2sta - Revision history

OCA at 11:59, 30 August 2023

2023-08-30T11:59:24Z

← Older revision		Revision as of 11:59, 30 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [https://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2STA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [https://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2STA FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4]~~ </~~span~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [https://pdbe.org/2sta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [https://www.ebi.ac.uk/pdbsum/2sta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2sta ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [https://pdbe.org/2sta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [https://www.ebi.ac.uk/pdbsum/2sta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2sta ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~ITR1_CUCMA ITR1_CUCMA~~]~~] Inhibits trypsin.~~		[https://www.uniprot.org/uniprot/TRY1_SALSA TRY1_SALSA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Salmo salar]]		[[Category: Salmo salar]]
	~~[[Category: Trypsin]]~~		[[Category: Andersen OA]]
	[[Category: Andersen~~, O A~~]]		[[Category: Apostoluk W]]
	[[Category: Apostoluk, W]]		[[Category: Berglund GI]]
	[[Category: Berglund~~, G I~~]]		[[Category: Helland R]]
	[[Category: Helland, R]]		[[Category: Otlewski J]]
	[[Category: Otlewski, J]]		[[Category: Smalas AO]]
	[[Category: Smalas~~, A O~~]]		[[Category: Willassen NP]]
	[[Category: Willassen~~, N P]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Serine proteinase]]~~
	~~[[Category: Trypsin inhibitor~~]]

OCA at 12:28, 23 March 2022

2022-03-23T12:28:16Z

← Older revision		Revision as of 12:28, 23 March 2022
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	<StructureSection load='2sta' size='340' side='right'caption='[[2sta]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2sta' size='340' side='right'caption='[[2sta]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [~~http~~://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2STA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [https://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2STA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [~~http~~://pdbe.org/2sta PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2sta PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2sta ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [https://pdbe.org/2sta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [https://www.ebi.ac.uk/pdbsum/2sta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2sta ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ITR1_CUCMA ITR1_CUCMA]] Inhibits trypsin.		[[https://www.uniprot.org/uniprot/ITR1_CUCMA ITR1_CUCMA]] Inhibits trypsin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:07, 17 June 2020

2020-06-17T11:07:35Z

← Older revision		Revision as of 11:07, 17 June 2020
Line 1:		Line 1:

	==ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA MAXIMA TRYPSIN INHIBITOR I)==		==ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA MAXIMA TRYPSIN INHIBITOR I)==
	<StructureSection load='2sta' size='340' side='right' caption='[[2sta]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2sta' size='340' side='right'caption='[[2sta]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2STA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2STA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [http://pdbe.org/2sta PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [http://www.ebi.ac.uk/pdbsum/2sta PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2sta ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [http://pdbe.org/2sta PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [http://www.ebi.ac.uk/pdbsum/2sta PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2sta ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
	*[[Trypsin\|Trypsin]]		*[[Trypsin 3D structures\|Trypsin 3D structures]]
	*[[Trypsin inhibitor\|Trypsin inhibitor]]		*[[Trypsin inhibitor\|Trypsin inhibitor]]
			*[[Trypsin inhibitor 3D structures\|Trypsin inhibitor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Cucurbita maxima]]		[[Category: Cucurbita maxima]]
			[[Category: Large Structures]]
	[[Category: Salmo salar]]		[[Category: Salmo salar]]
	[[Category: Trypsin]]		[[Category: Trypsin]]

OCA at 08:31, 12 September 2018

2018-09-12T08:31:55Z

← Older revision		Revision as of 08:31, 12 September 2018
Line 1:		Line 1:

	==ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA MAXIMA TRYPSIN INHIBITOR I)==		==ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA MAXIMA TRYPSIN INHIBITOR I)==
	<StructureSection load='2sta' size='340' side='right' caption='[[2sta]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2sta' size='340' side='right' caption='[[2sta]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Atlantic_salmon Atlantic salmon~~] and [http://en.wikipedia.org/wiki/~~Cucurbita_maxima Cucurbita maxima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2STA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2STA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [http://pdbe.org/2sta PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [http://www.ebi.ac.uk/pdbsum/2sta PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [http://pdbe.org/2sta PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [http://www.ebi.ac.uk/pdbsum/2sta PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2sta ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/st/2sta_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/st/2sta_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atlantic salmon]]~~
	[[Category: Cucurbita maxima]]		[[Category: Cucurbita maxima]]
			[[Category: Salmo salar]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
	[[Category: Andersen, O A]]		[[Category: Andersen, O A]]

OCA at 18:28, 8 February 2016

2016-02-08T18:28:42Z

← Older revision		Revision as of 18:28, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2sta' size='340' side='right' caption='[[2sta]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2sta' size='340' side='right' caption='[[2sta]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cucurbita_maxima Cucurbita maxima~~] and [http://en.wikipedia.org/wiki/~~Salmo_salar Salmo salar~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2STA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atlantic_salmon Atlantic salmon] and [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2STA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [http://www.ebi.ac.uk/pdbsum/2sta PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [http://pdbe.org/2sta PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [http://www.ebi.ac.uk/pdbsum/2sta PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2sta ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2sta" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Atlantic salmon]]
	[[Category: Cucurbita maxima]]		[[Category: Cucurbita maxima]]
	~~[[Category: Salmo salar]]~~
	[[Category: Trypsin]]		[[Category: Trypsin]]
	[[Category: Andersen, O A]]		[[Category: Andersen, O A]]

