2vbc - Revision history

OCA at 15:13, 13 December 2023

2023-12-13T15:13:34Z

← Older revision		Revision as of 15:13, 13 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VBC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [https://pdbe.org/2vbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [https://www.ebi.ac.uk/pdbsum/2vbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbc ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.15Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [https://pdbe.org/2vbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [https://www.ebi.ac.uk/pdbsum/2vbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/Q2TN89_9FLAV Q2TN89_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]		[https://www.uniprot.org/uniprot/Q2TN89_9FLAV Q2TN89_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Gruber, G]]		[[Category: Gruber G]]
	[[Category: Hunke, C]]		[[Category: Hunke C]]
	[[Category: Lescar, J]]		[[Category: Lescar J]]
	[[Category: Luo~~, D H~~]]		[[Category: Luo DH]]
	[[Category: Vasudevan~~, S G~~]]		[[Category: Vasudevan SG]]
	[[Category: Xu, T]]		[[Category: Xu T]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Ns2b-ns3 protease]]~~
	~~[[Category: Ns3 bifunctional enzyme]]~~
	~~[[Category: Nucleotide-binding]]~~
	~~[[Category: Rna replication]]~~
	~~[[Category: Transmembrane~~]]

OCA at 12:43, 23 March 2022

2022-03-23T12:43:26Z

← Older revision		Revision as of 12:43, 23 March 2022
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	<StructureSection load='2vbc' size='340' side='right'caption='[[2vbc]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2vbc' size='340' side='right'caption='[[2vbc]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VBC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [~~http~~://pdbe.org/2vbc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vbc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbc ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [https://pdbe.org/2vbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [https://www.ebi.ac.uk/pdbsum/2vbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/Q2TN89_9FLAV Q2TN89_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]		[[https://www.uniprot.org/uniprot/Q2TN89_9FLAV Q2TN89_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Helicase 3D structures\|Helicase 3D structures]]		*[[Helicase 3D structures\|Helicase 3D structures]]
	*[[Virus ~~proteases~~ 3D ~~strutures~~\|Virus ~~proteases~~ 3D ~~strutures~~]]		*[[Virus protease 3D structures\|Virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:25, 17 June 2020

2020-06-17T11:25:54Z

← Older revision		Revision as of 11:25, 17 June 2020
Line 1:		Line 1:

	==Crystal structure of the NS3 protease-helicase from Dengue virus==		==Crystal structure of the NS3 protease-helicase from Dengue virus==
	<StructureSection load='2vbc' size='340' side='right' caption='[[2vbc]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2vbc' size='340' side='right'caption='[[2vbc]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VBC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [http://pdbe.org/2vbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [http://www.ebi.ac.uk/pdbsum/2vbc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbc ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [http://pdbe.org/2vbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [http://www.ebi.ac.uk/pdbsum/2vbc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:

	==See Also==		==See Also==
	*[[Helicase\|Helicase]]		*[[Helicase 3D structures\|Helicase 3D structures]]
			*[[Virus proteases 3D strutures\|Virus proteases 3D strutures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 37:
	[[Category: Dengue Virus]]		[[Category: Dengue Virus]]
	[[Category: Dengue virus 4]]		[[Category: Dengue virus 4]]
			[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Gruber, G]]		[[Category: Gruber, G]]

OCA at 08:45, 12 September 2018

2018-09-12T08:45:46Z

← Older revision		Revision as of 08:45, 12 September 2018
Line 1:		Line 1:

	==~~CRYSTAL STRUCTURE OF THE~~ NS3 ~~PROTEASE~~-~~HELICASE FROM DENGUE VIRUS~~==		==Crystal structure of the NS3 protease-helicase from Dengue virus==
	<StructureSection load='2vbc' size='340' side='right' caption='[[2vbc]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2vbc' size='340' side='right' caption='[[2vbc]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vbc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vbc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:07, 4 August 2016

2016-08-04T22:07:22Z

← Older revision		Revision as of 22:07, 4 August 2016
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE NS3 PROTEASE-HELICASE FROM DENGUE VIRUS==		==CRYSTAL STRUCTURE OF THE NS3 PROTEASE-HELICASE FROM DENGUE VIRUS==
	<StructureSection load='2vbc' size='340' side='right' caption='[[2vbc]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2vbc' size='340' side='right' caption='[[2vbc]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [http://www.ebi.ac.uk/pdbsum/2vbc PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [http://pdbe.org/2vbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [http://www.ebi.ac.uk/pdbsum/2vbc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vbc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2vbc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:32, 25 December 2014

2014-12-25T13:32:27Z

← Older revision		Revision as of 13:32, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [http://www.ebi.ac.uk/pdbsum/2vbc PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [http://www.ebi.ac.uk/pdbsum/2vbc PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/Q2TN89_9FLAV Q2TN89_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Dengue virus 4]]		[[Category: Dengue virus 4]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Gruber, G.]]		[[Category: Gruber, G]]
	[[Category: Hunke, C.]]		[[Category: Hunke, C]]
	[[Category: Lescar, J.]]		[[Category: Lescar, J]]
	[[Category: Luo, D H.]]		[[Category: Luo, D H]]
	[[Category: Vasudevan, S G.]]		[[Category: Vasudevan, S G]]
	[[Category: Xu, T.]]		[[Category: Xu, T]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Ns2b-ns3 protease]]		[[Category: Ns2b-ns3 protease]]

