2plf - Revision history

OCA at 01:19, 21 November 2024

2024-11-21T01:19:04Z

← Older revision		Revision as of 01:19, 21 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/2plf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/2plf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:04, 30 August 2023

2023-08-30T11:04:11Z

← Older revision		Revision as of 11:04, 30 August 2023
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	<StructureSection load='2plf' size='340' side='right'caption='[[2plf]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2plf' size='340' side='right'caption='[[2plf]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~'saccharolobus_solfataricus' 'saccharolobus~~ solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PLF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PLF FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2aho\|2aho]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">eif2g ([https://www.ncbi~~.~~nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=2287 'Saccharolobus solfataricus'])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [https://pdbe.org/2plf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [https://www.ebi.ac.uk/pdbsum/2plf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2plf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [https://pdbe.org/2plf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [https://www.ebi.ac.uk/pdbsum/2plf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2plf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~IF2G_SULSO IF2G_SULSO]~~] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA ~~(By similarity)~~.		[https://www.uniprot.org/uniprot/IF2G_SACS2 IF2G_SACS2] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.[HAMAP-Rule:MF_00119]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Saccharolobus solfataricus]]		[[Category: Saccharolobus solfataricus]]
	~~[[Category: Large Structures]]~~		[[Category: Blaesi U]]
	[[Category: Blaesi, U]]		[[Category: Fedorov RV]]
	[[Category: Fedorov~~, R V~~]]		[[Category: Garber MB]]
	[[Category: Garber~~, M B~~]]		[[Category: Hasenohrl D]]
	[[Category: Hasenohrl, D]]		[[Category: Manstein DJ]]
	[[Category: Manstein~~, D J~~]]		[[Category: Nikonov OS]]
	[[Category: Nikonov~~, O S~~]]		[[Category: Nikonov SV]]
	[[Category: Nikonov~~, S V~~]]		[[Category: Nikulin AD]]
	[[Category: Nikulin~~, A D~~]]		[[Category: Stolboushkina EA]]
	[[Category: Stolboushkina~~, E A]]~~
	~~[[Category: Aif2]]~~
	~~[[Category: Initiation factor 2 gamma subunit]]~~
	~~[[Category: Initiation of the translation]]~~
	~~[[Category: Nucleotide binding]]~~
	~~[[Category: Translation~~]]

OCA at 15:26, 17 June 2021

2021-06-17T15:26:44Z

← Older revision		Revision as of 15:26, 17 June 2021
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	==The structure of aIF2gamma subunit from the archaeon Sulfolobus solfataricus in the nucleotide-free form.==		==The structure of aIF2gamma subunit from the archaeon Sulfolobus solfataricus in the nucleotide-free form.==
	<StructureSection load='2plf' size='340' side='right' caption='[[2plf]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2plf' size='340' side='right'caption='[[2plf]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PLF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PLF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aho\|2aho]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2aho\|2aho]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eif2g ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 'Saccharolobus solfataricus'])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eif2g ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 'Saccharolobus solfataricus'])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [~~http~~://pdbe.org/2plf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2plf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2plf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [https://pdbe.org/2plf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [https://www.ebi.ac.uk/pdbsum/2plf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2plf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/IF2G_SULSO IF2G_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).		[[https://www.uniprot.org/uniprot/IF2G_SULSO IF2G_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Saccharolobus solfataricus]]		[[Category: Saccharolobus solfataricus]]
			[[Category: Large Structures]]
	[[Category: Blaesi, U]]		[[Category: Blaesi, U]]
	[[Category: Fedorov, R V]]		[[Category: Fedorov, R V]]

OCA at 08:29, 29 August 2018

2018-08-29T08:29:41Z

← Older revision		Revision as of 08:29, 29 August 2018
Line 1:		Line 1:

	==The structure of aIF2gamma subunit from the archaeon Sulfolobus solfataricus in the nucleotide-free form.==		==The structure of aIF2gamma subunit from the archaeon Sulfolobus solfataricus in the nucleotide-free form.==
	<StructureSection load='2plf' size='340' side='right' caption='[[2plf]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2plf' size='340' side='right' caption='[[2plf]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Atcc_35091 Atcc 35091~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PLF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PLF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aho\|2aho]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aho\|2aho]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eif2g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ~~ATCC 35091~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eif2g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 'Saccharolobus solfataricus'])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [http://pdbe.org/2plf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [http://www.ebi.ac.uk/pdbsum/2plf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [http://pdbe.org/2plf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [http://www.ebi.ac.uk/pdbsum/2plf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2plf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/2plf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/2plf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Atcc 35091~~]]		[[Category: Saccharolobus solfataricus]]
	[[Category: Blaesi, U]]		[[Category: Blaesi, U]]
	[[Category: Fedorov, R V]]		[[Category: Fedorov, R V]]

OCA at 07:40, 9 February 2016

2016-02-09T07:40:49Z

← Older revision		Revision as of 07:40, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2plf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:04, 10 September 2015

2015-09-10T20:04:15Z

← Older revision		Revision as of 20:04, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2plf' size='340' side='right' caption='[[2plf]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2plf' size='340' side='right' caption='[[2plf]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_solfataricus Sulfolobus solfataricus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PLF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PLF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aho\|2aho]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aho\|2aho]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eif2g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ~~Sulfolobus solfataricus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eif2g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [http://www.ebi.ac.uk/pdbsum/2plf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [http://pdbe.org/2plf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [http://www.ebi.ac.uk/pdbsum/2plf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2plf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Sulfolobus solfataricus~~]]		[[Category: Atcc 35091]]
	[[Category: Blaesi, U]]		[[Category: Blaesi, U]]
	[[Category: Fedorov, R V]]		[[Category: Fedorov, R V]]

