2py0 - Revision history

OCA at 11:11, 30 August 2023

2023-08-30T11:11:57Z

← Older revision		Revision as of 11:11, 30 August 2023
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	<StructureSection load='2py0' size='340' side='right'caption='[[2py0]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2py0' size='340' side='right'caption='[[2py0]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2py0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PY0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2py0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PY0 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)~~-1~~-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1dzo\|1dzo]], [[1qve\|1qve]]~~</~~div></td></tr~~>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilA, fimA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [https://pdbe.org/2py0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [https://www.ebi.ac.uk/pdbsum/2py0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2py0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [https://pdbe.org/2py0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [https://www.ebi.ac.uk/pdbsum/2py0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2py0 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/FMPA_PSEAI FMPA_PSEAI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Churchill, M E]]~~
	~~[[Category: Hodges, R S]]~~
	~~[[Category: Kao, D J]]~~
	~~[[Category: Cell adhesion]]~~
	~~[[Category: Consensus sequence]]~~
	~~[[Category: Monomeric pilin]]~~
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: ~~Type iv pilus~~]]		[[Category: Churchill ME]]
			[[Category: Hodges RS]]
			[[Category: Kao DJ]]

OCA at 15:35, 17 June 2021

2021-06-17T15:35:56Z

← Older revision		Revision as of 15:35, 17 June 2021
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	==Crystal structure of Cs1 pilin chimera==		==Crystal structure of Cs1 pilin chimera==
	<StructureSection load='2py0' size='340' side='right' caption='[[2py0]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2py0' size='340' side='right'caption='[[2py0]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2py0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PY0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2py0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PY0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzo\|1dzo]], [[1qve\|1qve]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dzo\|1dzo]], [[1qve\|1qve]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilA, fimA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilA, fimA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [~~http~~://pdbe.org/2py0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2py0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2py0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [https://pdbe.org/2py0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [https://www.ebi.ac.uk/pdbsum/2py0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2py0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Pilin\|Pilin]]		*[[Pilin 3D structures\|Pilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Churchill, M E]]		[[Category: Churchill, M E]]
	[[Category: Hodges, R S]]		[[Category: Hodges, R S]]

OCA at 08:57, 29 August 2018

2018-08-29T08:57:25Z

← Older revision		Revision as of 08:57, 29 August 2018
Line 1:		Line 1:

	==Crystal structure of Cs1 pilin chimera==		==Crystal structure of Cs1 pilin chimera==
	<StructureSection load='2py0' size='340' side='right' caption='[[2py0]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2py0' size='340' side='right' caption='[[2py0]], [[Resolution\|resolution]] 1.35Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzo\|1dzo]], [[1qve\|1qve]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzo\|1dzo]], [[1qve\|1qve]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilA, fimA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilA, fimA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [http://pdbe.org/2py0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [http://www.ebi.ac.uk/pdbsum/2py0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [http://pdbe.org/2py0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [http://www.ebi.ac.uk/pdbsum/2py0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2py0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/2py0_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/2py0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:45, 7 February 2016

2016-02-07T09:45:13Z

← Older revision		Revision as of 09:45, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2py0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:14, 10 September 2015

2015-09-10T00:14:22Z

← Older revision		Revision as of 00:14, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2py0' size='340' side='right' caption='[[2py0]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2py0' size='340' side='right' caption='[[2py0]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2py0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa Pseudomonas aeruginosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PY0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2py0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PY0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzo\|1dzo]], [[1qve\|1qve]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzo\|1dzo]], [[1qve\|1qve]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilA, fimA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 ~~Pseudomonas aeruginosa~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilA, fimA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [http://www.ebi.ac.uk/pdbsum/2py0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [http://pdbe.org/2py0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [http://www.ebi.ac.uk/pdbsum/2py0 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2py0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Pseudomonas aeruginosa]]~~
	[[Category: Churchill, M E]]		[[Category: Churchill, M E]]
	[[Category: Hodges, R S]]		[[Category: Hodges, R S]]
Line 40:		Line 40:
	[[Category: Consensus sequence]]		[[Category: Consensus sequence]]
	[[Category: Monomeric pilin]]		[[Category: Monomeric pilin]]
			[[Category: Pseudomonas aeruginosa]]
	[[Category: Type iv pilus]]		[[Category: Type iv pilus]]

OCA at 18:37, 19 January 2015

2015-01-19T18:37:00Z

← Older revision		Revision as of 18:37, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2py0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PY0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2py0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PY0 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzo\|1dzo]], [[1qve\|1qve]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzo\|1dzo]], [[1qve\|1qve]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilA, fimA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilA, fimA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [http://www.ebi.ac.uk/pdbsum/2py0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [http://www.ebi.ac.uk/pdbsum/2py0 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Churchill, M E.]]		[[Category: Churchill, M E]]
	[[Category: Hodges, R S.]]		[[Category: Hodges, R S]]
	[[Category: Kao, D J.]]		[[Category: Kao, D J]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Consensus sequence]]		[[Category: Consensus sequence]]
	[[Category: Monomeric pilin]]		[[Category: Monomeric pilin]]
	~~[[Category: Pseudomonas aeruginosa]]~~
	[[Category: Type iv pilus]]		[[Category: Type iv pilus]]

