2vb8 - Revision history

OCA at 15:13, 13 December 2023

2023-12-13T15:13:29Z

← Older revision		Revision as of 15:13, 13 December 2023
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	<StructureSection load='2vb8' size='340' side='right'caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>		<StructureSection load='2vb8' size='340' side='right'caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.52Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[1f91\|1f91]], [[1fj8\|1fj8]], [[1g5x\|1g5x]], [[1h4f\|1h4f]], [[2aq7\|2aq7]], [[2aqb\|2aqb]], [[2buh\|2buh]], [[2bui\|2bui]], [[2byx\|2byx]], [[2bz3\|2bz3]], [[1dd8\|1dd8]], [[1ek4\|1ek4]], [[1fj4\|1fj4]], [[2byw\|2byw]], [[2byy\|2byy]], [[2byz\|2byz]], [[2bz4\|2bz4]], [[2vb7\|2vb7]], [[2vb9\|2vb9]], [[2vba\|2vba]]</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [https://pdbe.org/2vb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [https://pdbe.org/2vb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.		[https://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bailly, J]]		[[Category: Bailly J]]
	[[Category: Hennig, M]]		[[Category: Hennig M]]
	[[Category: Pappenberger, G]]		[[Category: Pappenberger G]]
	[[Category: Schulz-Gasch, T]]		[[Category: Schulz-Gasch T]]
	~~[[Category: Acyltransferase]]~~
	~~[[Category: Antibiotic]]~~
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Fatty acid biosynthesis]]~~
	~~[[Category: Fatty acid synthesis]]~~
	~~[[Category: Lipid synthesis]]~~
	~~[[Category: Thiolactomycin]]~~
	~~[[Category: Transferase~~]]

OCA at 10:43, 7 July 2021

2021-07-07T10:43:47Z

← Older revision		Revision as of 10:43, 7 July 2021
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	<StructureSection load='2vb8' size='340' side='right'caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>		<StructureSection load='2vb8' size='340' side='right'caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f91\|1f91]], [[1fj8\|1fj8]], [[1g5x\|1g5x]], [[1h4f\|1h4f]], [[2aq7\|2aq7]], [[2aqb\|2aqb]], [[2buh\|2buh]], [[2bui\|2bui]], [[2byx\|2byx]], [[2bz3\|2bz3]], [[1dd8\|1dd8]], [[1ek4\|1ek4]], [[1fj4\|1fj4]], [[2byw\|2byw]], [[2byy\|2byy]], [[2byz\|2byz]], [[2bz4\|2bz4]], [[2vb7\|2vb7]], [[2vb9\|2vb9]], [[2vba\|2vba]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1f91\|1f91]], [[1fj8\|1fj8]], [[1g5x\|1g5x]], [[1h4f\|1h4f]], [[2aq7\|2aq7]], [[2aqb\|2aqb]], [[2buh\|2buh]], [[2bui\|2bui]], [[2byx\|2byx]], [[2bz3\|2bz3]], [[1dd8\|1dd8]], [[1ek4\|1ek4]], [[1fj4\|1fj4]], [[2byw\|2byw]], [[2byy\|2byy]], [[2byz\|2byz]], [[2bz4\|2bz4]], [[2vb7\|2vb7]], [[2vb9\|2vb9]], [[2vba\|2vba]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [~~http~~://pdbe.org/2vb8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vb8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [https://pdbe.org/2vb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.		[[https://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:10, 10 May 2019

2019-05-10T12:10:58Z

← Older revision		Revision as of 12:10, 10 May 2019
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	==beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound inhibitor thiolactomycin==		==beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound inhibitor thiolactomycin==
	<StructureSection load='2vb8' size='340' side='right' caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>		<StructureSection load='2vb8' size='340' side='right'caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]		*[[Acyl carrier protein synthase 3D structures\|Acyl carrier protein synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Bailly, J]]		[[Category: Bailly, J]]
	[[Category: Hennig, M]]		[[Category: Hennig, M]]