OCA at 05:26, 25 December 2014

2014-12-25T05:26:37Z

← Older revision		Revision as of 05:26, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PLF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PLF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aho\|2aho]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aho\|2aho]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eif2g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eif2g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [http://www.ebi.ac.uk/pdbsum/2plf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [http://www.ebi.ac.uk/pdbsum/2plf PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/IF2G_SULSO IF2G_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Blaesi, U.]]		[[Category: Blaesi, U]]
	[[Category: Fedorov, R V.]]		[[Category: Fedorov, R V]]
	[[Category: Garber, M B.]]		[[Category: Garber, M B]]
	[[Category: Hasenohrl, D.]]		[[Category: Hasenohrl, D]]
	[[Category: Manstein, D J.]]		[[Category: Manstein, D J]]
	[[Category: Nikonov, O S.]]		[[Category: Nikonov, O S]]
	[[Category: Nikonov, S V.]]		[[Category: Nikonov, S V]]
	[[Category: Nikulin, A D.]]		[[Category: Nikulin, A D]]
	[[Category: Stolboushkina, E A.]]		[[Category: Stolboushkina, E A]]
	[[Category: Aif2]]		[[Category: Aif2]]
	[[Category: Initiation factor 2 gamma subunit]]		[[Category: Initiation factor 2 gamma subunit]]

OCA at 18:44, 30 September 2014

2014-09-30T18:44:57Z

← Older revision		Revision as of 18:44, 30 September 2014
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	[[Image:~~2plf~~.~~png~~\|~~left~~\|~~200px~~]]		==The structure of aIF2gamma subunit from the archaeon Sulfolobus solfataricus in the nucleotide-free form.==
			<StructureSection load='2plf' size='340' side='right' caption='[[2plf]], [[Resolution\|resolution]] 2.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2plf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PLF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aho\|2aho]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eif2g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2plf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2plf RCSB], [http://www.ebi.ac.uk/pdbsum/2plf PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/2plf_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Heterotrimeric a/eIF2alphabetagamma (archaeal homologue of the eukaryotic translation initiation factor 2 with alpha, beta and gamma subunits) delivers charged initiator tRNA (tRNAi) to the small ribosomal subunit. In this work, we determined the structures of aIF2gamma from the archaeon Sulfolobus solfataricus in the nucleotide-free and GDP-bound forms. Comparison of the free, GDP and Gpp(NH)p-Mg2+ forms of aIF2gamma revealed a sequence of conformational changes upon GDP and GTP binding. Our results show that the affinity of GDP to the G domain of the gamma subunit is higher than that of Gpp(NH)p. In analyzing a pyrophosphate molecule binding to domain II of the gamma subunit, we found a cleft that is very suitable for the acceptor stem of tRNA accommodation. It allows the suggestion of an alternative position for Met-tRNA i Met on the alphagamma intersubunit dimer, at variance with a recently published one. In the model reported here, the acceptor stem of the tRNAi is approximately perpendicular to that of tRNA in the ternary complex elongation factor Tu-Gpp(NH)p-tRNA. According to our analysis, the elbow and T stem of Met-tRNA i Met in this position should make extensive contact with the alpha subunit of aIF2. Thus, this model is in good agreement with experimental data showing that the alpha subunit of aIF2 is necessary for the stable interaction of aIF2gamma with Met-tRNA i Met.

	~~{{STRUCTURE_2plf\| PDB=2plf \| SCENE= }}~~		New insights into the interactions of the translation initiation factor 2 from archaea with guanine nucleotides and initiator tRNA.,Nikonov O, Stolboushkina E, Nikulin A, Hasenohrl D, Blasi U, Manstein DJ, Fedorov R, Garber M, Nikonov S J Mol Biol. 2007 Oct 19;373(2):328-36. Epub 2007 Aug 2. PMID:17825838<ref>PMID:17825838</ref>

	~~===The structure~~ of ~~aIF2gamma subunit from the archaeon Sulfolobus solfataricus in~~ the ~~nucleotide-free form~~.~~===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17825838}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2plf]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017825838<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Blaesi, U.]]		[[Category: Blaesi, U.]]

OCA: Protected "2plf" [edit=sysop:move=sysop]

2013-01-07T13:38:39Z

Protected "2plf" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:38, 7 January 2013
(No difference)

OCA at 13:38, 7 January 2013

2013-01-07T13:38:36Z

← Older revision		Revision as of 13:38, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2plf.png\|left\|200px]]		[[Image:2plf.png\|left\|200px]]

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	{{STRUCTURE_2plf\| PDB=2plf \| SCENE= }}		{{STRUCTURE_2plf\| PDB=2plf \| SCENE= }}

	===The structure of aIF2gamma subunit from the archaeon Sulfolobus solfataricus in the nucleotide-free form.===		===The structure of aIF2gamma subunit from the archaeon Sulfolobus solfataricus in the nucleotide-free form.===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17825838}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_17825838}}		{{ABSTRACT_PUBMED_17825838}}

	==About this Structure==		==About this Structure==
	~~2PLF~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA].		[[2plf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLF OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17825838~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017825838</ref><references group="xtra"/>
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Blaesi, U.]]		[[Category: Blaesi, U.]]
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	[[Category: Initiation of the translation]]		[[Category: Initiation of the translation]]
	[[Category: Nucleotide binding]]		[[Category: Nucleotide binding]]
			[[Category: Translation]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 08:03:11 2009''~~