2prf - Revision history

OCA at 07:05, 1 May 2024

2024-05-01T07:05:09Z

← Older revision		Revision as of 07:05, 1 May 2024
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	==THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I==		==THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I==
	<StructureSection load='2prf' size='340' side='right'caption='[[2prf~~]], [[NMR_Ensembles_of_Models \| 19 NMR models~~]]' scene=''>		<StructureSection load='2prf' size='340' side='right'caption='[[2prf]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PRF FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [https://pdbe.org/2prf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [https://www.ebi.ac.uk/pdbsum/2prf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2prf ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [https://pdbe.org/2prf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [https://www.ebi.ac.uk/pdbsum/2prf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2prf ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/PRO1A_ACACA PRO1A_ACACA] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2prf ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2prf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	We have determined a medium resolution three-dimensional solution structure of Acanthamoeba profilin-I by multidimensional nuclear magnetic resonance spectroscopy. This 13-kD actin binding protein consists of a five stranded antiparallel beta sheet flanked by NH2- and COOH-terminal helices on one face and by a third helix and a two stranded beta sheet on the other face. Data from actin-profilin cross-linking experiments and the localization of conserved residues between profilins in different phyla indicate that actin binding occurs on the molecular face occupied by the terminal helices. The other face of the molecule contains the residues that differ between Acanthamoeba profilins-I and II and may be important in determining the difference in polyphosphoinositide binding between these isoforms. This suggests that lipids and actin bind to different faces of the molecule.

	~~Three-dimensional solution structure of Acanthamoeba profilin-I.,Vinson VK, Archer SJ, Lattman EE, Pollard TD, Torchia DA J Cell Biol. 1993 Sep;122(6):1277-83. PMID:8397216<ref>PMID:8397216</ref>~~

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2prf" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Profilin 3D Structures\|Profilin 3D Structures]]		*[[Profilin 3D Structures\|Profilin 3D Structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Acanthamoeba sp]]		[[Category: Acanthamoeba sp]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Archer~~, S J~~]]		[[Category: Archer SJ]]
	[[Category: Lattman~~, E E~~]]		[[Category: Lattman EE]]
	[[Category: Pollard~~, T D~~]]		[[Category: Pollard TD]]
	[[Category: Torchia~~, D A~~]]		[[Category: Torchia DA]]
	[[Category: Vinson~~, V K]]~~		[[Category: Vinson VK]]
	~~[[Category: Actin-binding~~]]

OCA at 20:52, 20 October 2021

2021-10-20T20:52:36Z

← Older revision		Revision as of 20:52, 20 October 2021
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	<StructureSection load='2prf' size='340' side='right'caption='[[2prf]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='2prf' size='340' side='right'caption='[[2prf]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PRF FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [~~http~~://pdbe.org/2prf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2prf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2prf ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [https://pdbe.org/2prf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [https://www.ebi.ac.uk/pdbsum/2prf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2prf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 14:01, 18 December 2019

2019-12-18T14:01:08Z

← Older revision		Revision as of 14:01, 18 December 2019
Line 1:		Line 1:

	==THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I==		==THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I==
	<StructureSection load='2prf' size='340' side='right' caption='[[2prf]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='2prf' size='340' side='right'caption='[[2prf]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRF FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2prf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2prf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 25:
	</div>		</div>
	<div class="pdbe-citations 2prf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2prf" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Profilin 3D Structures\|Profilin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Acanthamoeba sp]]		[[Category: Acanthamoeba sp]]
			[[Category: Large Structures]]
	[[Category: Archer, S J]]		[[Category: Archer, S J]]
	[[Category: Lattman, E E]]		[[Category: Lattman, E E]]

OCA at 07:11, 29 November 2017

2017-11-29T07:11:32Z

← Older revision		Revision as of 07:11, 29 November 2017
Line 1:		Line 1:

	==THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I==		==THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I==
	<StructureSection load='2prf' size='340' side='right' caption='[[2prf]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='2prf' size='340' side='right' caption='[[2prf]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRF FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [http://pdbe.org/2prf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [http://www.ebi.ac.uk/pdbsum/2prf PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [http://pdbe.org/2prf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [http://www.ebi.ac.uk/pdbsum/2prf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2prf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2prf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 25:
	</div>		</div>
	<div class="pdbe-citations 2prf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2prf" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Profilin\|Profilin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:59, 11 September 2015

2015-09-11T12:59:11Z

← Older revision		Revision as of 12:59, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRF FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [http://www.ebi.ac.uk/pdbsum/2prf PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [http://pdbe.org/2prf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [http://www.ebi.ac.uk/pdbsum/2prf PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2prf" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Profilin\|Profilin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:49, 19 January 2015

