2uvb - Revision history

OCA: Redirecting to 4v59

2014-12-10T15:14:00Z

Redirecting to 4v59

← Older revision		Revision as of 15:14, 10 December 2014
Line 1:		Line 1:
	==CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE COMPLEXED WITH NADP+ FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE ALPHA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400==		#REDIRECT [[4v59]] This PDB entry is obsolete and replaced by 4v59
	~~<StructureSection load='2uvb' size='340' side='right' caption='[[2uvb]],~~ [[~~Resolution\|resolution]] 3.10Å' scene=''>~~
	~~== Structural highlights ==~~
	~~<table><tr><td colspan='2'>[[2uvb]~~] ~~is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus~~]~~. The June 2007 RCSB~~ PDB ~~[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase'' by David S. Goodsell~~ is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UVB FirstGlance]. <br>
	~~</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>~~
	~~<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uvc\|2uvc]]</td></tr>~~
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uvb RCSB], [http://www.ebi.ac.uk/pdbsum/2uvb PDBsum]</span></td></tr>
	~~<table>~~
	~~== Evolutionary Conservation ==~~
	~~[[Image:Consurf_key_small.gif\|200px\|right]]~~
	~~Check<jmol>~~
	~~<jmolCheckbox>~~
	~~<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uvb_consurf.spt"</scriptWhenChecked>~~
	~~<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>~~
	~~<text>to colour the structure by Evolutionary Conservation</text>~~
	~~</jmolCheckbox>~~
	~~</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method~~ and ~~the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].~~
	~~<div style="clear:both"></div>~~
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	We report crystal structures of the 2.6-megadalton alpha6beta6 heterododecameric fatty acid synthase from Thermomyces lanuginosus at 3.1 angstrom resolution. The alpha and beta polypeptide chains form the six catalytic domains required for fatty acid synthesis and numerous expansion segments responsible for extensive intersubunit connections. Detailed views of all active sites provide insights into substrate specificities and catalytic mechanisms and reveal their unique characteristics, which are due to the integration into the multienzyme. The mode of acyl carrier protein attachment in the reaction chamber, together with the spatial distribution of active sites, suggests that iterative substrate shuttling is achieved by ~~a relatively restricted circular motion of the carrier domain in the multifunctional enzyme.~~

	Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.,Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N Science. 2007 Apr 13;316(5822):254-61. PMID:17431175<ref>PMID:17431175</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~

	~~==See Also==~~
	*[[Fatty acid synthase\|Fatty acid synthase]]
	~~== References ==~~
	~~<references/>~~
	~~__TOC__~~
	~~</StructureSection>~~
	~~[[Category: Fatty Acid Synthase]]~~
	~~[[Category: RCSB PDB Molecule of the Month]]~~
	~~[[Category: Thermomyces lanuginosus]]~~
	~~[[Category: Ban, N.]]~~
	~~[[Category: Boehringer, D.]]~~
	~~[[Category: Frick, C.]]~~
	~~[[Category: Jenni, S.]]~~
	~~[[Category: Leibundgut, M.]]~~
	~~[[Category: Mikolasek, B.]]~~
	~~[[Category: Acetyl transferase]]~~
	~~[[Category: Acyl carrier protein]]~~
	~~[[Category: Dehydratase]]~~
	~~[[Category: Enoyl reductase]]~~
	~~[[Category: Fatty acid synthase]]~~
	~~[[Category: Fatty acid synthesis]]~~
	~~[[Category: Fungal]]~~
	~~[[Category: Ketoacyl reductase]]~~
	~~[[Category: Ketoacyl synthase]]~~
	~~[[Category: Malonyl/palmitoyl transferase]]~~
	~~[[Category: Multifunctional enzyme]]~~
	~~[[Category: Substrate shuttling]]~~
	~~[[Category: Transferase]]~~