OCA at 08:24, 12 September 2018

2018-09-12T08:24:11Z

← Older revision		Revision as of 08:24, 12 September 2018
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	==~~BETA~~-~~KETOACYL~~-ACP ~~SYNTHASE~~ I (KAS) ~~FROM~~ E. ~~COLI WITH BOUND INHIBITOR THIOLACTOMYCIN~~==
			==beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound inhibitor thiolactomycin==
	<StructureSection load='2vb8' size='340' side='right' caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>		<StructureSection load='2vb8' size='340' side='right' caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f91\|1f91]], [[1fj8\|1fj8]], [[1g5x\|1g5x]], [[1h4f\|1h4f]], [[2aq7\|2aq7]], [[2aqb\|2aqb]], [[2buh\|2buh]], [[2bui\|2bui]], [[2byx\|2byx]], [[2bz3\|2bz3]], [[1dd8\|1dd8]], [[1ek4\|1ek4]], [[1fj4\|1fj4]], [[2byw\|2byw]], [[2byy\|2byy]], [[2byz\|2byz]], [[2bz4\|2bz4]], [[2vb7\|2vb7]], [[2vb9\|2vb9]], [[2vba\|2vba]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f91\|1f91]], [[1fj8\|1fj8]], [[1g5x\|1g5x]], [[1h4f\|1h4f]], [[2aq7\|2aq7]], [[2aqb\|2aqb]], [[2buh\|2buh]], [[2bui\|2bui]], [[2byx\|2byx]], [[2bz3\|2bz3]], [[1dd8\|1dd8]], [[1ek4\|1ek4]], [[1fj4\|1fj4]], [[2byw\|2byw]], [[2byy\|2byy]], [[2byz\|2byz]], [[2bz4\|2bz4]], [[2vb7\|2vb7]], [[2vb9\|2vb9]], [[2vba\|2vba]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [http://pdbe.org/2vb8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [http://pdbe.org/2vb8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vb8_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vb8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
			[[Category: Cytoplasm]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]
	[[Category: Fatty acid synthesis]]		[[Category: Fatty acid synthesis]]

OCA at 02:55, 10 February 2016

2016-02-10T02:55:02Z

← Older revision		Revision as of 02:55, 10 February 2016
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	<StructureSection load='2vb8' size='340' side='right' caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>		<StructureSection load='2vb8' size='340' side='right' caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f91\|1f91]], [[1fj8\|1fj8]], [[1g5x\|1g5x]], [[1h4f\|1h4f]], [[2aq7\|2aq7]], [[2aqb\|2aqb]], [[2buh\|2buh]], [[2bui\|2bui]], [[2byx\|2byx]], [[2bz3\|2bz3]], [[1dd8\|1dd8]], [[1ek4\|1ek4]], [[1fj4\|1fj4]], [[2byw\|2byw]], [[2byy\|2byy]], [[2byz\|2byz]], [[2bz4\|2bz4]], [[2vb7\|2vb7]], [[2vb9\|2vb9]], [[2vba\|2vba]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f91\|1f91]], [[1fj8\|1fj8]], [[1g5x\|1g5x]], [[1h4f\|1h4f]], [[2aq7\|2aq7]], [[2aqb\|2aqb]], [[2buh\|2buh]], [[2bui\|2bui]], [[2byx\|2byx]], [[2bz3\|2bz3]], [[1dd8\|1dd8]], [[1ek4\|1ek4]], [[1fj4\|1fj4]], [[2byw\|2byw]], [[2byy\|2byy]], [[2byz\|2byz]], [[2bz4\|2bz4]], [[2vb7\|2vb7]], [[2vb9\|2vb9]], [[2vba\|2vba]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-~~protein_synthase_I~~ Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [http://pdbe.org/2vb8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vb8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2vb8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Beta-ketoacyl-acyl-carrier-protein synthase I]]~~		[[Category: Bacillus coli migula 1895]]
	~~[[Category: Escherichia~~ coli]]
	[[Category: Bailly, J]]		[[Category: Bailly, J]]
	[[Category: Hennig, M]]		[[Category: Hennig, M]]

OCA at 11:18, 25 December 2014

2014-12-25T11:18:27Z

← Older revision		Revision as of 11:18, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f91\|1f91]], [[1fj8\|1fj8]], [[1g5x\|1g5x]], [[1h4f\|1h4f]], [[2aq7\|2aq7]], [[2aqb\|2aqb]], [[2buh\|2buh]], [[2bui\|2bui]], [[2byx\|2byx]], [[2bz3\|2bz3]], [[1dd8\|1dd8]], [[1ek4\|1ek4]], [[1fj4\|1fj4]], [[2byw\|2byw]], [[2byy\|2byy]], [[2byz\|2byz]], [[2bz4\|2bz4]], [[2vb7\|2vb7]], [[2vb9\|2vb9]], [[2vba\|2vba]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f91\|1f91]], [[1fj8\|1fj8]], [[1g5x\|1g5x]], [[1h4f\|1h4f]], [[2aq7\|2aq7]], [[2aqb\|2aqb]], [[2buh\|2buh]], [[2bui\|2bui]], [[2byx\|2byx]], [[2bz3\|2bz3]], [[1dd8\|1dd8]], [[1ek4\|1ek4]], [[1fj4\|1fj4]], [[2byw\|2byw]], [[2byy\|2byy]], [[2byz\|2byz]], [[2bz4\|2bz4]], [[2vb7\|2vb7]], [[2vb9\|2vb9]], [[2vba\|2vba]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb8 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Bailly, J.]]		[[Category: Bailly, J]]
	[[Category: Hennig, M.]]		[[Category: Hennig, M]]
	[[Category: Pappenberger, G.]]		[[Category: Pappenberger, G]]
	[[Category: Schulz-Gasch, T.]]		[[Category: Schulz-Gasch, T]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]

