2vb6 - Revision history

OCA at 17:29, 8 September 2026

2026-09-08T17:29:36Z

← Older revision		Revision as of 17:29, 8 September 2026
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vb6_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vb6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 09:57, 9 May 2024

2024-05-09T09:57:02Z

← Older revision		Revision as of 09:57, 9 May 2024
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	<StructureSection load='2vb6' size='340' side='right'caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vb6' size='340' side='right'caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chick Chick~~] and [https://en.wikipedia.org/wiki/~~Pig Pig~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [https://pdbe.org/2vb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [https://pdbe.org/2vb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [[https://www.uniprot.org/uniprot/CALM_CHICK CALM_CHICK]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.		[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Chick~~]]		[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Pig~~]]		[[Category: Sus scrofa]]
	[[Category: Cicolari, J]]		[[Category: Cicolari J]]
	[[Category: Houdusse, A]]		[[Category: Houdusse A]]
	[[Category: Li, A]]		[[Category: Li A]]
	[[Category: Liu, X]]		[[Category: Liu X]]
	[[Category: Llinas, P]]		[[Category: Llinas P]]
	[[Category: Menetrey, J]]		[[Category: Menetrey J]]
	[[Category: Squires, G]]		[[Category: Squires G]]
	[[Category: Sweeney~~, H L]]~~		[[Category: Sweeney HL]]
	~~[[Category: Calmodulin]]~~
	~~[[Category: Cam]]~~
	~~[[Category: Mg adp befx]]~~
	~~[[Category: Molecular motor]]~~
	~~[[Category: Motor protein]]~~
	~~[[Category: Myosin vi]]~~
	~~[[Category: Post-rigor state~~]]

OCA at 12:43, 23 March 2022

2022-03-23T12:43:17Z

← Older revision		Revision as of 12:43, 23 March 2022
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	<StructureSection load='2vb6' size='340' side='right'caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vb6' size='340' side='right'caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chick Chick] and [~~http~~://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick] and [https://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [~~http~~://pdbe.org/2vb6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vb6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [https://pdbe.org/2vb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [[~~http~~://www.uniprot.org/uniprot/CALM_CHICK CALM_CHICK]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.		[[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [[https://www.uniprot.org/uniprot/CALM_CHICK CALM_CHICK]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:25, 17 June 2020

2020-06-17T11:25:46Z

← Older revision		Revision as of 11:25, 17 June 2020
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	==Myosin VI (MD-insert2-CaM, Delta Insert1) Post-rigor state (crystal form 2)==		==Myosin VI (MD-insert2-CaM, Delta Insert1) Post-rigor state (crystal form 2)==
	<StructureSection load='2vb6' size='340' side='right' caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vb6' size='340' side='right'caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://pdbe.org/2vb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://pdbe.org/2vb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Calmodulin\|Calmodulin]]		*[[Calmodulin 3D structures\|Calmodulin 3D structures]]
	*[[Myosin\|Myosin]]		*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Chick]]		[[Category: Chick]]
			[[Category: Large Structures]]
	[[Category: Pig]]		[[Category: Pig]]
	[[Category: Cicolari, J]]		[[Category: Cicolari, J]]

OCA at 08:09, 12 September 2018

2018-09-12T08:09:28Z

← Older revision		Revision as of 08:09, 12 September 2018
Line 1:		Line 1:
	==~~MYOSIN~~ VI (MD-~~INSERT2~~-~~CAM~~, ~~DELTA INSERT1~~) ~~POST~~-~~RIGOR STATE~~ (~~CRYSTAL FORM~~ 2)==
			==Myosin VI (MD-insert2-CaM, Delta Insert1) Post-rigor state (crystal form 2)==
	<StructureSection load='2vb6' size='340' side='right' caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vb6' size='340' side='right' caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://pdbe.org/2vb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://pdbe.org/2vb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vb6_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vb6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:05, 9 February 2016

2016-02-09T02:05:59Z

← Older revision		Revision as of 02:05, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2vb6' size='340' side='right' caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vb6' size='340' side='right' caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~] and [http://en.wikipedia.org/wiki/~~Sus_scrofa Sus scrofa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://pdbe.org/2vb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vb6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2vb6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
			*[[Calmodulin\|Calmodulin]]
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
	== References ==		== References ==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Gallus gallus~~]]		[[Category: Chick]]
	[[Category: ~~Sus scrofa~~]]		[[Category: Pig]]
	[[Category: Cicolari, J]]		[[Category: Cicolari, J]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]

OCA at 03:40, 25 December 2014

2014-12-25T03:40:47Z

← Older revision		Revision as of 03:40, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [[http://www.uniprot.org/uniprot/CALM_CHICK CALM_CHICK]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 29:

