2pyb - Revision history

OCA at 09:12, 21 February 2024

2024-02-21T09:12:49Z

← Older revision		Revision as of 09:12, 21 February 2024
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	<StructureSection load='2pyb' size='340' side='right'caption='[[2pyb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2pyb' size='340' side='right'caption='[[2pyb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pyb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Borrelia_burgdorferi Borrelia~~ burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PYB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pyb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_B31 Borreliella burgdorferi B31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PYB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~NAPA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [https://pdbe.org/2pyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [https://www.ebi.ac.uk/pdbsum/2pyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [https://pdbe.org/2pyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [https://www.ebi.ac.uk/pdbsum/2pyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyb ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/O51633_BORBU O51633_BORBU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pyb ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pyb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	NapA from Borrelia burgdorferi is a member of the Dps-like protein family with specific immunomodulatory properties; in particular, NapA is able to induce the expression of IL-23 in neutrophils and monocytes, as well as the expression of IL-6, IL-1beta, and transforming growth factor beta (TGF-beta) in monocytes, via Toll-like receptor (TLR) 2. Such an activity on innate immune cells triggers a synovial fluid Th17 response. Here we report the crystal structure of NapA, determined at 2.6A resolution, which shows that the quaternary structure of the protein is that of a dodecamer with 23 symmetry, typical of the proteins of the family. We also demonstrate that the N- and C-terminal tails, which are flexible and not visible in the crystal, are not relevant for its pro-Th17 activity. Based on the crystal structure and on the comparison with the structure of the orthologous protein from Helicobacter pylori, HP-NAP, we hypothesize that the charge distributions on the two proteins' surfaces are responsible for the interaction with TLR2 and for the different behaviors in modulating the immune response.

	Structure and immunomodulatory property relationship in NapA of Borrelia burgdorferi.,Codolo G, Papinutto E, Polenghi A, D'Elios MM, Zanotti G, de Bernard M Biochim Biophys Acta. 2010 Dec;1804(12):2191-7. doi:, 10.1016/j.bbapap.2010.09.004. Epub 2010 Sep 19. PMID:20851780<ref>PMID:20851780</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2pyb" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Borrelia~~ burgdorferi]]		[[Category: Borreliella burgdorferi B31]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bernard, M De]]		[[Category: De Bernard M]]
	[[Category: Papinutto, E]]		[[Category: Papinutto E]]
	[[Category: Zanotti, G]]		[[Category: Zanotti G]]
	~~[[Category: Dp]]~~
	~~[[Category: Ferritin]]~~
	~~[[Category: Four-helix bundle]]~~
	~~[[Category: Metal transport~~]]

OCA at 15:36, 17 June 2021

2021-06-17T15:36:12Z

← Older revision		Revision as of 15:36, 17 June 2021
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	==Napa protein from borrelia burgdorferi==		==Napa protein from borrelia burgdorferi==
	<StructureSection load='2pyb' size='340' side='right' caption='[[2pyb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2pyb' size='340' side='right'caption='[[2pyb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pyb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PYB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pyb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PYB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [~~http~~://pdbe.org/2pyb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2pyb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [https://pdbe.org/2pyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [https://www.ebi.ac.uk/pdbsum/2pyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Borrelia burgdorferi]]		[[Category: Borrelia burgdorferi]]
			[[Category: Large Structures]]
	[[Category: Bernard, M De]]		[[Category: Bernard, M De]]
	[[Category: Papinutto, E]]		[[Category: Papinutto, E]]

OCA at 08:26, 29 August 2018

2018-08-29T08:26:37Z

← Older revision		Revision as of 08:26, 29 August 2018
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Borrelia burgdorferi])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [http://pdbe.org/2pyb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [http://www.ebi.ac.uk/pdbsum/2pyb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [http://pdbe.org/2pyb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [http://www.ebi.ac.uk/pdbsum/2pyb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyb ProSAT]</span></td></tr>
	</table>		</table>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/2pyb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/2pyb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:03, 26 October 2016

2016-10-26T11:03:31Z

← Older revision		Revision as of 11:03, 26 October 2016
Line 1:		Line 1:

