2oit - Revision history

OCA at 00:19, 28 December 2023

2023-12-28T00:19:18Z

← Older revision		Revision as of 00:19, 28 December 2023
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	<StructureSection load='2oit' size='340' side='right'caption='[[2oit]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2oit' size='340' side='right'caption='[[2oit]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIT FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MES:2~~-~~(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~NUP214 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]~~)</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [https://pdbe.org/2oit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [https://www.ebi.ac.uk/pdbsum/2oit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oit ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [https://pdbe.org/2oit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [https://www.ebi.ac.uk/pdbsum/2oit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oit ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.		[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.		[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blobel, G]]		[[Category: Blobel G]]
	[[Category: Hoelz, A]]		[[Category: Hoelz A]]
	[[Category: Napetschnig, J]]		[[Category: Napetschnig J]]
	~~[[Category: Beta-propeller]]~~
	~~[[Category: Dbp5/ddx19]]~~
	~~[[Category: Leukemia]]~~
	~~[[Category: Mrna export]]~~
	~~[[Category: Nh2 terminal domain of nup214/can]]~~
	~~[[Category: Npc assembly]]~~
	~~[[Category: Nup214/can fusion]]~~
	~~[[Category: Oncoprotein~~]]

OCA at 12:57, 9 June 2021

2021-06-09T12:57:41Z

← Older revision		Revision as of 12:57, 9 June 2021
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	==Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN==		==Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN==
	<StructureSection load='2oit' size='340' side='right' caption='[[2oit]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2oit' size='340' side='right'caption='[[2oit]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oit]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [~~http~~://pdbe.org/2oit PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2oit PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2oit ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [https://pdbe.org/2oit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [https://www.ebi.ac.uk/pdbsum/2oit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oit ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.		[[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.		[[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/2oit_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/2oit_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2oit" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2oit" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Nucleoporin 3D structures\|Nucleoporin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Blobel, G]]		[[Category: Blobel, G]]
	[[Category: Hoelz, A]]		[[Category: Hoelz, A]]

OCA at 09:01, 18 October 2017

2017-10-18T09:01:54Z

← Older revision		Revision as of 09:01, 18 October 2017
Line 1:		Line 1:

	==Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN==		==Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN==
	<StructureSection load='2oit' size='340' side='right' caption='[[2oit]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2oit' size='340' side='right' caption='[[2oit]], [[Resolution\|resolution]] 1.65Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [http://pdbe.org/2oit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [http://www.ebi.ac.uk/pdbsum/2oit PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [http://pdbe.org/2oit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [http://www.ebi.ac.uk/pdbsum/2oit PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2oit ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oit ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2oit" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2oit" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Nucleoporin\|Nucleoporin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:47, 11 September 2015

2015-09-11T10:47:32Z

← Older revision		Revision as of 10:47, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2oit' size='340' side='right' caption='[[2oit]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2oit' size='340' side='right' caption='[[2oit]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OIT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [http://www.ebi.ac.uk/pdbsum/2oit PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [http://pdbe.org/2oit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [http://www.ebi.ac.uk/pdbsum/2oit PDBsum]</span></td></tr>
	</table>		</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
			== Function ==
			[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2oit" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Blobel, G]]		[[Category: Blobel, G]]
	[[Category: Hoelz, A]]		[[Category: Hoelz, A]]

OCA at 13:48, 19 January 2015

2015-01-19T13:48:26Z

← Older revision		Revision as of 13:48, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OIT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [http://www.ebi.ac.uk/pdbsum/2oit PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [http://www.ebi.ac.uk/pdbsum/2oit PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blobel, G.]]		[[Category: Blobel, G]]
	[[Category: Hoelz, A.]]		[[Category: Hoelz, A]]
	[[Category: Napetschnig, J.]]		[[Category: Napetschnig, J]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Dbp5/ddx19]]		[[Category: Dbp5/ddx19]]