OCA at 06:14, 29 September 2014

2014-09-29T06:14:31Z

← Older revision		Revision as of 06:14, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2uvb~~.~~png~~\|~~left~~\|~~200px~~]]		==CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE COMPLEXED WITH NADP+ FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE ALPHA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400==
			<StructureSection load='2uvb' size='340' side='right' caption='[[2uvb]], [[Resolution\|resolution]] 3.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2uvb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The June 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UVB FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uvc\|2uvc]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uvb RCSB], [http://www.ebi.ac.uk/pdbsum/2uvb PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uvb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We report crystal structures of the 2.6-megadalton alpha6beta6 heterododecameric fatty acid synthase from Thermomyces lanuginosus at 3.1 angstrom resolution. The alpha and beta polypeptide chains form the six catalytic domains required for fatty acid synthesis and numerous expansion segments responsible for extensive intersubunit connections. Detailed views of all active sites provide insights into substrate specificities and catalytic mechanisms and reveal their unique characteristics, which are due to the integration into the multienzyme. The mode of acyl carrier protein attachment in the reaction chamber, together with the spatial distribution of active sites, suggests that iterative substrate shuttling is achieved by a relatively restricted circular motion of the carrier domain in the multifunctional enzyme.

	~~{{STRUCTURE_2uvb\| PDB=2uvb \| SCENE= }}~~		Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.,Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N Science. 2007 Apr 13;316(5822):254-61. PMID:17431175<ref>PMID:17431175</ref>

	===CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE COMPLEXED WITH NADP+ FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE ALPHA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400===		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17431175}}~~

	~~==About this Structure==~~
	~~[[2uvb]] is~~ a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The June 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the ~~Month] feature on ''Fatty Acid Synthase'' by David~~ S. ~~Goodsell is [http://dx~~.~~doi.org/10.2210~~/~~rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].~~

	==See Also==		==See Also==
	*[[Fatty acid synthase\|Fatty acid synthase]]		*[[Fatty acid synthase\|Fatty acid synthase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017431175<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Fatty Acid Synthase]]		[[Category: Fatty Acid Synthase]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]

OCA at 17:05, 20 October 2012

2012-10-20T17:05:07Z

← Older revision		Revision as of 17:05, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2uvb]] is a 6 chain structure ~~of [[Fatty acid synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The June 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].		[[2uvb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The June 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].

	==See Also==		==See Also==

OCA: Protected "2uvb" [edit=sysop:move=sysop]

2012-07-26T23:47:03Z

Protected "2uvb" [edit=sysop:move=sysop]

← Older revision	Revision as of 23:47, 26 July 2012
(No difference)

OCA at 23:47, 26 July 2012

2012-07-26T23:47:01Z

← Older revision		Revision as of 23:47, 26 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2uvb.png\|left\|200px]]		[[Image:2uvb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2uvb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2uvb\| PDB=2uvb \| SCENE= }}		{{STRUCTURE_2uvb\| PDB=2uvb \| SCENE= }}

	===CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE COMPLEXED WITH NADP+ FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE ALPHA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400===		===CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE COMPLEXED WITH NADP+ FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE ALPHA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17431175}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17431175 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17431175}}		{{ABSTRACT_PUBMED_17431175}}

	==About this Structure==		==About this Structure==
	~~2UVB~~ is a 6 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The June 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].		[[2uvb]] is a 6 chain structure of [[Fatty acid synthase]] with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The June 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].

			==See Also==
			*[[Fatty acid synthase\|Fatty acid synthase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17431175~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017431175</ref><references group="xtra"/>
	[[Category: Fatty Acid Synthase]]		[[Category: Fatty Acid Synthase]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
Line 46:		Line 37:
	[[Category: Substrate shuttling]]		[[Category: Substrate shuttling]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 22:41:23 2010''~~

OCA at 20:41, 20 January 2010

2010-01-20T20:41:24Z

← Older revision		Revision as of 20:41, 20 January 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2UVB is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The June 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].		2UVB is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The June 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:17431175</ref><references group="xtra"/>		<ref group="xtra">PMID:17431175</ref><references group="xtra"/>
	[[Category: Fatty Acid Synthase]]		[[Category: Fatty Acid Synthase]]
			[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Thermomyces lanuginosus]]		[[Category: Thermomyces lanuginosus]]
	[[Category: Ban, N.]]		[[Category: Ban, N.]]
Line 46:		Line 47:
	[[Category: Transferase]]		[[Category: Transferase]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Feb 17 17~~:05:~~47 2009~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 22:41:23 2010''