	==Napa protein from borrelia burgdorferi==		==Napa protein from borrelia burgdorferi==
	<StructureSection load='2pyb' size='340' side='right' caption='[[2pyb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2pyb' size='340' side='right' caption='[[2pyb]], [[Resolution\|resolution]] 2.60Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~139~~ Borrelia burgdorferi])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Borrelia burgdorferi])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [http://pdbe.org/2pyb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [http://www.ebi.ac.uk/pdbsum/2pyb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [http://pdbe.org/2pyb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [http://www.ebi.ac.uk/pdbsum/2pyb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pyb ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pyb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			NapA from Borrelia burgdorferi is a member of the Dps-like protein family with specific immunomodulatory properties; in particular, NapA is able to induce the expression of IL-23 in neutrophils and monocytes, as well as the expression of IL-6, IL-1beta, and transforming growth factor beta (TGF-beta) in monocytes, via Toll-like receptor (TLR) 2. Such an activity on innate immune cells triggers a synovial fluid Th17 response. Here we report the crystal structure of NapA, determined at 2.6A resolution, which shows that the quaternary structure of the protein is that of a dodecamer with 23 symmetry, typical of the proteins of the family. We also demonstrate that the N- and C-terminal tails, which are flexible and not visible in the crystal, are not relevant for its pro-Th17 activity. Based on the crystal structure and on the comparison with the structure of the orthologous protein from Helicobacter pylori, HP-NAP, we hypothesize that the charge distributions on the two proteins' surfaces are responsible for the interaction with TLR2 and for the different behaviors in modulating the immune response.

			Structure and immunomodulatory property relationship in NapA of Borrelia burgdorferi.,Codolo G, Papinutto E, Polenghi A, D'Elios MM, Zanotti G, de Bernard M Biochim Biophys Acta. 2010 Dec;1804(12):2191-7. doi:, 10.1016/j.bbapap.2010.09.004. Epub 2010 Sep 19. PMID:20851780<ref>PMID:20851780</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 2pyb" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:35, 7 February 2016

2016-02-07T10:35:48Z

← Older revision		Revision as of 10:35, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pyb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	__TOC__		__TOC__

OCA at 00:42, 10 September 2015

2015-09-10T00:42:26Z

← Older revision		Revision as of 00:42, 10 September 2015
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [http://www.ebi.ac.uk/pdbsum/2pyb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [http://pdbe.org/2pyb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [http://www.ebi.ac.uk/pdbsum/2pyb PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 13:29, 19 January 2015

2015-01-19T13:29:02Z

← Older revision		Revision as of 13:29, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pyb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PYB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pyb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PYB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [http://www.ebi.ac.uk/pdbsum/2pyb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [http://www.ebi.ac.uk/pdbsum/2pyb PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Borrelia burgdorferi]]		[[Category: Borrelia burgdorferi]]
	[[Category: Bernard, M De.]]		[[Category: Bernard, M De]]
	[[Category: Papinutto, E.]]		[[Category: Papinutto, E]]
	[[Category: Zanotti, G.]]		[[Category: Zanotti, G]]
	[[Category: Dp]]		[[Category: Dp]]
	[[Category: Ferritin]]		[[Category: Ferritin]]
	[[Category: Four-helix bundle]]		[[Category: Four-helix bundle]]
	[[Category: Metal transport]]		[[Category: Metal transport]]

OCA at 18:07, 30 September 2014

2014-09-30T18:07:14Z

← Older revision		Revision as of 18:07, 30 September 2014
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	~~[[Image:2pyb.png\|left\|200px]]~~		==Napa protein from borrelia burgdorferi==
			<StructureSection load='2pyb' size='340' side='right' caption='[[2pyb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	~~{{STRUCTURE_2pyb\| PDB=2pyb \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2pyb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PYB FirstGlance]. <br>
	===Napa protein from borrelia burgdorferi===		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ji4\|1ji4]], [[1ji5\|1ji5]], [[1jig\|1jig]], [[1dps\|1dps]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])</td></tr>
	==~~About this Structure~~==		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pyb RCSB], [http://www.ebi.ac.uk/pdbsum/2pyb PDBsum]</span></td></tr>
	[[2pyb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYB OCA].		<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/2pyb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			__TOC__
			</StructureSection>
	[[Category: Borrelia burgdorferi]]		[[Category: Borrelia burgdorferi]]
	[[Category: Bernard, M De.]]		[[Category: Bernard, M De.]]

OCA: Protected "2pyb" [edit=sysop:move=sysop]

2013-01-07T20:45:09Z

Protected "2pyb" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:45, 7 January 2013
(No difference)

OCA at 20:45, 7 January 2013

2013-01-07T20:45:06Z

← Older revision		Revision as of 20:45, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2pyb.png\|left\|200px]]		[[Image:2pyb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2pyb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2pyb\| PDB=2pyb \| SCENE= }}		{{STRUCTURE_2pyb\| PDB=2pyb \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2PYB~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYB OCA].		[[2pyb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYB OCA].
	[[Category: Borrelia burgdorferi]]		[[Category: Borrelia burgdorferi]]
	[[Category: Bernard, M De.]]		[[Category: Bernard, M De.]]
Line 23:		Line 16:
	[[Category: Four-helix bundle]]		[[Category: Four-helix bundle]]
	[[Category: Metal transport]]		[[Category: Metal transport]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:13:52 2009''~~