2os7 - Revision history

OCA at 10:47, 30 August 2023

2023-08-30T10:47:39Z

← Older revision		Revision as of 10:47, 30 August 2023
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	<StructureSection load='2os7' size='340' side='right'caption='[[2os7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2os7' size='340' side='right'caption='[[2os7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2os7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus~~ pestis~~" (lehmann and neumann 1896) migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2os7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS7 FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1p5u\|1p5u]], [[1p5v\|1p5v]], [[1z9s\|1z9s]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">caf1M ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax~~.~~cgi?mode=Info~~&~~srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [https://pdbe.org/2os7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [https://www.ebi.ac.uk/pdbsum/2os7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [https://pdbe.org/2os7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [https://www.ebi.ac.uk/pdbsum/2os7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CAF1M_YERPE CAF1M_YERPE]] Has a stimulatory role for the envelope antigen F1 secretion. It seems to interact with the subunit polypeptide and to prevent it from digestion by a protease.		[https://www.uniprot.org/uniprot/CAF1M_YERPE CAF1M_YERPE] Has a stimulatory role for the envelope antigen F1 secretion. It seems to interact with the subunit polypeptide and to prevent it from digestion by a protease.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Knight, S D~~]]		[[Category: Yersinia pestis]]
	[[Category: ~~Zavialov, A Z~~]]		[[Category: Knight SD]]
	[[Category: ~~Chaperone]]~~		[[Category: Zavialov AZ]]
	~~[[Category: Hetero beta barrel]]~~
	~~[[Category: Immunoglobulin fold~~]]

OCA at 13:04, 9 June 2021

2021-06-09T13:04:39Z

← Older revision		Revision as of 13:04, 9 June 2021
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	==Caf1M periplasmic chaperone tetramer==		==Caf1M periplasmic chaperone tetramer==
	<StructureSection load='2os7' size='340' side='right' caption='[[2os7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2os7' size='340' side='right'caption='[[2os7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2os7]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2os7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS7 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5u\|1p5u]], [[1p5v\|1p5v]], [[1z9s\|1z9s]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p5u\|1p5u]], [[1p5v\|1p5v]], [[1z9s\|1z9s]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caf1M ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caf1M ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [~~http~~://pdbe.org/2os7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2os7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2os7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [https://pdbe.org/2os7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [https://www.ebi.ac.uk/pdbsum/2os7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CAF1M_YERPE CAF1M_YERPE]] Has a stimulatory role for the envelope antigen F1 secretion. It seems to interact with the subunit polypeptide and to prevent it from digestion by a protease.		[[https://www.uniprot.org/uniprot/CAF1M_YERPE CAF1M_YERPE]] Has a stimulatory role for the envelope antigen F1 secretion. It seems to interact with the subunit polypeptide and to prevent it from digestion by a protease.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Knight, S D]]		[[Category: Knight, S D]]
	[[Category: Zavialov, A Z]]		[[Category: Zavialov, A Z]]

OCA at 07:01, 22 August 2018

2018-08-22T07:01:46Z

← Older revision		Revision as of 07:01, 22 August 2018
Line 1:		Line 1:

	==Caf1M periplasmic chaperone tetramer==		==Caf1M periplasmic chaperone tetramer==
	<StructureSection load='2os7' size='340' side='right' caption='[[2os7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2os7' size='340' side='right' caption='[[2os7]], [[Resolution\|resolution]] 2.90Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5u\|1p5u]], [[1p5v\|1p5v]], [[1z9s\|1z9s]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5u\|1p5u]], [[1p5v\|1p5v]], [[1z9s\|1z9s]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caf1M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caf1M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [http://pdbe.org/2os7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [http://www.ebi.ac.uk/pdbsum/2os7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [http://pdbe.org/2os7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [http://www.ebi.ac.uk/pdbsum/2os7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2os7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os7_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:12, 8 February 2016

2016-02-08T11:12:27Z

← Older revision		Revision as of 11:12, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2os7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:59, 10 September 2015

2015-09-10T10:59:16Z

← Older revision		Revision as of 10:59, 10 September 2015
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	<StructureSection load='2os7' size='340' side='right' caption='[[2os7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2os7' size='340' side='right' caption='[[2os7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2os7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Yersinia_pestis Yersinia~~ pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2os7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS7 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5u\|1p5u]], [[1p5v\|1p5v]], [[1z9s\|1z9s]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5u\|1p5u]], [[1p5v\|1p5v]], [[1z9s\|1z9s]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caf1M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 ~~Yersinia~~ pestis])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caf1M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [http://www.ebi.ac.uk/pdbsum/2os7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [http://pdbe.org/2os7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [http://www.ebi.ac.uk/pdbsum/2os7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2os7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Yersinia pestis]]~~
	[[Category: Knight, S D]]		[[Category: Knight, S D]]
	[[Category: Zavialov, A Z]]		[[Category: Zavialov, A Z]]

OCA at 22:53, 24 December 2014

2014-12-24T22:53:59Z

← Older revision		Revision as of 22:53, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2os7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2os7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS7 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5u\|1p5u]], [[1p5v\|1p5v]], [[1z9s\|1z9s]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5u\|1p5u]], [[1p5v\|1p5v]], [[1z9s\|1z9s]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caf1M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caf1M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [http://www.ebi.ac.uk/pdbsum/2os7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [http://www.ebi.ac.uk/pdbsum/2os7 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CAF1M_YERPE CAF1M_YERPE]] Has a stimulatory role for the envelope antigen F1 secretion. It seems to interact with the subunit polypeptide and to prevent it from digestion by a protease.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Yersinia pestis]]		[[Category: Yersinia pestis]]
	[[Category: Knight, S D.]]		[[Category: Knight, S D]]
	[[Category: Zavialov, A Z.]]		[[Category: Zavialov, A Z]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Hetero beta barrel]]		[[Category: Hetero beta barrel]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

