2vcd - Revision history

OCA at 10:43, 7 July 2021

2021-07-07T10:43:59Z

← Older revision		Revision as of 10:43, 7 July 2021
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	==Solution structure of the FKBP-domain of Legionella pneumophila Mip in complex with rapamycin==		==Solution structure of the FKBP-domain of Legionella pneumophila Mip in complex with rapamycin==
	<StructureSection load='2vcd' size='340' side='right' caption='[[2vcd]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>		<StructureSection load='2vcd' size='340' side='right'caption='[[2vcd]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vcd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mip, lpg0791 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mip, lpg0791 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcd OCA], [~~http~~://pdbe.org/2vcd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vcd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vcd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcd OCA], [https://pdbe.org/2vcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vcd RCSB], [https://www.ebi.ac.uk/pdbsum/2vcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MIP_LEGPH MIP_LEGPH]] Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.		[[https://www.uniprot.org/uniprot/MIP_LEGPH MIP_LEGPH]] Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Peptidyl-prolyl cis-trans isomerase\|Peptidyl-prolyl cis-trans isomerase]]		*[[Peptidyl-prolyl cis-trans isomerase 3D structures\|Peptidyl-prolyl cis-trans isomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 33152]]		[[Category: Atcc 33152]]
			[[Category: Large Structures]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Ceymann, A]]		[[Category: Ceymann, A]]

OCA at 06:23, 9 May 2018

2018-05-09T06:23:45Z

← Older revision		Revision as of 06:23, 9 May 2018
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	==~~SOLUTION STRUCTURE OF THE~~ FKBP-~~DOMAIN OF LEGIONELLA PNEUMOPHILA MIP IN COMPLEX WITH RAPAMYCIN~~==
			==Solution structure of the FKBP-domain of Legionella pneumophila Mip in complex with rapamycin==
	<StructureSection load='2vcd' size='340' side='right' caption='[[2vcd]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>		<StructureSection load='2vcd' size='340' side='right' caption='[[2vcd]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Legionella_pneumophila Legionella pneumophila~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mip, lpg0791 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcd OCA], [http://pdbe.org/2vcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcd RCSB], [http://www.ebi.ac.uk/pdbsum/2vcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcd OCA], [http://pdbe.org/2vcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcd RCSB], [http://www.ebi.ac.uk/pdbsum/2vcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcd_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Legionella pneumophila~~]]		[[Category: Atcc 33152]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Ceymann, A]]		[[Category: Ceymann, A]]
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	[[Category: Fkbp-domain]]		[[Category: Fkbp-domain]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
			[[Category: Legionella pneumophila]]
	[[Category: Legionnaires disease]]		[[Category: Legionnaires disease]]
	[[Category: Macrolide antibiotic]]		[[Category: Macrolide antibiotic]]

OCA at 01:14, 8 February 2016

2016-02-08T01:14:25Z

← Older revision		Revision as of 01:14, 8 February 2016
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcd RCSB], [http://www.ebi.ac.uk/pdbsum/2vcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcd OCA], [http://pdbe.org/2vcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcd RCSB], [http://www.ebi.ac.uk/pdbsum/2vcd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vcd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2vcd" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Peptidyl-prolyl cis-trans isomerase\|Peptidyl-prolyl cis-trans isomerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:29, 24 December 2014

2014-12-24T19:29:48Z

← Older revision		Revision as of 19:29, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCD FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcd RCSB], [http://www.ebi.ac.uk/pdbsum/2vcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcd RCSB], [http://www.ebi.ac.uk/pdbsum/2vcd PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MIP_LEGPH MIP_LEGPH]] Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Legionella pneumophila]]		[[Category: Legionella pneumophila]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Ceymann, A.]]		[[Category: Ceymann, A]]
	[[Category: Ehses, P.]]		[[Category: Ehses, P]]
	[[Category: Faber, C.]]		[[Category: Faber, C]]
	[[Category: Fischer, G.]]		[[Category: Fischer, G]]
	[[Category: Horstmann, M.]]		[[Category: Horstmann, M]]
	[[Category: Paschke, A K.]]		[[Category: Paschke, A K]]
	[[Category: Roesch, P.]]		[[Category: Roesch, P]]
	[[Category: Schweimer, K.]]		[[Category: Schweimer, K]]
	[[Category: Fkbp]]		[[Category: Fkbp]]
	[[Category: Fkbp-domain]]		[[Category: Fkbp-domain]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	~~[[Category: Legionella pneumophila]]~~
	[[Category: Legionnaires disease]]		[[Category: Legionnaires disease]]
	[[Category: Macrolide antibiotic]]		[[Category: Macrolide antibiotic]]

OCA at 02:10, 1 October 2014

2014-10-01T02:10:34Z

← Older revision		Revision as of 02:10, 1 October 2014
Line 1:		Line 1:
	[[Image:~~2vcd~~.~~png~~\|~~left~~\|~~200px~~]]		==SOLUTION STRUCTURE OF THE FKBP-DOMAIN OF LEGIONELLA PNEUMOPHILA MIP IN COMPLEX WITH RAPAMYCIN==
			<StructureSection load='2vcd' size='340' side='right' caption='[[2vcd]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2vcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCD FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcd RCSB], [http://www.ebi.ac.uk/pdbsum/2vcd PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcd_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			BACKGROUND: Legionella pneumphila is the causative agent of Legionnaires' disease. A major virulence factor of the pathogen is the homodimeric surface protein Mip. It shows peptidyl-prolyl cis/trans isomerase activty and is a receptor of FK506 and rapamycin, which both inhibit its enzymatic function. Insight into the binding process may be used for the design of novel Mip inhibitors as potential drugs against Legionnaires' disease. RESULTS: We have solved the solution structure of free Mip77-213 and the Mip77-213-rapamycin complex by NMR spectroscopy. Mip77-213 showed the typical FKBP-fold and only minor rearrangements upon binding of rapamycin. Apart from the configuration of a flexible hairpin loop, which is partly stabilized upon binding, the solution structure confirms the crystal structure. Comparisons to the structures of free FKBP12 and the FKBP12-rapamycin complex suggested an identical binding mode for both proteins. CONCLUSION: The structural similarity of the Mip-rapamycin and FKBP12-rapamycin complexes suggests that FKBP12 ligands may be promising starting points for the design of novel Mip inhibitors. The search for a novel drug against Legionnaires' disease may therefore benefit from the large variety of known FKBP12 inhibitors.

