2sam - Revision history

OCA at 01:25, 21 November 2024

2024-11-21T01:25:07Z

← Older revision		Revision as of 01:25, 21 November 2024
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	<StructureSection load='2sam' size='340' side='right'caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2sam' size='340' side='right'caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Civ Civ~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2SAM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2SAM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [https://pdbe.org/2sam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [https://www.ebi.ac.uk/pdbsum/2sam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2sam ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [https://pdbe.org/2sam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [https://www.ebi.ac.uk/pdbsum/2sam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2sam ProSAT]</span></td></tr>
	</table>		</table>
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/2sam_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/2sam_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Civ]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Craik~~, C S~~]]		[[Category: Simian immunodeficiency virus]]
	[[Category: Rose~~, J R~~]]		[[Category: Craik CS]]
	[[Category: Rose~~, R B~~]]		[[Category: Rose JR]]
	[[Category: Salto, R]]		[[Category: Rose RB]]
	[[Category: Stroud~~, R M~~]]		[[Category: Salto R]]
			[[Category: Stroud RM]]

OCA at 20:54, 20 October 2021

2021-10-20T20:54:51Z

← Older revision		Revision as of 20:54, 20 October 2021
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	<StructureSection load='2sam' size='340' side='right'caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2sam' size='340' side='right'caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2SAM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2SAM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [~~http~~://pdbe.org/2sam PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2sam PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2sam ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [https://pdbe.org/2sam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [https://www.ebi.ac.uk/pdbsum/2sam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2sam ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 13:50, 18 December 2019

2019-12-18T13:50:35Z

← Older revision		Revision as of 13:50, 18 December 2019
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	==STRUCTURE OF THE PROTEASE FROM SIMIAN IMMUNODEFICIENCY VIRUS: COMPLEX WITH AN IRREVERSIBLE NON-PEPTIDE INHIBITOR==		==STRUCTURE OF THE PROTEASE FROM SIMIAN IMMUNODEFICIENCY VIRUS: COMPLEX WITH AN IRREVERSIBLE NON-PEPTIDE INHIBITOR==
	<StructureSection load='2sam' size='340' side='right' caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2sam' size='340' side='right'caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SAM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SAM FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/2sam_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/2sam_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2sam" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2sam" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Immunodeficiency virus protease 3D structures\|Immunodeficiency virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Civ]]		[[Category: Civ]]
			[[Category: Large Structures]]
	[[Category: Craik, C S]]		[[Category: Craik, C S]]
	[[Category: Rose, J R]]		[[Category: Rose, J R]]

OCA at 07:11, 29 November 2017

2017-11-29T07:11:41Z

← Older revision		Revision as of 07:11, 29 November 2017
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	==STRUCTURE OF THE PROTEASE FROM SIMIAN IMMUNODEFICIENCY VIRUS: COMPLEX WITH AN IRREVERSIBLE NON-PEPTIDE INHIBITOR==		==STRUCTURE OF THE PROTEASE FROM SIMIAN IMMUNODEFICIENCY VIRUS: COMPLEX WITH AN IRREVERSIBLE NON-PEPTIDE INHIBITOR==
	<StructureSection load='2sam' size='340' side='right' caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2sam' size='340' side='right' caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SAM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SAM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [http://pdbe.org/2sam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [http://www.ebi.ac.uk/pdbsum/2sam PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [http://pdbe.org/2sam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [http://www.ebi.ac.uk/pdbsum/2sam PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2sam ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 2sam" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2sam" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Virus protease\|Virus protease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:12, 7 February 2016

2016-02-07T02:12:57Z

← Older revision		Revision as of 02:12, 7 February 2016
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	<StructureSection load='2sam' size='340' side='right' caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2sam' size='340' side='right' caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Simian_immunodeficiency_virus Simian immunodeficiency virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SAM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Civ Civ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SAM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [http://www.ebi.ac.uk/pdbsum/2sam PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [http://pdbe.org/2sam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [http://www.ebi.ac.uk/pdbsum/2sam PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2sam ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2sam" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Simian immunodeficiency virus~~]]		[[Category: Civ]]
	[[Category: Craik, C S]]		[[Category: Craik, C S]]
	[[Category: Rose, J R]]		[[Category: Rose, J R]]

OCA at 13:28, 19 January 2015

2015-01-19T13:28:58Z

← Older revision		Revision as of 13:28, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SAM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SAM FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [http://www.ebi.ac.uk/pdbsum/2sam PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [http://www.ebi.ac.uk/pdbsum/2sam PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Simian immunodeficiency virus]]		[[Category: Simian immunodeficiency virus]]
	[[Category: Craik, C S.]]		[[Category: Craik, C S]]
	[[Category: Rose, J R.]]		[[Category: Rose, J R]]
	[[Category: Rose, R B.]]		[[Category: Rose, R B]]
	[[Category: Salto, R.]]		[[Category: Salto, R]]
	[[Category: Stroud, R M.]]		[[Category: Stroud, R M]]