OCA at 06:34, 29 September 2014

2014-09-29T06:34:33Z

← Older revision		Revision as of 06:34, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2vb8~~.~~png~~\|~~left~~\|~~200px~~]]		==BETA-KETOACYL-ACP SYNTHASE I (KAS) FROM E. COLI WITH BOUND INHIBITOR THIOLACTOMYCIN==
			<StructureSection load='2vb8' size='340' side='right' caption='[[2vb8]], [[Resolution\|resolution]] 1.52Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f91\|1f91]], [[1fj8\|1fj8]], [[1g5x\|1g5x]], [[1h4f\|1h4f]], [[2aq7\|2aq7]], [[2aqb\|2aqb]], [[2buh\|2buh]], [[2bui\|2bui]], [[2byx\|2byx]], [[2bz3\|2bz3]], [[1dd8\|1dd8]], [[1ek4\|1ek4]], [[1fj4\|1fj4]], [[2byw\|2byw]], [[2byy\|2byy]], [[2byz\|2byz]], [[2bz4\|2bz4]], [[2vb7\|2vb7]], [[2vb9\|2vb9]], [[2vba\|2vba]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb8 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vb8_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Fatty-acid synthesis in bacteria is of great interest as a target for the discovery of antibacterial compounds. The addition of a new acetyl moiety to the growing fatty-acid chain, an essential step in this process, is catalyzed by beta-ketoacyl-ACP synthase (KAS). It is inhibited by natural antibiotics such as cerulenin and thiolactomycin; however, these lack the requirements for optimal drug development. Structure-based biophysical screening revealed a novel synthetic small molecule, 2-phenylamino-4-methyl-5-acetylthiazole, that binds to Escherichia coli KAS I with a binding constant of 25 microM as determined by fluorescence titration. A 1.35 A crystal structure of its complex with its target reveals noncovalent interactions with the active-site Cys163 and hydrophobic residues of the fatty-acid binding pocket. The active site is accessible through an open conformation of the Phe392 side chain and no conformational changes are induced at the active site upon ligand binding. This represents a novel binding mode that differs from thiolactomycin or cerulenin interaction. The structural information on the protein-ligand interaction offers strategies for further optimization of this low-molecular-weight compound.

	~~{{STRUCTURE_2vb8\| PDB=2vb8 \| SCENE= }}~~		Structure-assisted discovery of an aminothiazole derivative as a lead molecule for inhibition of bacterial fatty-acid synthesis.,Pappenberger G, Schulz-Gasch T, Kusznir E, Muller F, Hennig M Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1208-16. Epub 2007, Nov 16. PMID:18084068<ref>PMID:18084068</ref>

	~~===BETA-KETOACYL-ACP SYNTHASE I (KAS) FROM E. COLI WITH BOUND INHIBITOR THIOLACTOMYCIN===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18084068}}~~

	~~==About this Structure==~~
	~~[[2vb8]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA].~~

	==See Also==		==See Also==
	*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]		*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018084068<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]

OCA at 16:04, 20 October 2012

2012-10-20T16:04:49Z

← Older revision		Revision as of 16:04, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2vb8]] is a 4 chain structure ~~of [[Acyl carrier protein synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA].		[[2vb8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA].

	==See Also==		==See Also==

OCA: Protected "2vb8" [edit=sysop:move=sysop]

2012-07-26T20:32:44Z

Protected "2vb8" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:32, 26 July 2012
(No difference)

OCA at 20:32, 26 July 2012

2012-07-26T20:32:42Z

← Older revision		Revision as of 20:32, 26 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2vb8.png\|left\|200px]]		[[Image:2vb8.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2vb8", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2vb8\| PDB=2vb8 \| SCENE= }}		{{STRUCTURE_2vb8\| PDB=2vb8 \| SCENE= }}

	===BETA-KETOACYL-ACP SYNTHASE I (KAS) FROM E. COLI WITH BOUND INHIBITOR THIOLACTOMYCIN===		===BETA-KETOACYL-ACP SYNTHASE I (KAS) FROM E. COLI WITH BOUND INHIBITOR THIOLACTOMYCIN===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18084068}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18084068 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18084068}}		{{ABSTRACT_PUBMED_18084068}}

	==About this Structure==		==About this Structure==
	~~2VB8~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA].		[[2vb8]] is a 4 chain structure of [[Acyl carrier protein synthase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA].

			==See Also==
			*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18084068~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018084068</ref><references group="xtra"/>
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
Line 32:		Line 23:
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]
	[[Category: Fatty acid synthesis]]		[[Category: Fatty acid synthesis]]
Line 38:		Line 28:
	[[Category: Thiolactomycin]]		[[Category: Thiolactomycin]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:51:11 2009''~~