2v2f - Revision history

OCA at 15:02, 13 December 2023

2023-12-13T15:02:56Z

← Older revision		Revision as of 15:02, 13 December 2023
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	<StructureSection load='2v2f' size='340' side='right'caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2v2f' size='340' side='right'caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus~~ pneumoniae~~" (klein 1884) weichselbaum 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2F FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BA:BARIUM+ION'>BA</scene>~~, ~~<scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:~~/~~/en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase]~~, ~~with EC number [https~~:~~//www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129]~~ </~~span~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [https://pdbe.org/2v2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [https://www.ebi.ac.uk/pdbsum/2v2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [https://pdbe.org/2v2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [https://www.ebi.ac.uk/pdbsum/2v2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2f ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9RET4_STREE Q9RET4_STREE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Peptidoglycan glycosyltransferase~~]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Carapito, R]]		[[Category: Carapito R]]
	[[Category: Dessen, A]]		[[Category: Dessen A]]
	[[Category: Dideberg, O]]		[[Category: Dideberg O]]
	[[Category: Job, V]]		[[Category: Job V]]
	[[Category: Vernet, T]]		[[Category: Vernet T]]
	[[Category: Zapun, A]]		[[Category: Zapun A]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Peptidoglycan synthesis]]~~
	~~[[Category: Transferase]]~~
	~~[[Category: Transpeptidase activity~~]]

OCA at 12:36, 23 March 2022

2022-03-23T12:36:43Z

← Older revision		Revision as of 12:36, 23 March 2022
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	<StructureSection load='2v2f' size='340' side='right'caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2v2f' size='340' side='right'caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2V2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [~~http~~://pdbe.org/2v2f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v2f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [https://pdbe.org/2v2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [https://www.ebi.ac.uk/pdbsum/2v2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2f ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:17, 17 June 2020

2020-06-17T11:17:34Z

← Older revision		Revision as of 11:17, 17 June 2020
Line 1:		Line 1:

	==Crystal structure of PBP1a from drug-resistant strain 5204 from Streptococcus pneumoniae==		==Crystal structure of PBP1a from drug-resistant strain 5204 from Streptococcus pneumoniae==
	<StructureSection load='2v2f' size='340' side='right' caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2v2f' size='340' side='right'caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V2F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [http://pdbe.org/2v2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [http://www.ebi.ac.uk/pdbsum/2v2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [http://pdbe.org/2v2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [http://www.ebi.ac.uk/pdbsum/2v2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2f ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Penicillin-binding protein\|Penicillin-binding protein]]		*[[Penicillin-binding protein 3D structures\|Penicillin-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Peptidoglycan glycosyltransferase]]		[[Category: Peptidoglycan glycosyltransferase]]
	[[Category: Carapito, R]]		[[Category: Carapito, R]]

OCA at 09:01, 12 September 2018

2018-09-12T09:01:36Z

← Older revision		Revision as of 09:01, 12 September 2018
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	==~~CRYSTAL STRUCTURE OF PBP1A FROM DRUG~~-~~RESISTANT STRAIN~~ 5204 ~~FROM STREPTOCOCCUS PNEUMONIAE~~==
			==Crystal structure of PBP1a from drug-resistant strain 5204 from Streptococcus pneumoniae==
	<StructureSection load='2v2f' size='340' side='right' caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2v2f' size='340' side='right' caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [http://pdbe.org/2v2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [http://www.ebi.ac.uk/pdbsum/2v2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [http://pdbe.org/2v2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [http://www.ebi.ac.uk/pdbsum/2v2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2f ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2f_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:03, 9 February 2016

2016-02-09T16:03:22Z

← Older revision		Revision as of 16:03, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2v2f' size='340' side='right' caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2v2f' size='340' side='right' caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae Streptococcus~~ pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [http://www.ebi.ac.uk/pdbsum/2v2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [http://pdbe.org/2v2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [http://www.ebi.ac.uk/pdbsum/2v2f PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v2f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2v2f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Peptidoglycan glycosyltransferase]]		[[Category: Peptidoglycan glycosyltransferase]]
	~~[[Category: Streptococcus pneumoniae]]~~
	[[Category: Carapito, R]]		[[Category: Carapito, R]]
	[[Category: Dessen, A]]		[[Category: Dessen, A]]

OCA at 16:03, 19 January 2015

2015-01-19T16:03:49Z

← Older revision		Revision as of 16:03, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2F FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [http://www.ebi.ac.uk/pdbsum/2v2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [http://www.ebi.ac.uk/pdbsum/2v2f PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Peptidoglycan glycosyltransferase]]		[[Category: Peptidoglycan glycosyltransferase]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Carapito, R.]]		[[Category: Carapito, R]]
	[[Category: Dessen, A.]]		[[Category: Dessen, A]]
	[[Category: Dideberg, O.]]		[[Category: Dideberg, O]]
	[[Category: Job, V.]]		[[Category: Job, V]]
	[[Category: Vernet, T.]]		[[Category: Vernet, T]]
	[[Category: Zapun, A.]]		[[Category: Zapun, A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Peptidoglycan synthesis]]		[[Category: Peptidoglycan synthesis]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transpeptidase activity]]		[[Category: Transpeptidase activity]]

