2os5 - Revision history

OCA at 09:05, 21 February 2024

2024-02-21T09:05:56Z

← Older revision		Revision as of 09:05, 21 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [https://pdbe.org/2os5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [https://www.ebi.ac.uk/pdbsum/2os5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [https://pdbe.org/2os5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [https://www.ebi.ac.uk/pdbsum/2os5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os5 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/A4GRE3_9BILA A4GRE3_9BILA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2os5 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2os5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Hookworms, parasitic nematodes that infect nearly one billion people worldwide, are a major cause of anemia and malnutrition. We hypothesize that hookworms actively manipulate the host immune response through the production of specific molecules designed to facilitate infection by larval stages and adult worm survival within the intestine. A full-length cDNA encoding a secreted orthologue of the human cytokine, Macrophage Migration Inhibitory Factor (MIF) has been cloned from the hookworm Ancylostoma ceylanicum. Elucidation of the three-dimensional crystal structure of recombinant AceMIF (rAceMIF) revealed an overall structural homology with significant differences in the tautomerase sites of the human and hookworm proteins. The relative bioactivities of human and hookworm MIF proteins were compared using in vitro assays of tautomerase activity, macrophage migration, and binding to MIF receptor CD74. The activity of rAceMIF was not inhibited by the ligand ISO-1, which was previously determined to be an inhibitor of the catalytic site of human MIF. These data define unique immunological, structural, and functional characteristics of AceMIF, thereby establishing the potential for selectively inhibiting the hookworm cytokine as a means of reducing parasite survival and disease pathogenesis.

	Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74.,Cho Y, Jones BF, Vermeire JJ, Leng L, DiFedele L, Harrison LM, Xiong H, Kwong YK, Chen Y, Bucala R, Lolis E, Cappello M J Biol Chem. 2007 Aug 10;282(32):23447-56. Epub 2007 Jun 13. PMID:17567581<ref>PMID:17567581</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2os5" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]		*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Ancylostoma ceylanicum]]		[[Category: Ancylostoma ceylanicum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cho, Y]]		[[Category: Cho Y]]
	[[Category: Lolis, E]]		[[Category: Lolis E]]
	~~[[Category: Cytokine]]~~
	~~[[Category: Hookworm]]~~
	~~[[Category: Macrophage migration inhibitory factor]]~~
	~~[[Category: Nematode~~]]

OCA at 07:52, 2 March 2022

2022-03-02T07:52:42Z

← Older revision		Revision as of 07:52, 2 March 2022
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	<StructureSection load='2os5' size='340' side='right'caption='[[2os5]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2os5' size='340' side='right'caption='[[2os5]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [~~http~~://pdbe.org/2os5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2os5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2os5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [https://pdbe.org/2os5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [https://www.ebi.ac.uk/pdbsum/2os5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 2os5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2os5" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:03, 27 May 2020

2020-05-27T08:03:54Z

← Older revision		Revision as of 08:03, 27 May 2020
Line 1:		Line 1:

	==Macrophage migration inhibitory factor from Ancylostoma ceylanicum==		==Macrophage migration inhibitory factor from Ancylostoma ceylanicum==
	<StructureSection load='2os5' size='340' side='right' caption='[[2os5]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2os5' size='340' side='right'caption='[[2os5]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [http://pdbe.org/2os5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [http://www.ebi.ac.uk/pdbsum/2os5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2os5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [http://pdbe.org/2os5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [http://www.ebi.ac.uk/pdbsum/2os5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2os5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Ancylostoma ceylanicum]]		[[Category: Ancylostoma ceylanicum]]
			[[Category: Large Structures]]
	[[Category: Cho, Y]]		[[Category: Cho, Y]]
	[[Category: Lolis, E]]		[[Category: Lolis, E]]

OCA at 07:30, 22 August 2018

2018-08-22T07:30:48Z

← Older revision		Revision as of 07:30, 22 August 2018
Line 1:		Line 1:

	==Macrophage migration inhibitory factor from Ancylostoma ceylanicum==		==Macrophage migration inhibitory factor from Ancylostoma ceylanicum==
	<StructureSection load='2os5' size='340' side='right' caption='[[2os5]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2os5' size='340' side='right' caption='[[2os5]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [http://pdbe.org/2os5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [http://www.ebi.ac.uk/pdbsum/2os5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [http://pdbe.org/2os5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [http://www.ebi.ac.uk/pdbsum/2os5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2os5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os5_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:46, 7 February 2016

2016-02-07T23:46:27Z

← Older revision		Revision as of 23:46, 7 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2os5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:57, 10 September 2015

