2vbq - Revision history

OCA at 17:28, 15 December 2021

2021-12-15T17:28:01Z

← Older revision		Revision as of 17:28, 15 December 2021
Line 3:		Line 3:
	<StructureSection load='2vbq' size='340' side='right'caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2vbq' size='340' side='right'caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSJ:(3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-AMINO-6-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL]-3-HYDROXY-2,2-DIMETHYL-4,8,15-TRIOXO-12-THIA-5,9,16-TRIAZAHEPTADEC-9-EN-1-YL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>BSJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BSJ:(3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-AMINO-6-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL]-3-HYDROXY-2,2-DIMETHYL-4,8,15-TRIOXO-12-THIA-5,9,16-TRIAZAHEPTADEC-9-EN-1-YL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>BSJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s3z\|1s3z]], [[1s5k\|1s5k]], [[1s60\|1s60]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s3z\|1s3z]], [[1s5k\|1s5k]], [[1s60\|1s60]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbq OCA], [~~http~~://pdbe.org/2vbq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vbq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vbq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbq OCA], [https://pdbe.org/2vbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vbq RCSB], [https://www.ebi.ac.uk/pdbsum/2vbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:39, 11 March 2020

2020-03-11T07:39:51Z

← Older revision		Revision as of 07:39, 11 March 2020
Line 1:		Line 1:

	==Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine.==		==Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine.==
	<StructureSection load='2vbq' size='340' side='right' caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2vbq' size='340' side='right'caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Auclair, K]]		[[Category: Auclair, K]]
	[[Category: Blanchard, J S]]		[[Category: Blanchard, J S]]

OCA at 07:50, 6 March 2019

2019-03-06T07:50:00Z

← Older revision		Revision as of 07:50, 6 March 2019
Line 1:		Line 1:

	==Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine.==		==Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine.==
	<StructureSection load='2vbq' size='340' side='right' caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2vbq' size='340' side='right' caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vbq_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vbq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:23, 16 November 2017

2017-11-16T07:23:44Z

← Older revision		Revision as of 07:23, 16 November 2017
Line 1:		Line 1:
	==~~STRUCTURE OF~~ AAC(6')-~~IY IN COMPLEX WITH BISUBSTRATE ANALOG COA~~-S-~~MONOMETHYL~~-~~ACETYLNEAMINE~~.==
			==Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine.==
	<StructureSection load='2vbq' size='340' side='right' caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2vbq' size='340' side='right' caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s3z\|1s3z]], [[1s5k\|1s5k]], [[1s60\|1s60]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s3z\|1s3z]], [[1s5k\|1s5k]], [[1s60\|1s60]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbq OCA], [http://pdbe.org/2vbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vbq RCSB], [http://www.ebi.ac.uk/pdbsum/2vbq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbq OCA], [http://pdbe.org/2vbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vbq RCSB], [http://www.ebi.ac.uk/pdbsum/2vbq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 21:50, 7 February 2016

2016-02-07T21:50:12Z

← Older revision		Revision as of 21:50, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2vbq' size='340' side='right' caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2vbq' size='340' side='right' caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSJ:(3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-AMINO-6-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL]-3-HYDROXY-2,2-DIMETHYL-4,8,15-TRIOXO-12-THIA-5,9,16-TRIAZAHEPTADEC-9-EN-1-YL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>BSJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSJ:(3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-AMINO-6-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL]-3-HYDROXY-2,2-DIMETHYL-4,8,15-TRIOXO-12-THIA-5,9,16-TRIAZAHEPTADEC-9-EN-1-YL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>BSJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s3z\|1s3z]], [[1s5k\|1s5k]], [[1s60\|1s60]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s3z\|1s3z]], [[1s5k\|1s5k]], [[1s60\|1s60]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vbq RCSB], [http://www.ebi.ac.uk/pdbsum/2vbq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbq OCA], [http://pdbe.org/2vbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vbq RCSB], [http://www.ebi.ac.uk/pdbsum/2vbq PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vbq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2vbq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Salmonella enterica]]~~
	[[Category: Auclair, K]]		[[Category: Auclair, K]]
	[[Category: Blanchard, J S]]		[[Category: Blanchard, J S]]