OCA at 01:18, 25 December 2014

2014-12-25T01:18:33Z

← Older revision		Revision as of 01:18, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2STA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2STA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [http://www.ebi.ac.uk/pdbsum/2sta PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [http://www.ebi.ac.uk/pdbsum/2sta PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ITR1_CUCMA ITR1_CUCMA]] Inhibits trypsin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Salmo salar]]		[[Category: Salmo salar]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
	[[Category: Andersen, O A.]]		[[Category: Andersen, O A]]
	[[Category: Apostoluk, W.]]		[[Category: Apostoluk, W]]
	[[Category: Berglund, G I.]]		[[Category: Berglund, G I]]
	[[Category: Helland, R.]]		[[Category: Helland, R]]
	[[Category: Otlewski, J.]]		[[Category: Otlewski, J]]
	[[Category: Smalas, A O.]]		[[Category: Smalas, A O]]
	[[Category: Willassen, N P.]]		[[Category: Willassen, N P]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Serine proteinase]]		[[Category: Serine proteinase]]
	[[Category: Trypsin inhibitor]]		[[Category: Trypsin inhibitor]]

OCA at 07:46, 29 September 2014

2014-09-29T07:46:24Z

← Older revision		Revision as of 07:46, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2sta~~.~~png~~\|~~left~~\|~~200px~~]]		==ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA MAXIMA TRYPSIN INHIBITOR I)==
			<StructureSection load='2sta' size='340' side='right' caption='[[2sta]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2sta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2STA FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sta OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2sta RCSB], [http://www.ebi.ac.uk/pdbsum/2sta PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/st/2sta_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			An anionic trypsin from Atlantic salmon and bovine trypsin have been complexed with the squash-seed inhibitors, CMTI-I (Cucurbita maxima trypsin inhibitor I, P1 Arg) and CPTI-II (Cucurbita pepo trypsin inhibitor II, P1 Lys). The crystal structures of three such complexes have been determined to 1.5-1.8 A resolution and refined to crystallographic R factors ranging from 17.6 to 19.3%. The two anionic salmon-trypsin complexes (ST-CPTI and ST-CMTI) and the bovine-trypsin complex (BT-CPTI) have been compared to other trypsin-inhibitor complexes by means of general structure and primary and secondary binding features. In all three new structures, the primary binding residue of the inhibitor binds to trypsin in the classical manner, but with small differences in the primary and secondary binding patterns. Lysine in CPTI-II binds deeper in the specificity pocket of bovine trypsin than lysine in other known lysine-bovine-trypsin complexes, and anionic salmon trypsin lacks some of the secondary binding interactions found in the complexes formed between squash inhibitors and bovine trypsin. The ST-CMTI complex was formed from the reactive-site-cleaved form of the inhibitor. However, well defined electron density was observed for the P1-P1' peptide bond, together with a hydrogen-bonding pattern virtually identical to those of all serine-protease-protein-inhibitor complexes, indicating a resynthesis of the scissile bond.

	~~{{STRUCTURE_2sta\| PDB=2sta \| SCENE= }}~~		High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes.,Helland R, Berglund GI, Otlewski J, Apostoluk W, Andersen OA, Willassen NP, Smalas AO Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):139-48. Epub 1999, Jan 1. PMID:10089404<ref>PMID:10089404</ref>

	~~===ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA MAXIMA TRYPSIN INHIBITOR I)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_10089404}}~~

	~~==About this Structure==~~
	~~[[2sta]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en~~.~~wikipedia~~.~~org/wiki/Salmo_salar Salmo salar]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2STA OCA].~~

	==See Also==		==See Also==
	*[[Trypsin\|Trypsin]]		*[[Trypsin\|Trypsin]]
			*[[Trypsin inhibitor\|Trypsin inhibitor]]
	==~~Reference~~==		== References ==
	<~~ref group="xtra">PMID:010089404<~~/~~ref~~><~~references group="xtra"~~/>		<references/>
			__TOC__
			</StructureSection>
	[[Category: Cucurbita maxima]]		[[Category: Cucurbita maxima]]
	[[Category: Salmo salar]]		[[Category: Salmo salar]]

OCA at 11:04, 20 October 2012

2012-10-20T11:04:15Z

← Older revision		Revision as of 11:04, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2sta]] is a 2 chain structure ~~of [[Trypsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA].		[[2sta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA].

	==See Also==		==See Also==

OCA: Protected "2sta" [edit=sysop:move=sysop]

2012-07-26T04:09:04Z

Protected "2sta" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:09, 26 July 2012
(No difference)

OCA at 04:09, 26 July 2012

2012-07-26T04:09:03Z

← Older revision		Revision as of 04:09, 26 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2sta.png\|left\|200px]]		[[Image:2sta.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2sta", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2sta\| PDB=2sta \| SCENE= }}		{{STRUCTURE_2sta\| PDB=2sta \| SCENE= }}

	===ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA MAXIMA TRYPSIN INHIBITOR I)===		===ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA MAXIMA TRYPSIN INHIBITOR I)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_10089404}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 10089404 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_10089404}}		{{ABSTRACT_PUBMED_10089404}}

	==About this Structure==		==About this Structure==
	~~2STA~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA].		[[2sta]] is a 2 chain structure of [[Trypsin]] with sequence from [http://en.wikipedia.org/wiki/Cucurbita_maxima Cucurbita maxima] and [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2STA OCA].

			==See Also==
			*[[Trypsin\|Trypsin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~10089404~~</ref><references group="xtra"/>		<ref group="xtra">PMID:010089404</ref><references group="xtra"/>
	[[Category: Cucurbita maxima]]		[[Category: Cucurbita maxima]]
	[[Category: Salmo salar]]		[[Category: Salmo salar]]
Line 34:		Line 25:
	[[Category: Smalas, A O.]]		[[Category: Smalas, A O.]]
	[[Category: Willassen, N P.]]		[[Category: Willassen, N P.]]
			[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Serine proteinase]]		[[Category: Serine proteinase]]
	[[Category: Trypsin inhibitor]]		[[Category: Trypsin inhibitor]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:30:53 2009''~~