2pc0 - Revision history

OCA at 10:58, 30 August 2023

2023-08-30T10:58:43Z

← Older revision		Revision as of 10:58, 30 August 2023
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	<StructureSection load='2pc0' size='340' side='right'caption='[[2pc0]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2pc0' size='340' side='right'caption='[[2pc0]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pc0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pc0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PC0 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGR:R~~-1,~~2-PROPANEDIOL'>PGR</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[2hb4\|2hb4]], [[2hb2\|2hb2]], [[2az8\|2az8]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>pol ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~11676 9HIV1])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/HIV-1_retropepsin HIV~~-1 ~~retropepsin]~~, ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [https://pdbe.org/2pc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2pc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pc0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [https://pdbe.org/2pc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2pc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pc0 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q903N5_9HIV1 Q903N5_9HIV1]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Immunodeficiency virus protease\|Immunodeficiency virus protease]]		*[[Immunodeficiency virus protease\|Immunodeficiency virus protease]]
			*[[Immunodeficiency virus protease 3D structures\|Immunodeficiency virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~HIV-~~1 ~~retropepsin~~]]		[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Elder~~, J H~~]]		[[Category: Elder JH]]
	[[Category: Giffin~~, M J~~]]		[[Category: Giffin MJ]]
	[[Category: Heaslet, H]]		[[Category: Heaslet H]]
	[[Category: McRee~~, D E~~]]		[[Category: McRee DE]]
	[[Category: Rosenfeld, R]]		[[Category: Rosenfeld R]]
	[[Category: Stout~~, C D]]~~		[[Category: Stout CD]]
	~~[[Category: Hiv protease]]~~
	~~[[Category: Hydrolase~~]]

OCA at 15:20, 17 June 2021

2021-06-17T15:20:51Z

← Older revision		Revision as of 15:20, 17 June 2021
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	==Apo Wild-type HIV Protease in the open conformation==		==Apo Wild-type HIV Protease in the open conformation==
	<StructureSection load='2pc0' size='340' side='right' caption='[[2pc0]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2pc0' size='340' side='right'caption='[[2pc0]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pc0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pc0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hb4\|2hb4]], [[2hb2\|2hb2]], [[2az8\|2az8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hb4\|2hb4]], [[2hb2\|2hb2]], [[2az8\|2az8]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [~~http~~://pdbe.org/2pc0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2pc0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2pc0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [https://pdbe.org/2pc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2pc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pc0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/2pc0_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/2pc0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[Immunodeficiency virus protease\|Immunodeficiency virus protease]]		*[[Immunodeficiency virus protease\|Immunodeficiency virus protease]]
	*[[Journal:JBSD:36\|Journal:JBSD:36]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
			[[Category: Large Structures]]
	[[Category: Elder, J H]]		[[Category: Elder, J H]]
	[[Category: Giffin, M J]]		[[Category: Giffin, M J]]

OCA at 09:22, 18 October 2017

2017-10-18T09:22:41Z

← Older revision		Revision as of 09:22, 18 October 2017
Line 1:		Line 1:

	==Apo Wild-type HIV Protease in the open conformation==		==Apo Wild-type HIV Protease in the open conformation==
	<StructureSection load='2pc0' size='340' side='right' caption='[[2pc0]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2pc0' size='340' side='right' caption='[[2pc0]], [[Resolution\|resolution]] 1.40Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [http://pdbe.org/2pc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2pc0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [http://pdbe.org/2pc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2pc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pc0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[~~HIV-1~~ protease\|~~HIV-1~~ protease]]		*[[Immunodeficiency virus protease\|Immunodeficiency virus protease]]
	*[[Journal:JBSD:36\|Journal:JBSD:36]]		*[[Journal:JBSD:36\|Journal:JBSD:36]]
	*[[Virus protease\|Virus protease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:35, 7 February 2016

2016-02-07T21:35:00Z

← Older revision		Revision as of 21:35, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pc0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:10, 10 September 2015

2015-09-10T05:10:02Z

← Older revision		Revision as of 05:10, 10 September 2015
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	<StructureSection load='2pc0' size='340' side='right' caption='[[2pc0]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2pc0' size='340' side='right' caption='[[2pc0]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pc0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_immunodeficiency_virus_1 Human immunodeficiency virus 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pc0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hb4\|2hb4]], [[2hb2\|2hb2]], [[2az8\|2az8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hb4\|2hb4]], [[2hb2\|2hb2]], [[2az8\|2az8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 ~~Human immunodeficiency virus 1~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2pc0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [http://pdbe.org/2pc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2pc0 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2pc0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
	~~[[Category: Human immunodeficiency virus 1]]~~
	[[Category: Elder, J H]]		[[Category: Elder, J H]]
	[[Category: Giffin, M J]]		[[Category: Giffin, M J]]