2015-01-19T17:49:26Z

← Older revision		Revision as of 17:49, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [http://www.ebi.ac.uk/pdbsum/2prf PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [http://www.ebi.ac.uk/pdbsum/2prf PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Acanthamoeba sp.]]		[[Category: Acanthamoeba sp]]
	[[Category: Archer, S J.]]		[[Category: Archer, S J]]
	[[Category: Lattman, E E.]]		[[Category: Lattman, E E]]
	[[Category: Pollard, T D.]]		[[Category: Pollard, T D]]
	[[Category: Torchia, D A.]]		[[Category: Torchia, D A]]
	[[Category: Vinson, V K.]]		[[Category: Vinson, V K]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]

OCA at 20:04, 30 September 2014

2014-09-30T20:04:31Z

← Older revision		Revision as of 20:04, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2prf~~.~~png~~\|~~left~~\|~~200px~~]]		==THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I==
			<StructureSection load='2prf' size='340' side='right' caption='[[2prf]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PRF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [http://www.ebi.ac.uk/pdbsum/2prf PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2prf_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We have determined a medium resolution three-dimensional solution structure of Acanthamoeba profilin-I by multidimensional nuclear magnetic resonance spectroscopy. This 13-kD actin binding protein consists of a five stranded antiparallel beta sheet flanked by NH2- and COOH-terminal helices on one face and by a third helix and a two stranded beta sheet on the other face. Data from actin-profilin cross-linking experiments and the localization of conserved residues between profilins in different phyla indicate that actin binding occurs on the molecular face occupied by the terminal helices. The other face of the molecule contains the residues that differ between Acanthamoeba profilins-I and II and may be important in determining the difference in polyphosphoinositide binding between these isoforms. This suggests that lipids and actin bind to different faces of the molecule.

	~~{{STRUCTURE_2prf\| PDB=2prf \| SCENE= }}~~		Three-dimensional solution structure of Acanthamoeba profilin-I.,Vinson VK, Archer SJ, Lattman EE, Pollard TD, Torchia DA J Cell Biol. 1993 Sep;122(6):1277-83. PMID:8397216<ref>PMID:8397216</ref>

	~~===THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_8397216}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2prf]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Acanthamoeba_sp~~. ~~Acanthamoeba sp.]. Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:008397216<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Acanthamoeba sp.]]		[[Category: Acanthamoeba sp.]]
	[[Category: Archer, S J.]]		[[Category: Archer, S J.]]

OCA: Protected "2prf" [edit=sysop:move=sysop]

2013-01-07T12:26:36Z

Protected "2prf" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:26, 7 January 2013
(No difference)

OCA at 12:26, 7 January 2013

2013-01-07T12:26:33Z

← Older revision		Revision as of 12:26, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2prf.png\|left\|200px]]		[[Image:2prf.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2prf", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2prf\| PDB=2prf \| SCENE= }}		{{STRUCTURE_2prf\| PDB=2prf \| SCENE= }}

	===THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I===		===THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_8397216}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 8397216 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_8397216}}		{{ABSTRACT_PUBMED_8397216}}

	==About this Structure==		==About this Structure==
	~~2PRF~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA].		[[2prf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~8397216~~</ref><references group="xtra"/>		<ref group="xtra">PMID:008397216</ref><references group="xtra"/>
	[[Category: Acanthamoeba sp.]]		[[Category: Acanthamoeba sp.]]
	[[Category: Archer, S J.]]		[[Category: Archer, S J.]]
Line 31:		Line 19:
	[[Category: Vinson, V K.]]		[[Category: Vinson, V K.]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:08:51 2009''~~

OCA at 20:08, 17 February 2009

2009-02-17T20:08:53Z

← Older revision		Revision as of 20:08, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2PRF is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA].		2PRF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA].

	==Reference==		==Reference==
	~~Three-dimensional solution structure of Acanthamoeba profilin-I., Vinson VK, Archer SJ, Lattman EE, Pollard TD, Torchia DA, J Cell Biol. 1993 Sep;122(6):1277-83.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/8397216 8397216]~~		<ref group="xtra">PMID:8397216</ref><references group="xtra"/>
	[[Category: Acanthamoeba sp.]]		[[Category: Acanthamoeba sp.]]
	~~[[Category: Single protein]]~~
	[[Category: Archer, S J.]]		[[Category: Archer, S J.]]
	[[Category: Lattman, E E.]]		[[Category: Lattman, E E.]]
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	[[Category: Actin-binding]]		[[Category: Actin-binding]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:24:~~09 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:08:51 2009''