2ror - Revision history

OCA at 08:39, 30 October 2024

2024-10-30T08:39:35Z

← Older revision		Revision as of 08:39, 30 October 2024
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	==Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76==		==Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76==
	<StructureSection load='2ror' size='340' side='right'caption='[[2ror~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2ror' size='340' side='right'caption='[[2ror]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROR FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~VAV1 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [https://pdbe.org/2ror PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [https://www.ebi.ac.uk/pdbsum/2ror PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ror ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [https://pdbe.org/2ror PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [https://www.ebi.ac.uk/pdbsum/2ror PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ror ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN]] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation~~. [[https://www.uniprot.org/uniprot/LCP2_HUMAN LCP2_HUMAN]] Involved in T-cell antigen receptor mediated signaling~~.		[https://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2ror_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2ror_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kasai, T]]		[[Category: Kasai T]]
	[[Category: Kigawa, T]]		[[Category: Kigawa T]]
	[[Category: Koshiba, S]]		[[Category: Koshiba S]]
	~~[[Category: Structural genomic~~]]		[[Category: Tanaka M]]
	[[Category: Tanaka, M]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Guanine-nucleotide releasing factor]]~~
	~~[[Category: Metal-binding]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Phorbol-ester binding]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Phosphorylated peptide recognition]]~~
	~~[[Category: Phosphotyrosine binding domain]]~~
	~~[[Category: Protein-peptide complex]]~~
	~~[[Category: Proto-oncogene]]~~
	~~[[Category: Rsgi]]~~
	~~[[Category: Sh2 domain]]~~
	~~[[Category: Sh3 domain]]~~
	~~[[Category: Signal transduction]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Zinc]]~~
	~~[[Category: Zinc-finger~~]]

OCA at 10:34, 7 July 2021

2021-07-07T10:34:33Z

← Older revision		Revision as of 10:34, 7 July 2021
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	==Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76==		==Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76==
	<StructureSection load='2ror' size='340' side='right' caption='[[2ror]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ror' size='340' side='right'caption='[[2ror]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ROR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAV1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAV1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [~~http~~://pdbe.org/2ror PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ror PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ror ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [https://pdbe.org/2ror PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [https://www.ebi.ac.uk/pdbsum/2ror PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ror ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN]] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. [[~~http~~://www.uniprot.org/uniprot/LCP2_HUMAN LCP2_HUMAN]] Involved in T-cell antigen receptor mediated signaling.		[[https://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN]] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. [[https://www.uniprot.org/uniprot/LCP2_HUMAN LCP2_HUMAN]] Involved in T-cell antigen receptor mediated signaling.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Kasai, T]]		[[Category: Kasai, T]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 08:31, 12 September 2018

2018-09-12T08:31:24Z

← Older revision		Revision as of 08:31, 12 September 2018
Line 1:		Line 1:

	==Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76==		==Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76==
	<StructureSection load='2ror' size='340' side='right' caption='[[2ror]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ror' size='340' side='right' caption='[[2ror]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAV1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAV1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [http://pdbe.org/2ror PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [http://www.ebi.ac.uk/pdbsum/2ror PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [http://pdbe.org/2ror PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [http://www.ebi.ac.uk/pdbsum/2ror PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ror ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2ror_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2ror_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 43:		Line 44:
	[[Category: Signal transduction]]		[[Category: Signal transduction]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
			[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 06:08, 9 February 2016

2016-02-09T06:08:57Z

← Older revision		Revision as of 06:08, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2ror' size='340' side='right' caption='[[2ror]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ror' size='340' side='right' caption='[[2ror]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ROR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ROR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAV1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAV1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [http://www.ebi.ac.uk/pdbsum/2ror PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [http://pdbe.org/2ror PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [http://www.ebi.ac.uk/pdbsum/2ror PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ror ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Kasai, T]]		[[Category: Kasai, T]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 04:55, 25 December 2014

2014-12-25T04:55:58Z

← Older revision		Revision as of 04:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ROR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ROR FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAV1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAV1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [http://www.ebi.ac.uk/pdbsum/2ror PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [http://www.ebi.ac.uk/pdbsum/2ror PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN]] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. [[http://www.uniprot.org/uniprot/LCP2_HUMAN LCP2_HUMAN]] Involved in T-cell antigen receptor mediated signaling.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kasai, T.]]		[[Category: Kasai, T]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T]]
	[[Category: Koshiba, S.]]		[[Category: Koshiba, S]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Tanaka, M.]]		[[Category: Tanaka, M]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Guanine-nucleotide releasing factor]]		[[Category: Guanine-nucleotide releasing factor]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
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	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]
	[[Category: Proto-oncogene]]		[[Category: Proto-oncogene]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Sh2 domain]]		[[Category: Sh2 domain]]
Line 42:		Line 43:
	[[Category: Signal transduction]]		[[Category: Signal transduction]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	~~[[Category: Structural genomic]]~~
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 01:27, 1 October 2014

2014-10-01T01:27:32Z

← Older revision		Revision as of 01:27, 1 October 2014
Line 1:		Line 1:
	~~[[Image:2ror.png\|left\|200px]]~~		==Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76==
			<StructureSection load='2ror' size='340' side='right' caption='[[2ror]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{STRUCTURE_2ror\| PDB=2ror \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ROR FirstGlance]. <br>
	===Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76===		</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAV1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [http://www.ebi.ac.uk/pdbsum/2ror PDBsum]</span></td></tr>
	==~~About this Structure~~==		<table>
	[[2ror]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA].		== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2ror_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kasai, T.]]		[[Category: Kasai, T.]]

OCA: Protected "2ror" [edit=sysop:move=sysop]

2013-01-07T20:51:41Z

Protected "2ror" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:51, 7 January 2013
(No difference)

OCA at 20:51, 7 January 2013

2013-01-07T20:51:38Z

← Older revision		Revision as of 20:51, 7 January 2013
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	~~{{Seed}}~~		[[Image:2ror.png\|left\|200px]]
	[[Image:2ror.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ror", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ror\| PDB=2ror \| SCENE= }}		{{STRUCTURE_2ror\| PDB=2ror \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2ROR~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA].		[[2ror]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kasai, T.]]		[[Category: Kasai, T.]]
Line 39:		Line 32:
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	~~[[Category: Zinc]]~~
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 11:25:04 2009''~~

OCA at 08:25, 22 April 2009

2009-04-22T08:25:07Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 2ror is ON HOLD  until Paper Publication
+<!--
-Authors: Tanaka, M., Kasai, T., Koshiba, S., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
+===Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:49:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 11:25:04 2009''

OCA: New page: '''Unreleased structure''' The entry 2ror is ON HOLD until Paper Publication Authors: Tanaka, M., Kasai, T., Koshiba, S., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics ...

2008-06-11T05:49:53Z

New page: '''Unreleased structure''' The entry 2ror is ON HOLD until Paper Publication Authors: Tanaka, M., Kasai, T., Koshiba, S., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics ...

New page

'''Unreleased structure'''

The entry 2ror is ON HOLD until Paper Publication

Authors: Tanaka, M., Kasai, T., Koshiba, S., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Description:

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:49:52 2008''