FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
	~~<tr id='related'><td class="sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1b73\|1b73]]~~, [[~~1zuw~~\|~~1zuw]], [[2ohg\|2ohg]], [[2ohv\|2ohv~~]]~~</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>murI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~160490 Streptococcus pyogenes (serotype 1 / M1 GAS)])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [https://pdbe.org/2oho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [https://www.ebi.ac.uk/pdbsum/2oho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oho ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [https://pdbe.org/2oho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [https://www.ebi.ac.uk/pdbsum/2oho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oho ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MURI_STRP1 MURI_STRP1]] Provides the (R)-glutamate required for cell wall biosynthesis (By similarity).		[https://www.uniprot.org/uniprot/MURI_STRP1 MURI_STRP1] Provides the (R)-glutamate required for cell wall biosynthesis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Glutamate racemase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Kim, E E~~]]		[[Category: Streptococcus pyogenes M1 GAS]]
	[[Category: ~~Isomerase]]~~		[[Category: Kim EE]]
	~~[[Category: Racemase~~]]

OCA at 12:56, 9 June 2021

2021-06-09T12:56:51Z

← Older revision		Revision as of 12:56, 9 June 2021
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	==Structural Basis for Glutamate Racemase Inhibitor==		==Structural Basis for Glutamate Racemase Inhibitor==
	<StructureSection load='2oho' size='340' side='right' caption='[[2oho]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2oho' size='340' side='right'caption='[[2oho]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oho]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Streptococcus_pyogenes_(serotype_1_/_m1_gas) Streptococcus pyogenes (serotype 1 / m1 gas)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OHO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oho]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_(serotype_1_/_m1_gas) Streptococcus pyogenes (serotype 1 / m1 gas)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OHO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b73\|1b73]], [[1zuw\|1zuw]], [[2ohg\|2ohg]], [[2ohv\|2ohv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1b73\|1b73]], [[1zuw\|1zuw]], [[2ohg\|2ohg]], [[2ohv\|2ohv]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murI ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes (serotype 1 / M1 GAS)])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes (serotype 1 / M1 GAS)])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [~~http~~://pdbe.org/2oho PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2oho PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2oho ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [https://pdbe.org/2oho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [https://www.ebi.ac.uk/pdbsum/2oho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oho ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MURI_STRP1 MURI_STRP1]] Provides the (R)-glutamate required for cell wall biosynthesis (By similarity).		[[https://www.uniprot.org/uniprot/MURI_STRP1 MURI_STRP1]] Provides the (R)-glutamate required for cell wall biosynthesis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Glutamate racemase\|Glutamate racemase]]		*[[Glutamate racemase 3D structures\|Glutamate racemase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Glutamate racemase]]		[[Category: Glutamate racemase]]
			[[Category: Large Structures]]
	[[Category: Kim, E E]]		[[Category: Kim, E E]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Racemase]]		[[Category: Racemase]]

OCA at 07:20, 22 August 2018

2018-08-22T07:20:22Z

← Older revision		Revision as of 07:20, 22 August 2018
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	==Structural Basis for Glutamate Racemase Inhibitor==		==Structural Basis for Glutamate Racemase Inhibitor==
	<StructureSection load='2oho' size='340' side='right' caption='[[2oho]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2oho' size='340' side='right' caption='[[2oho]], [[Resolution\|resolution]] 2.25Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes (serotype 1 / M1 GAS)])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes (serotype 1 / M1 GAS)])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [http://pdbe.org/2oho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [http://www.ebi.ac.uk/pdbsum/2oho PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [http://pdbe.org/2oho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [http://www.ebi.ac.uk/pdbsum/2oho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2oho ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oh/2oho_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oh/2oho_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:02, 9 February 2016

2016-02-09T10:02:39Z

← Older revision		Revision as of 10:02, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oho ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:08, 10 September 2015

2015-09-10T21:08:25Z

← Older revision		Revision as of 21:08, 10 September 2015
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	<StructureSection load='2oho' size='340' side='right' caption='[[2oho]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2oho' size='340' side='right' caption='[[2oho]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oho]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pyogenes_m1_gas~~ Streptococcus pyogenes m1 gas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OHO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oho]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_(serotype_1_/_m1_gas) Streptococcus pyogenes (serotype 1 / m1 gas)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OHO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b73\|1b73]], [[1zuw\|1zuw]], [[2ohg\|2ohg]], [[2ohv\|2ohv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b73\|1b73]], [[1zuw\|1zuw]], [[2ohg\|2ohg]], [[2ohv\|2ohv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes M1 GAS])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes (serotype 1 / M1 GAS)])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [http://www.ebi.ac.uk/pdbsum/2oho PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [http://pdbe.org/2oho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [http://www.ebi.ac.uk/pdbsum/2oho PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2oho" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: Glutamate racemase]]		[[Category: Glutamate racemase]]
	~~[[Category: Streptococcus pyogenes m1 gas]]~~
	[[Category: Kim, E E]]		[[Category: Kim, E E]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Racemase]]		[[Category: Racemase]]

OCA at 06:08, 25 December 2014

2014-12-25T06:08:16Z

← Older revision		Revision as of 06:08, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oho]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_m1_gas Streptococcus pyogenes m1 gas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OHO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oho]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_m1_gas Streptococcus pyogenes m1 gas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OHO FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b73\|1b73]], [[1zuw\|1zuw]], [[2ohg\|2ohg]], [[2ohv\|2ohv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b73\|1b73]], [[1zuw\|1zuw]], [[2ohg\|2ohg]], [[2ohv\|2ohv]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes M1 GAS])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes M1 GAS])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [http://www.ebi.ac.uk/pdbsum/2oho PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [http://www.ebi.ac.uk/pdbsum/2oho PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MURI_STRP1 MURI_STRP1]] Provides the (R)-glutamate required for cell wall biosynthesis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Glutamate racemase]]		[[Category: Glutamate racemase]]
	[[Category: Streptococcus pyogenes m1 gas]]		[[Category: Streptococcus pyogenes m1 gas]]
	[[Category: Kim, E E.]]		[[Category: Kim, E E]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Racemase]]		[[Category: Racemase]]

