2roc - Revision history

OCA at 19:14, 29 May 2024

2024-05-29T19:14:56Z

← Older revision		Revision as of 19:14, 29 May 2024
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	==Solution structure of Mcl-1 Complexed with Puma==		==Solution structure of Mcl-1 Complexed with Puma==
	<StructureSection load='2roc' size='340' side='right'caption='[[2roc~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2roc' size='340' side='right'caption='[[2roc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2roc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2roc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROC FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1wsx\|1wsx]], [[2jm6\|2jm6]], [[2rod\|2rod]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Puma ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [https://pdbe.org/2roc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [https://www.ebi.ac.uk/pdbsum/2roc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2roc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [https://pdbe.org/2roc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [https://www.ebi.ac.uk/pdbsum/2roc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2roc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. [[https://www.uniprot.org/uniprot/BBC3_MOUSE BBC3_MOUSE]] Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (By similarity). Regulates ER stress-induced neuronal apoptosis.<ref>PMID:21159964</ref> <ref>PMID:22761832</ref>		[https://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Day~~, C L~~]]		[[Category: Day CL]]
	[[Category: Fairlie~~, W D~~]]		[[Category: Fairlie WD]]
	[[Category: Fan~~, F C~~]]		[[Category: Fan FC]]
	[[Category: Hinds~~, M G~~]]		[[Category: Hinds MG]]
	[[Category: Lee~~, E F~~]]		[[Category: Lee EF]]
	[[Category: Smits, C]]		[[Category: Smits C]]
	~~[[Category: Apoptosis]]~~
	~~[[Category: Bcl-2]]~~
	~~[[Category: Bh3-only]]~~
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Developmental protein]]~~
	~~[[Category: Differentiation]]~~
	~~[[Category: Mcl-1]]~~
	~~[[Category: Membrane]]~~
	~~[[Category: Mitochondrion]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Puma]]~~
	~~[[Category: Transmembrane]]~~
	~~[[Category: Ubl conjugation~~]]

OCA at 10:34, 7 July 2021

2021-07-07T10:34:23Z

← Older revision		Revision as of 10:34, 7 July 2021
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	==Solution structure of Mcl-1 Complexed with Puma==		==Solution structure of Mcl-1 Complexed with Puma==
	<StructureSection load='2roc' size='340' side='right' caption='[[2roc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2roc' size='340' side='right'caption='[[2roc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2roc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ROC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2roc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wsx\|1wsx]], [[2jm6\|2jm6]], [[2rod\|2rod]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wsx\|1wsx]], [[2jm6\|2jm6]], [[2rod\|2rod]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl-1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Puma ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Puma ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [~~http~~://pdbe.org/2roc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2roc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2roc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [https://pdbe.org/2roc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [https://www.ebi.ac.uk/pdbsum/2roc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2roc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. [[~~http~~://www.uniprot.org/uniprot/BBC3_MOUSE BBC3_MOUSE]] Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (By similarity). Regulates ER stress-induced neuronal apoptosis.<ref>PMID:21159964</ref> <ref>PMID:22761832</ref>		[[https://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. [[https://www.uniprot.org/uniprot/BBC3_MOUSE BBC3_MOUSE]] Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (By similarity). Regulates ER stress-induced neuronal apoptosis.<ref>PMID:21159964</ref> <ref>PMID:22761832</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[B-cell lymphoma ~~protein~~\|B-cell lymphoma ~~protein~~]]		*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Day, C L]]		[[Category: Day, C L]]

OCA at 10:51, 5 September 2018

2018-09-05T10:51:05Z

← Older revision		Revision as of 10:51, 5 September 2018
Line 1:		Line 1:

