2rjc - Revision history

OCA at 11:58, 30 August 2023

2023-08-30T11:58:10Z

← Older revision		Revision as of 11:58, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2rjc' size='340' side='right'caption='[[2rjc]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2rjc' size='340' side='right'caption='[[2rjc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rjc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rjc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJC FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MES:2-(N~~-~~MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2pqw\|2pqw]], [[2rjd\|2rjd]], [[2rje\|2rje]], [[2rjf\|2rjf]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">L3MBTL, KIAA0681, L3MBT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjc OCA], [https://pdbe.org/2rjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rjc RCSB], [https://www.ebi.ac.uk/pdbsum/2rjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjc OCA], [https://pdbe.org/2rjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rjc RCSB], [https://www.ebi.ac.uk/pdbsum/2rjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/LMBL1_HUMAN LMBL1_HUMAN]] Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.<ref>PMID:17540172</ref> <ref>PMID:18408754</ref> <ref>PMID:20870719</ref> <ref>PMID:20870725</ref>		[https://www.uniprot.org/uniprot/LMBL1_HUMAN LMBL1_HUMAN] Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.<ref>PMID:17540172</ref> <ref>PMID:18408754</ref> <ref>PMID:20870719</ref> <ref>PMID:20870725</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Allali-Hassani, A]]		[[Category: Allali-Hassani A]]
	[[Category: Arrowsmith~~, C H~~]]		[[Category: Arrowsmith CH]]
	[[Category: Bochkarev, A]]		[[Category: Bochkarev A]]
	[[Category: Crombet, L]]		[[Category: Crombet L]]
	[[Category: Edwards~~, A M~~]]		[[Category: Edwards AM]]
	[[Category: Herzanych, N]]		[[Category: Herzanych N]]
	[[Category: Kozieradzki, I]]		[[Category: Kozieradzki I]]
	[[Category: Liu, Y]]		[[Category: Liu Y]]
	[[Category: Loppnau, P]]		[[Category: Loppnau P]]
	[[Category: Mackenzie, F]]		[[Category: Mackenzie F]]
	[[Category: Min~~, J R~~]]		[[Category: Min JR]]
	[[Category: Ouyang, H]]		[[Category: Ouyang H]]
	~~[[Category: Structural genomic~~]]		[[Category: Sundstrom M]]
	[[Category: Sundstrom, M]]		[[Category: Vedadi M]]
	[[Category: Vedadi, M]]		[[Category: Weigelt J]]
	[[Category: Weigelt, J]]
	~~[[Category: Chromatin regulator]]~~
	~~[[Category: Dna-binding]]~~
	~~[[Category: Metal-binding]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Repressor]]~~
	~~[[Category: Sgc]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Transcription regulation]]~~
	~~[[Category: Zinc-finger~~]]

OCA at 04:27, 2 July 2021

2021-07-02T04:27:32Z

← Older revision		Revision as of 04:27, 2 July 2021
Line 1:		Line 1:

	==Crystal structure of L3MBTL1 protein in complex with MES==		==Crystal structure of L3MBTL1 protein in complex with MES==
	<StructureSection load='2rjc' size='340' side='right' caption='[[2rjc]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2rjc' size='340' side='right'caption='[[2rjc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rjc]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RJC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rjc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pqw\|2pqw]], [[2rjd\|2rjd]], [[2rje\|2rje]], [[2rjf\|2rjf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2pqw\|2pqw]], [[2rjd\|2rjd]], [[2rje\|2rje]], [[2rjf\|2rjf]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L3MBTL, KIAA0681, L3MBT ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L3MBTL, KIAA0681, L3MBT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjc OCA], [~~http~~://pdbe.org/2rjc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rjc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rjc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjc OCA], [https://pdbe.org/2rjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rjc RCSB], [https://www.ebi.ac.uk/pdbsum/2rjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/LMBL1_HUMAN LMBL1_HUMAN]] Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.<ref>PMID:17540172</ref> <ref>PMID:18408754</ref> <ref>PMID:20870719</ref> <ref>PMID:20870725</ref>		[[https://www.uniprot.org/uniprot/LMBL1_HUMAN LMBL1_HUMAN]] Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.<ref>PMID:17540172</ref> <ref>PMID:18408754</ref> <ref>PMID:20870719</ref> <ref>PMID:20870725</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Allali-Hassani, A]]		[[Category: Allali-Hassani, A]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 10:50, 5 September 2018

