2vda - Revision history

OCA at 20:59, 20 October 2021

2021-10-20T20:59:36Z

← Older revision		Revision as of 20:59, 20 October 2021
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	<StructureSection load='2vda' size='340' side='right'caption='[[2vda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2vda' size='340' side='right'caption='[[2vda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VDA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tm6\|1tm6]], [[1tf5\|1tf5]], [[1m6n\|1m6n]], [[2fsf\|2fsf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tm6\|1tm6]], [[1tf5\|1tf5]], [[1m6n\|1m6n]], [[2fsf\|2fsf]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [~~http~~://pdbe.org/2vda PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vda PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vda ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [https://pdbe.org/2vda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [https://www.ebi.ac.uk/pdbsum/2vda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SECA_ECOLI SECA_ECOLI]] Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.<ref>PMID:15140892</ref> [[~~http~~://www.uniprot.org/uniprot/LAMB_ECOL6 LAMB_ECOL6]] Involved in the transport of maltose and maltodextrins (By similarity).		[[https://www.uniprot.org/uniprot/SECA_ECOLI SECA_ECOLI]] Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.<ref>PMID:15140892</ref> [[https://www.uniprot.org/uniprot/LAMB_ECOL6 LAMB_ECOL6]] Involved in the transport of maltose and maltodextrins (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:00, 18 December 2019

2019-12-18T14:00:31Z

← Older revision		Revision as of 14:00, 18 December 2019
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	~~{{Large structure}}~~
	==Solution structure of the SecA-signal peptide complex==		==Solution structure of the SecA-signal peptide complex==
	<StructureSection load='2vda' size='340' side='right' caption='[[2vda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2vda' size='340' side='right'caption='[[2vda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VDA FirstGlance]. <br>
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [http://pdbe.org/2vda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [http://www.ebi.ac.uk/pdbsum/2vda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vda ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [http://pdbe.org/2vda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [http://www.ebi.ac.uk/pdbsum/2vda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vda ProSAT]</span></td></tr>
	</table>		</table>
	~~{{Large structure}}~~
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SECA_ECOLI SECA_ECOLI]] Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.<ref>PMID:15140892</ref> [[http://www.uniprot.org/uniprot/LAMB_ECOL6 LAMB_ECOL6]] Involved in the transport of maltose and maltodextrins (By similarity).		[[http://www.uniprot.org/uniprot/SECA_ECOLI SECA_ECOLI]] Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.<ref>PMID:15140892</ref> [[http://www.uniprot.org/uniprot/LAMB_ECOL6 LAMB_ECOL6]] Involved in the transport of maltose and maltodextrins (By similarity).
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	</div>		</div>
	<div class="pdbe-citations 2vda" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2vda" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Preprotein translocase\|Preprotein translocase]]
			*[[SecA\|SecA]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Bonvin, A M.J J]]		[[Category: Bonvin, A M.J J]]
	[[Category: Economou, A]]		[[Category: Economou, A]]

OCA at 19:03, 24 January 2018

2018-01-24T19:03:12Z

← Older revision		Revision as of 19:03, 24 January 2018
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	==~~SOLUTION STRUCTURE OF THE SECA~~-~~SIGNAL PEPTIDE COMPLEX~~==		{{Large structure}}
			==Solution structure of the SecA-signal peptide complex==
	<StructureSection load='2vda' size='340' side='right' caption='[[2vda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2vda' size='340' side='right' caption='[[2vda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VDA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tm6\|1tm6]], [[1tf5\|1tf5]], [[1m6n\|1m6n]], [[2fsf\|2fsf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tm6\|1tm6]], [[1tf5\|1tf5]], [[1m6n\|1m6n]], [[2fsf\|2fsf]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [http://pdbe.org/2vda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [http://www.ebi.ac.uk/pdbsum/2vda PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [http://pdbe.org/2vda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [http://www.ebi.ac.uk/pdbsum/2vda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vda ProSAT]</span></td></tr>
	</table>		</table>
	{{Large structure}}		{{Large structure}}
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vda_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vda_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2vda" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2vda" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Preprotein translocase\|Preprotein translocase]]
	*[[SecA\|SecA]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:06, 9 February 2016

