2rmy - Revision history

OCA at 12:54, 20 December 2023

2023-12-20T12:54:17Z

← Older revision		Revision as of 12:54, 20 December 2023
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	==Structure of the N-terminal BARpeptide in SDS micelles==		==Structure of the N-terminal BARpeptide in SDS micelles==
	<StructureSection load='2rmy' size='340' side='right'caption='[[2rmy~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2rmy' size='340' side='right'caption='[[2rmy]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RMY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RMY FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmy OCA], [https://pdbe.org/2rmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rmy RCSB], [https://www.ebi.ac.uk/pdbsum/2rmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmy ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmy OCA], [https://pdbe.org/2rmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rmy RCSB], [https://www.ebi.ac.uk/pdbsum/2rmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[https://omim.org/entry/255200 255200]]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>		[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[https://omim.org/entry/255200 255200]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.		[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Balbach, J]]		[[Category: Balbach J]]
	[[Category: Loew, C]]		[[Category: Loew C]]
	[[Category: Weininger, U]]		[[Category: Weininger U]]
	~~[[Category: Alternative splicing]]~~
	~~[[Category: Anti-oncogene]]~~
	~~[[Category: Barpeptide]]~~
	~~[[Category: Cell cycle]]~~
	~~[[Category: Coiled coil]]~~
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Developmental protein]]~~
	~~[[Category: Differentiation]]~~
	~~[[Category: Endocytosis]]~~
	~~[[Category: Host-virus interaction]]~~
	~~[[Category: Micelle]]~~
	~~[[Category: Nmr-structure]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Sh3 domain~~]]

OCA at 06:52, 16 March 2022

2022-03-16T06:52:57Z

← Older revision		Revision as of 06:52, 16 March 2022
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	<StructureSection load='2rmy' size='340' side='right'caption='[[2rmy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2rmy' size='340' side='right'caption='[[2rmy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rmy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2RMY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RMY FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmy OCA], [~~http~~://pdbe.org/2rmy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rmy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rmy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmy ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmy OCA], [https://pdbe.org/2rmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rmy RCSB], [https://www.ebi.ac.uk/pdbsum/2rmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[~~http~~://omim.org/entry/255200 255200]]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>		[[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[https://omim.org/entry/255200 255200]]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.		[[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:13, 10 June 2020

2020-06-10T07:13:33Z

← Older revision		Revision as of 07:13, 10 June 2020
Line 1:		Line 1:

	==Structure of the N-terminal BARpeptide in SDS micelles==		==Structure of the N-terminal BARpeptide in SDS micelles==
	<StructureSection load='2rmy' size='340' side='right' caption='[[2rmy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2rmy' size='340' side='right'caption='[[2rmy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rmy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RMY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rmy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2RMY FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=2rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmy OCA], [http://pdbe.org/2rmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmy RCSB], [http://www.ebi.ac.uk/pdbsum/2rmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmy ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmy OCA], [http://pdbe.org/2rmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmy RCSB], [http://www.ebi.ac.uk/pdbsum/2rmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Balbach, J]]		[[Category: Balbach, J]]
	[[Category: Loew, C]]		[[Category: Loew, C]]

OCA at 11:22, 5 September 2018

2018-09-05T11:22:49Z

← Older revision		Revision as of 11:22, 5 September 2018
Line 27:		Line 27:
	[[Category: Loew, C]]		[[Category: Loew, C]]
	[[Category: Weininger, U]]		[[Category: Weininger, U]]
			[[Category: Alternative splicing]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]
	[[Category: Barpeptide]]		[[Category: Barpeptide]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
			[[Category: Coiled coil]]
			[[Category: Cytoplasm]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Differentiation]]		[[Category: Differentiation]]

OCA at 09:25, 4 August 2016

2016-08-04T09:25:13Z

← Older revision		Revision as of 09:25, 4 August 2016
Line 1:		Line 1:

	==Structure of the N-terminal BARpeptide in SDS micelles==		==Structure of the N-terminal BARpeptide in SDS micelles==
	<StructureSection load='2rmy' size='340' side='right' caption='[[2rmy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2rmy' size='340' side='right' caption='[[2rmy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rmy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rmy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMY FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rmy RCSB], [http://www.ebi.ac.uk/pdbsum/2rmy PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmy OCA], [http://pdbe.org/2rmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmy RCSB], [http://www.ebi.ac.uk/pdbsum/2rmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2rmy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Balbach, J]]		[[Category: Balbach, J]]
	[[Category: Loew, C]]		[[Category: Loew, C]]