OCA at 16:02, 19 January 2015

2015-01-19T16:02:25Z

← Older revision		Revision as of 16:02, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSJ:(3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-AMINO-6-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL]-3-HYDROXY-2,2-DIMETHYL-4,8,15-TRIOXO-12-THIA-5,9,16-TRIAZAHEPTADEC-9-EN-1-YL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>BSJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSJ:(3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-AMINO-6-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL]-3-HYDROXY-2,2-DIMETHYL-4,8,15-TRIOXO-12-THIA-5,9,16-TRIAZAHEPTADEC-9-EN-1-YL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>BSJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s3z\|1s3z]], [[1s5k\|1s5k]], [[1s60\|1s60]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s3z\|1s3z]], [[1s5k\|1s5k]], [[1s60\|1s60]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vbq RCSB], [http://www.ebi.ac.uk/pdbsum/2vbq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vbq RCSB], [http://www.ebi.ac.uk/pdbsum/2vbq PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Salmonella enterica]]		[[Category: Salmonella enterica]]
	[[Category: Auclair, K.]]		[[Category: Auclair, K]]
	[[Category: Blanchard, J S.]]		[[Category: Blanchard, J S]]
	[[Category: Freiburger, L.]]		[[Category: Freiburger, L]]
	[[Category: Gao, F.]]		[[Category: Gao, F]]
	[[Category: Magalhaes, M L.]]		[[Category: Magalhaes, M L]]
	[[Category: Vetting, M W.]]		[[Category: Vetting, M W]]
	[[Category: Acetyltransferase]]		[[Category: Acetyltransferase]]
	[[Category: Aminoglycoside]]		[[Category: Aminoglycoside]]

OCA at 02:20, 1 October 2014

2014-10-01T02:20:35Z

← Older revision		Revision as of 02:20, 1 October 2014
Line 1:		Line 1:
	[[Image:~~2vbq~~.~~png~~\|~~left~~\|~~200px~~]]		==STRUCTURE OF AAC(6')-IY IN COMPLEX WITH BISUBSTRATE ANALOG COA-S-MONOMETHYL-ACETYLNEAMINE.==
			<StructureSection load='2vbq' size='340' side='right' caption='[[2vbq]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2vbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VBQ FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSJ:(3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-AMINO-6-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL]-3-HYDROXY-2,2-DIMETHYL-4,8,15-TRIOXO-12-THIA-5,9,16-TRIAZAHEPTADEC-9-EN-1-YL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>BSJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s3z\|1s3z]], [[1s5k\|1s5k]], [[1s60\|1s60]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vbq RCSB], [http://www.ebi.ac.uk/pdbsum/2vbq PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vbq_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Aminoglycosides are antibacterial compounds that act by binding to the A site of the small 30S bacterial ribosomal subunit and inhibiting protein translation. Clinical resistance to aminoglycosides is generally the result of the expression of enzymes that covalently modify the antibiotic, including phosphorylation, adenylylation, and acetylation. Bisubstrate analogs for the aminoglycoside N-acetyltransferases are nanomolar inhibitors of Enterococcus faecium AAC(6')-Ii. However, in the case of the Salmonella enterica aac(6')-Iy-encoded aminoglycoside N-acetyltransferase, we demonstrate that a series of bisubstrate analogs are only micromolar inhibitors. In contrast to studies with AAC(6')-Ii, the inhibition constants toward AAC(6')-Iy are essentially independent of both the identity of the aminoglycoside component of the bisubstrate and the number of carbon atoms that are used to link the CoA and aminoglycoside components. The patterns of inhibition suggest that the CoA portion of the bisubstrate analog can bind to the enzyme-aminoglycoside substrate complex and that the aminoglycoside portion can bind to the enzyme-CoA product complex. However, at the high concentrations of bisubstrate analog used in crystallization experiments, we could crystallize and solve the three-dimensional structure of the enzyme-bisubstrate complex. The structure reveals that both the CoA and aminoglycoside portions bind in essentially the same positions as those previously observed for the enzyme-CoA-ribostamycin complex, with only a modest adjustment to accommodate the "linker". These results are compared to previous studies of the interaction of similar bisubstrate analogs with other aminoglycoside N-acetyltransferases.