	==Solution structure of Mcl-1 Complexed with Puma==		==Solution structure of Mcl-1 Complexed with Puma==
	<StructureSection load='2roc' size='340' side='right' caption='[[2roc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2roc' size='340' side='right' caption='[[2roc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wsx\|1wsx]], [[2jm6\|2jm6]], [[2rod\|2rod]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wsx\|1wsx]], [[2jm6\|2jm6]], [[2rod\|2rod]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Puma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Puma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [http://pdbe.org/2roc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [http://www.ebi.ac.uk/pdbsum/2roc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [http://pdbe.org/2roc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [http://www.ebi.ac.uk/pdbsum/2roc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2roc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2roc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2roc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:

	==See Also==		==See Also==
	*[[~~Bcl~~-2\|~~Bcl~~-2]]		*[[B-cell lymphoma protein\|B-cell lymphoma protein]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Bcl-2]]		[[Category: Bcl-2]]
	[[Category: Bh3-only]]		[[Category: Bh3-only]]
			[[Category: Cytoplasm]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Differentiation]]		[[Category: Differentiation]]
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	[[Category: Puma]]		[[Category: Puma]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
			[[Category: Ubl conjugation]]

OCA at 14:20, 8 February 2016

2016-02-08T14:20:21Z

← Older revision		Revision as of 14:20, 8 February 2016
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wsx\|1wsx]], [[2jm6\|2jm6]], [[2rod\|2rod]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wsx\|1wsx]], [[2jm6\|2jm6]], [[2rod\|2rod]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Puma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Puma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [http://www.ebi.ac.uk/pdbsum/2roc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [http://pdbe.org/2roc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [http://www.ebi.ac.uk/pdbsum/2roc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2roc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2roc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 23:57, 24 December 2014

2014-12-24T23:57:15Z

← Older revision		Revision as of 23:57, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2roc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ROC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2roc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ROC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wsx\|1wsx]], [[2jm6\|2jm6]], [[2rod\|2rod]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wsx\|1wsx]], [[2jm6\|2jm6]], [[2rod\|2rod]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Puma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Puma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [http://www.ebi.ac.uk/pdbsum/2roc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [http://www.ebi.ac.uk/pdbsum/2roc PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. [[http://www.uniprot.org/uniprot/BBC3_MOUSE BBC3_MOUSE]] Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (By similarity). Regulates ER stress-induced neuronal apoptosis.<ref>PMID:21159964</ref> <ref>PMID:22761832</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Day, C L.]]		[[Category: Day, C L]]
	[[Category: Fairlie, W D.]]		[[Category: Fairlie, W D]]
	[[Category: Fan, F C.]]		[[Category: Fan, F C]]
	[[Category: Hinds, M G.]]		[[Category: Hinds, M G]]
	[[Category: Lee, E F.]]		[[Category: Lee, E F]]
	[[Category: Smits, C.]]		[[Category: Smits, C]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Bcl-2]]		[[Category: Bcl-2]]

OCA at 09:34, 29 September 2014

2014-09-29T09:34:08Z

← Older revision		Revision as of 09:34, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2roc~~.~~png~~\|~~left~~\|~~200px~~]]		==Solution structure of Mcl-1 Complexed with Puma==
			<StructureSection load='2roc' size='340' side='right' caption='[[2roc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2roc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ROC FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wsx\|1wsx]], [[2jm6\|2jm6]], [[2rod\|2rod]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mcl-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Puma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2roc RCSB], [http://www.ebi.ac.uk/pdbsum/2roc PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2roc_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Pro-survival proteins in the B-cell lymphoma-2 (Bcl-2) family have a defined specificity profile for their cell death-inducing BH3-only antagonists. Solution structures of myeloid cell leukaemia-1 (Mcl-1) in complex with the BH3 domains from Noxa and Puma, two proteins regulated by the tumour suppressor p53, show that they bind as amphipathic alpha-helices in the same hydrophobic groove of Mcl-1, using conserved residues for binding. Thermodynamic parameters for the interaction of Noxa, Puma and the related BH3 domains of Bmf, Bim, Bid and Bak with Mcl-1 were determined by calorimetry. These unstructured BH3 domains bind Mcl-1 with affinities that span 3 orders of magnitude, and binding is an enthalpically driven and entropy-enthalpy-compensated process. Alanine scanning analysis of Noxa demonstrated that only a subset of residues is required for interaction with Mcl-1, and these residues are localised to a short highly conserved sequence motif that defines the BH3 domain. Chemical shift mapping of Mcl-1:BH3 complexes showed that Mcl-1 engages all BH3 ligands in a similar way and that, in addition to changes in the immediate vicinity of the binding site, small molecule-wide structural adjustments accommodate ligand binding. Our studies show that unstructured peptides, such as the BH3 domains, behave like their structured counterparts and can bind tightly and selectively in an enthalpically driven process.