OCA at 18:16, 30 September 2014

2014-09-30T18:16:25Z

← Older revision		Revision as of 18:16, 30 September 2014
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	~~{{STRUCTURE_2oit\| PDB=2oit \| SCENE= }}~~		==Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN==
	===Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN===		<StructureSection load='2oit' size='340' side='right' caption='[[2oit]], [[Resolution\|resolution]] 1.65Å' scene=''>
	~~{{ABSTRACT_PUBMED_17264208}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2oit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OIT FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [http://www.ebi.ac.uk/pdbsum/2oit PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/2oit_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The mammalian nuclear pore complex (NPC) is an approximately 120-MDa proteinaceous assembly consisting of approximately 30 proteins and is the sole gate in the nuclear envelope. The human protooncogene Nup214 was first identified as a target for chromosomal translocation involved in leukemogenesis. Nup214 is located on the cytoplasmic face of the NPC and is implicated in anchoring the cytoplasmic filaments of the NPC and recruiting the RNA helicase Ddx19. Here, we present the crystal structure of the human Nup214 N-terminal domain at 1.65-A resolution. The structure reveals a seven-bladed beta-propeller followed by a 30-residue C-terminal extended peptide segment, which folds back onto the beta-propeller and binds to its bottom face. The beta-propeller repeats lack any recognizable sequence motif and are distinguished by extensive insertions between the canonical beta-strands. We propose a mechanism by which the C-terminal peptide extension is involved in NPC assembly.

	~~==About this Structure==~~		Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN.,Napetschnig J, Blobel G, Hoelz A Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1783-8. Epub 2007 Jan 30. PMID:17264208<ref>PMID:17264208</ref>
	~~[[2oit]] is a 1 chain~~ structure ~~with sequence from [http:~~/~~/en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=2OIT OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Nucleoporin\|Nucleoporin]]		*[[Nucleoporin\|Nucleoporin]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:017264208</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blobel, G.]]		[[Category: Blobel, G.]]

OCA at 09:48, 24 March 2013

2013-03-24T09:48:12Z

← Older revision		Revision as of 09:48, 24 March 2013
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	~~[[Image:2oit.png\|left\|200px]]~~

	{{STRUCTURE_2oit\| PDB=2oit \| SCENE= }}		{{STRUCTURE_2oit\| PDB=2oit \| SCENE= }}

	===Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN===		===Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN===

	{{ABSTRACT_PUBMED_17264208}}		{{ABSTRACT_PUBMED_17264208}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:017264208</ref><references group="xtra"/>		<ref group="xtra">PMID:017264208</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blobel, G.]]		[[Category: Blobel, G.]]

OCA at 18:18, 20 October 2012

2012-10-20T18:18:07Z

← Older revision		Revision as of 18:18, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2oit]] is a 1 chain structure ~~of [[Nucleoporin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA].		[[2oit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA].

	==See Also==		==See Also==

OCA at 03:40, 27 July 2012

2012-07-27T03:40:40Z

← Older revision		Revision as of 03:40, 27 July 2012
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	[[Image:2oit.png\|left\|200px]]		[[Image:2oit.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2oit", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2oit\| PDB=2oit \| SCENE= }}		{{STRUCTURE_2oit\| PDB=2oit \| SCENE= }}

	===Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN===		===Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17264208}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17264208 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17264208}}		{{ABSTRACT_PUBMED_17264208}}

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	==See Also==		==See Also==
	*[[Nucleoporin]]		*[[Nucleoporin\|Nucleoporin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17264208~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017264208</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blobel, G.]]		[[Category: Blobel, G.]]
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	[[Category: Nup214/can fusion]]		[[Category: Nup214/can fusion]]
	[[Category: Oncoprotein]]		[[Category: Oncoprotein]]
	~~[[Category: Structure]]~~
	~~[[Category: X-ray crystallography]]~~

OCA: Protected "2oit" [edit=sysop:move=sysop]

2010-12-26T08:55:20Z

Protected "2oit" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:55, 26 December 2010
(No difference)