2pr4 - Revision history

OCA at 09:25, 6 November 2024

2024-11-06T09:25:51Z

← Older revision		Revision as of 09:25, 6 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2p8l\|2p8l]]~~, [[~~2p8m~~\|~~2p8m~~]]~~, [[2p8p\|2p8p]]</div>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [https://pdbe.org/2pr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [https://www.ebi.ac.uk/pdbsum/2pr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pr4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [https://pdbe.org/2pr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [https://www.ebi.ac.uk/pdbsum/2pr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pr4 ProSAT]</span></td></tr>
	</table>		</table>
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2pr4_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2pr4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bryson, S]]		[[Category: Bryson S]]
	[[Category: Julien, J P]]		[[Category: Julien J-P]]
	[[Category: Pai~~, E F]]~~		[[Category: Pai EF]]
	~~[[Category: Gp41]]~~
	~~[[Category: Hiv]]~~
	~~[[Category: Nmab 2f5]]~~
	~~[[Category: Viral protein~~]]

OCA at 07:47, 9 March 2022

2022-03-09T07:47:03Z

← Older revision		Revision as of 07:47, 9 March 2022
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	<StructureSection load='2pr4' size='340' side='right'caption='[[2pr4]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2pr4' size='340' side='right'caption='[[2pr4]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [~~http~~://pdbe.org/2pr4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2pr4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2pr4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [https://pdbe.org/2pr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [https://www.ebi.ac.uk/pdbsum/2pr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pr4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:57, 3 June 2020

2020-06-03T06:57:10Z

← Older revision		Revision as of 06:57, 3 June 2020
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	==Crystal Structure of Fab' from the HIV-1 Neutralizing Antibody 2F5==		==Crystal Structure of Fab' from the HIV-1 Neutralizing Antibody 2F5==
	<StructureSection load='2pr4' size='340' side='right' caption='[[2pr4]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2pr4' size='340' side='right'caption='[[2pr4]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [http://pdbe.org/2pr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pr4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pr4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [http://pdbe.org/2pr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pr4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pr4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
			[[Category: Large Structures]]
	[[Category: Bryson, S]]		[[Category: Bryson, S]]
	[[Category: Julien, J P]]		[[Category: Julien, J P]]

OCA at 08:52, 29 August 2018

2018-08-29T08:52:43Z

← Older revision		Revision as of 08:52, 29 August 2018
Line 1:		Line 1:

	==Crystal Structure of Fab' from the HIV-1 Neutralizing Antibody 2F5==		==Crystal Structure of Fab' from the HIV-1 Neutralizing Antibody 2F5==
	<StructureSection load='2pr4' size='340' side='right' caption='[[2pr4]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2pr4' size='340' side='right' caption='[[2pr4]], [[Resolution\|resolution]] 2.05Å' scene=''>
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	<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [http://pdbe.org/2pr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pr4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [http://pdbe.org/2pr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pr4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pr4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2pr4_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2pr4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:

	==See Also==		==See Also==
	*[[Monoclonal ~~Antibody~~\|Monoclonal ~~Antibody~~]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:24, 8 February 2016

2016-02-08T01:24:50Z

← Older revision		Revision as of 01:24, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pr4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:34, 10 September 2015

2015-09-10T06:34:56Z

← Older revision		Revision as of 06:34, 10 September 2015
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	<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pr4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [http://pdbe.org/2pr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pr4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2pr4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:30, 19 January 2015

2015-01-19T18:30:29Z

← Older revision		Revision as of 18:30, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pr4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pr4 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bryson, S.]]		[[Category: Bryson, S]]
	[[Category: Julien, J P.]]		[[Category: Julien, J P]]
	[[Category: Pai, E F.]]		[[Category: Pai, E F]]
	[[Category: Gp41]]		[[Category: Gp41]]
	[[Category: Hiv]]		[[Category: Hiv]]
	[[Category: Nmab 2f5]]		[[Category: Nmab 2f5]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 10:20, 29 September 2014

2014-09-29T10:20:13Z

← Older revision		Revision as of 10:20, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2pr4~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of Fab' from the HIV-1 Neutralizing Antibody 2F5==
			<StructureSection load='2pr4' size='340' side='right' caption='[[2pr4]], [[Resolution\|resolution]] 2.05Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2pr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PR4 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p8l\|2p8l]], [[2p8m\|2p8m]], [[2p8p\|2p8p]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2pr4 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2pr4_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			2F5 is a monoclonal antibody with potent and broadly neutralizing activity against HIV-1. It targets the membrane-proximal external region (MPER) of the gp41 subunit of the envelope glycoprotein and interferes with the process of fusion between viral and host cell membranes. This study presents eight 2F5 F(ab)' crystal structures in complex with various gp41 peptide epitopes. These structures reveal several key features of this antibody-antigen interaction. (1) Whenever free of contacts caused by crystal artifacts, the extended complementarity-determining region H3 loop is mobile; this is true for ligand-free and epitope-bound forms. (2) The interaction between the antibody and the gp41 ELDKWA epitope core is absolutely critical, and there are also close and specific contacts with residues located N-terminal to the epitope core. (3) Residues located at the C-terminus of the gp41 ELDKWA core do not interact as tightly with the antibody. However, in the presence of a larger peptide containing the gp41 fusion peptide segment, these residues adopt a conformation consistent with the start of an alpha-helix. (4) At high sulfate concentrations, the electron density maps of 2F5 F(ab)'-peptide complexes contain a peak that may mark a binding site for phosphate groups of negatively charged lipid headgroups. The refined atomic-level details of 2F5 paratope-epitope interactions revealed here should contribute to a better understanding of the mechanism of 2F5-based virus neutralization, in general, and prove important for the design of potential vaccine candidates intended to elicit 2F5-like antibody production.

	~~{{STRUCTURE_2pr4\| PDB=2pr4 \| SCENE= }}~~		Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.,Julien JP, Bryson S, Nieva JL, Pai EF J Mol Biol. 2008 Dec 12;384(2):377-92. Epub 2008 Sep 18. PMID:18824005<ref>PMID:18824005</ref>

	~~===Crystal Structure~~ of ~~Fab' from~~ the ~~HIV-1 Neutralizing Antibody 2F5===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18824005}}~~

	~~==About this Structure==~~
	~~[[2pr4]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2PR4 OCA].~~

	==See Also==		==See Also==
	*[[Monoclonal Antibody\|Monoclonal Antibody]]		*[[Monoclonal Antibody\|Monoclonal Antibody]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018824005<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bryson, S.]]		[[Category: Bryson, S.]]

OCA at 08:26, 20 October 2012

2012-10-20T08:26:29Z

← Older revision		Revision as of 08:26, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2pr4]] is a 2 chain structure ~~of [[Monoclonal Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA].		[[2pr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR4 OCA].

	==See Also==		==See Also==

OCA: Protected "2pr4" [edit=sysop:move=sysop]

2012-07-25T19:32:30Z

Protected "2pr4" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:32, 25 July 2012
(No difference)