2pp4 - Revision history

OCA at 09:43, 22 May 2024

2024-05-22T09:43:53Z

← Older revision		Revision as of 09:43, 22 May 2024
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	==Solution Structure of ETO-TAFH refined in explicit solvent==		==Solution Structure of ETO-TAFH refined in explicit solvent==
	<StructureSection load='2pp4' size='340' side='right'caption='[[2pp4~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2pp4' size='340' side='right'caption='[[2pp4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [https://pdbe.org/2pp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [https://www.ebi.ac.uk/pdbsum/2pp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pp4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [https://pdbe.org/2pp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [https://www.ebi.ac.uk/pdbsum/2pp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pp4 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.<ref>PMID:8334990</ref> <ref>PMID:7541640</ref> <ref>PMID:8353289</ref> <ref>PMID:1423235</ref> Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500]].		[https://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN] Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.<ref>PMID:8334990</ref> <ref>PMID:7541640</ref> <ref>PMID:8353289</ref> <ref>PMID:1423235</ref> Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500].
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.<ref>PMID:10973986</ref> <ref>PMID:16803958</ref>		[https://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN] Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.<ref>PMID:10973986</ref> <ref>PMID:16803958</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Biris, N]]		[[Category: Biris N]]
	[[Category: Cho, S]]		[[Category: Cho S]]
	[[Category: Kobayashi, N]]		[[Category: Kobayashi N]]
	[[Category: Lausen, J]]		[[Category: Lausen J]]
	[[Category: Liu, S]]		[[Category: Liu S]]
	[[Category: Wei, Y]]		[[Category: Wei Y]]
	[[Category: Werner~~, M H~~]]		[[Category: Werner MH]]
	[[Category: Woodrell, C]]		[[Category: Woodrell C]]
	[[Category: Yokoyama, S]]		[[Category: Yokoyama S]]
	~~[[Category: 4-helix bundle]]~~
	~~[[Category: Leukemia]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Transcriptional cofactor~~]]

OCA at 15:29, 17 June 2021

2021-06-17T15:29:22Z

← Older revision		Revision as of 15:29, 17 June 2021
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	==Solution Structure of ETO-TAFH refined in explicit solvent==		==Solution Structure of ETO-TAFH refined in explicit solvent==
	<StructureSection load='2pp4' size='340' side='right' caption='[[2pp4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2pp4' size='340' side='right'caption='[[2pp4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [~~http~~://pdbe.org/2pp4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2pp4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2pp4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [https://pdbe.org/2pp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [https://www.ebi.ac.uk/pdbsum/2pp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pp4 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.<ref>PMID:8334990</ref> <ref>PMID:7541640</ref> <ref>PMID:8353289</ref> <ref>PMID:1423235</ref> Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[~~http~~://omim.org/entry/114500 114500]].		[[https://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.<ref>PMID:8334990</ref> <ref>PMID:7541640</ref> <ref>PMID:8353289</ref> <ref>PMID:1423235</ref> Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500]].
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.<ref>PMID:10973986</ref> <ref>PMID:16803958</ref>		[[https://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.<ref>PMID:10973986</ref> <ref>PMID:16803958</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Biris, N]]		[[Category: Biris, N]]
	[[Category: Cho, S]]		[[Category: Cho, S]]

OCA at 08:57, 29 August 2018

2018-08-29T08:57:05Z

← Older revision		Revision as of 08:57, 29 August 2018
Line 1:		Line 1:

	==Solution Structure of ETO-TAFH refined in explicit solvent==		==Solution Structure of ETO-TAFH refined in explicit solvent==
	<StructureSection load='2pp4' size='340' side='right' caption='[[2pp4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2pp4' size='340' side='right' caption='[[2pp4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [http://pdbe.org/2pp4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pp4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [http://pdbe.org/2pp4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pp4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pp4 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pp/2pp4_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pp/2pp4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pp4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:25, 11 September 2015