OCA at 15:05, 17 February 2009

2009-02-17T15:05:49Z

← Older revision		Revision as of 15:05, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2UVB is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. ~~Additional information on 2UVB is available in a page on~~ [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/~~pdb90_1~~.html Fatty Acid Synthase~~] at the RCSB PDB~~ [http://~~pdb~~.~~rcsb~~.org/~~pdb~~/~~static~~.~~do?p=education_discussion~~/~~molecule_of_the_month~~/~~index.html Molecule of the Month~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].		2UVB is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The June 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].

	==Reference==		==Reference==
	~~Structure of fungal fatty acid synthase and implications for iterative substrate shuttling., Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N, Science. 2007 Apr 13;316(5822):254-61.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17431175 17431175]~~		<ref group="xtra">PMID:17431175</ref><references group="xtra"/>
	[[Category: Fatty Acid Synthase]]		[[Category: Fatty Acid Synthase]]
	~~[[Category: Single protein]]~~
	[[Category: Thermomyces lanuginosus]]		[[Category: Thermomyces lanuginosus]]
	[[Category: Ban, N.]]		[[Category: Ban, N.]]
Line 47:		Line 46:
	[[Category: Transferase]]		[[Category: Transferase]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 23 10~~:44:~~54 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:05:47 2009''

OCA at 07:44, 23 July 2008

2008-07-23T07:44:54Z

← Older revision		Revision as of 07:44, 23 July 2008
Line 1:		Line 1:
			{{Seed}}
	[[Image:2uvb.png\|left\|200px]]		[[Image:2uvb.png\|left\|200px]]

Line 9:		Line 10:
	{{STRUCTURE_2uvb\| PDB=2uvb \| SCENE= }}		{{STRUCTURE_2uvb\| PDB=2uvb \| SCENE= }}

	~~'''~~CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE COMPLEXED WITH NADP+ FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE ALPHA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400~~'''~~		===CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE COMPLEXED WITH NADP+ FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE ALPHA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400===


	{{~~ABSTRACT_17431175~~}}		<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_17431175}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 17431175 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_17431175}}

	==About this Structure==		==About this Structure==
	2UVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. ~~The following page contains interesting~~ information on ~~the relation of~~ 2UVB ~~with [~~[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb90_1.html Fatty Acid Synthase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].		2UVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. Additional information on 2UVB is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb90_1.html Fatty Acid Synthase] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].

			==Reference==
			Structure of fungal fatty acid synthase and implications for iterative substrate shuttling., Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N, Science. 2007 Apr 13;316(5822):254-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17431175 17431175]
	[[Category: Fatty Acid Synthase]]		[[Category: Fatty Acid Synthase]]
	[[Category: Single protein]]		[[Category: Single protein]]
Line 39:		Line 47:
	[[Category: Transferase]]		[[Category: Transferase]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 26 18~~:23:50 2008''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:44:54 2008''

OCA at 15:23, 26 June 2008

2008-06-26T15:23:51Z

← Older revision		Revision as of 15:23, 26 June 2008
Line 1:		Line 1:
	[[Image:2uvb.~~gif~~\|left\|200px]]		[[Image:2uvb.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:


	~~==Overview==~~		{{ABSTRACT_17431175}}
	We report crystal structures of the 2.6-megadalton alpha6beta6 heterododecameric fatty acid synthase from Thermomyces lanuginosus at 3.1 angstrom resolution. The alpha and beta polypeptide chains form the six catalytic domains required for fatty acid synthesis and numerous expansion segments responsible for extensive intersubunit connections. Detailed views of all active sites provide insights into substrate specificities and catalytic mechanisms and reveal their unique characteristics, which are due to the integration into the multienzyme. The mode of acyl carrier protein attachment in the reaction chamber, together with the spatial distribution of active sites, suggests that iterative substrate shuttling is achieved by a relatively restricted circular motion of the carrier domain in the multifunctional enzyme.