	~~{{STRUCTURE_2vcd\| PDB=2vcd \| SCENE= }}~~		Solution structure of the Legionella pneumophila Mip-rapamycin complex.,Ceymann A, Horstmann M, Ehses P, Schweimer K, Paschke AK, Steinert M, Faber C BMC Struct Biol. 2008 Mar 17;8:17. PMID:18366641<ref>PMID:18366641</ref>

	~~===SOLUTION STRUCTURE OF THE FKBP-DOMAIN OF LEGIONELLA PNEUMOPHILA MIP IN COMPLEX WITH RAPAMYCIN===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18366641}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2vcd]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Legionella_pneumophila Legionella pneumophila]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:018366641<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Legionella pneumophila]]		[[Category: Legionella pneumophila]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]

OCA: Protected "2vcd" [edit=sysop:move=sysop]

2013-01-07T20:20:53Z

Protected "2vcd" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:20, 7 January 2013
(No difference)

OCA at 20:20, 7 January 2013

2013-01-07T20:20:50Z

← Older revision		Revision as of 20:20, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2vcd.png\|left\|200px]]		[[Image:2vcd.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2vcd", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2vcd\| PDB=2vcd \| SCENE= }}		{{STRUCTURE_2vcd\| PDB=2vcd \| SCENE= }}

	===SOLUTION STRUCTURE OF THE FKBP-DOMAIN OF LEGIONELLA PNEUMOPHILA MIP IN COMPLEX WITH RAPAMYCIN===		===SOLUTION STRUCTURE OF THE FKBP-DOMAIN OF LEGIONELLA PNEUMOPHILA MIP IN COMPLEX WITH RAPAMYCIN===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18366641}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18366641 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18366641}}		{{ABSTRACT_PUBMED_18366641}}

	==About this Structure==		==About this Structure==
	~~2VCD~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA].		[[2vcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18366641~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018366641</ref><references group="xtra"/>
	[[Category: Legionella pneumophila]]		[[Category: Legionella pneumophila]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
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	[[Category: Sirolimus]]		[[Category: Sirolimus]]
	[[Category: Virulence]]		[[Category: Virulence]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:44:41 2009''~~

OCA at 15:44, 16 February 2009

2009-02-16T15:44:42Z

← Older revision		Revision as of 15:44, 16 February 2009
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	{{Seed}}		{{Seed}}
	[[Image:2vcd.~~jpg~~\|left\|200px]]		[[Image:2vcd.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
	2VCD is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA].		2VCD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCD OCA].

	==Reference==		==Reference==
	~~Solution structure of the Legionella pneumophila Mip-rapamycin complex., Ceymann A, Horstmann M, Ehses P, Schweimer K, Paschke AK, Steinert M, Faber C, BMC Struct Biol. 2008 Mar 17;8:17.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18366641 18366641]~~		<ref group="xtra">PMID:18366641</ref><references group="xtra"/>
	[[Category: Legionella pneumophila]]		[[Category: Legionella pneumophila]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	~~[[Category: Single protein]]~~
	[[Category: Ceymann, A.]]		[[Category: Ceymann, A.]]
	[[Category: Ehses, P.]]		[[Category: Ehses, P.]]
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	[[Category: Virulence]]		[[Category: Virulence]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Sep 3 13~~:05:~~05 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:44:41 2009''

OCA at 10:05, 3 September 2008

2008-09-03T10:05:06Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 2vcd is ON HOLD  until Paper Publication
+<!--
-Authors: Ceymann, A., Horstmann, M., Ehses, P., Schweimer, K., Paschke, A., Fischer, G., Roesch, P., Faber, C.
+===SOLUTION STRUCTURE OF THE FKBP-DOMAIN OF LEGIONELLA PNEUMOPHILA MIP IN COMPLEX WITH RAPAMYCIN===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:51:12 2008''
+==About this Structure==

OCA: New page: '''Unreleased structure''' The entry 2vcd is ON HOLD until Paper Publication Authors: Ceymann, A., Horstmann, M., Ehses, P., Schweimer, K., Paschke, A., Fischer, G., Roesch, P., Faber, ...

2008-06-11T05:51:13Z

New page: '''Unreleased structure''' The entry 2vcd is ON HOLD until Paper Publication Authors: Ceymann, A., Horstmann, M., Ehses, P., Schweimer, K., Paschke, A., Fischer, G., Roesch, P., Faber, ...

New page

'''Unreleased structure'''

The entry 2vcd is ON HOLD until Paper Publication

Authors: Ceymann, A., Horstmann, M., Ehses, P., Schweimer, K., Paschke, A., Fischer, G., Roesch, P., Faber, C.

Description: Solution structure of the FKBP-domain of Legionella pneumophila Mip in complex with rapamycin

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:51:12 2008''