2oom - Revision history

OCA at 13:15, 1 July 2026

2026-07-01T13:15:28Z

← Older revision		Revision as of 13:15, 1 July 2026
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOM FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, models</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [https://pdbe.org/2oom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [https://www.ebi.ac.uk/pdbsum/2oom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oom ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [https://pdbe.org/2oom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [https://www.ebi.ac.uk/pdbsum/2oom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oom ProSAT]</span></td></tr>

OCA at 12:53, 20 December 2023

2023-12-20T12:53:13Z

← Older revision		Revision as of 12:53, 20 December 2023
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	==NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer==		==NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer==
	<StructureSection load='2oom' size='340' side='right'caption='[[2oom~~]], [[NMR_Ensembles_of_Models \| 12 NMR models~~]]' scene=''>		<StructureSection load='2oom' size='340' side='right'caption='[[2oom]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOM FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [https://pdbe.org/2oom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [https://www.ebi.ac.uk/pdbsum/2oom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oom ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [https://pdbe.org/2oom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [https://www.ebi.ac.uk/pdbsum/2oom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oom ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lebars, I~~]]		[[Category: Di Primo C]]
	[[Category: ~~Primo, C Di~~]]		[[Category: Lebars I]]
	[[Category: Richard, T]]		[[Category: Richard T]]
	[[Category: Toulme~~, J J]]~~		[[Category: Toulme JJ]]
	~~[[Category: Aptamer]]~~
	~~[[Category: Hiv-1]]~~
	~~[[Category: Lna]]~~
	~~[[Category: Locked nucleic acid]]~~
	~~[[Category: Nmr]]~~
	~~[[Category: Rna]]~~
	~~[[Category: Tar~~]]

OCA at 07:52, 2 March 2022

2022-03-02T07:52:18Z

← Older revision		Revision as of 07:52, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='2oom' size='340' side='right'caption='[[2oom]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>		<StructureSection load='2oom' size='340' side='right'caption='[[2oom]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2OOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOM FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [~~http~~://pdbe.org/2oom PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2oom PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2oom ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [https://pdbe.org/2oom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [https://www.ebi.ac.uk/pdbsum/2oom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oom ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:02, 27 May 2020

2020-05-27T08:02:58Z

← Older revision		Revision as of 08:02, 27 May 2020
Line 1:		Line 1:

	==NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer==		==NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer==
	<StructureSection load='2oom' size='340' side='right' caption='[[2oom]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>		<StructureSection load='2oom' size='340' side='right'caption='[[2oom]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2OOM FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [http://pdbe.org/2oom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [http://www.ebi.ac.uk/pdbsum/2oom PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2oom ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [http://pdbe.org/2oom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [http://www.ebi.ac.uk/pdbsum/2oom PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2oom ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lebars, I]]		[[Category: Lebars, I]]
	[[Category: Primo, C Di]]		[[Category: Primo, C Di]]

OCA at 06:44, 22 August 2018

2018-08-22T06:44:59Z

← Older revision		Revision as of 06:44, 22 August 2018
Line 1:		Line 1:

	==NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer==		==NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer==
	<StructureSection load='2oom' size='340' side='right' caption='[[2oom]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>		<StructureSection load='2oom' size='340' side='right' caption='[[2oom]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOM FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [http://pdbe.org/2oom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [http://www.ebi.ac.uk/pdbsum/2oom PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [http://pdbe.org/2oom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [http://www.ebi.ac.uk/pdbsum/2oom PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2oom ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:33, 9 September 2015

2015-09-09T21:33:34Z

← Older revision		Revision as of 21:33, 9 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOM FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [http://www.ebi.ac.uk/pdbsum/2oom PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [http://pdbe.org/2oom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [http://www.ebi.ac.uk/pdbsum/2oom PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2oom" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:28, 3 January 2015

2015-01-03T22:28:17Z

← Older revision		Revision as of 22:28, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOM FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [http://www.ebi.ac.uk/pdbsum/2oom PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [http://www.ebi.ac.uk/pdbsum/2oom PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Lebars, I.]]		[[Category: Lebars, I]]
	[[Category: Primo, C Di.]]		[[Category: Primo, C Di]]
	[[Category: Richard, T.]]		[[Category: Richard, T]]
	[[Category: Toulme, J J.]]		[[Category: Toulme, J J]]
	[[Category: Aptamer]]		[[Category: Aptamer]]
	[[Category: Hiv-1]]		[[Category: Hiv-1]]

