2pex - Revision history

OCA at 09:09, 21 February 2024

2024-02-21T09:09:14Z

← Older revision		Revision as of 09:09, 21 February 2024
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	<StructureSection load='2pex' size='340' side='right'caption='[[2pex]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2pex' size='340' side='right'caption='[[2pex]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pex]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_campestris"_pammel_1895 "bacillus~~ campestris~~" pammel 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PEX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pex]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris Xanthomonas campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PEX FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1z91\|1z91]], [[1z9c\|1z9c]], [[2pfb\|2pfb]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~ohrR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339 "Bacillus campestris" Pammel 1895])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [https://pdbe.org/2pex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [https://www.ebi.ac.uk/pdbsum/2pex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pex ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [https://pdbe.org/2pex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [https://www.ebi.ac.uk/pdbsum/2pex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pex ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q93R11_XANCH Q93R11_XANCH]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pex ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pex ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The Xanthomonas campestris transcription regulator OhrR contains a reactive cysteine residue (C22) that upon oxidation by organic hydroperoxides (OHPs) forms an intersubunit disulphide bond with residue C127'. Such modification induces the expression of a peroxidase that reduces OHPs to their less toxic alcohols. Here, we describe the structures of reduced and OHP-oxidized OhrR, visualizing the structural mechanism of OHP induction. Reduced OhrR takes a canonical MarR family fold with C22 and C127' separated by 15.5 A. OHP oxidation results in the disruption of the Y36'-C22-Y47' interaction network and dissection of helix alpha5, which then allows the 135 degrees rotation and 8.2 A translation of C127', formation of the C22-C127' disulphide bond, and alpha6-alpha6' helix-swapped reconfiguration of the dimer interface. These changes result in the 28 degrees rigid body rotations of each winged helix-turn-helix motif and DNA dissociation. Similar effector-induced rigid body rotations are expected for most MarR family members.

	Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR.,Newberry KJ, Fuangthong M, Panmanee W, Mongkolsuk S, Brennan RG Mol Cell. 2007 Nov 30;28(4):652-64. PMID:18042459<ref>PMID:18042459</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2pex" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Organic hydroperoxide resistance protein\|Organic hydroperoxide resistance protein]]		*[[Organic hydroperoxide resistance protein\|Organic hydroperoxide resistance protein]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Bacillus campestris pammel 1895]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Brennan, R G~~]]		[[Category: Xanthomonas campestris]]
	[[Category: ~~Newberry, K J~~]]		[[Category: Brennan RG]]
	[[Category: ~~Transcription regulator~~]]		[[Category: Newberry KJ]]

OCA at 15:22, 17 June 2021

2021-06-17T15:22:29Z

← Older revision		Revision as of 15:22, 17 June 2021
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	==Structure of reduced C22S OhrR from Xanthamonas Campestris==		==Structure of reduced C22S OhrR from Xanthamonas Campestris==
	<StructureSection load='2pex' size='340' side='right' caption='[[2pex]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2pex' size='340' side='right'caption='[[2pex]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pex]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_campestris"_pammel_1895 "bacillus campestris" pammel 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PEX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pex]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_campestris"_pammel_1895 "bacillus campestris" pammel 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PEX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z91\|1z91]], [[1z9c\|1z9c]], [[2pfb\|2pfb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1z91\|1z91]], [[1z9c\|1z9c]], [[2pfb\|2pfb]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ohrR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339 "Bacillus campestris" Pammel 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ohrR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339 "Bacillus campestris" Pammel 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [~~http~~://pdbe.org/2pex PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2pex PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2pex ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [https://pdbe.org/2pex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [https://www.ebi.ac.uk/pdbsum/2pex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pex ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus campestris pammel 1895]]		[[Category: Bacillus campestris pammel 1895]]
			[[Category: Large Structures]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Newberry, K J]]		[[Category: Newberry, K J]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

OCA at 08:58, 29 August 2018

2018-08-29T08:58:14Z

← Older revision		Revision as of 08:58, 29 August 2018
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	==Structure of reduced C22S OhrR from Xanthamonas Campestris==		==Structure of reduced C22S OhrR from Xanthamonas Campestris==
	<StructureSection load='2pex' size='340' side='right' caption='[[2pex]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2pex' size='340' side='right' caption='[[2pex]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z91\|1z91]], [[1z9c\|1z9c]], [[2pfb\|2pfb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z91\|1z91]], [[1z9c\|1z9c]], [[2pfb\|2pfb]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ohrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339 "Bacillus campestris" Pammel 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ohrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339 "Bacillus campestris" Pammel 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [http://pdbe.org/2pex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [http://www.ebi.ac.uk/pdbsum/2pex PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [http://pdbe.org/2pex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [http://www.ebi.ac.uk/pdbsum/2pex PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pex ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/2pex_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/2pex_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:47, 7 February 2016

2016-02-07T15:47:32Z

← Older revision		Revision as of 15:47, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pex ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:55, 10 September 2015

