2rnf - Revision history

OCA at 01:24, 21 November 2024

2024-11-21T01:24:54Z

← Older revision		Revision as of 01:24, 21 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rnf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rnf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:59, 30 August 2023

2023-08-30T11:59:00Z

← Older revision		Revision as of 11:59, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2rnf' size='340' side='right'caption='[[2rnf]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2rnf' size='340' side='right'caption='[[2rnf]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [https://pdbe.org/2rnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [https://www.ebi.ac.uk/pdbsum/2rnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [https://pdbe.org/2rnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [https://www.ebi.ac.uk/pdbsum/2rnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/RNAS4_HUMAN RNAS4_HUMAN]] This RNase has marked specificity towards the 3' side of uridine nucleotides.		[https://www.uniprot.org/uniprot/RNAS4_HUMAN RNAS4_HUMAN] This RNase has marked specificity towards the 3' side of uridine nucleotides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Coll, M]]		[[Category: Coll M]]
	[[Category: ~~Gomis-Ruth, F X~~]]		[[Category: De Llorens R]]
	[[Category: ~~Llorens, R De~~]]		[[Category: Gomis-Ruth FX]]
	[[Category: Peracaula, R]]		[[Category: Peracaula R]]
	[[Category: Seno, M]]		[[Category: Seno M]]
	[[Category: Terzyan~~, S S~~]]		[[Category: Terzyan SS]]
	[[Category: Tsushima, Y]]		[[Category: Tsushima Y]]
	[[Category: Yamada, H]]		[[Category: Yamada H]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Phosphodiesterase]]~~
	~~[[Category: Ribonuclease~~]]

OCA at 07:48, 16 March 2022

2022-03-16T07:48:22Z

← Older revision		Revision as of 07:48, 16 March 2022
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	<StructureSection load='2rnf' size='340' side='right'caption='[[2rnf]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2rnf' size='340' side='right'caption='[[2rnf]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2RNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [~~http~~://pdbe.org/2rnf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rnf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [https://pdbe.org/2rnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [https://www.ebi.ac.uk/pdbsum/2rnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/RNAS4_HUMAN RNAS4_HUMAN]] This RNase has marked specificity towards the 3' side of uridine nucleotides.		[[https://www.uniprot.org/uniprot/RNAS4_HUMAN RNAS4_HUMAN]] This RNase has marked specificity towards the 3' side of uridine nucleotides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]		*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	*[[Temp\|Temp]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:13, 10 June 2020

2020-06-10T07:13:40Z

← Older revision		Revision as of 07:13, 10 June 2020
Line 1:		Line 1:

	==X-RAY CRYSTAL STRUCTURE OF HUMAN RIBONUCLEASE 4 IN COMPLEX WITH D(UP)==		==X-RAY CRYSTAL STRUCTURE OF HUMAN RIBONUCLEASE 4 IN COMPLEX WITH D(UP)==
	<StructureSection load='2rnf' size='340' side='right' caption='[[2rnf]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2rnf' size='340' side='right'caption='[[2rnf]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2RNF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [http://pdbe.org/2rnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [http://www.ebi.ac.uk/pdbsum/2rnf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [http://pdbe.org/2rnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [http://www.ebi.ac.uk/pdbsum/2rnf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
	== References ==		== References ==
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Coll, M]]		[[Category: Coll, M]]
	[[Category: Gomis-Ruth, F X]]		[[Category: Gomis-Ruth, F X]]

OCA at 11:17, 5 September 2018

2018-09-05T11:17:12Z

← Older revision		Revision as of 11:17, 5 September 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rnf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rnf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:30, 5 August 2016

2016-08-05T20:30:07Z

← Older revision		Revision as of 20:30, 5 August 2016
Line 1:		Line 1:

	==X-RAY CRYSTAL STRUCTURE OF HUMAN RIBONUCLEASE 4 IN COMPLEX WITH D(UP)==		==X-RAY CRYSTAL STRUCTURE OF HUMAN RIBONUCLEASE 4 IN COMPLEX WITH D(UP)==
	<StructureSection load='2rnf' size='340' side='right' caption='[[2rnf]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2rnf' size='340' side='right' caption='[[2rnf]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [http://www.ebi.ac.uk/pdbsum/2rnf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [http://pdbe.org/2rnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [http://www.ebi.ac.uk/pdbsum/2rnf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rnf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2rnf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Coll, M]]		[[Category: Coll, M]]
	[[Category: Gomis-Ruth, F X]]		[[Category: Gomis-Ruth, F X]]