2015-09-11T23:25:52Z

← Older revision		Revision as of 23:25, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2pp4' size='340' side='right' caption='[[2pp4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2pp4' size='340' side='right' caption='[[2pp4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pp4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [http://pdbe.org/2pp4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pp4 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2pp4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Biris, N]]		[[Category: Biris, N]]
	[[Category: Cho, S]]		[[Category: Cho, S]]

OCA at 18:36, 19 January 2015

2015-01-19T18:36:40Z

← Older revision		Revision as of 18:36, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pp4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pp4 PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.<ref>PMID:8334990</ref> <ref>PMID:7541640</ref> <ref>PMID:8353289</ref> <ref>PMID:1423235</ref> Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[http://omim.org/entry/114500 114500]].		[[http://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.<ref>PMID:8334990</ref> <ref>PMID:7541640</ref> <ref>PMID:8353289</ref> <ref>PMID:1423235</ref> Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[http://omim.org/entry/114500 114500]].
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Biris, N.]]		[[Category: Biris, N]]
	[[Category: Cho, S.]]		[[Category: Cho, S]]
	[[Category: Kobayashi, N.]]		[[Category: Kobayashi, N]]
	[[Category: Lausen, J.]]		[[Category: Lausen, J]]
	[[Category: Liu, S.]]		[[Category: Liu, S]]
	[[Category: Wei, Y.]]		[[Category: Wei, Y]]
	[[Category: Werner, M H.]]		[[Category: Werner, M H]]
	[[Category: Woodrell, C.]]		[[Category: Woodrell, C]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]
	[[Category: Leukemia]]		[[Category: Leukemia]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcriptional cofactor]]		[[Category: Transcriptional cofactor]]

OCA at 20:18, 30 September 2014

2014-09-30T20:18:41Z

← Older revision		Revision as of 20:18, 30 September 2014
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	~~{{STRUCTURE_2pp4~~\| ~~PDB~~=2pp4 \| ~~SCENE~~= }}		==Solution Structure of ETO-TAFH refined in explicit solvent==
	===~~Solution Structure~~ of ~~ETO~~-~~TAFH refined in explicit solvent~~===		<StructureSection load='2pp4' size='340' side='right' caption='[[2pp4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_17572682}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pp4 PDBsum]</span></td></tr>
			<table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.<ref>PMID:8334990</ref> <ref>PMID:7541640</ref> <ref>PMID:8353289</ref> <ref>PMID:1423235</ref> Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[http://omim.org/entry/114500 114500]].
			== Function ==
			[[http://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.<ref>PMID:10973986</ref> <ref>PMID:16803958</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pp/2pp4_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the four ETO domains related to Drosophila melanogaster Nervy, only two are required to induce spontaneous myeloid leukemia upon transplantation into the mouse. One of these domains is related in sequence to TAF4, a component of TFIID. The structure of this domain, ETO-TAFH, is similar to yeast Rpb4 and to Escherichia coli sigma(70); it is the first TAF-related protein with structural similarity to the multisubunit RNA polymerases. Overlapping surfaces of ETO-TAFH interact with an autonomous repression domain of the nuclear receptor corepressor N-CoR and with a conserved activation domain from the E-box family of transcription factors. Thus, ETO-TAFH acts as a structural platform that can interchange negative and positive coregulatory proteins to control transcription.

	~~==Disease==~~		A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription.,Wei Y, Liu S, Lausen J, Woodrell C, Cho S, Biris N, Kobayashi N, Wei Y, Yokoyama S, Werner MH Nat Struct Mol Biol. 2007 Jul;14(7):653-61. Epub 2007 Jun 17. PMID:17572682<ref>PMID:17572682</ref>
	~~[[http://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Note=~~A ~~chromosomal aberration involving RUNX1T1~~ is a ~~cause~~ of ~~acute myeloid leukemia (AML-M2)~~. ~~Translocation t(8~~;~~21)~~(~~q22;q22~~) ~~with RUNX1/AML1~~.~~<ref>PMID:8334990</ref><ref>PMID:7541640</ref><ref>~~PMID:~~8353289</ref>~~<ref>PMID:~~1423235~~</ref> ~~Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[http://omim.org/entry/114500 114500]].~~

