2opt - Revision history

OCA at 00:21, 28 December 2023

2023-12-28T00:21:43Z

← Older revision		Revision as of 00:21, 28 December 2023
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	<StructureSection load='2opt' size='340' side='right'caption='[[2opt]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2opt' size='340' side='right'caption='[[2opt]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces~~ coelicolor~~" (muller 1908) lieske 1921~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPT FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>actII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1902~~ "~~Actinomyces coelicolor~~" ~~(Muller 1908) Lieske 1921~~])</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [https://pdbe.org/2opt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [https://www.ebi.ac.uk/pdbsum/2opt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [https://pdbe.org/2opt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [https://www.ebi.ac.uk/pdbsum/2opt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opt ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q53901_STRCH Q53901_STRCH]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Junop, M S~~]]		[[Category: Streptomyces coelicolor]]
	[[Category: ~~Willems, A R~~]]		[[Category: Junop MS]]
	[[Category: ~~Apo-protein]]~~		[[Category: Willems AR]]
	~~[[Category: Helical protein]]~~
	~~[[Category: Tetr family]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Transcriptional repressor~~]]

OCA at 13:02, 9 June 2021

2021-06-09T13:02:55Z

← Older revision		Revision as of 13:02, 9 June 2021
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	==Crystal Structure of Apo ActR from Streptomyces coelicolor.==		==Crystal Structure of Apo ActR from Streptomyces coelicolor.==
	<StructureSection load='2opt' size='340' side='right' caption='[[2opt]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2opt' size='340' side='right'caption='[[2opt]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPT FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actII ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [~~http~~://pdbe.org/2opt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2opt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2opt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [https://pdbe.org/2opt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [https://www.ebi.ac.uk/pdbsum/2opt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Junop, M S]]		[[Category: Junop, M S]]
	[[Category: Willems, A R]]		[[Category: Willems, A R]]

OCA at 06:58, 22 August 2018

2018-08-22T06:58:35Z

← Older revision		Revision as of 06:58, 22 August 2018
Line 1:		Line 1:

	==Crystal Structure of Apo ActR from Streptomyces coelicolor.==		==Crystal Structure of Apo ActR from Streptomyces coelicolor.==
	<StructureSection load='2opt' size='340' side='right' caption='[[2opt]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2opt' size='340' side='right' caption='[[2opt]], [[Resolution\|resolution]] 2.05Å' scene=''>
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	<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPT FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [http://pdbe.org/2opt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [http://www.ebi.ac.uk/pdbsum/2opt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [http://pdbe.org/2opt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [http://www.ebi.ac.uk/pdbsum/2opt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2opt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2opt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2opt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:29, 7 February 2016

2016-02-07T20:29:46Z

← Older revision		Revision as of 20:29, 7 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2opt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:44, 10 September 2015

2015-09-10T04:44:35Z

← Older revision		Revision as of 04:44, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2opt' size='340' side='right' caption='[[2opt]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2opt' size='340' side='right' caption='[[2opt]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptomyces_coelicolor Streptomyces~~ coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPT FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 ~~Streptomyces~~ coelicolor])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [http://www.ebi.ac.uk/pdbsum/2opt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [http://pdbe.org/2opt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [http://www.ebi.ac.uk/pdbsum/2opt PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2opt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Streptomyces coelicolor]]~~
	[[Category: Junop, M S]]		[[Category: Junop, M S]]
	[[Category: Willems, A R]]		[[Category: Willems, A R]]

OCA at 15:12, 19 January 2015

2015-01-19T15:12:34Z

← Older revision		Revision as of 15:12, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 Streptomyces coelicolor])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 Streptomyces coelicolor])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [http://www.ebi.ac.uk/pdbsum/2opt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [http://www.ebi.ac.uk/pdbsum/2opt PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Junop, M S.]]		[[Category: Junop, M S]]
	[[Category: Willems, A R.]]		[[Category: Willems, A R]]
	[[Category: Apo-protein]]		[[Category: Apo-protein]]
	[[Category: Helical protein]]		[[Category: Helical protein]]