OCA at 19:33, 30 September 2014

2014-09-30T19:33:36Z

← Older revision		Revision as of 19:33, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2oho~~.~~png~~\|~~left~~\|~~200px~~]]		==Structural Basis for Glutamate Racemase Inhibitor==
			<StructureSection load='2oho' size='340' side='right' caption='[[2oho]], [[Resolution\|resolution]] 2.25Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2oho]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_m1_gas Streptococcus pyogenes m1 gas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OHO FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b73\|1b73]], [[1zuw\|1zuw]], [[2ohg\|2ohg]], [[2ohv\|2ohv]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes M1 GAS])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oho RCSB], [http://www.ebi.ac.uk/pdbsum/2oho PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oh/2oho_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			D-Glutamic acid is a required biosynthetic building block for peptidoglycan, and the enzyme glutamate racemase (GluR) catalyzes the inter-conversion of D and L-glutamate enantiomers. Therefore, GluR is considered as an attractive target for the design of new antibacterial drugs. Here, we report the crystal structures of GluR from Streptococcus pyogenes in both inhibitor-free and inhibitor-bound forms. The inhibitor free GluR crystallized in two different forms, which diffracted to 2.25 A and 2.5 A resolution, while the inhibitor-bound crystal diffracted to 2.5 A resolution. GluR is composed of two domains of alpha/beta protein that are related by pseudo-2-fold symmetry and the active site is located at the domain interface. The inhibitor, gamma-2-naphthylmethyl-D-glutamate, which was reported earlier as a novel potent competitive inhibitor, makes several hydrogen bonds with protein atoms, and the naphthyl moiety is located in the hydrophobic pocket. The inhibitor binding induces a disorder in one of the loops near the active site. In both crystal forms, GluR exists as a dimer and the interactions seen at the dimer interface are almost identical. This agrees well with the results from gel filtration and dynamic light-scattering studies.

	~~{{STRUCTURE_2oho\| PDB=2oho \| SCENE= }}~~		Structural basis for glutamate racemase inhibition.,Kim KH, Bong YJ, Park JK, Shin KJ, Hwang KY, Kim EE J Mol Biol. 2007 Sep 14;372(2):434-43. Epub 2007 May 10. PMID:17658548<ref>PMID:17658548</ref>

	~~===Structural Basis for Glutamate Racemase Inhibitor===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_17658548}}~~		==See Also==
			*[[Glutamate racemase\|Glutamate racemase]]
	==~~About this Structure~~==		== References ==
	[[~~2oho]~~] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_m1_gas Streptococcus pyogenes m1 gas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:017658548<~~/~~ref~~><~~ref group="xtra">PMID:017315856</ref><references group="xtra"~~/>
	[[Category: Glutamate racemase]]		[[Category: Glutamate racemase]]
	[[Category: Streptococcus pyogenes m1 gas]]		[[Category: Streptococcus pyogenes m1 gas]]

OCA: Protected "2oho" [edit=sysop:move=sysop]

2013-01-07T14:34:37Z

Protected "2oho" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:34, 7 January 2013
(No difference)

OCA at 14:34, 7 January 2013

2013-01-07T14:34:34Z

← Older revision		Revision as of 14:34, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2oho.png\|left\|200px]]		[[Image:2oho.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2oho", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2oho\| PDB=2oho \| SCENE= }}		{{STRUCTURE_2oho\| PDB=2oho \| SCENE= }}

	===Structural Basis for Glutamate Racemase Inhibitor===		===Structural Basis for Glutamate Racemase Inhibitor===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17658548}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17658548 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17658548}}		{{ABSTRACT_PUBMED_17658548}}

	==About this Structure==		==About this Structure==
	~~2OHO~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Streptococcus_pyogenes~~ Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA].		[[2oho]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_m1_gas Streptococcus pyogenes m1 gas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17658548~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017658548</ref><ref group="xtra">PMID:017315856</ref><references group="xtra"/>
	[[Category: Glutamate racemase]]		[[Category: Glutamate racemase]]
	[[Category: Streptococcus pyogenes]]		[[Category: Streptococcus pyogenes m1 gas]]
	[[Category: Kim, E E.]]		[[Category: Kim, E E.]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Racemase]]		[[Category: Racemase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:59:23 2009''~~

OCA at 06:59, 17 February 2009

2009-02-17T06:59:24Z

← Older revision		Revision as of 06:59, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2OHO is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA].		2OHO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHO OCA].

	==Reference==		==Reference==
	~~Structural basis for glutamate racemase inhibition., Kim KH, Bong YJ, Park JK, Shin KJ, Hwang KY, Kim EE, J Mol Biol. 2007 Sep 14;372(2):434-43. Epub 2007 May 10.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17658548 17658548]~~		<ref group="xtra">PMID:17658548</ref><references group="xtra"/>
	[[Category: Glutamate racemase]]		[[Category: Glutamate racemase]]
	~~[[Category: Single protein]]~~
	[[Category: Streptococcus pyogenes]]		[[Category: Streptococcus pyogenes]]
	[[Category: Kim, E E.]]		[[Category: Kim, E E.]]
Line 31:		Line 30:
	[[Category: Racemase]]		[[Category: Racemase]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 12~~:27:~~03 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:59:23 2009''