OCA at 21:39, 25 December 2014

2014-12-25T21:39:07Z

← Older revision		Revision as of 21:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [http://www.ebi.ac.uk/pdbsum/2rnf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [http://www.ebi.ac.uk/pdbsum/2rnf PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/RNAS4_HUMAN RNAS4_HUMAN]] This RNase has marked specificity towards the 3' side of uridine nucleotides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 29:
	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
			*[[Temp\|Temp]]
			*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Coll, M.]]		[[Category: Coll, M]]
	[[Category: Gomis-Ruth, F X.]]		[[Category: Gomis-Ruth, F X]]
	[[Category: Llorens, R De.]]		[[Category: Llorens, R De]]
	[[Category: Peracaula, R.]]		[[Category: Peracaula, R]]
	[[Category: Seno, M.]]		[[Category: Seno, M]]
	[[Category: Terzyan, S S.]]		[[Category: Terzyan, S S]]
	[[Category: Tsushima, Y.]]		[[Category: Tsushima, Y]]
	[[Category: Yamada, H.]]		[[Category: Yamada, H]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Phosphodiesterase]]		[[Category: Phosphodiesterase]]
	[[Category: Ribonuclease]]		[[Category: Ribonuclease]]

OCA at 07:55, 29 September 2014

2014-09-29T07:55:17Z

← Older revision		Revision as of 07:55, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2rnf~~.~~png~~\|~~left~~\|~~200px~~]]		==X-RAY CRYSTAL STRUCTURE OF HUMAN RIBONUCLEASE 4 IN COMPLEX WITH D(UP)==
			<StructureSection load='2rnf' size='340' side='right' caption='[[2rnf]], [[Resolution\|resolution]] 2.40Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2rnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UM3:2-DEOXYURIDINE+3-MONOPHOSPHATE'>UM3</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rnf RCSB], [http://www.ebi.ac.uk/pdbsum/2rnf PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rnf_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The RNase 4 family is unique among RNase enzymes, displaying the highest level of sequence similarity and encompassing the shortest polypeptide chain. It is the only one showing high specificity. The human representative is an intracellular and plasma enzyme, first isolated from colon adenocarcinoma cell line HT-29. The crystal structures of human recombinant RNase 4, unliganded and in complex with d(Up), have been determined, revealing in the unique active site an explanation for the uridine specificity. Arg101, at a position not involved in catalysis in the other RNase enzymes, penetrates the enzyme moiety shaping the recognition pocket, a flip that is mediated by the interaction with the (shorter chain) C-terminal carboxylate group, providing an anchoring point for the O4 atom of the substrate uridine. The bulky Phe42 side-chain forces Asp80 to be in the chi1=-72.49 degrees rotamer, accepting a hydrogen bond from Thr44, further converting the latter into a hydrogen bond acceptor. This favours an interaction with the -NH-donor group of uridine at position 3 over that with the =N-acceptor of cytidine. The two chemical groups that distinguish uracyl from cytosine are used by the enzyme to discriminate between these two bases.

	~~{{STRUCTURE_2rnf\| PDB=2rnf \| SCENE= }}~~		The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity.,Terzyan SS, Peracaula R, de Llorens R, Tsushima Y, Yamada H, Seno M, Gomis-Ruth FX, Coll M J Mol Biol. 1999 Jan 8;285(1):205-14. PMID:9878400<ref>PMID:9878400</ref>

	~~===X-RAY CRYSTAL STRUCTURE OF HUMAN RIBONUCLEASE 4 IN COMPLEX WITH D(UP)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_9878400}}~~

	~~==About this Structure==~~
	~~[[2rnf]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2RNF OCA].~~

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:009878400<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Coll, M.]]		[[Category: Coll, M.]]

OCA at 21:58, 20 October 2012

2012-10-20T21:58:34Z

← Older revision		Revision as of 21:58, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2rnf]] is a 2 chain structure ~~of [[Ribonuclease]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA].		[[2rnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNF OCA].

	==See Also==		==See Also==

OCA: Protected "2rnf" [edit=sysop:move=sysop]

2012-07-27T14:49:29Z

Protected "2rnf" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:49, 27 July 2012
(No difference)