2018-09-05T10:50:56Z

← Older revision		Revision as of 10:50, 5 September 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rjc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rjc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:08, 5 August 2016

2016-08-05T21:08:00Z

← Older revision		Revision as of 21:08, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of L3MBTL1 protein in complex with MES==		==Crystal structure of L3MBTL1 protein in complex with MES==
	<StructureSection load='2rjc' size='340' side='right' caption='[[2rjc]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2rjc' size='340' side='right' caption='[[2rjc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rjc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rjc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pqw\|2pqw]], [[2rjd\|2rjd]], [[2rje\|2rje]], [[2rjf\|2rjf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pqw\|2pqw]], [[2rjd\|2rjd]], [[2rje\|2rje]], [[2rjf\|2rjf]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rjc RCSB], [http://www.ebi.ac.uk/pdbsum/2rjc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjc OCA], [http://pdbe.org/2rjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rjc RCSB], [http://www.ebi.ac.uk/pdbsum/2rjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~LMBTL_HUMAN LMBTL_HUMAN~~]] Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.<ref>PMID:17540172</ref> <ref>PMID:18408754</ref> <ref>PMID:20870719</ref> <ref>PMID:20870725</ref>		[[http://www.uniprot.org/uniprot/LMBL1_HUMAN LMBL1_HUMAN]] Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.<ref>PMID:17540172</ref> <ref>PMID:18408754</ref> <ref>PMID:20870719</ref> <ref>PMID:20870725</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rjc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2rjc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Allali-Hassani, A]]		[[Category: Allali-Hassani, A]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 21:54, 25 December 2014

2014-12-25T21:54:58Z

← Older revision		Revision as of 21:54, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rjc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rjc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pqw\|2pqw]], [[2rjd\|2rjd]], [[2rje\|2rje]], [[2rjf\|2rjf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pqw\|2pqw]], [[2rjd\|2rjd]], [[2rje\|2rje]], [[2rjf\|2rjf]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rjc RCSB], [http://www.ebi.ac.uk/pdbsum/2rjc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rjc RCSB], [http://www.ebi.ac.uk/pdbsum/2rjc PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/LMBTL_HUMAN LMBTL_HUMAN]] Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.<ref>PMID:17540172</ref> <ref>PMID:18408754</ref> <ref>PMID:20870719</ref> <ref>PMID:20870725</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allali-Hassani, A.]]		[[Category: Allali-Hassani, A]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H]]
	[[Category: Bochkarev, A.]]		[[Category: Bochkarev, A]]
	[[Category: Crombet, L.]]		[[Category: Crombet, L]]
	[[Category: Edwards, A M.]]		[[Category: Edwards, A M]]
	[[Category: Herzanych, N.]]		[[Category: Herzanych, N]]
	[[Category: Kozieradzki, I.]]		[[Category: Kozieradzki, I]]
	[[Category: Liu, Y.]]		[[Category: Liu, Y]]
	[[Category: Loppnau, P.]]		[[Category: Loppnau, P]]
	[[Category: Mackenzie, F.]]		[[Category: Mackenzie, F]]
	[[Category: Min, J R.]]		[[Category: Min, J R]]
	[[Category: Ouyang, H.]]		[[Category: Ouyang, H]]
	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Sundstrom, M.]]		[[Category: Sundstrom, M]]
	[[Category: Vedadi, M.]]		[[Category: Vedadi, M]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
Line 53:		Line 55:
	[[Category: Repressor]]		[[Category: Repressor]]
	[[Category: Sgc]]		[[Category: Sgc]]
	~~[[Category: Structural genomic]]~~
	~~[[Category: Structural genomics consortium]]~~
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 19:14, 30 September 2014