OCA at 12:40, 18 December 2014

2014-12-18T12:40:15Z

← Older revision		Revision as of 12:40, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2rmy\| PDB=2rmy \| SCENE= }}~~		==Structure of the N-terminal BARpeptide in SDS micelles==
	===Structure of the N-terminal BARpeptide in SDS micelles===		<StructureSection load='2rmy' size='340' side='right' caption='[[2rmy]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_18658220}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2rmy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMY FirstGlance]. <br>
	==Disease==		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rmy RCSB], [http://www.ebi.ac.uk/pdbsum/2rmy PDBsum]</span></td></tr>
	[[http://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[http://omim.org/entry/255200 255200]]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>		</table>
			== Disease ==
	==Function==		[[http://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[http://omim.org/entry/255200 255200]]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>
			== Function ==
	[[http://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.		[[http://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			BAR domains (Bin/Amphiphysin/Rvs-homology) generate and sense membrane curvature by binding the negatively charged membrane to their positively charged concave surfaces. N-BAR domains contain an N-terminal extension (helix-0) predicted to form an amphipathic helix upon membrane binding. We determined the NMR structure and nano-to-picosecond dynamics of helix-0 of the human Bin1/Amphiphysin II BAR domain in SDS and DPC micelles. Molecular dynamic simulations of this 34 amino acid peptide revealed electrostatic and hydrophobic interactions with the detergent molecules, which induce helical structure formation from residues 8-10 towards the C-terminus. The orientation in the micelles was experimentally confirmed by backbone amide proton exchange. Both simulation and experiment indicate that the N-terminal region is disordered, and the peptide curves to adopt the micelle shape. Deletion of helix-0 reduces tubulation of liposomes by the BAR domain, whereas the helix-0 peptide itself was fusogenic. These findings support models for membrane curving by BAR domains, where helix-0 increases the binding affinity to the membrane and enhances curvature generation.

	~~==About this~~ Structure==		Structure and dynamics of Helix-0 of the N-BAR domain in Lipid Micelles and Bilayers.,Low C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck-Sickinger AG, Pastor RW, Balbach J Biophys J. 2008 Jul 25. PMID:18658220<ref>PMID:18658220</ref>
	~~[[2rmy]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Balbach, J.]]		[[Category: Balbach, J]]
	[[Category: Loew, C.]]		[[Category: Loew, C]]
	[[Category: Weininger, U.]]		[[Category: Weininger, U]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]
	[[Category: Barpeptide]]		[[Category: Barpeptide]]

OCA at 11:38, 24 March 2013

2013-03-24T11:38:46Z

← Older revision		Revision as of 11:38, 24 March 2013
Line 1:		Line 1:
	~~[[Image:2rmy.png\|left\|200px]]~~

	{{STRUCTURE_2rmy\| PDB=2rmy \| SCENE= }}		{{STRUCTURE_2rmy\| PDB=2rmy \| SCENE= }}
			===Structure of the N-terminal BARpeptide in SDS micelles===
			{{ABSTRACT_PUBMED_18658220}}

	===~~Structure~~ of the ~~N-terminal BARpeptide~~ in ~~SDS micelles===~~		==Disease==
			[[http://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[http://omim.org/entry/255200 255200]]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>

	~~{{ABSTRACT_PUBMED_18658220}}~~		==Function==
			[[http://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

	==About this Structure==		==About this Structure==
	[[2rmy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA].		[[2rmy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Balbach, J.]]		[[Category: Balbach, J.]]

OCA: Protected "2rmy" [edit=sysop:move=sysop]

2013-01-07T18:59:09Z

Protected "2rmy" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:59, 7 January 2013
(No difference)

OCA at 18:59, 7 January 2013

2013-01-07T18:59:06Z

← Older revision		Revision as of 18:59, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2rmy.png\|left\|200px]]		[[Image:2rmy.png\|left\|200px]]

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	{{STRUCTURE_2rmy\| PDB=2rmy \| SCENE= }}		{{STRUCTURE_2rmy\| PDB=2rmy \| SCENE= }}

	===Structure of the N-terminal BARpeptide in SDS micelles===		===Structure of the N-terminal BARpeptide in SDS micelles===


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	~~(as it appears on PubMed at http://www.pubmed.gov), where 18658220 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18658220}}		{{ABSTRACT_PUBMED_18658220}}

	==About this Structure==		==About this Structure==
	~~2RMY~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA].		[[2rmy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA].

	~~==Reference==~~
	Structure and dynamics of Helix-0 of the N-BAR domain in Lipid Micelles and Bilayers., Low C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck-Sickinger AG, Pastor RW, Balbach J, Biophys J. 2008 Jul 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18658220 18658220]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Balbach, J.]]		[[Category: Balbach, J.]]
	[[Category: Loew, C.]]		[[Category: Loew, C.]]
	[[Category: Weininger, U.]]		[[Category: Weininger, U.]]
	~~[[Category: Alternative splicing]]~~
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]
	[[Category: Barpeptide]]		[[Category: Barpeptide]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	~~[[Category: Coiled coil]]~~
	~~[[Category: Cytoplasm]]~~
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Differentiation]]		[[Category: Differentiation]]
Line 43:		Line 25:
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Sh3 domain]]		[[Category: Sh3 domain]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 27 13:49:54 2008''~~

OCA at 11:49, 27 November 2008

2008-11-27T11:49:58Z

← Older revision		Revision as of 11:49, 27 November 2008
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2RMY is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA].		2RMY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMY OCA].

	==Reference==		==Reference==
	Structure and dynamics of Helix-0 of the N-BAR domain in Lipid Micelles and Bilayers., Low C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck-Sickinger AG, Pastor RW, Balbach J, Biophys J. 2008 Jul 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18658220 18658220]		Structure and dynamics of Helix-0 of the N-BAR domain in Lipid Micelles and Bilayers., Low C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck-Sickinger AG, Pastor RW, Balbach J, Biophys J. 2008 Jul 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18658220 18658220]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Balbach, J.]]		[[Category: Balbach, J.]]
	[[Category: Loew, C.]]		[[Category: Loew, C.]]
Line 45:		Line 44:
	[[Category: Sh3 domain]]		[[Category: Sh3 domain]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Nov ~~26 20~~:11:54 2008''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 27 13:49:54 2008''