	==See Also==		==See Also==
	*[[Calmodulin\|Calmodulin]]
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
	== References ==		== References ==
Line 35:		Line 36:
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Cicolari, J.]]		[[Category: Cicolari, J]]
	[[Category: Houdusse, A.]]		[[Category: Houdusse, A]]
	[[Category: Li, A.]]		[[Category: Li, A]]
	[[Category: Liu, X.]]		[[Category: Liu, X]]
	[[Category: Llinas, P.]]		[[Category: Llinas, P]]
	[[Category: Menetrey, J.]]		[[Category: Menetrey, J]]
	[[Category: Squires, G.]]		[[Category: Squires, G]]
	[[Category: Sweeney, H L.]]		[[Category: Sweeney, H L]]
	[[Category: Calmodulin]]		[[Category: Calmodulin]]
	[[Category: Cam]]		[[Category: Cam]]

OCA at 08:20, 29 September 2014

2014-09-29T08:20:02Z

← Older revision		Revision as of 08:20, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2vb6~~.~~png~~\|~~left~~\|~~200px~~]]		==MYOSIN VI (MD-INSERT2-CAM, DELTA INSERT1) POST-RIGOR STATE (CRYSTAL FORM 2)==
			<StructureSection load='2vb6' size='340' side='right' caption='[[2vb6]], [[Resolution\|resolution]] 2.30Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bkh\|2bkh]], [[2v26\|2v26]], [[2bki\|2bki]], [[2vas\|2vas]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vb6_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Myosin VI has an unexpectedly large swing of its lever arm (powerstroke) that optimizes its unique reverse direction movement. The basis for this is an unprecedented rearrangement of the subdomain to which the lever arm is attached, referred to as the converter. It is unclear at what point(s) in the myosin VI ATPase cycle rearrangements in the converter occur, and how this would effect lever arm position. We solved the structure of myosin VI with an ATP analogue (ADP.BeF3) bound in its nucleotide-binding pocket. The structure reveals that no rearrangement in the converter occur upon ATP binding. Based on previously solved myosin structures, our structure suggests that no reversal of the powerstroke occurs during detachment of myosin VI from actin. The structure also reveals novel features of the myosin VI motor that may be important in maintaining the converter conformation during detachment from actin, and other features that may promote rapid rearrangements in the structure following actin detachment that enable hydrolysis of ATP.

	~~{{STRUCTURE_2vb6\| PDB=2vb6 \| SCENE= }}~~		The post-rigor structure of myosin VI and implications for the recovery stroke.,Menetrey J, Llinas P, Cicolari J, Squires G, Liu X, Li A, Sweeney HL, Houdusse A EMBO J. 2008 Jan 9;27(1):244-52. Epub 2007 Nov 29. PMID:18046460<ref>PMID:18046460</ref>

	~~===MYOSIN VI (MD-INSERT2-CAM~~, ~~DELTA INSERT1) POST-RIGOR STATE (CRYSTAL FORM 2)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18046460}}~~

	~~==About this Structure==~~
	~~[[2vb6]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en~~.~~wikipedia~~.~~org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2VB6 OCA].~~

	==See Also==		==See Also==
	*[[Calmodulin\|Calmodulin]]		*[[Calmodulin\|Calmodulin]]
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018046460<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 12:16, 20 October 2012

2012-10-20T12:16:41Z

← Older revision		Revision as of 12:16, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2vb6]] is a 2 chain structure ~~of [[Calmodulin]] and [[Myosin]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA].		[[2vb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA].

	==See Also==		==See Also==

OCA at 08:11, 26 July 2012

2012-07-26T08:11:23Z

← Older revision		Revision as of 08:11, 26 July 2012
Line 1:		Line 1:
	[[Image:2vb6.png\|left\|200px]]		[[Image:2vb6.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2vb6", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2vb6\| PDB=2vb6 \| SCENE= }}		{{STRUCTURE_2vb6\| PDB=2vb6 \| SCENE= }}

	===MYOSIN VI (MD-INSERT2-CAM, DELTA INSERT1) POST-RIGOR STATE (CRYSTAL FORM 2)===		===MYOSIN VI (MD-INSERT2-CAM, DELTA INSERT1) POST-RIGOR STATE (CRYSTAL FORM 2)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18046460}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18046460 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18046460}}		{{ABSTRACT_PUBMED_18046460}}

	==About this Structure==		==About this Structure==
	[[2vb6]] is a 2 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA].		[[2vb6]] is a 2 chain structure of [[Calmodulin]] and [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA].

	==See Also==		==See Also==
	*[[Myosin]]		*[[Calmodulin\|Calmodulin]]
			*[[Myosin\|Myosin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18046460~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018046460</ref><references group="xtra"/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]