OCA at 06:45, 9 June 2014

2014-06-09T06:45:13Z

← Older revision		Revision as of 06:45, 9 June 2014
Line 1:		Line 1:
	[[~~Image~~:2oom.~~png\|left\|200px~~]]		==NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer==
			<StructureSection load='2oom' size='340' side='right' caption='[[2oom]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOM FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=10C:4-AMINO-1-{2,5-ANHYDRO-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-LYXOFURANOSYL}PYRIMIDIN-2(1H)-ONE'>10C</scene>, <scene name='pdbligand=LCA:[(1R,3R,4R,7S)-7-HYDROXY-3-(ADENIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCA</scene></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oom RCSB], [http://www.ebi.ac.uk/pdbsum/2oom PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The trans-activating responsive (TAR) RNA element located in the 5' untranslated region of the HIV-1 genome is a 57-nt imperfect stem-loop essential for the viral replication. TAR regulates transcription by interacting with both viral and cellular proteins. RNA hairpin aptamers specific for TAR were previously identified by in vitro selection [Duconge,F. and Toulme,J.J. (1999) In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1. RNA, 5, 1605-1614]. These aptamers display a 5'-GUCCCAGA-3' consensus apical loop, partially complementary to the TAR one, leading to the formation of a TAR-aptamer kissing complex. The conserved GA combination (underlined in the consensus sequence) has been shown to be crucial for the formation of a highly stable complex. To improve the nuclease resistance of the aptamer and to increase its affinity for TAR, locked nucleic acid (LNA) nucleotides were introduced in the aptamer apical loop. LNA are nucleic acids analogues that contain a 2'-O,4'-C methylene linkage and that raise the thermostablity of duplexes. We solved the NMR solution structure of the TAR-LNA-modified aptamer kissing complex. Structural analysis revealed the formation of a non-canonical G*A pair leading to increased stacking at the stem-loop junction. Our data also showed that the introduction of LNA residues provides an enhanced stability while maintaining a normal Watson-Crick base pairing with a loop-loop conformation close to an A-type.

	~~{{STRUCTURE_2oom\| PDB=2oom \| SCENE= }}~~		NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA-modified aptamer.,Lebars I, Richard T, Di Primo C, Toulme JJ Nucleic Acids Res. 2007;35(18):6103-14. Epub 2007 Sep 3. PMID:17768146<ref>PMID:17768146</ref>

	~~===NMR structure~~ of ~~a kissing complex formed between~~ the ~~TAR RNA element of HIV-1 and a LNA/RNA aptamer===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17768146}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2oom]] is a 2 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2OOM OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017768146<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Lebars, I.]]		[[Category: Lebars, I.]]
	[[Category: Primo, C Di.]]		[[Category: Primo, C Di.]]

OCA: Protected "2oom" [edit=sysop:move=sysop]

2012-08-14T17:10:17Z

Protected "2oom" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:10, 14 August 2012
(No difference)

OCA at 17:10, 14 August 2012

2012-08-14T17:10:15Z

← Older revision		Revision as of 17:10, 14 August 2012
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	~~{{Seed}}~~
	[[Image:2oom.png\|left\|200px]]		[[Image:2oom.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2oom", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2oom\| PDB=2oom \| SCENE= }}		{{STRUCTURE_2oom\| PDB=2oom \| SCENE= }}

	===NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer===		===NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17768146}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17768146 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17768146}}		{{ABSTRACT_PUBMED_17768146}}

	==About this Structure==		==About this Structure==
	~~2OOM is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA].		[[2oom]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOM OCA].

	==Reference==		==Reference==
	NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA-modified aptamer., Lebars I, Richard T, Di Primo C, Toulme JJ, Nucleic Acids Res. 2007;35(18):6103-14. Epub 2007 Sep 3. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17768146 17768146]~~		<ref group="xtra">PMID:017768146</ref><references group="xtra"/>
	~~[[Category: Single protein]]~~
	[[Category: Lebars, I.]]		[[Category: Lebars, I.]]
	[[Category: Primo, C Di.]]		[[Category: Primo, C Di.]]
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	[[Category: Rna]]		[[Category: Rna]]
	[[Category: Tar]]		[[Category: Tar]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:08:15 2008''~~