2pff - Revision history

OCA at 11:00, 30 August 2023

2023-08-30T11:00:40Z

← Older revision		Revision as of 11:00, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pff]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pff]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PFF FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4Å</td></tr>
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl~~-~~CoA synthase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86~~] ~~</span>~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [https://pdbe.org/2pff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [https://www.ebi.ac.uk/pdbsum/2pff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [https://pdbe.org/2pff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [https://www.ebi.ac.uk/pdbsum/2pff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FAS2_YEAST FAS2_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.[HAMAP-Rule:MF_00101] [[https://www.uniprot.org/uniprot/FAS1_YEAST FAS1_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.		[https://www.uniprot.org/uniprot/FAS2_YEAST FAS2_YEAST] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.[HAMAP-Rule:MF_00101]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Fatty-acyl-CoA synthase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Lomakin~~, I B~~]]		[[Category: Lomakin IB]]
	[[Category: Steitz~~, T A~~]]		[[Category: Steitz TA]]
	[[Category: Xiong, Y]]		[[Category: Xiong Y]]
	~~[[Category: Acetyltransferase]]~~
	~~[[Category: Acyl-carrier-protein]]~~
	~~[[Category: Beta-ketoacyl reductase]]~~
	~~[[Category: Beta-ketoacyl synthase]]~~
	~~[[Category: Dehydratase]]~~
	~~[[Category: Fatty acid synthase]]~~
	~~[[Category: Malonyltransferase]]~~
	~~[[Category: Transferase~~]]

OCA at 07:45, 9 March 2022

2022-03-09T07:45:18Z

← Older revision		Revision as of 07:45, 9 March 2022
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	<StructureSection load='2pff' size='340' side='right'caption='[[2pff]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='2pff' size='340' side='right'caption='[[2pff]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pff]] is a 9 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2PFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pff]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PFF FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [~~http~~://pdbe.org/2pff PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2pff PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2pff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [https://pdbe.org/2pff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [https://www.ebi.ac.uk/pdbsum/2pff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/FAS2_YEAST FAS2_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.[HAMAP-Rule:MF_00101] [[~~http~~://www.uniprot.org/uniprot/FAS1_YEAST FAS1_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.		[[https://www.uniprot.org/uniprot/FAS2_YEAST FAS2_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.[HAMAP-Rule:MF_00101] [[https://www.uniprot.org/uniprot/FAS1_YEAST FAS1_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:54, 3 June 2020

2020-06-03T06:54:47Z

← Older revision		Revision as of 06:54, 3 June 2020
Line 1:		Line 1:

	==Structural Insights of Yeast Fatty Acid Synthase==		==Structural Insights of Yeast Fatty Acid Synthase==
	<StructureSection load='2pff' size='340' side='right' caption='[[2pff]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='2pff' size='340' side='right'caption='[[2pff]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pff]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pff]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2PFF FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [http://pdbe.org/2pff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [http://www.ebi.ac.uk/pdbsum/2pff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [http://pdbe.org/2pff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [http://www.ebi.ac.uk/pdbsum/2pff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Fatty acid synthase\|Fatty acid synthase]]		*[[Fatty acid synthase 3D structures\|Fatty acid synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Fatty-acyl-CoA synthase]]		[[Category: Fatty-acyl-CoA synthase]]
			[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Lomakin, I B]]		[[Category: Lomakin, I B]]

OCA at 08:22, 29 August 2018

2018-08-29T08:22:54Z

← Older revision		Revision as of 08:22, 29 August 2018
Line 1:		Line 1:

	==Structural Insights of Yeast Fatty Acid Synthase==		==Structural Insights of Yeast Fatty Acid Synthase==
	<StructureSection load='2pff' size='340' side='right' caption='[[2pff]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='2pff' size='340' side='right' caption='[[2pff]], [[Resolution\|resolution]] 4.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [http://pdbe.org/2pff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [http://www.ebi.ac.uk/pdbsum/2pff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [http://pdbe.org/2pff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [http://www.ebi.ac.uk/pdbsum/2pff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:15, 11 September 2015

2015-09-11T11:15:31Z

← Older revision		Revision as of 11:15, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [http://www.ebi.ac.uk/pdbsum/2pff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [http://pdbe.org/2pff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [http://www.ebi.ac.uk/pdbsum/2pff PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2pff" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:42, 25 December 2014