OCA at 18:42, 30 September 2014

2014-09-30T18:42:54Z

← Older revision		Revision as of 18:42, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2opt~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of Apo ActR from Streptomyces coelicolor.==
			<StructureSection load='2opt' size='340' side='right' caption='[[2opt]], [[Resolution\|resolution]] 2.05Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2opt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPT FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 Streptomyces coelicolor])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2opt RCSB], [http://www.ebi.ac.uk/pdbsum/2opt PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2opt_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Actinorhodin, an antibiotic produced by Streptomyces coelicolor, is exported from the cell by the ActA efflux pump. actA is divergently transcribed from actR, which encodes a TetR-like transcriptional repressor. We showed previously that ActR represses transcription by binding to an operator from the actA/actR intergenic region. Importantly, actinorhodin itself or various actinorhodin biosynthetic intermediates can cause ActR to dissociate from its operator, leading to derepression. This suggests that ActR may mediate timely self-resistance to an endogenously produced antibiotic by responding to one of its biosynthetic precursors. Here, we report the structural basis for this precursor-mediated derepression with crystal structures of homodimeric ActR by itself and in complex with either actinorhodin or the actinorhodin biosynthetic intermediate (S)-DNPA [4-dihydro-9-hydroxy-1-methyl-10-oxo-3-H-naphtho-[2,3-c]-pyran-3-(S)-aceti c acid]. The ligand-binding tunnel in each ActR monomer has a striking hydrophilic/hydrophobic/hydrophilic arrangement of surface residues that accommodate either one hexacyclic actinorhodin molecule or two back-to-back tricyclic (S)-DNPA molecules. Moreover, our work also reveals the strongest structural evidence to date that TetR-mediated antibiotic resistance may have been acquired from an antibiotic-producer organism.

	~~{{STRUCTURE_2opt\| PDB=2opt \| SCENE= }}~~		Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA.,Willems AR, Tahlan K, Taguchi T, Zhang K, Lee ZZ, Ichinose K, Junop MS, Nodwell JR J Mol Biol. 2008 Mar 7;376(5):1377-87. Epub 2008 Jan 4. PMID:18207163<ref>PMID:18207163</ref>

	~~===Crystal Structure~~ of ~~Apo ActR from Streptomyces coelicolor~~.~~===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18207163}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2opt]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:018207163<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Junop, M S.]]		[[Category: Junop, M S.]]

OCA: Protected "2opt" [edit=sysop:move=sysop]

2013-01-07T11:00:09Z

Protected "2opt" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:00, 7 January 2013
(No difference)

OCA at 11:00, 7 January 2013

2013-01-07T11:00:06Z

← Older revision		Revision as of 11:00, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2opt.png\|left\|200px]]		[[Image:2opt.png\|left\|200px]]

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	{{STRUCTURE_2opt\| PDB=2opt \| SCENE= }}		{{STRUCTURE_2opt\| PDB=2opt \| SCENE= }}

	===Crystal Structure of Apo ActR from Streptomyces coelicolor.===		===Crystal Structure of Apo ActR from Streptomyces coelicolor.===


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	{{ABSTRACT_PUBMED_18207163}}		{{ABSTRACT_PUBMED_18207163}}

	==About this Structure==		==About this Structure==
	~~2OPT~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA].		[[2opt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18207163~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018207163</ref><references group="xtra"/>
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Junop, M S.]]		[[Category: Junop, M S.]]
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	[[Category: Helical protein]]		[[Category: Helical protein]]
	[[Category: Tetr family]]		[[Category: Tetr family]]
			[[Category: Transcription]]
	[[Category: Transcriptional repressor]]		[[Category: Transcriptional repressor]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:18:54 2009''~~

OCA at 14:18, 16 February 2009

2009-02-16T14:18:55Z

← Older revision		Revision as of 14:18, 16 February 2009
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	==About this Structure==		==About this Structure==
	2OPT is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA].		2OPT is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPT OCA].

	==Reference==		==Reference==
	Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA., Willems AR, Tahlan K, Taguchi T, Zhang K, Lee ZZ, Ichinose K, Junop MS, Nodwell JR, J Mol Biol. 2008 Mar 7;376(5):1377-87. Epub 2008 Jan 4. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18207163 18207163]~~		<ref group="xtra">PMID:18207163</ref><references group="xtra"/>
	~~[[Category: Single protein]]~~
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Junop, M S.]]		[[Category: Junop, M S.]]
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	[[Category: Transcriptional repressor]]		[[Category: Transcriptional repressor]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 19~~:26:~~53 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:18:54 2009''