	~~{{STRUCTURE_2vbq\| PDB=2vbq \| SCENE= }}~~		Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase.,Magalhaes ML, Vetting MW, Gao F, Freiburger L, Auclair K, Blanchard JS Biochemistry. 2008 Jan 15;47(2):579-84. Epub 2007 Dec 21. PMID:18095712<ref>PMID:18095712</ref>

	~~===STRUCTURE OF AAC(6')-IY IN COMPLEX WITH BISUBSTRATE ANALOG COA-~~S~~-MONOMETHYL-ACETYLNEAMINE~~.~~===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18095712}}~~		== References ==
			<references/>
	==~~About this Structure~~==		__TOC__
	~~[[2vbq]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA].~~		</StructureSection>
	[[Category: Salmonella enterica]]		[[Category: Salmonella enterica]]
	[[Category: Auclair, K.]]		[[Category: Auclair, K.]]

OCA: Protected "2vbq" [edit=sysop:move=sysop]

2013-01-07T19:07:23Z

Protected "2vbq" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:07, 7 January 2013
(No difference)

OCA at 19:07, 7 January 2013

2013-01-07T19:07:21Z

← Older revision		Revision as of 19:07, 7 January 2013
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2vbq.png\|left\|200px]]		[[Image:2vbq.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2vbq", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2vbq\| PDB=2vbq \| SCENE= }}		{{STRUCTURE_2vbq\| PDB=2vbq \| SCENE= }}

	===STRUCTURE OF AAC(6')-IY IN COMPLEX WITH BISUBSTRATE ANALOG COA-S-MONOMETHYL-ACETYLNEAMINE.===		===STRUCTURE OF AAC(6')-IY IN COMPLEX WITH BISUBSTRATE ANALOG COA-S-MONOMETHYL-ACETYLNEAMINE.===

			{{ABSTRACT_PUBMED_18095712}}

	==About this Structure==		==About this Structure==
	~~2VBQ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Salmonella_choleraesuis~~ Salmonella ~~choleraesuis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA].		[[2vbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA].
	[[Category: Salmonella ~~choleraesuis~~]]		[[Category: Salmonella enterica]]
	[[Category: Auclair, K.]]		[[Category: Auclair, K.]]
	[[Category: Blanchard, J S.]]		[[Category: Blanchard, J S.]]
Line 27:		Line 21:
	[[Category: Drug resistance]]		[[Category: Drug resistance]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:43:51 2009''~~

OCA at 14:43, 16 February 2009

2009-02-16T14:43:52Z

← Older revision		Revision as of 14:43, 16 February 2009
Line 1:		Line 1:
	[[Image:2vbq.~~jpg~~\|left\|200px]]		{{Seed}}
			[[Image:2vbq.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2vbq\| PDB=2vbq \| SCENE= }}		{{STRUCTURE_2vbq\| PDB=2vbq \| SCENE= }}

	~~'''~~STRUCTURE OF AAC(6')-IY IN COMPLEX WITH BISUBSTRATE ANALOG COA-S-MONOMETHYL-ACETYLNEAMINE.~~'''~~		===STRUCTURE OF AAC(6')-IY IN COMPLEX WITH BISUBSTRATE ANALOG COA-S-MONOMETHYL-ACETYLNEAMINE.===


	==About this Structure==		==About this Structure==
	2VBQ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Salmonella_choleraesuis Salmonella choleraesuis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA].		2VBQ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_choleraesuis Salmonella choleraesuis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBQ OCA].
	[[Category: Salmonella choleraesuis]]		[[Category: Salmonella choleraesuis]]
	~~[[Category: Single protein]]~~
	[[Category: Auclair, K.]]		[[Category: Auclair, K.]]
	[[Category: Blanchard, J S.]]		[[Category: Blanchard, J S.]]
Line 27:		Line 27:
	[[Category: Drug resistance]]		[[Category: Drug resistance]]
	[[Category: Transferase]]		[[Category: Transferase]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 18~~:33:~~20 2008~~''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:43:51 2009''