2oop - Revision history

OCA at 01:16, 21 November 2024

2024-11-21T01:16:58Z

← Older revision		Revision as of 01:16, 21 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOP FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [https://pdbe.org/2oop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [https://www.ebi.ac.uk/pdbsum/2oop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oop ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [https://pdbe.org/2oop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [https://www.ebi.ac.uk/pdbsum/2oop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oop ProSAT]</span></td></tr>
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oop_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oop_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 00:21, 28 December 2023

2023-12-28T00:21:18Z

← Older revision		Revision as of 00:21, 28 December 2023
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	==Structure of Tyr7-PYY in solution==		==Structure of Tyr7-PYY in solution==
	<StructureSection load='2oop' size='340' side='right'caption='[[2oop~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2oop' size='340' side='right'caption='[[2oop]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pig Pig~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOP FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[2ooo\|2ooo]], [[2oon\|2oon]], [[1ruu\|1ruu]]</div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">PYY ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [https://pdbe.org/2oop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [https://www.ebi.ac.uk/pdbsum/2oop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oop ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [https://pdbe.org/2oop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [https://www.ebi.ac.uk/pdbsum/2oop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oop ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PYY_PIG PYY_PIG]] This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.		[https://www.uniprot.org/uniprot/PYY_PIG PYY_PIG] This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Pig~~]]		[[Category: Sus scrofa]]
	[[Category: Mares, J]]		[[Category: Mares J]]
	[[Category: Neumoin, A]]		[[Category: Neumoin A]]
	[[Category: Zerbe, O]]		[[Category: Zerbe O]]
	~~[[Category: Folding]]~~
	~~[[Category: Helical haripin]]~~
	~~[[Category: Hormone~~]]

OCA at 13:01, 9 June 2021

2021-06-09T13:01:55Z

← Older revision		Revision as of 13:01, 9 June 2021
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	==Structure of Tyr7-PYY in solution==		==Structure of Tyr7-PYY in solution==
	<StructureSection load='2oop' size='340' side='right' caption='[[2oop]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2oop' size='340' side='right'caption='[[2oop]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OOP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOP FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ooo\|2ooo]], [[2oon\|2oon]], [[1ruu\|1ruu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ooo\|2ooo]], [[2oon\|2oon]], [[1ruu\|1ruu]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYY ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYY ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [~~http~~://pdbe.org/2oop PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2oop PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2oop ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [https://pdbe.org/2oop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [https://www.ebi.ac.uk/pdbsum/2oop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oop ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PYY_PIG PYY_PIG]] This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.		[[https://www.uniprot.org/uniprot/PYY_PIG PYY_PIG]] This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Pig]]		[[Category: Pig]]
	[[Category: Mares, J]]		[[Category: Mares, J]]

OCA at 07:02, 22 August 2018

2018-08-22T07:02:44Z

← Older revision		Revision as of 07:02, 22 August 2018
Line 1:		Line 1:

	==Structure of Tyr7-PYY in solution==		==Structure of Tyr7-PYY in solution==
	<StructureSection load='2oop' size='340' side='right' caption='[[2oop]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2oop' size='340' side='right' caption='[[2oop]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ooo\|2ooo]], [[2oon\|2oon]], [[1ruu\|1ruu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ooo\|2ooo]], [[2oon\|2oon]], [[1ruu\|1ruu]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [http://pdbe.org/2oop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [http://www.ebi.ac.uk/pdbsum/2oop PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [http://pdbe.org/2oop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [http://www.ebi.ac.uk/pdbsum/2oop PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2oop ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oop_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oop_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:13, 10 February 2016

2016-02-10T06:13:32Z

← Older revision		Revision as of 06:13, 10 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oop ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:10, 11 September 2015

2015-09-11T06:10:05Z

← Older revision		Revision as of 06:10, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2oop' size='340' side='right' caption='[[2oop]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2oop' size='340' side='right' caption='[[2oop]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sus_scrofa Sus scrofa~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOP FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ooo\|2ooo]], [[2oon\|2oon]], [[1ruu\|1ruu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ooo\|2ooo]], [[2oon\|2oon]], [[1ruu\|1ruu]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 ~~Sus scrofa~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [http://www.ebi.ac.uk/pdbsum/2oop PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [http://pdbe.org/2oop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [http://www.ebi.ac.uk/pdbsum/2oop PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2oop" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Sus scrofa~~]]		[[Category: Pig]]
	[[Category: Mares, J]]		[[Category: Mares, J]]
	[[Category: Neumoin, A]]		[[Category: Neumoin, A]]