OCA at 06:31, 29 September 2014

2014-09-29T06:31:05Z

← Older revision		Revision as of 06:31, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2sam~~.~~png~~\|~~left~~\|~~200px~~]]		==STRUCTURE OF THE PROTEASE FROM SIMIAN IMMUNODEFICIENCY VIRUS: COMPLEX WITH AN IRREVERSIBLE NON-PEPTIDE INHIBITOR==
			<StructureSection load='2sam' size='340' side='right' caption='[[2sam]], [[Resolution\|resolution]] 2.40Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2sam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SAM FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPN:3-(4-NITRO-PHENOXY)-PROPAN-1-OL'>EPN</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2sam RCSB], [http://www.ebi.ac.uk/pdbsum/2sam PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/2sam_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A variant of the simian immunodeficiency virus protease (SIV PR), covalently bound to the inhibitor 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP), was crystallized. The structure of the inhibited complex was determined by X-ray crystallography to a resolution of 2.4 A and refined to an R factor of 19%. The variant, SIV PR S4H, was shown to diminish the rate of autolysis by at least 4-fold without affecting enzymatic parameters. The overall root mean square (rms) deviation of the alpha-carbons from the structure of HIV-1PR complexed with a peptidomimetic inhibitor (7HVP) was 1.16 A. The major differences are concentrated in three surface loops with rms differences between 1.2 and 2.1 A. For 60% of the molecule the rms deviation was only 0.6 A. The structure reveals one molecule of EPNP bound per protease dimer, a stoichiometry confirmed by mass spectral analysis. The epoxide moiety forms a covalent bond with either of the active site aspartic acids of the dimer, and the phenyl moiety occupies the P1 binding site. The EPNP nitro group interacts with Arg 8. This structure suggests a starting template for the design of nonpeptide-based irreversible inhibitors of the SIV and related HIV-1 and HIV-2 PRs.

	~~{{STRUCTURE_2sam\| PDB=2sam \| SCENE= }}~~		Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor.,Rose RB, Rose JR, Salto R, Craik CS, Stroud RM Biochemistry. 1993 Nov 23;32(46):12498-507. PMID:8241141<ref>PMID:8241141</ref>

	~~===STRUCTURE OF THE PROTEASE FROM SIMIAN IMMUNODEFICIENCY VIRUS: COMPLEX WITH AN IRREVERSIBLE NON-PEPTIDE INHIBITOR===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_8241141}}~~

	~~==About this Structure==~~
	~~[[2sam]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2SAM OCA].~~

	==See Also==		==See Also==
	*[[Virus protease\|Virus protease]]		*[[Virus protease\|Virus protease]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:008241141<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Simian immunodeficiency virus]]		[[Category: Simian immunodeficiency virus]]
	[[Category: Craik, C S.]]		[[Category: Craik, C S.]]

OCA at 05:18, 20 October 2012

2012-10-20T05:18:51Z

← Older revision		Revision as of 05:18, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2sam]] is a 1 chain structure ~~of [[Virus protease]]~~ with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA].		[[2sam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA].

	==See Also==		==See Also==

OCA: Protected "2sam" [edit=sysop:move=sysop]

2012-07-25T09:38:32Z

Protected "2sam" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:38, 25 July 2012
(No difference)

OCA at 09:38, 25 July 2012

2012-07-25T09:38:30Z

← Older revision		Revision as of 09:38, 25 July 2012
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	~~{{Seed}}~~
	[[Image:2sam.png\|left\|200px]]		[[Image:2sam.png\|left\|200px]]

	~~<!--~~
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	{{STRUCTURE_2sam\| PDB=2sam \| SCENE= }}		{{STRUCTURE_2sam\| PDB=2sam \| SCENE= }}

	===STRUCTURE OF THE PROTEASE FROM SIMIAN IMMUNODEFICIENCY VIRUS: COMPLEX WITH AN IRREVERSIBLE NON-PEPTIDE INHIBITOR===		===STRUCTURE OF THE PROTEASE FROM SIMIAN IMMUNODEFICIENCY VIRUS: COMPLEX WITH AN IRREVERSIBLE NON-PEPTIDE INHIBITOR===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_8241141}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 8241141 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_8241141}}		{{ABSTRACT_PUBMED_8241141}}

	==About this Structure==		==About this Structure==
	~~2SAM~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA].		[[2sam]] is a 1 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAM OCA].

			==See Also==
			*[[Virus protease\|Virus protease]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~8241141~~</ref><references group="xtra"/>		<ref group="xtra">PMID:008241141</ref><references group="xtra"/>
	[[Category: Simian immunodeficiency virus]]		[[Category: Simian immunodeficiency virus]]
	[[Category: Craik, C S.]]		[[Category: Craik, C S.]]
Line 30:		Line 21:
	[[Category: Salto, R.]]		[[Category: Salto, R.]]
	[[Category: Stroud, R M.]]		[[Category: Stroud, R M.]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:12:16 2009''~~