2put - Revision history

OCA at 11:09, 30 August 2023

2023-08-30T11:09:21Z

← Older revision		Revision as of 11:09, 30 August 2023
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	<StructureSection load='2put' size='340' side='right'caption='[[2put]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2put' size='340' side='right'caption='[[2put]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2put]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Canal Canal~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2put]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2poc\|2poc]], [[2puv\|2puv]], [[2puw\|2puw]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFA1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [https://pdbe.org/2put PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [https://www.ebi.ac.uk/pdbsum/2put PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2put ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [https://pdbe.org/2put PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [https://www.ebi.ac.uk/pdbsum/2put PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2put ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GFA1_CANAL GFA1_CANAL]] Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).		[https://www.uniprot.org/uniprot/GFA1_CANAL GFA1_CANAL] Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Canal~~]]		[[Category: Candida albicans SC5314]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Milewski, S]]		[[Category: Milewski S]]
	[[Category: Olchowy, J]]		[[Category: Olchowy J]]
	[[Category: Raczynska, J]]		[[Category: Raczynska J]]
	[[Category: Rypniewski, W]]		[[Category: Rypniewski W]]
	~~[[Category: Aldose/ketose isomerase]]~~
	~~[[Category: Crystal structure]]~~
	~~[[Category: Glucosamine-6-phosphate synthase]]~~
	~~[[Category: Rossmann-like fold]]~~
	~~[[Category: Transferase~~]]

OCA at 15:33, 17 June 2021

2021-06-17T15:33:19Z

← Older revision		Revision as of 15:33, 17 June 2021
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	==The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans==		==The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans==
	<StructureSection load='2put' size='340' side='right' caption='[[2put]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2put' size='340' side='right'caption='[[2put]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2put]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2put]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2poc\|2poc]], [[2puv\|2puv]], [[2puw\|2puw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2poc\|2poc]], [[2puv\|2puv]], [[2puw\|2puw]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFA1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFA1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [~~http~~://pdbe.org/2put PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2put PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2put ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [https://pdbe.org/2put PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [https://www.ebi.ac.uk/pdbsum/2put PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2put ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GFA1_CANAL GFA1_CANAL]] Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).		[[https://www.uniprot.org/uniprot/GFA1_CANAL GFA1_CANAL]] Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pu/2put_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pu/2put_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2put" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2put" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Glucosamine 6-phosphate synthase\|Glucosamine 6-phosphate synthase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Canal]]		[[Category: Canal]]
			[[Category: Large Structures]]
	[[Category: Milewski, S]]		[[Category: Milewski, S]]
	[[Category: Olchowy, J]]		[[Category: Olchowy, J]]

OCA at 09:33, 18 October 2017

2017-10-18T09:33:18Z

← Older revision		Revision as of 09:33, 18 October 2017
Line 1:		Line 1:

	==The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans==		==The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans==
	<StructureSection load='2put' size='340' side='right' caption='[[2put]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2put' size='340' side='right' caption='[[2put]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [http://pdbe.org/2put PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [http://www.ebi.ac.uk/pdbsum/2put PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [http://pdbe.org/2put PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [http://www.ebi.ac.uk/pdbsum/2put PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2put ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 19:15, 7 February 2016

2016-02-07T19:15:31Z

← Older revision		Revision as of 19:15, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2put ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:17, 10 September 2015

2015-09-10T04:17:38Z

← Older revision		Revision as of 04:17, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2put' size='340' side='right' caption='[[2put]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2put' size='340' side='right' caption='[[2put]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2put]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Candida_albicans Candida albicans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2put]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2poc\|2poc]], [[2puv\|2puv]], [[2puw\|2puw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2poc\|2poc]], [[2puv\|2puv]], [[2puw\|2puw]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~5476 Candida albicans~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [http://www.ebi.ac.uk/pdbsum/2put PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [http://pdbe.org/2put PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [http://www.ebi.ac.uk/pdbsum/2put PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2put" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Candida albicans~~]]		[[Category: Canal]]
	[[Category: Milewski, S]]		[[Category: Milewski, S]]
	[[Category: Olchowy, J]]		[[Category: Olchowy, J]]

OCA at 17:39, 24 December 2014

2014-12-24T17:39:18Z

← Older revision		Revision as of 17:39, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2put]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2put]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PUT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2poc\|2poc]], [[2puv\|2puv]], [[2puw\|2puw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2poc\|2poc]], [[2puv\|2puv]], [[2puw\|2puw]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [http://www.ebi.ac.uk/pdbsum/2put PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [http://www.ebi.ac.uk/pdbsum/2put PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GFA1_CANAL GFA1_CANAL]] Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
	[[Category: Milewski, S.]]		[[Category: Milewski, S]]
	[[Category: Olchowy, J.]]		[[Category: Olchowy, J]]
	[[Category: Raczynska, J.]]		[[Category: Raczynska, J]]
	[[Category: Rypniewski, W.]]		[[Category: Rypniewski, W]]
	[[Category: Aldose/ketose isomerase]]		[[Category: Aldose/ketose isomerase]]
	[[Category: Crystal structure]]		[[Category: Crystal structure]]