	==About this Structure==		==About this Structure==
	2UVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The following page contains interesting information on the relation of 2UVB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb90_1.html Fatty Acid Synthase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].		2UVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The following page contains interesting information on the relation of 2UVB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb90_1.html Fatty Acid Synthase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVB OCA].

	~~==Reference==~~
	Structure of fungal fatty acid synthase and implications for iterative substrate shuttling., Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N, Science. 2007 Apr 13;316(5822):254-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17431175 17431175]
	[[Category: Fatty Acid Synthase]]		[[Category: Fatty Acid Synthase]]
	[[Category: Single protein]]		[[Category: Single protein]]
Line 42:		Line 38:
	[[Category: Substrate shuttling]]		[[Category: Substrate shuttling]]
	[[Category: Transferase]]		[[Category: Transferase]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 17~~:34:04 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:23:50 2008''

OCA at 14:34, 4 May 2008

2008-05-04T14:34:05Z

← Older revision		Revision as of 14:34, 4 May 2008
Line 1:		Line 1:
	[[Image:2uvb.gif\|left\|200px]]		[[Image:2uvb.gif\|left\|200px]]

	{{Structure		<!--
	\|PDB~~= 2uvb \|SIZE=350\|CAPTION= <~~scene ~~name='initialview01'>2uvb</scene>~~, ~~resolution 3~~.~~1Å~~		The line below this paragraph, containing "STRUCTURE_2uvb", creates the "Structure Box" on the page.
	\|SITE= <scene name='pdbsite=AC1:Nap+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Nap+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:Nap+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:Nap+Binding+Site+For+Chain+D'>AC4</scene>, <scene name='pdbsite=AC5:Nap+Binding+Site+For+Chain+E'>AC5</scene> and <scene name='pdbsite=AC6:Nap+Binding+Site+For+Chain+F'>AC6</scene>		You may change the PDB parameter (which sets the PDB file loaded into the applet)
	~~\|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE~~-~~ADENINE~~-~~DINUCLEOTIDE+PHOSPHATE'>NAP</scene~~>		or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
	\|~~ACTIVITY~~=		or leave the SCENE parameter empty for the default display.
	\|~~GENE~~=		-->
	~~\|DOMAIN=~~		{{STRUCTURE_2uvb\| PDB=2uvb \| SCENE= }}
	~~\|RELATEDENTRY=[[2uvc\|2UVC]]~~
	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvb OCA], [http://www.ebi.ac.uk/pdbsum/2uvb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uvb RCSB]</span>
	}}

	'''CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE COMPLEXED WITH NADP+ FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE ALPHA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400'''		'''CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE COMPLEXED WITH NADP+ FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE ALPHA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400'''
Line 32:		Line 29:
	[[Category: Leibundgut, M.]]		[[Category: Leibundgut, M.]]
	[[Category: Mikolasek, B.]]		[[Category: Mikolasek, B.]]
	[[Category: ~~acetyl~~ transferase]]		[[Category: Acetyl transferase]]
	[[Category: ~~acyl~~ carrier protein]]		[[Category: Acyl carrier protein]]
	[[Category: ~~dehydratase~~]]		[[Category: Dehydratase]]
	[[Category: ~~enoyl~~ reductase]]		[[Category: Enoyl reductase]]
	[[Category: ~~fatty~~ acid synthase]]		[[Category: Fatty acid synthase]]
	[[Category: ~~fatty~~ acid synthesis]]		[[Category: Fatty acid synthesis]]
	[[Category: ~~fungal~~]]		[[Category: Fungal]]
	[[Category: ~~ketoacyl~~ reductase]]		[[Category: Ketoacyl reductase]]
	[[Category: ~~ketoacyl~~ synthase]]		[[Category: Ketoacyl synthase]]
	[[Category: ~~malonyl~~/palmitoyl transferase]]		[[Category: Malonyl/palmitoyl transferase]]
	[[Category: ~~multifunctional~~ enzyme]]		[[Category: Multifunctional enzyme]]
	[[Category: ~~substrate~~ shuttling]]		[[Category: Substrate shuttling]]
	[[Category: ~~transferase~~]]		[[Category: Transferase]]
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:34:04 2008''
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:05:01 2008''