2014-09-30T19:14:00Z

← Older revision		Revision as of 19:14, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2rjc~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of L3MBTL1 protein in complex with MES==
			<StructureSection load='2rjc' size='340' side='right' caption='[[2rjc]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2rjc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJC FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pqw\|2pqw]], [[2rjd\|2rjd]], [[2rje\|2rje]], [[2rjf\|2rjf]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rjc RCSB], [http://www.ebi.ac.uk/pdbsum/2rjc PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rjc_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.

	~~{{STRUCTURE_2rjc\| PDB=2rjc \| SCENE= }}~~		L3MBTL1 recognition of mono- and dimethylated histones.,Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:18026117<ref>PMID:18026117</ref>

	~~===Crystal structure~~ of ~~L3MBTL1 protein in complex with MES===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18026117}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2rjc]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:018026117<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allali-Hassani, A.]]		[[Category: Allali-Hassani, A.]]

OCA: Protected "2rjc" [edit=sysop:move=sysop]

2013-01-07T21:56:00Z

Protected "2rjc" [edit=sysop:move=sysop]

← Older revision	Revision as of 21:56, 7 January 2013
(No difference)

OCA at 21:55, 7 January 2013

2013-01-07T21:55:57Z

← Older revision		Revision as of 21:55, 7 January 2013
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2rjc.png\|left\|200px]]		[[Image:2rjc.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2rjc", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2rjc\| PDB=2rjc \| SCENE= }}		{{STRUCTURE_2rjc\| PDB=2rjc \| SCENE= }}

	===Crystal structure of L3MBTL1 protein in complex with MES===		===Crystal structure of L3MBTL1 protein in complex with MES===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18026117}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18026117 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18026117}}		{{ABSTRACT_PUBMED_18026117}}

	==About this Structure==		==About this Structure==
	~~2RJC~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA].		[[2rjc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18026117~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018026117</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allali-Hassani, A.]]		[[Category: Allali-Hassani, A.]]
Line 41:		Line 29:
	[[Category: Vedadi, M.]]		[[Category: Vedadi, M.]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
	~~[[Category: Alternative splicing]]~~
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
Line 52:		Line 39:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	~~[[Category: Zinc]]~~
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:03:09 2009''~~

OCA at 07:03, 18 February 2009

2009-02-18T07:03:11Z

← Older revision		Revision as of 07:03, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2RJC is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA].		2RJC is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA].

	==Reference==		==Reference==
	L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18026117 18026117]~~		<ref group="xtra">PMID:18026117</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Allali-Hassani, A.]]		[[Category: Allali-Hassani, A.]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 56:		Line 55:
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15~~:16:~~14 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:03:09 2009''

OCA at 12:16, 29 July 2008

2008-07-29T12:16:18Z

← Older revision		Revision as of 12:16, 29 July 2008
Line 1:		Line 1:
	[[Image:2rjc.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:2rjc.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2rjc\| PDB=2rjc \| SCENE= }}		{{STRUCTURE_2rjc\| PDB=2rjc \| SCENE= }}

	~~'''~~Crystal structure of L3MBTL1 protein in complex with MES~~'''~~		===Crystal structure of L3MBTL1 protein in complex with MES===


	~~==Overview==~~		<!--
	~~Crystal structures of~~ the ~~L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated~~ on ~~Lys20 (H4K20me2~~) ~~show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and~~ is ~~able to recognize~~ the ~~degree of histone lysine methylation~~. ~~An unexpected mode of peptide~~-~~mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.~~		The line below this paragraph, {{ABSTRACT_PUBMED_18026117}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 18026117 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_18026117}}

	==About this Structure==		==About this Structure==
Line 51:		Line 55:
	[[Category: Zinc]]		[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 17~~:01:20 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:16:14 2008''