2015-09-10T02:55:36Z

← Older revision		Revision as of 02:55, 10 September 2015
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	<StructureSection load='2pex' size='340' side='right' caption='[[2pex]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2pex' size='340' side='right' caption='[[2pex]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pex]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Xanthomonas_campestris Xanthomonas~~ campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PEX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pex]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_campestris"_pammel_1895 "bacillus campestris" pammel 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PEX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z91\|1z91]], [[1z9c\|1z9c]], [[2pfb\|2pfb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z91\|1z91]], [[1z9c\|1z9c]], [[2pfb\|2pfb]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ohrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339 ~~Xanthomonas~~ campestris])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ohrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339 "Bacillus campestris" Pammel 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [http://www.ebi.ac.uk/pdbsum/2pex PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [http://pdbe.org/2pex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [http://www.ebi.ac.uk/pdbsum/2pex PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2pex" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Xanthomonas~~ campestris]]		[[Category: Bacillus campestris pammel 1895]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Newberry, K J]]		[[Category: Newberry, K J]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

OCA at 17:07, 19 January 2015

2015-01-19T17:07:40Z

← Older revision		Revision as of 17:07, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pex]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris Xanthomonas campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PEX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pex]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris Xanthomonas campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PEX FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z91\|1z91]], [[1z9c\|1z9c]], [[2pfb\|2pfb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z91\|1z91]], [[1z9c\|1z9c]], [[2pfb\|2pfb]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ohrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339 Xanthomonas campestris])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ohrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339 Xanthomonas campestris])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [http://www.ebi.ac.uk/pdbsum/2pex PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [http://www.ebi.ac.uk/pdbsum/2pex PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[OhrR\|OhrR]]
	*[[Organic hydroperoxide resistance protein\|Organic hydroperoxide resistance protein]]		*[[Organic hydroperoxide resistance protein\|Organic hydroperoxide resistance protein]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Xanthomonas campestris]]		[[Category: Xanthomonas campestris]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G]]
	[[Category: Newberry, K J.]]		[[Category: Newberry, K J]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

OCA at 19:41, 30 September 2014

2014-09-30T19:41:19Z

← Older revision		Revision as of 19:41, 30 September 2014
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	~~{{STRUCTURE_2pex~~\| ~~PDB~~=2pex \| ~~SCENE~~= }}		==Structure of reduced C22S OhrR from Xanthamonas Campestris==
	===~~Structure~~ of ~~reduced C22S OhrR~~ from ~~Xanthamonas Campestris~~===		<StructureSection load='2pex' size='340' side='right' caption='[[2pex]], [[Resolution\|resolution]] 1.90Å' scene=''>
	~~{{ABSTRACT_PUBMED_18042459}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2pex]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris Xanthomonas campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PEX FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z91\|1z91]], [[1z9c\|1z9c]], [[2pfb\|2pfb]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ohrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339 Xanthomonas campestris])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pex RCSB], [http://www.ebi.ac.uk/pdbsum/2pex PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/2pex_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The Xanthomonas campestris transcription regulator OhrR contains a reactive cysteine residue (C22) that upon oxidation by organic hydroperoxides (OHPs) forms an intersubunit disulphide bond with residue C127'. Such modification induces the expression of a peroxidase that reduces OHPs to their less toxic alcohols. Here, we describe the structures of reduced and OHP-oxidized OhrR, visualizing the structural mechanism of OHP induction. Reduced OhrR takes a canonical MarR family fold with C22 and C127' separated by 15.5 A. OHP oxidation results in the disruption of the Y36'-C22-Y47' interaction network and dissection of helix alpha5, which then allows the 135 degrees rotation and 8.2 A translation of C127', formation of the C22-C127' disulphide bond, and alpha6-alpha6' helix-swapped reconfiguration of the dimer interface. These changes result in the 28 degrees rigid body rotations of each winged helix-turn-helix motif and DNA dissociation. Similar effector-induced rigid body rotations are expected for most MarR family members.

	~~==About this Structure==~~		Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR.,Newberry KJ, Fuangthong M, Panmanee W, Mongkolsuk S, Brennan RG Mol Cell. 2007 Nov 30;28(4):652-64. PMID:18042459<ref>PMID:18042459</ref>
	~~[[2pex]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Xanthomonas_campestris Xanthomonas campestris]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=2PEX OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[OhrR\|OhrR]]		*[[OhrR\|OhrR]]
	*[[Organic hydroperoxide resistance protein\|Organic hydroperoxide resistance protein]]		*[[Organic hydroperoxide resistance protein\|Organic hydroperoxide resistance protein]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018042459<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Xanthomonas campestris]]		[[Category: Xanthomonas campestris]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]
	[[Category: Newberry, K J.]]		[[Category: Newberry, K J.]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

OCA at 10:40, 11 March 2013

2013-03-11T10:40:04Z

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	~~[[Image:2pex.png\|left\|200px]]~~

	{{STRUCTURE_2pex\| PDB=2pex \| SCENE= }}		{{STRUCTURE_2pex\| PDB=2pex \| SCENE= }}

	===Structure of reduced C22S OhrR from Xanthamonas Campestris===		===Structure of reduced C22S OhrR from Xanthamonas Campestris===

	{{ABSTRACT_PUBMED_18042459}}		{{ABSTRACT_PUBMED_18042459}}

OCA at 07:07, 20 October 2012

2012-10-20T07:07:23Z

← Older revision		Revision as of 07:07, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2pex]] is a 2 chain structure ~~of [[Organic hydroperoxide resistance protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris Xanthomonas campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA].		[[2pex]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris Xanthomonas campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEX OCA].

	==See Also==		==See Also==

OCA: Protected "2pex" [edit=sysop:move=sysop]

2012-07-25T15:20:12Z

Protected "2pex" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:20, 25 July 2012
(No difference)