2014-12-25T15:42:27Z

← Older revision		Revision as of 15:42, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pff]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pff]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PFF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [http://www.ebi.ac.uk/pdbsum/2pff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [http://www.ebi.ac.uk/pdbsum/2pff PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/FAS2_YEAST FAS2_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.[HAMAP-Rule:MF_00101] [[http://www.uniprot.org/uniprot/FAS1_YEAST FAS1_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 26:
	[[Category: Fatty-acyl-CoA synthase]]		[[Category: Fatty-acyl-CoA synthase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Lomakin, I B.]]		[[Category: Lomakin, I B]]
	[[Category: Steitz, T A.]]		[[Category: Steitz, T A]]
	[[Category: Xiong, Y.]]		[[Category: Xiong, Y]]
	[[Category: Acetyltransferase]]		[[Category: Acetyltransferase]]
	[[Category: Acyl-carrier-protein]]		[[Category: Acyl-carrier-protein]]

OCA at 00:57, 2 October 2014

2014-10-02T00:57:44Z

← Older revision		Revision as of 00:57, 2 October 2014
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	[[~~Image~~:2pff.~~png\|left\|200px~~]]		==Structural Insights of Yeast Fatty Acid Synthase==
			<StructureSection load='2pff' size='340' side='right' caption='[[2pff]], [[Resolution\|resolution]] 4.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2pff]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PFF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase Fatty-acyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.86 2.3.1.86] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pff RCSB], [http://www.ebi.ac.uk/pdbsum/2pff PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			In yeast, the whole metabolic pathway for making 16- and 18-carbon fatty acids is carried out by fatty acid synthase, a 2.6 megadalton molecular-weight macromolecular assembly containing six copies of all eight catalytic centers. We have determined its crystal structure, which illuminates how this enzyme is initially activated and then carries out multiple steps of synthesis in each of six sterically isolated reaction chambers. Six of the catalytic sites are in the wall of the assembly facing an acyl carrier protein (ACP) bound to the ketoacyl synthase domain. Two-dimensional diffusion of substrates to the catalytic sites may be achieved by the electrostatically negative ACP swinging to each of the six electrostatically positive catalytic sites. The phosphopantetheinyl transferase domain lies outside the shell of the assembly, inaccessible to ACP that lies inside, suggesting that the attachment of the pantetheine arm to ACP must occur before complete assembly of the complex.

	~~{{STRUCTURE_2pff\| PDB=2pff \| SCENE= }}~~		The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together.,Lomakin IB, Xiong Y, Steitz TA Cell. 2007 Apr 20;129(2):319-32. PMID:17448991<ref>PMID:17448991</ref>

	~~===Structural Insights~~ of ~~Yeast Fatty Acid Synthase===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17448991}}~~

	~~==About this Structure==~~
	~~[[2pff]] is a 9 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2PFF OCA].~~

	==See Also==		==See Also==
	*[[Fatty acid synthase\|Fatty acid synthase]]		*[[Fatty acid synthase\|Fatty acid synthase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017448991<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Fatty-acyl-CoA synthase]]		[[Category: Fatty-acyl-CoA synthase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA at 18:28, 20 October 2012

2012-10-20T18:28:42Z

← Older revision		Revision as of 18:28, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2pff]] is a 9 chain structure ~~of [[Fatty acid synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA].		[[2pff]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA].

	==See Also==		==See Also==

OCA: Protected "2pff" [edit=sysop:move=sysop]

2012-07-27T04:12:32Z

Protected "2pff" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:12, 27 July 2012
(No difference)

OCA at 04:12, 27 July 2012

2012-07-27T04:12:31Z

← Older revision		Revision as of 04:12, 27 July 2012
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	~~{{Seed}}~~
	[[Image:2pff.png\|left\|200px]]		[[Image:2pff.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2pff", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2pff\| PDB=2pff \| SCENE= }}		{{STRUCTURE_2pff\| PDB=2pff \| SCENE= }}

	===Structural Insights of Yeast Fatty Acid Synthase===		===Structural Insights of Yeast Fatty Acid Synthase===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17448991}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17448991 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17448991}}		{{ABSTRACT_PUBMED_17448991}}

	==About this Structure==		==About this Structure==
	~~2PFF~~ is a 9 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA].		[[2pff]] is a 9 chain structure of [[Fatty acid synthase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFF OCA].

			==See Also==
			*[[Fatty acid synthase\|Fatty acid synthase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17448991~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017448991</ref><references group="xtra"/>
	[[Category: Fatty-acyl-CoA synthase]]		[[Category: Fatty-acyl-CoA synthase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
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	[[Category: Malonyltransferase]]		[[Category: Malonyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 09:57:44 2010''~~