OCA at 15:55, 19 January 2015

2015-01-19T15:55:33Z

← Older revision		Revision as of 15:55, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pc0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pc0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PC0 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hb4\|2hb4]], [[2hb2\|2hb2]], [[2az8\|2az8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hb4\|2hb4]], [[2hb2\|2hb2]], [[2az8\|2az8]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2pc0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2pc0 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
	[[Category: Elder, J H.]]		[[Category: Elder, J H]]
	[[Category: Giffin, M J.]]		[[Category: Giffin, M J]]
	[[Category: Heaslet, H.]]		[[Category: Heaslet, H]]
	[[Category: McRee, D E.]]		[[Category: McRee, D E]]
	[[Category: Rosenfeld, R.]]		[[Category: Rosenfeld, R]]
	[[Category: Stout, C D.]]		[[Category: Stout, C D]]
	[[Category: Hiv protease]]		[[Category: Hiv protease]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 19:01, 30 September 2014

2014-09-30T19:01:59Z

← Older revision		Revision as of 19:01, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2pc0~~\| ~~PDB~~=2pc0 \| ~~SCENE~~= }}		==Apo Wild-type HIV Protease in the open conformation==
	===~~Apo Wild~~-type HIV ~~Protease~~ in the open conformation~~===~~		<StructureSection load='2pc0' size='340' side='right' caption='[[2pc0]], [[Resolution\|resolution]] 1.40Å' scene=''>
	~~{{ABSTRACT_PUBMED_17642513}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2pc0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PC0 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hb4\|2hb4]], [[2hb2\|2hb2]], [[2az8\|2az8]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2pc0 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/2pc0_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The crystal structures of wild-type HIV protease (HIV PR) in the absence of substrate or inhibitor in two related crystal forms at 1.4 and 2.15 A resolution are reported. In one crystal form HIV PR adopts an 'open' conformation with a 7.7 A separation between the tips of the flaps in the homodimer. In the other crystal form the tips of the flaps are 'curled' towards the 80s loop, forming contacts across the local twofold axis. The 2.3 A resolution crystal structure of a sixfold mutant of HIV PR in the absence of substrate or inhibitor is also reported. The mutant HIV PR, which evolved in response to treatment with the potent inhibitor TL-3, contains six point mutations relative to the wild-type enzyme (L24I, M46I, F53L, L63P, V77I, V82A). In this structure the flaps also adopt a 'curled' conformation, but are separated and not in contact. Comparison of the apo structures to those with TL-3 bound demonstrates the extent of conformational change induced by inhibitor binding, which includes reorganization of the packing between twofold-related flaps. Further comparison with six other apo HIV PR structures reveals that the 'open' and 'curled' conformations define two distinct families in HIV PR. These conformational states include hinge motion of residues at either end of the flaps, opening and closing the entire beta-loop, and translational motion of the flap normal to the dimer twofold axis and relative to the 80s loop. The alternate conformations also entail changes in the beta-turn at the tip of the flap. These observations provide insight into the plasticity of the flap domains, the nature of their motions and their critical role in binding substrates and inhibitors.

	~~==About this Structure==~~		Conformational flexibility in the flap domains of ligand-free HIV protease.,Heaslet H, Rosenfeld R, Giffin M, Lin YC, Tam K, Torbett BE, Elder JH, McRee DE, Stout CD Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):866-75. Epub 2007, Jul 17. PMID:17642513<ref>PMID:17642513</ref>
	~~[[2pc0]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=2PC0 OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
			*[[HIV-1 protease\|HIV-1 protease]]
	*[[Journal:JBSD:36\|Journal:JBSD:36]]		*[[Journal:JBSD:36\|Journal:JBSD:36]]
	*[[Virus protease\|Virus protease]]		*[[Virus protease\|Virus protease]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017642513<~~/~~ref><ref group="xtra">doi 10.1080/07391102.2012.736774</ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]

OCA at 10:06, 11 March 2013

2013-03-11T10:06:51Z

← Older revision		Revision as of 10:06, 11 March 2013
Line 1:		Line 1:
	~~[[Image:2pc0.png\|left\|200px]]~~

	{{STRUCTURE_2pc0\| PDB=2pc0 \| SCENE= }}		{{STRUCTURE_2pc0\| PDB=2pc0 \| SCENE= }}

	===Apo Wild-type HIV Protease in the open conformation===		===Apo Wild-type HIV Protease in the open conformation===

	{{ABSTRACT_PUBMED_17642513}}		{{ABSTRACT_PUBMED_17642513}}

Line 11:		Line 7:

	==See Also==		==See Also==
			*[[Journal:JBSD:36\|Journal:JBSD:36]]
	*[[Virus protease\|Virus protease]]		*[[Virus protease\|Virus protease]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:017642513</ref><references group="xtra"/>		<ref group="xtra">PMID:017642513</ref><ref group="xtra">doi 10.1080/07391102.2012.736774</ref><references group="xtra"/>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]

OCA at 07:55, 20 October 2012

2012-10-20T07:55:11Z

← Older revision		Revision as of 07:55, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2pc0]] is a 1 chain structure ~~of [[Virus protease]]~~ with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA].		[[2pc0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC0 OCA].

	==See Also==		==See Also==

OCA: Protected "2pc0" [edit=sysop:move=sysop]

2012-07-25T17:53:45Z

Protected "2pc0" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:53, 25 July 2012
(No difference)