OCA at 18:44, 30 September 2014

2014-09-30T18:44:43Z

← Older revision		Revision as of 18:44, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2os7~~.~~png~~\|~~left~~\|~~200px~~]]		==Caf1M periplasmic chaperone tetramer==
			<StructureSection load='2os7' size='340' side='right' caption='[[2os7]], [[Resolution\|resolution]] 2.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2os7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OS7 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5u\|1p5u]], [[1p5v\|1p5v]], [[1z9s\|1z9s]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caf1M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2os7 RCSB], [http://www.ebi.ac.uk/pdbsum/2os7 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os7_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The chaperone Caf1M belongs to a family of ATP-independent periplasmic chaperones that together with outer membrane ushers assemble and secrete filamentous adhesion organelles in Gram-negative pathogens. It assists in folding and transport of Caf1 subunits of the F1 capsular antigen of Yersinia pestis, the microbe causing bubonic plague. In the periplasm, Caf1M prevents subunit aggregation by capping the extensive hydrophobic surface of activated Caf1. We found that subunit-free Caf1M exists predominantly as a tetramer [K(d) = (2-30) x 10(-14) M(3) in the 12-37 degrees C interval]. A 2.9 A resolution crystal structure of the Caf1M tetramer reveals that each of the four molecules contribute its subunit binding sequences (the A(1) and G(1) strands) to form an eight-stranded hetero-sandwich with a well-packed phenylalanine-rich hydrophobic core. Tetramerization protects chaperone molecules against enzymatic proteolysis. Deletions in the subunit binding motifs completely abolish tetramer assembly, suggesting that the hetero-sandwich is the main structural feature holding the tetramer together. Arresting tetramer assembly by a deletion of the N-terminal binding motif, while leaving the major subunit binding motif VGVFVQFAI (G(1) strand) intact, results in accumulation of unspecific aggregates. Deletions in the VGVFVQFAI motif abolish both tetramer assembly and aggregation, consistent with the predicted high beta-aggregation propensity for this motif. These results suggest that the packing of the aggregation-prone subunit binding sequences into the hetero-domain is a novel molecular mechanism preventing unspecific aggregation of the free chaperone.

	~~{{STRUCTURE_2os7\| PDB=2os7 \| SCENE= }}~~		A novel self-capping mechanism controls aggregation of periplasmic chaperone Caf1M.,Zavialov AV, Knight SD Mol Microbiol. 2007 Apr;64(1):153-64. PMID:17376079<ref>PMID:17376079</ref>

	~~===Caf1M periplasmic chaperone tetramer===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17376079}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2os7]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Yersinia_pestis Yersinia pestis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017376079<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Yersinia pestis]]		[[Category: Yersinia pestis]]
	[[Category: Knight, S D.]]		[[Category: Knight, S D.]]

OCA: Protected "2os7" [edit=sysop:move=sysop]

2013-01-07T11:01:55Z

Protected "2os7" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:01, 7 January 2013
(No difference)

OCA at 11:01, 7 January 2013

2013-01-07T11:01:52Z

← Older revision		Revision as of 11:01, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2os7.png\|left\|200px]]		[[Image:2os7.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2os7", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2os7\| PDB=2os7 \| SCENE= }}		{{STRUCTURE_2os7\| PDB=2os7 \| SCENE= }}

	===Caf1M periplasmic chaperone tetramer===		===Caf1M periplasmic chaperone tetramer===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17376079}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17376079 is the PubMed ID number.~~
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	{{ABSTRACT_PUBMED_17376079}}		{{ABSTRACT_PUBMED_17376079}}

	==About this Structure==		==About this Structure==
	~~2OS7~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA].		[[2os7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17376079~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017376079</ref><references group="xtra"/>
	[[Category: Yersinia pestis]]		[[Category: Yersinia pestis]]
	[[Category: Knight, S D.]]		[[Category: Knight, S D.]]
	[[Category: Zavialov, A Z.]]		[[Category: Zavialov, A Z.]]
			[[Category: Chaperone]]
	[[Category: Hetero beta barrel]]		[[Category: Hetero beta barrel]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:34:10 2009''~~

OCA at 19:34, 16 February 2009

2009-02-16T19:34:10Z

← Older revision		Revision as of 19:34, 16 February 2009
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	==About this Structure==		==About this Structure==
	2OS7 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA].		2OS7 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS7 OCA].

	==Reference==		==Reference==
	~~A novel self-capping mechanism controls aggregation of periplasmic chaperone Caf1M., Zavialov AV, Knight SD, Mol Microbiol. 2007 Apr;64(1):153-64.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~17376079 17376079]~~		<ref group="xtra">PMID:17376079</ref><references group="xtra"/>
	~~[[Category: Single protein]]~~
	[[Category: Yersinia pestis]]		[[Category: Yersinia pestis]]
	[[Category: Knight, S D.]]		[[Category: Knight, S D.]]
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	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 02~~:27:~~45 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:34:10 2009''