	~~==Function==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12~~.<~~ref~~>~~PMID:10973986</ref><ref>PMID:16803958~~</~~ref~~>		</div>
			== References ==
	==~~About this Structure~~==		<references/>
	[[2pp4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA].		__TOC__
			</StructureSection>
	~~==Reference==~~
	~~<ref group="xtra">PMID:017572682</ref>~~<references ~~group="xtra"~~/><~~references~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Biris, N.]]		[[Category: Biris, N.]]

OCA at 02:58, 25 March 2013

2013-03-25T02:58:14Z

← Older revision		Revision as of 02:58, 25 March 2013
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	~~[[Image:2pp4.png\|left\|200px]]~~

	{{STRUCTURE_2pp4\| PDB=2pp4 \| SCENE= }}		{{STRUCTURE_2pp4\| PDB=2pp4 \| SCENE= }}
			===Solution Structure of ETO-TAFH refined in explicit solvent===
			{{ABSTRACT_PUBMED_17572682}}

	===~~Solution Structure~~ of ~~ETO~~-~~TAFH refined~~ in ~~explicit solvent===~~		==Disease==
			[[http://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.<ref>PMID:8334990</ref><ref>PMID:7541640</ref><ref>PMID:8353289</ref><ref>PMID:1423235</ref> Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[http://omim.org/entry/114500 114500]].

	~~{{ABSTRACT_PUBMED_17572682}}~~		==Function==
			[[http://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.<ref>PMID:10973986</ref><ref>PMID:16803958</ref>

	==About this Structure==		==About this Structure==
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	==Reference==		==Reference==
	<ref group="xtra">PMID:017572682</ref><references group="xtra"/>		<ref group="xtra">PMID:017572682</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Biris, N.]]		[[Category: Biris, N.]]

OCA: Protected "2pp4" [edit=sysop:move=sysop]

2013-01-07T12:41:19Z

Protected "2pp4" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:41, 7 January 2013
(No difference)

OCA at 12:41, 7 January 2013

2013-01-07T12:41:13Z

← Older revision		Revision as of 12:41, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2pp4.png\|left\|200px]]		[[Image:2pp4.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2pp4", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2pp4\| PDB=2pp4 \| SCENE= }}		{{STRUCTURE_2pp4\| PDB=2pp4 \| SCENE= }}

	===Solution Structure of ETO-TAFH refined in explicit solvent===		===Solution Structure of ETO-TAFH refined in explicit solvent===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17572682}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17572682 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17572682}}		{{ABSTRACT_PUBMED_17572682}}

	==About this Structure==		==About this Structure==
	~~2PP4~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA].		[[2pp4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17572682~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017572682</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Biris, N.]]		[[Category: Biris, N.]]
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	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]
	[[Category: Leukemia]]		[[Category: Leukemia]]
			[[Category: Transcription]]
	[[Category: Transcriptional cofactor]]		[[Category: Transcriptional cofactor]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:47:45 2009''~~

OCA at 04:47, 18 February 2009

2009-02-18T04:47:48Z

← Older revision		Revision as of 04:47, 18 February 2009
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	==About this Structure==		==About this Structure==
	2PP4 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA].		2PP4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA].

	==Reference==		==Reference==
	A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription., Wei Y, Liu S, Lausen J, Woodrell C, Cho S, Biris N, Kobayashi N, Wei Y, Yokoyama S, Werner MH, Nat Struct Mol Biol. 2007 Jul;14(7):653-61. Epub 2007 Jun 17. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17572682 17572682]~~		<ref group="xtra">PMID:17572682</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Biris, N.]]		[[Category: Biris, N.]]
	[[Category: Cho, S.]]		[[Category: Cho, S.]]
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	[[Category: Transcriptional cofactor]]		[[Category: Transcriptional cofactor]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 13~~:33:~~03 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:47:45 2009''