2oos - Revision history

OCA at 10:46, 30 August 2023

2023-08-30T10:46:22Z

← Older revision		Revision as of 10:46, 30 August 2023
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	<StructureSection load='2oos' size='340' side='right'caption='[[2oos]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2oos' size='340' side='right'caption='[[2oos]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOS FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=JPJ:2-(2,4-DICHLOROPHENOXY)-5~~-~~(2-PHENYLETHYL)PHENOL'>JPJ</scene>~~, ~~<scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JPJ:2-(2,4-DICHLOROPHENOXY)-5-(2-PHENYLETHYL)PHENOL'>JPJ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>FabI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>~~
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Enoyl~~-~~[acyl~~-~~carrier-protein]_reductase_(NADH~~) ~~Enoyl~~-~~[acyl~~-~~carrier~~-~~protein] reductase (NADH~~)], ~~with EC number [https~~:~~//www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [https://pdbe.org/2oos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [https://www.ebi.ac.uk/pdbsum/2oos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [https://pdbe.org/2oos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [https://www.ebi.ac.uk/pdbsum/2oos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oos ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9BJJ9_PLAFA Q9BJJ9_PLAFA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Plafa~~]]		[[Category: Plasmodium falciparum]]
	[[Category: Tsai, H]]		[[Category: Tsai H]]
	~~[[Category: Malaria]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Pfenr]]~~
	~~[[Category: Triclosan analog~~]]

OCA at 13:01, 9 June 2021

2021-06-09T13:01:59Z

← Older revision		Revision as of 13:01, 9 June 2021
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	==Crystal structure of plasmodium falciparum enoyl ACP reductase with triclosan reductase==		==Crystal structure of plasmodium falciparum enoyl ACP reductase with triclosan reductase==
	<StructureSection load='2oos' size='340' side='right' caption='[[2oos]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2oos' size='340' side='right'caption='[[2oos]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oos]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JPJ:2-(2,4-DICHLOROPHENOXY)-5-(2-PHENYLETHYL)PHENOL'>JPJ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JPJ:2-(2,4-DICHLOROPHENOXY)-5-(2-PHENYLETHYL)PHENOL'>JPJ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FabI ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FabI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [~~http~~://pdbe.org/2oos PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2oos PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2oos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [https://pdbe.org/2oos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [https://www.ebi.ac.uk/pdbsum/2oos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oos ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]		*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures\|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Tsai, H]]		[[Category: Tsai, H]]

OCA at 06:53, 22 August 2018

2018-08-22T06:53:38Z

← Older revision		Revision as of 06:53, 22 August 2018
Line 1:		Line 1:

	==Crystal structure of plasmodium falciparum enoyl ACP reductase with triclosan reductase==		==Crystal structure of plasmodium falciparum enoyl ACP reductase with triclosan reductase==
	<StructureSection load='2oos' size='340' side='right' caption='[[2oos]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2oos' size='340' side='right' caption='[[2oos]], [[Resolution\|resolution]] 2.10Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [http://pdbe.org/2oos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [http://www.ebi.ac.uk/pdbsum/2oos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [http://pdbe.org/2oos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [http://www.ebi.ac.uk/pdbsum/2oos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2oos ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oos_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oos_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:14, 7 February 2016

2016-02-07T18:14:14Z

← Older revision		Revision as of 18:14, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oos ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:56, 10 September 2015

2015-09-10T03:56:53Z

← Older revision		Revision as of 03:56, 10 September 2015
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	<StructureSection load='2oos' size='340' side='right' caption='[[2oos]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2oos' size='340' side='right' caption='[[2oos]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JPJ:2-(2,4-DICHLOROPHENOXY)-5-(2-PHENYLETHYL)PHENOL'>JPJ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JPJ:2-(2,4-DICHLOROPHENOXY)-5-(2-PHENYLETHYL)PHENOL'>JPJ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 ~~Plasmodium falciparum~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [http://www.ebi.ac.uk/pdbsum/2oos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [http://pdbe.org/2oos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [http://www.ebi.ac.uk/pdbsum/2oos PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2oos" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Plasmodium falciparum~~]]		[[Category: Plafa]]
	[[Category: Tsai, H]]		[[Category: Tsai, H]]
	[[Category: Malaria]]		[[Category: Malaria]]

OCA at 13:24, 19 January 2015

2015-01-19T13:24:10Z

← Older revision		Revision as of 13:24, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JPJ:2-(2,4-DICHLOROPHENOXY)-5-(2-PHENYLETHYL)PHENOL'>JPJ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JPJ:2-(2,4-DICHLOROPHENOXY)-5-(2-PHENYLETHYL)PHENOL'>JPJ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [http://www.ebi.ac.uk/pdbsum/2oos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [http://www.ebi.ac.uk/pdbsum/2oos PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Tsai, H.]]		[[Category: Tsai, H]]
	[[Category: Malaria]]		[[Category: Malaria]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Pfenr]]		[[Category: Pfenr]]
	[[Category: Triclosan analog]]		[[Category: Triclosan analog]]

