2rum - Revision history

OCA at 10:04, 14 June 2023

2023-06-14T10:04:53Z

← Older revision		Revision as of 10:04, 14 June 2023
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	==Solution structure of Fusion peptide==		==Solution structure of Fusion peptide==
	<StructureSection load='2rum' size='340' side='right'caption='[[2rum~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2rum' size='340' side='right'caption='[[2rum]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rum]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RUM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rum]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RUM FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2run\|2run]], [[2ruo\|2ruo]]</div></td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [https://pdbe.org/2rum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [https://www.ebi.ac.uk/pdbsum/2rum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rum ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [https://pdbe.org/2rum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [https://www.ebi.ac.uk/pdbsum/2rum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rum ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~SPIKE_CVHSA SPIKE_CVHSA~~]~~] S1 attaches~~ the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR~~, initiating the infection. Binding to the receptor~~ and internalization of the virus into the endosomes of the host cell ~~probably~~ induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate ~~membranes~~ fusion within endosomes. ~~S2 is~~ a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.		[https://www.uniprot.org/uniprot/SPIKE_SARS SPIKE_SARS] May down-regulate host tetherin (BST2) by lysosomal degradation, thereby counteracting its antiviral activity.<ref>PMID:31199522</ref> Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membrane fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:14670965</ref> <ref>PMID:15496474</ref> Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]<ref>PMID:19321428</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Bhattacharjya, S~~]]		[[Category: Severe acute respiratory syndrome-related coronavirus]]
	[[Category: ~~Mahajan, M~~]]		[[Category: Bhattacharjya S]]
	[[Category: ~~Fusion peptide]]~~		[[Category: Mahajan M]]
	~~[[Category: Sars-cov]]~~
	~~[[Category: Viral protein~~]]

OCA at 12:27, 23 March 2022

2022-03-23T12:27:10Z

← Older revision		Revision as of 12:27, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='2rum' size='340' side='right'caption='[[2rum]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rum' size='340' side='right'caption='[[2rum]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rum]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2RUM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rum]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RUM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2run\|2run]], [[2ruo\|2ruo]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2run\|2run]], [[2ruo\|2ruo]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [~~http~~://pdbe.org/2rum PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rum PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rum ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [https://pdbe.org/2rum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [https://www.ebi.ac.uk/pdbsum/2rum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rum ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SPIKE_CVHSA SPIKE_CVHSA]] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.		[[https://www.uniprot.org/uniprot/SPIKE_CVHSA SPIKE_CVHSA]] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:06, 17 June 2020

2020-06-17T11:06:20Z

← Older revision		Revision as of 11:06, 17 June 2020
Line 1:		Line 1:

	==Solution structure of Fusion peptide==		==Solution structure of Fusion peptide==
	<StructureSection load='2rum' size='340' side='right' caption='[[2rum]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rum' size='340' side='right'caption='[[2rum]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rum]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RUM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rum]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2RUM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2run\|2run]], [[2ruo\|2ruo]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2run\|2run]], [[2ruo\|2ruo]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [http://pdbe.org/2rum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [http://www.ebi.ac.uk/pdbsum/2rum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rum ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [http://pdbe.org/2rum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [http://www.ebi.ac.uk/pdbsum/2rum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rum ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 11:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Bhattacharjya, S]]		[[Category: Bhattacharjya, S]]
	[[Category: Mahajan, M]]		[[Category: Mahajan, M]]

OCA at 22:19, 5 August 2016

2016-08-05T22:19:25Z

← Older revision		Revision as of 22:19, 5 August 2016
Line 1:		Line 1:

	==Solution structure of Fusion peptide==		==Solution structure of Fusion peptide==
	<StructureSection load='2rum' size='340' side='right' caption='[[2rum]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rum' size='340' side='right' caption='[[2rum]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2rum]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RUM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rum]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RUM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2run\|2run]], [[2ruo\|2ruo]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2run\|2run]], [[2ruo\|2ruo]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [http://www.ebi.ac.uk/pdbsum/2rum PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [http://pdbe.org/2rum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [http://www.ebi.ac.uk/pdbsum/2rum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rum ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 22:23, 25 December 2014

2014-12-25T22:23:48Z

← Older revision		Revision as of 22:23, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [http://www.ebi.ac.uk/pdbsum/2rum PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [http://www.ebi.ac.uk/pdbsum/2rum PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/SPIKE_CVHSA SPIKE_CVHSA]] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:04, 26 November 2014

2014-11-26T08:04:11Z

← Older revision		Revision as of 08:04, 26 November 2014
Line 1:		Line 1:
	'''~~Unreleased structure~~'''		==Solution structure of Fusion peptide==
			<StructureSection load='2rum' size='340' side='right' caption='[[2rum]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~The entry~~ 2rum is ~~ON HOLD~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2rum]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RUM FirstGlance]. <br>
	~~Authors~~: ~~Mahajan~~, M., Bhattacharjya, S.		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2run\|2run]], [[2ruo\|2ruo]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rum RCSB], [http://www.ebi.ac.uk/pdbsum/2rum PDBsum]</span></td></tr>
	~~Description~~: ~~Solution structure of~~ Fusion peptide		</table>
			__TOC__
			</StructureSection>
			[[Category: Bhattacharjya, S]]
			[[Category: Mahajan, M]]
			[[Category: Fusion peptide]]
			[[Category: Sars-cov]]
			[[Category: Viral protein]]

OCA: Protected "2rum" [edit=sysop:move=sysop]

2014-11-19T11:00:39Z

Protected "2rum" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:00, 19 November 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 2rum is ON HOLD Authors: Mahajan, M., Bhattacharjya, S. Description: Solution structure of Fusion peptide

2014-11-19T11:00:38Z

New page: '''Unreleased structure''' The entry 2rum is ON HOLD Authors: Mahajan, M., Bhattacharjya, S. Description: Solution structure of Fusion peptide

New page

'''Unreleased structure'''

The entry 2rum is ON HOLD

Authors: Mahajan, M., Bhattacharjya, S.

Description: Solution structure of Fusion peptide