OCA at 18:19, 30 September 2014

2014-09-30T18:19:52Z

← Older revision		Revision as of 18:19, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2put~~.~~png~~\|~~left~~\|~~200px~~]]		==The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans==
			<StructureSection load='2put' size='340' side='right' caption='[[2put]], [[Resolution\|resolution]] 1.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2put]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PUT FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2poc\|2poc]], [[2puv\|2puv]], [[2puw\|2puw]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2put FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2put OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2put RCSB], [http://www.ebi.ac.uk/pdbsum/2put PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pu/2put_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Glucosamine 6-phosphate (GlcN-6-P) synthase is an ubiquitous enzyme that catalyses the first committed step in the reaction pathway that leads to formation of uridine 5'-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), a precursor of macromolecules that contain amino sugars. Despite sequence similarities, the enzyme in eukaryotes is tetrameric, whereas in prokaryotes it is a dimer. The activity of eukaryotic GlcN-6-P synthase (known as Gfa1p) is regulated by feedback inhibition by UDP-GlcNAc, the end product of the reaction pathway, whereas in prokaryotes the GlcN-6-P synthase (known as GlmS) is not regulated at the post-translational level. In bacteria and fungi the enzyme is essential for cell wall synthesis. In human the enzyme is a mediator of insulin resistance. For these reasons, Gfa1p is a target in anti-fungal chemotherapy and in therapeutics for type-2 diabetes. The crystal structure of the Gfa1p isomerase domain from Candida albicans has been analysed in complex with the allosteric inhibitor UDP-GlcNAc and in the presence of glucose 6-phosphate, fructose 6-phosphate and an analogue of the reaction intermediate, 2-amino-2-deoxy-d-mannitol 6-phosphate (ADMP). A solution structure of the native Gfa1p has been deduced using small-angle X-ray scattering (SAXS). The tetrameric Gfa1p can be described as a dimer of dimers, with each half similar to the related enzyme from Escherichia coli. The core of the protein consists of the isomerase domains. UDP-GlcNAc binds, together with a metal cation, in a well-defined pocket on the surface of the isomerase domain. The residues responsible for tetramerisation and for binding UDP-GlcNAc are conserved only among eukaryotic sequences. Comparison with the previously studied GlmS from E. coli reveals differences as well as similarities in the isomerase active site. This study of Gfa1p focuses on the features that distinguish it from the prokaryotic homologue in terms of quaternary structure, control of the enzymatic activity and details of the isomerase active site.

	~~{{STRUCTURE_2put\| PDB=2put \| SCENE= }}~~		The crystal and solution studies of glucosamine-6-phosphate synthase from Candida albicans.,Raczynska J, Olchowy J, Konariev PV, Svergun DI, Milewski S, Rypniewski W J Mol Biol. 2007 Sep 21;372(3):672-88. Epub 2007 Jul 12. PMID:17681543<ref>PMID:17681543</ref>

	~~===The crystal structure~~ of ~~isomerase domain of glucosamine-6-phosphate synthase from Candida albicans===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17681543}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2put]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Candida_albicans Candida albicans]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017681543<~~/~~ref~~><~~ref group="xtra">PMID:016511216</ref><references group="xtra"~~/>
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
	[[Category: Milewski, S.]]		[[Category: Milewski, S.]]

OCA at 13:01, 30 January 2013

2013-01-30T13:01:24Z

← Older revision		Revision as of 13:01, 30 January 2013
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	[[Image:2put.png\|left\|200px]]		[[Image:2put.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2put", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2put\| PDB=2put \| SCENE= }}		{{STRUCTURE_2put\| PDB=2put \| SCENE= }}

	===The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans===		===The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17681543}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17681543 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17681543}}		{{ABSTRACT_PUBMED_17681543}}

	==About this Structure==		==About this Structure==
	[[2put]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Candida_albicans_sc5314~~ Candida albicans ~~sc5314~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA].		[[2put]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17681543~~</ref><ref group="xtra">PMID:~~16511216~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017681543</ref><ref group="xtra">PMID:016511216</ref><references group="xtra"/>
	[[Category: Candida albicans ~~sc5314~~]]		[[Category: Candida albicans]]
	[[Category: Milewski, S.]]		[[Category: Milewski, S.]]
	[[Category: Olchowy, J.]]		[[Category: Olchowy, J.]]

OCA: Protected "2put" [edit=sysop:move=sysop]

2011-03-14T18:52:23Z

Protected "2put" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:52, 14 March 2011
(No difference)

OCA at 18:52, 14 March 2011

2011-03-14T18:52:21Z

← Older revision		Revision as of 18:52, 14 March 2011
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2put.png\|left\|200px]]		[[Image:2put.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
	~~2PUT~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Candida_albicans~~ Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA].		[[2put]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans_sc5314 Candida albicans sc5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUT OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:17681543</ref><ref group="xtra">PMID:16511216</ref><references group="xtra"/>		<ref group="xtra">PMID:17681543</ref><ref group="xtra">PMID:16511216</ref><references group="xtra"/>
	[[Category: Candida albicans]]		[[Category: Candida albicans sc5314]]
	[[Category: Milewski, S.]]		[[Category: Milewski, S.]]
	[[Category: Olchowy, J.]]		[[Category: Olchowy, J.]]
Line 32:		Line 31:
	[[Category: Crystal structure]]		[[Category: Crystal structure]]
	[[Category: Glucosamine-6-phosphate synthase]]		[[Category: Glucosamine-6-phosphate synthase]]
	[[Category: Rossmann-like fold;]]		[[Category: Rossmann-like fold]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:57:20 2009''~~