OCA at 06:25, 29 September 2014

2014-09-29T06:25:41Z

← Older revision		Revision as of 06:25, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2oos~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of plasmodium falciparum enoyl ACP reductase with triclosan reductase==
			<StructureSection load='2oos' size='340' side='right' caption='[[2oos]], [[Resolution\|resolution]] 2.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2oos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OOS FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JPJ:2-(2,4-DICHLOROPHENOXY)-5-(2-PHENYLETHYL)PHENOL'>JPJ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oos RCSB], [http://www.ebi.ac.uk/pdbsum/2oos PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oos_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The x-ray crystal structures of five triclosan analogs, in addition to that of the isoniazid-NAD adduct, are described in relation to their integral role in the design of potent inhibitors of the malarial enzyme Plasmodium falciparum enoyl acyl carrier protein reductase (PfENR). Many of the novel 5-substituted analogs exhibit low micromolar potency against in vitro cultures of drug-resistant and drug-sensitive strains of the P. falciparum parasite and inhibit purified PfENR enzyme with IC50 values of <200 nM. This study has significantly expanded the knowledge base with regard to the structure-activity relationship of triclosan while affording gains against cultured parasites and purified PfENR enzyme. In contrast to a recent report in the literature, these results demonstrate the ability to improve the in vitro potency of triclosan significantly by replacing the suboptimal 5-chloro group with larger hydrophobic moieties. The biological and x-ray crystallographic data thus demonstrate the flexibility of the active site and point to future rounds of optimization to improve compound potency against purified enzyme and intracellular Plasmodium parasites.

	~~{{STRUCTURE_2oos\| PDB=2oos \| SCENE= }}~~		X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.,Freundlich JS, Wang F, Tsai HC, Kuo M, Shieh HM, Anderson JW, Nkrumah LJ, Valderramos JC, Yu M, Kumar TR, Valderramos SG, Jacobs WR Jr, Schiehser GA, Jacobus DP, Fidock DA, Sacchettini JC J Biol Chem. 2007 Aug 31;282(35):25436-44. Epub 2007 Jun 13. PMID:17567585<ref>PMID:17567585</ref>

	~~===Crystal structure~~ of ~~plasmodium falciparum enoyl ACP reductase with triclosan reductase===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17567585}}~~

	~~==About this Structure==~~
	~~[[2oos]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2OOS OCA].~~

	==See Also==		==See Also==
	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]		*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017567585<~~/~~ref~~><~~ref group="xtra">PMID:017469802</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Tsai, H.]]		[[Category: Tsai, H.]]

OCA at 07:29, 20 October 2012

2012-10-20T07:29:16Z

← Older revision		Revision as of 07:29, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2oos]] is a 2 chain structure ~~of [[Enoyl-Acyl-Carrier Protein Reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA].		[[2oos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA].

	==See Also==		==See Also==

OCA: Protected "2oos" [edit=sysop:move=sysop]

2012-07-25T16:29:20Z

Protected "2oos" [edit=sysop:move=sysop]

← Older revision	Revision as of 16:29, 25 July 2012
(No difference)

OCA at 16:29, 25 July 2012

2012-07-25T16:29:18Z

← Older revision		Revision as of 16:29, 25 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2oos.png\|left\|200px]]		[[Image:2oos.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2oos", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2oos\| PDB=2oos \| SCENE= }}		{{STRUCTURE_2oos\| PDB=2oos \| SCENE= }}

	===Crystal structure of plasmodium falciparum enoyl ACP reductase with triclosan reductase===		===Crystal structure of plasmodium falciparum enoyl ACP reductase with triclosan reductase===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17567585}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17567585 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17567585}}		{{ABSTRACT_PUBMED_17567585}}

	==About this Structure==		==About this Structure==
	~~2OOS~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA].		[[2oos]] is a 2 chain structure of [[Enoyl-Acyl-Carrier Protein Reductase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOS OCA].

			==See Also==
			*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17567585~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017567585</ref><ref group="xtra">PMID:017469802</ref><references group="xtra"/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Tsai, H.]]		[[Category: Tsai, H.]]
	[[Category: Malaria]]		[[Category: Malaria]]
			[[Category: Oxidoreductase]]
	[[Category: Pfenr]]		[[Category: Pfenr]]
	[[Category: Triclosan analog]]		[[Category: Triclosan analog]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:40:33 2009''~~