OCA at 12:22, 25 December 2014

2014-12-25T12:22:14Z

← Older revision		Revision as of 12:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOP FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ooo\|2ooo]], [[2oon\|2oon]], [[1ruu\|1ruu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ooo\|2ooo]], [[2oon\|2oon]], [[1ruu\|1ruu]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [http://www.ebi.ac.uk/pdbsum/2oop PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [http://www.ebi.ac.uk/pdbsum/2oop PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PYY_PIG PYY_PIG]] This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Mares, J.]]		[[Category: Mares, J]]
	[[Category: Neumoin, A.]]		[[Category: Neumoin, A]]
	[[Category: Zerbe, O.]]		[[Category: Zerbe, O]]
	[[Category: Folding]]		[[Category: Folding]]
	[[Category: Helical haripin]]		[[Category: Helical haripin]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 19:21, 30 September 2014

2014-09-30T19:21:26Z

← Older revision		Revision as of 19:21, 30 September 2014
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	[[Image:~~2oop~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of Tyr7-PYY in solution==
			<StructureSection load='2oop' size='340' side='right' caption='[[2oop]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2oop]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOP FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ooo\|2ooo]], [[2oon\|2oon]], [[1ruu\|1ruu]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oop OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oop RCSB], [http://www.ebi.ac.uk/pdbsum/2oop PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oop_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The minimal model system to study the basic principles of protein folding is the hairpin. The formation of beta-hairpins, which are the basic components of antiparallel beta-sheets, has been studied extensively in the past decade, but much less is known about helical hairpins. Here, we probe hairpin formation between a polyproline type-II helix and an alpha-helix as present in the natural miniprotein peptide YY (PYY). Both turn sequence and interactions of aromatic side chains from the C-terminal alpha-helix with the pockets formed by N-terminal Pro residues are shown by site-directed mutagenesis and solution NMR spectroscopy in different solvent systems to be important determinants of backbone dynamics and hairpin stability, suggesting a close analogy with some beta-hairpin structures. It is shown that multiple relatively weak contacts between the helices are necessary for the formation of the helical hairpin studied here, whereas the type-I beta-turn acts like a hinge, which through certain single amino acid substitutions is destabilized such that hairpin formation is completely abolished. Denaturation and renaturation of tertiary structure by temperature or cosolvents were probed by measuring changes of chemical shifts. Folding of PYY is both reversible and cooperative as inferred from the sigmoidal denaturation curves displayed by residues at the interface of the helical hairpin. Such miniproteins thus feature an important hallmark of globular proteins and should provide a convenient system to study basic aspects of helical hairpin folding that are complementary to those derived from studies of beta-hairpins.

	~~{{STRUCTURE_2oop\| PDB=2oop \| SCENE= }}~~		Probing the formation of stable tertiary structure in a model miniprotein at atomic resolution: determinants of stability of a helical hairpin.,Neumoin A, Mares J, Lerch-Bader M, Bader R, Zerbe O J Am Chem Soc. 2007 Jul 18;129(28):8811-7. Epub 2007 Jun 20. PMID:17580866<ref>PMID:17580866</ref>

	~~===Structure~~ of ~~Tyr7-PYY in solution===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17580866}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2oop]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017580866<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Mares, J.]]		[[Category: Mares, J.]]

OCA: Protected "2oop" [edit=sysop:move=sysop]

2013-01-07T11:41:56Z

Protected "2oop" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:41, 7 January 2013
(No difference)

OCA at 11:41, 7 January 2013

2013-01-07T11:41:54Z

← Older revision		Revision as of 11:41, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2oop.png\|left\|200px]]		[[Image:2oop.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2oop", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2oop\| PDB=2oop \| SCENE= }}		{{STRUCTURE_2oop\| PDB=2oop \| SCENE= }}

	===Structure of Tyr7-PYY in solution===		===Structure of Tyr7-PYY in solution===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17580866}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17580866 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17580866}}		{{ABSTRACT_PUBMED_17580866}}

	==About this Structure==		==About this Structure==
	~~2OOP~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA].		[[2oop]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOP OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17580866~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017580866</ref><references group="xtra"/>
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Mares, J.]]		[[Category: Mares, J.]]
Line 31:		Line 19:
	[[Category: Helical haripin]]		[[Category: Helical haripin]]
	[[Category: Hormone]]		[[Category: Hormone]]
	~~[[Category: Nmr]]~~

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:03:23 2009''~~