	~~{{STRUCTURE_2roc\| PDB=2roc \| SCENE= }}~~		Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1.,Day CL, Smits C, Fan FC, Lee EF, Fairlie WD, Hinds MG J Mol Biol. 2008 Jul 25;380(5):958-71. Epub 2008 Jun 4. PMID:18589438<ref>PMID:18589438</ref>

	~~===Solution structure~~ of ~~Mcl-1 Complexed with Puma===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18589438}}~~

	~~==About this Structure==~~
	~~[[2roc]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2ROC OCA].~~

	==See Also==		==See Also==
	*[[Bcl-2\|Bcl-2]]		*[[Bcl-2\|Bcl-2]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018589438<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Day, C L.]]		[[Category: Day, C L.]]

OCA at 10:26, 20 October 2012

2012-10-20T10:26:23Z

← Older revision		Revision as of 10:26, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2roc]] is a 2 chain structure ~~of [[Bcl-2]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA].		[[2roc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA].

	==See Also==		==See Also==

OCA: Protected "2roc" [edit=sysop:move=sysop]

2012-07-26T02:07:59Z

Protected "2roc" [edit=sysop:move=sysop]

← Older revision	Revision as of 02:07, 26 July 2012
(No difference)

OCA at 02:07, 26 July 2012

2012-07-26T02:07:58Z

← Older revision		Revision as of 02:07, 26 July 2012
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	~~{{Seed}}~~
	[[Image:2roc.png\|left\|200px]]		[[Image:2roc.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2roc", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2roc\| PDB=2roc \| SCENE= }}		{{STRUCTURE_2roc\| PDB=2roc \| SCENE= }}

	===Solution structure of Mcl-1 Complexed with Puma===		===Solution structure of Mcl-1 Complexed with Puma===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18589438}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18589438 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18589438}}		{{ABSTRACT_PUBMED_18589438}}

	==About this Structure==		==About this Structure==
	~~2ROC~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA].		[[2roc]] is a 2 chain structure of [[Bcl-2]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA].

			==See Also==
			*[[Bcl-2\|Bcl-2]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18589438~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018589438</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Day, C L.]]		[[Category: Day, C L.]]
Line 34:		Line 25:
	[[Category: Bcl-2]]		[[Category: Bcl-2]]
	[[Category: Bh3-only]]		[[Category: Bh3-only]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Differentiation]]		[[Category: Differentiation]]
Line 44:		Line 34:
	[[Category: Puma]]		[[Category: Puma]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	~~[[Category: Ubl conjugation]]~~

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:35:23 2009''~~

OCA at 21:35, 16 February 2009

2009-02-16T21:35:24Z

← Older revision		Revision as of 21:35, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2ROC is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA].		2ROC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROC OCA].

	==Reference==		==Reference==
	Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1., Day CL, Smits C, Fan FC, Lee EF, Fairlie WD, Hinds MG, J Mol Biol. 2008 Jul 25;380(5):958-71. Epub 2008 Jun 4. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18589438 18589438]~~		<ref group="xtra">PMID:18589438</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	~~[[Category: Protein complex]]~~
	[[Category: Day, C L.]]		[[Category: Day, C L.]]
	[[Category: Fairlie, W D.]]		[[Category: Fairlie, W D.]]
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	[[Category: Ubl conjugation]]		[[Category: Ubl conjugation]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 03~~:52:~~47 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:35:23 2009''