OCA at 20:18, 30 September 2014

2014-09-30T20:18:51Z

← Older revision		Revision as of 20:18, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2py0~~\| ~~PDB~~=2py0 \| ~~SCENE~~= }}		==Crystal structure of Cs1 pilin chimera==
	===~~Crystal~~ structure of ~~Cs1 pilin chimera~~===		<StructureSection load='2py0' size='340' side='right' caption='[[2py0]], [[Resolution\|resolution]] 1.35Å' scene=''>
	~~{{ABSTRACT_PUBMED_17936788}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2py0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PY0 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzo\|1dzo]], [[1qve\|1qve]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilA, fimA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2py0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2py0 RCSB], [http://www.ebi.ac.uk/pdbsum/2py0 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/2py0_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			One of the main obstacles in the development of a vaccine against Pseudomonas aeruginosa is the requirement that it is protective against a wide range of virulent strains. We have developed a synthetic-peptide consensus-sequence vaccine (Cs1) that targets the host receptor-binding domain (RBD) of the type IV pilus of P. aeruginosa. Here, we show that this vaccine provides increased protection against challenge by the four piliated strains that we have examined (PAK, PAO, KB7 and P1) in the A.BY/SnJ mouse model of acute P. aeruginosa infection. To further characterize the consensus sequence, we engineered Cs1 into the PAK monomeric pilin protein and determined the crystal structure of the chimeric Cs1 pilin to 1.35 A resolution. The substitutions (T130K and E135P) used to create Cs1 do not disrupt the conserved backbone conformation of the pilin RBD. In fact, based on the Cs1 pilin structure, we hypothesize that the E135P substitution bolsters the conserved backbone conformation and may partially explain the immunological activity of Cs1. Structural analysis of Cs1, PAK and K122-4 pilins reveal substitutions of non-conserved residues in the RBD are compensated for by complementary changes in the rest of the pilin monomer. Thus, the interactions between the RBD and the rest of the pilin can either be mediated by polar interactions of a hydrogen bond network in some strains or by hydrophobic interactions in others. Both configurations maintain a conserved backbone conformation of the RBD. Thus, the backbone conformation is critical in our consensus-sequence vaccine design and that cross-reactivity of the antibody response may be modulated by the composition of exposed side-chains on the surface of the RBD. This structure will guide our future vaccine design by focusing our investigation on the four variable residue positions that are exposed on the RBD surface.

	~~==About this Structure==~~		Animal protection and structural studies of a consensus sequence vaccine targeting the receptor binding domain of the type IV pilus of Pseudomonas aeruginosa.,Kao DJ, Churchill ME, Irvin RT, Hodges RS J Mol Biol. 2007 Nov 23;374(2):426-42. Epub 2007 Sep 19. PMID:17936788<ref>PMID:17936788</ref>
	~~[[2py0]] is~~ a ~~1 chain structure with~~ sequence ~~from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2PY0 OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Pilin\|Pilin]]		*[[Pilin\|Pilin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017936788<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Churchill, M E.]]		[[Category: Churchill, M E.]]

OCA at 11:12, 11 March 2013

2013-03-11T11:12:36Z

← Older revision		Revision as of 11:12, 11 March 2013
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	~~[[Image:2py0.png\|left\|200px]]~~

	{{STRUCTURE_2py0\| PDB=2py0 \| SCENE= }}		{{STRUCTURE_2py0\| PDB=2py0 \| SCENE= }}

	===Crystal structure of Cs1 pilin chimera===		===Crystal structure of Cs1 pilin chimera===

	{{ABSTRACT_PUBMED_17936788}}		{{ABSTRACT_PUBMED_17936788}}

OCA: Protected "2py0" [edit=sysop:move=sysop]

2013-01-07T20:28:11Z

Protected "2py0" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:28, 7 January 2013
(No difference)

OCA at 20:28, 7 January 2013

2013-01-07T20:28:08Z

← Older revision		Revision as of 20:28, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2py0.png\|left\|200px]]		[[Image:2py0.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2py0", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2py0\| PDB=2py0 \| SCENE= }}		{{STRUCTURE_2py0\| PDB=2py0 \| SCENE= }}

	===Crystal structure of Cs1 pilin chimera===		===Crystal structure of Cs1 pilin chimera===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17936788}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17936788 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17936788}}		{{ABSTRACT_PUBMED_17936788}}

	==About this Structure==		==About this Structure==
	~~2PY0~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA].		[[2py0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PY0 OCA].

			==See Also==
			*[[Pilin\|Pilin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17936788~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017936788</ref><references group="xtra"/>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Churchill, M E.]]		[[Category: Churchill, M E.]]
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	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Type iv pilus]]		[[Category: Type iv pilus]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:58:29 2009''~~