2015-09-10T05:57:49Z

← Older revision		Revision as of 05:57, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [http://www.ebi.ac.uk/pdbsum/2os5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [http://pdbe.org/2os5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [http://www.ebi.ac.uk/pdbsum/2os5 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2os5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:08, 19 January 2015

2015-01-19T17:08:00Z

← Older revision		Revision as of 17:08, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [http://www.ebi.ac.uk/pdbsum/2os5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [http://www.ebi.ac.uk/pdbsum/2os5 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Ancylostoma ceylanicum]]		[[Category: Ancylostoma ceylanicum]]
	[[Category: Cho, Y.]]		[[Category: Cho, Y]]
	[[Category: Lolis, E.]]		[[Category: Lolis, E]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Hookworm]]		[[Category: Hookworm]]
	[[Category: Macrophage migration inhibitory factor]]		[[Category: Macrophage migration inhibitory factor]]
	[[Category: Nematode]]		[[Category: Nematode]]

OCA at 19:41, 30 September 2014

2014-09-30T19:41:45Z

← Older revision		Revision as of 19:41, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2os5~~.~~png~~\|~~left~~\|~~200px~~]]		==Macrophage migration inhibitory factor from Ancylostoma ceylanicum==
			<StructureSection load='2os5' size='340' side='right' caption='[[2os5]], [[Resolution\|resolution]] 1.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2os5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS5 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2os5 RCSB], [http://www.ebi.ac.uk/pdbsum/2os5 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os5_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Hookworms, parasitic nematodes that infect nearly one billion people worldwide, are a major cause of anemia and malnutrition. We hypothesize that hookworms actively manipulate the host immune response through the production of specific molecules designed to facilitate infection by larval stages and adult worm survival within the intestine. A full-length cDNA encoding a secreted orthologue of the human cytokine, Macrophage Migration Inhibitory Factor (MIF) has been cloned from the hookworm Ancylostoma ceylanicum. Elucidation of the three-dimensional crystal structure of recombinant AceMIF (rAceMIF) revealed an overall structural homology with significant differences in the tautomerase sites of the human and hookworm proteins. The relative bioactivities of human and hookworm MIF proteins were compared using in vitro assays of tautomerase activity, macrophage migration, and binding to MIF receptor CD74. The activity of rAceMIF was not inhibited by the ligand ISO-1, which was previously determined to be an inhibitor of the catalytic site of human MIF. These data define unique immunological, structural, and functional characteristics of AceMIF, thereby establishing the potential for selectively inhibiting the hookworm cytokine as a means of reducing parasite survival and disease pathogenesis.

	~~{{STRUCTURE_2os5\| PDB=2os5 \| SCENE= }}~~		Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74.,Cho Y, Jones BF, Vermeire JJ, Leng L, DiFedele L, Harrison LM, Xiong H, Kwong YK, Chen Y, Bucala R, Lolis E, Cappello M J Biol Chem. 2007 Aug 10;282(32):23447-56. Epub 2007 Jun 13. PMID:17567581<ref>PMID:17567581</ref>

	~~===Macrophage migration inhibitory factor from Ancylostoma ceylanicum===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17567581}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2os5]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017567581<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Ancylostoma ceylanicum]]		[[Category: Ancylostoma ceylanicum]]
	[[Category: Cho, Y.]]		[[Category: Cho, Y.]]

OCA: Protected "2os5" [edit=sysop:move=sysop]

2013-01-07T12:04:30Z

Protected "2os5" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:04, 7 January 2013
(No difference)

OCA at 12:04, 7 January 2013

2013-01-07T12:04:27Z

← Older revision		Revision as of 12:04, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2os5.png\|left\|200px]]		[[Image:2os5.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2os5", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_2os5\| PDB=2os5 \| SCENE= }}		{{STRUCTURE_2os5\| PDB=2os5 \| SCENE= }}

	===Macrophage migration inhibitory factor from Ancylostoma ceylanicum===		===Macrophage migration inhibitory factor from Ancylostoma ceylanicum===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17567581}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_17567581}}		{{ABSTRACT_PUBMED_17567581}}

	==About this Structure==		==About this Structure==
	~~2OS5~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA].		[[2os5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS5 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17567581~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017567581</ref><references group="xtra"/>
	[[Category: Ancylostoma ceylanicum]]		[[Category: Ancylostoma ceylanicum]]
	[[Category: Cho, Y.]]		[[Category: Cho, Y.]]
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	[[Category: Macrophage migration inhibitory factor]]		[[Category: Macrophage migration inhibitory factor]]
	[[Category: Nematode]]		[[Category: Nematode]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:17:05 2009''~~