2prb - Revision history

OCA at 18:28, 20 October 2021

2021-10-20T18:28:32Z

← Older revision		Revision as of 18:28, 20 October 2021
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	<StructureSection load='2prb' size='340' side='right'caption='[[2prb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2prb' size='340' side='right'caption='[[2prb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2prb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2PRB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2prb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PRB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pr8\|2pr8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2pr8\|2pr8]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [~~http~~://pdbe.org/2prb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2prb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2prb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [https://pdbe.org/2prb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [https://www.ebi.ac.uk/pdbsum/2prb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2prb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:57, 3 June 2020

2020-06-03T06:57:15Z

← Older revision		Revision as of 06:57, 3 June 2020
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	==crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A==		==crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A==
	<StructureSection load='2prb' size='340' side='right' caption='[[2prb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2prb' size='340' side='right'caption='[[2prb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2prb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PRB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2prb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2PRB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pr8\|2pr8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pr8\|2pr8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [http://pdbe.org/2prb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [http://www.ebi.ac.uk/pdbsum/2prb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2prb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [http://pdbe.org/2prb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [http://www.ebi.ac.uk/pdbsum/2prb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2prb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Benas, P]]		[[Category: Benas, P]]
	[[Category: Broutin, I]]		[[Category: Broutin, I]]

OCA at 08:55, 29 August 2018

2018-08-29T08:55:40Z

← Older revision		Revision as of 08:55, 29 August 2018
Line 1:		Line 1:

	==crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A==		==crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A==
	<StructureSection load='2prb' size='340' side='right' caption='[[2prb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2prb' size='340' side='right' caption='[[2prb]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pr8\|2pr8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pr8\|2pr8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [http://pdbe.org/2prb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [http://www.ebi.ac.uk/pdbsum/2prb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [http://pdbe.org/2prb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [http://www.ebi.ac.uk/pdbsum/2prb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2prb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2prb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2prb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:48, 8 February 2016

2016-02-08T20:48:27Z

← Older revision		Revision as of 20:48, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2prb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:15, 10 September 2015

2015-09-10T15:15:39Z

← Older revision		Revision as of 15:15, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2prb' size='340' side='right' caption='[[2prb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2prb' size='340' side='right' caption='[[2prb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2prb]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2prb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pr8\|2pr8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pr8\|2pr8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [http://www.ebi.ac.uk/pdbsum/2prb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [http://pdbe.org/2prb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [http://www.ebi.ac.uk/pdbsum/2prb PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2prb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]~~
	[[Category: Benas, P]]		[[Category: Benas, P]]
	[[Category: Broutin, I]]		[[Category: Broutin, I]]

OCA at 17:04, 19 January 2015

2015-01-19T17:04:37Z

← Older revision		Revision as of 17:04, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2prb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2prb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pr8\|2pr8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pr8\|2pr8]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [http://www.ebi.ac.uk/pdbsum/2prb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [http://www.ebi.ac.uk/pdbsum/2prb PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Benas, P.]]		[[Category: Benas, P]]
	[[Category: Broutin, I.]]		[[Category: Broutin, I]]
	[[Category: Collatz, E.]]		[[Category: Collatz, E]]
	[[Category: Dardel, F.]]		[[Category: Dardel, F]]
	[[Category: Maurice, F.]]		[[Category: Maurice, F]]
	[[Category: Podglajen, I.]]		[[Category: Podglajen, I]]
	[[Category: Aminoglycoside acetyltransferase]]		[[Category: Aminoglycoside acetyltransferase]]
	[[Category: Gnat]]		[[Category: Gnat]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 19:38, 30 September 2014

2014-09-30T19:38:14Z

← Older revision		Revision as of 19:38, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2prb~~.~~png~~\|~~left~~\|~~200px~~]]		==crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A==
			<StructureSection load='2prb' size='340' side='right' caption='[[2prb]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2prb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRB FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pr8\|2pr8]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [http://www.ebi.ac.uk/pdbsum/2prb PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2prb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The emergence of multi-resistant pathogenic bacteria is a worldwide health issue. Recently, clinical variants of a single antibiotic-modifying acetyltransferase, AAC(6')-Ib-a variant of aminoglycoside 6'-N-acetyltransferase-have been identified that confer extended resistance to most aminoglycosides and, more surprisingly, to structurally unrelated fluoroquinolones. The corresponding gene is carried by mobile genetic elements and is present in most multi-resistant pathogenic strains, hence making it a serious threat to current therapies. Here, we report the crystal structures of both narrow- and broad-spectrum resistance variants of this enzyme, which reveal the structural basis for the emergence of extended resistance. The active site shows an important plasticity and has adapted to new substrates by a large-scale gaping process. We have also obtained co-crystals with both substrates, and with a simple transition state analogue, which provides new clues for the design of inhibitors of this resistance mechanism.

	~~{{STRUCTURE_2prb\| PDB=2prb \| SCENE= }}~~		Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance.,Maurice F, Broutin I, Podglajen I, Benas P, Collatz E, Dardel F EMBO Rep. 2008 Apr;9(4):344-9. Epub 2008 Feb 22. PMID:18292754<ref>PMID:18292754</ref>

	~~===crystal structure~~ of ~~aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18292754}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2prb]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Salmonella_enterica_subsp~~.~~_enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:018292754<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Benas, P.]]		[[Category: Benas, P.]]

OCA: Protected "2prb" [edit=sysop:move=sysop]

2013-01-07T14:40:04Z

Protected "2prb" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:40, 7 January 2013
(No difference)

OCA at 14:40, 7 January 2013

2013-01-07T14:40:01Z

← Older revision		Revision as of 14:40, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2prb.png\|left\|200px]]		[[Image:2prb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2prb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2prb\| PDB=2prb \| SCENE= }}		{{STRUCTURE_2prb\| PDB=2prb \| SCENE= }}

	===crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A===		===crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18292754}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18292754 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18292754}}		{{ABSTRACT_PUBMED_18292754}}

	==About this Structure==		==About this Structure==
	~~2PRB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Salmonella_typhimurium~~ Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA].		[[2prb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18292754~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018292754</ref><references group="xtra"/>
	[[Category: Salmonella typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Benas, P.]]		[[Category: Benas, P.]]
	[[Category: Broutin, I.]]		[[Category: Broutin, I.]]
Line 33:		Line 21:
	[[Category: Aminoglycoside acetyltransferase]]		[[Category: Aminoglycoside acetyltransferase]]
	[[Category: Gnat]]		[[Category: Gnat]]
			[[Category: Transferase]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 02:59:38 2009''~~

OCA at 00:59, 17 February 2009

2009-02-17T00:59:39Z

← Older revision		Revision as of 00:59, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2PRB is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA].		2PRB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA].

	==Reference==		==Reference==
	Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance., Maurice F, Broutin I, Podglajen I, Benas P, Collatz E, Dardel F, EMBO Rep. 2008 Apr;9(4):344-349. Epub 2008 Feb 22. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18292754 18292754]~~		<ref group="xtra">PMID:18292754</ref><references group="xtra"/>
	[[Category: Salmonella typhimurium]]		[[Category: Salmonella typhimurium]]
	~~[[Category: Single protein]]~~
	[[Category: Benas, P.]]		[[Category: Benas, P.]]
	[[Category: Broutin, I.]]		[[Category: Broutin, I.]]
Line 35:		Line 34:
	[[Category: Gnat]]		[[Category: Gnat]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 21~~:24:~~11 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:59:38 2009''