OCA at 02:21, 1 October 2014

2014-10-01T02:21:25Z

← Older revision		Revision as of 02:21, 1 October 2014
Line 1:		Line 1:
	[[Image:~~2v2f~~.~~png~~\|~~left~~\|~~200px~~]]		==CRYSTAL STRUCTURE OF PBP1A FROM DRUG-RESISTANT STRAIN 5204 FROM STREPTOCOCCUS PNEUMONIAE==
			<StructureSection load='2v2f' size='340' side='right' caption='[[2v2f]], [[Resolution\|resolution]] 1.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2v2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2F FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidoglycan_glycosyltransferase Peptidoglycan glycosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.129 2.4.1.129] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2f RCSB], [http://www.ebi.ac.uk/pdbsum/2v2f PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2f_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The development of high level beta-lactam resistance in the pneumococcus requires the expression of an altered form of PBP1a, in addition to modified forms of PBP2b and PBP2x, which are necessary for the appearance of low levels of resistance. Here, we present the crystal structure of a soluble form of PBP1a from the highly resistant Streptococcus pneumoniae strain 5204 (minimal inhibitory concentration of cefotaxime is 12 mg.liter(-1)). Mutations T371A, which is adjacent to the catalytic nucleophile Ser(370), and TSQF(574-577)NTGY, which lie in a loop bordering the active site cleft, were investigated by site-directed mutagenesis. The consequences of these substitutions on reaction kinetics with beta-lactams were probed in vitro, and their effect on resistance was measured in vivo. The results are interpreted in the framework of the crystal structure, which displays a narrower, discontinuous active site cavity, compared with that of PBP1a from the beta-lactam susceptible strain R6, as well as a reorientation of the catalytic Ser(370).

	{~~{STRUCTURE_2v2f\| PDB=2v2f \| SCENE= }~~}		Common Alterations in PBP1a from Resistant Streptococcus pneumoniae Decrease Its Reactivity toward {beta}-Lactams: STRUCTURAL INSIGHTS.,Job V, Carapito R, Vernet T, Dessen A, Zapun A J Biol Chem. 2008 Feb 22;283(8):4886-4894. Epub 2007 Nov 30. PMID:18055459<ref>PMID:18055459</ref>

	~~===CRYSTAL STRUCTURE OF PBP1A FROM DRUG-RESISTANT STRAIN 5204 FROM STREPTOCOCCUS PNEUMONIAE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_18055459}}~~		==See Also==
			*[[Penicillin-binding protein\|Penicillin-binding protein]]
	==~~About this Structure~~==		== References ==
	[[~~2v2f~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA].~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Peptidoglycan glycosyltransferase]]		[[Category: Peptidoglycan glycosyltransferase]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]

OCA: Protected "2v2f" [edit=sysop:move=sysop]

2013-01-07T19:08:00Z

Protected "2v2f" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:08, 7 January 2013
(No difference)

OCA at 19:07, 7 January 2013

2013-01-07T19:07:57Z

← Older revision		Revision as of 19:07, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2v2f.png\|left\|200px]]		[[Image:2v2f.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2v2f", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2v2f\| PDB=2v2f \| SCENE= }}		{{STRUCTURE_2v2f\| PDB=2v2f \| SCENE= }}

	===CRYSTAL STRUCTURE OF PBP1A FROM DRUG-RESISTANT STRAIN 5204 FROM STREPTOCOCCUS PNEUMONIAE===		===CRYSTAL STRUCTURE OF PBP1A FROM DRUG-RESISTANT STRAIN 5204 FROM STREPTOCOCCUS PNEUMONIAE===

			{{ABSTRACT_PUBMED_18055459}}

	==About this Structure==		==About this Structure==
	~~2V2F~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA].		[[2v2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA].
	[[Category: Peptidoglycan glycosyltransferase]]		[[Category: Peptidoglycan glycosyltransferase]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
Line 27:		Line 21:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transpeptidase activity]]		[[Category: Transpeptidase activity]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:01:54 2009''~~

OCA at 09:01, 17 February 2009

2009-02-17T09:01:56Z

← Older revision		Revision as of 09:01, 17 February 2009
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
	2V2F is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA].		2V2F is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2F OCA].
	[[Category: Peptidoglycan glycosyltransferase]]		[[Category: Peptidoglycan glycosyltransferase]]
	~~[[Category: Single protein]]~~
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Carapito, R.]]		[[Category: Carapito, R.]]
Line 29:		Line 28:
	[[Category: Transpeptidase activity]]		[[Category: Transpeptidase activity]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 15~~:02:~~45 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:01:54 2009''