OCA at 06:58, 29 September 2014

2014-09-29T06:58:39Z

← Older revision		Revision as of 06:58, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2vbc~~.~~png~~\|~~left~~\|~~200px~~]]		==CRYSTAL STRUCTURE OF THE NS3 PROTEASE-HELICASE FROM DENGUE VIRUS==
			<StructureSection load='2vbc' size='340' side='right' caption='[[2vbc]], [[Resolution\|resolution]] 3.15Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2vbc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBC FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vbc RCSB], [http://www.ebi.ac.uk/pdbsum/2vbc PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vbc_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Several flaviviruses are important human pathogens, including dengue virus, a disease against which neither a vaccine nor specific antiviral therapies currently exist. During infection, the flavivirus RNA genome is translated into a polyprotein, which is cleaved into several components. Nonstructural protein 3 (NS3) carries out enzymatic reactions essential for viral replication, including proteolysis of the polyprotein through its serine protease N-terminal domain, with a segment of 40 residues from the NS2B protein acting as a cofactor. The ATPase/helicase domain is located at the C terminus of NS3. Atomic structures are available for these domains separately, but a molecular view of the full-length flavivirus NS3 polypeptide is still lacking. We report a crystallographic structure of a complete NS3 molecule fused to 18 residues of the NS2B cofactor at a resolution of 3.15 A. The relative orientation between the protease and helicase domains is drastically different than the single-chain NS3-NS4A molecule from hepatitis C virus, which was caught in the act of cis cleavage at the NS3-NS4A junction. Here, the protease domain sits beneath the ATP binding site, giving the molecule an elongated shape. The domain arrangement found in the crystal structure fits nicely into an envelope determined ab initio using small-angle X-ray scattering experiments in solution, suggesting a stable molecular conformation. We propose that a basic patch located at the surface of the protease domain increases the affinity for nucleotides and could also participate in RNA binding, explaining the higher unwinding activity of the full-length enzyme compared to that of the isolated helicase domain.

	~~{{STRUCTURE_2vbc\| PDB=2vbc \| SCENE= }}~~		Crystal structure of the NS3 protease-helicase from dengue virus.,Luo D, Xu T, Hunke C, Gruber G, Vasudevan SG, Lescar J J Virol. 2008 Jan;82(1):173-83. Epub 2007 Oct 17. PMID:17942558<ref>PMID:17942558</ref>

	~~===CRYSTAL STRUCTURE OF THE NS3 PROTEASE-HELICASE FROM DENGUE VIRUS===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17942558}}~~

	~~==About this Structure==~~
	~~[[2vbc]] is~~ a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the ~~Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx~~.~~doi~~.~~org/10~~.~~2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2VBC OCA].~~

	==See Also==		==See Also==
	*[[Helicase\|Helicase]]		*[[Helicase\|Helicase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017942558<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Dengue Virus]]		[[Category: Dengue Virus]]
	[[Category: Dengue virus 4]]		[[Category: Dengue virus 4]]

OCA at 17:16, 20 October 2012

2012-10-20T17:16:33Z

← Older revision		Revision as of 17:16, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2vbc]] is a 2 chain structure ~~of [[Helicase]]~~ with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA].		[[2vbc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA].

	==See Also==		==See Also==

OCA: Protected "2vbc" [edit=sysop:move=sysop]

2012-07-27T00:23:10Z

Protected "2vbc" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:23, 27 July 2012
(No difference)

OCA at 00:23, 27 July 2012

2012-07-27T00:23:08Z

← Older revision		Revision as of 00:23, 27 July 2012
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	~~{{Seed}}~~
	[[Image:2vbc.png\|left\|200px]]		[[Image:2vbc.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2vbc", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2vbc\| PDB=2vbc \| SCENE= }}		{{STRUCTURE_2vbc\| PDB=2vbc \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE NS3 PROTEASE-HELICASE FROM DENGUE VIRUS===		===CRYSTAL STRUCTURE OF THE NS3 PROTEASE-HELICASE FROM DENGUE VIRUS===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17942558}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17942558 is the PubMed ID number.~~
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	{{ABSTRACT_PUBMED_17942558}}		{{ABSTRACT_PUBMED_17942558}}

	==About this Structure==		==About this Structure==
	~~2VBC~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA].		[[2vbc]] is a 2 chain structure of [[Helicase]] with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBC OCA].

			==See Also==
			*[[Helicase\|Helicase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17942558~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017942558</ref><references group="xtra"/>
	[[Category: Dengue Virus]]		[[Category: Dengue Virus]]
	[[Category: Dengue virus 4]]		[[Category: Dengue virus 4]]
Line 33:		Line 24:
	[[Category: Vasudevan, S G.]]		[[Category: Vasudevan, S G.]]
	[[Category: Xu, T.]]		[[Category: Xu, T.]]
	~~[[Category: Helicase]]~~
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	~~[[Category: Membrane]]~~
	[[Category: Ns2b-ns3 protease]]		[[Category: Ns2b-ns3 protease]]
	[[Category: Ns3 bifunctional enzyme ~~structure crystal structure]]~~		[[Category: Ns3 bifunctional enzyme]]
	~~[[Category: Ns3 helicase~~]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Rna replication]]		[[Category: Rna replication]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 21 09:42:14 2010''~~