2016-02-09T06:06:32Z

← Older revision		Revision as of 06:06, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2vda' size='340' side='right' caption='[[2vda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2vda' size='340' side='right' caption='[[2vda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VDA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tm6\|1tm6]], [[1tf5\|1tf5]], [[1m6n\|1m6n]], [[2fsf\|2fsf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tm6\|1tm6]], [[1tf5\|1tf5]], [[1m6n\|1m6n]], [[2fsf\|2fsf]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [http://www.ebi.ac.uk/pdbsum/2vda PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [http://pdbe.org/2vda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [http://www.ebi.ac.uk/pdbsum/2vda PDBsum]</span></td></tr>
	</table>		</table>
			{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SECA_ECOLI SECA_ECOLI]] Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.<ref>PMID:15140892</ref> [[http://www.uniprot.org/uniprot/LAMB_ECOL6 LAMB_ECOL6]] Involved in the transport of maltose and maltodextrins (By similarity).		[[http://www.uniprot.org/uniprot/SECA_ECOLI SECA_ECOLI]] Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.<ref>PMID:15140892</ref> [[http://www.uniprot.org/uniprot/LAMB_ECOL6 LAMB_ECOL6]] Involved in the transport of maltose and maltodextrins (By similarity).
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vda ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2vda" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia~~ coli]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Bonvin, A M.J J]]		[[Category: Bonvin, A M.J J]]
	[[Category: Economou, A]]		[[Category: Economou, A]]

OCA at 04:55, 25 December 2014

2014-12-25T04:55:25Z

← Older revision		Revision as of 04:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VDA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tm6\|1tm6]], [[1tf5\|1tf5]], [[1m6n\|1m6n]], [[2fsf\|2fsf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tm6\|1tm6]], [[1tf5\|1tf5]], [[1m6n\|1m6n]], [[2fsf\|2fsf]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [http://www.ebi.ac.uk/pdbsum/2vda PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [http://www.ebi.ac.uk/pdbsum/2vda PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/SECA_ECOLI SECA_ECOLI]] Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.<ref>PMID:15140892</ref> [[http://www.uniprot.org/uniprot/LAMB_ECOL6 LAMB_ECOL6]] Involved in the transport of maltose and maltodextrins (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Bonvin, A M.J J.]]		[[Category: Bonvin, A M.J J]]
	[[Category: Economou, A.]]		[[Category: Economou, A]]
	[[Category: Gelis, I.]]		[[Category: Gelis, I]]
	[[Category: Gouridis, G.]]		[[Category: Gouridis, G]]
	[[Category: Kalodimos, C G.]]		[[Category: Kalodimos, C G]]
	[[Category: Karamanou, S.]]		[[Category: Karamanou, S]]
	[[Category: Keramisanou, D.]]		[[Category: Keramisanou, D]]
	[[Category: Koukaki, M.]]		[[Category: Koukaki, M]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: High molecular weight complex]]		[[Category: High molecular weight complex]]

OCA at 01:26, 1 October 2014

2014-10-01T01:26:48Z

← Older revision		Revision as of 01:26, 1 October 2014
Line 1:		Line 1:
	~~{{Large~~ structure}}		==SOLUTION STRUCTURE OF THE SECA-SIGNAL PEPTIDE COMPLEX==
	~~{{STRUCTURE_2vda~~\| ~~PDB~~=2vda \| ~~SCENE~~= }}		<StructureSection load='2vda' size='340' side='right' caption='[[2vda]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	===~~SOLUTION STRUCTURE OF THE SECA~~-~~SIGNAL PEPTIDE COMPLEX~~===		== Structural highlights ==
	~~{{ABSTRACT_PUBMED_18022369}}~~		<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VDA FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tm6\|1tm6]], [[1tf5\|1tf5]], [[1m6n\|1m6n]], [[2fsf\|2fsf]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [http://www.ebi.ac.uk/pdbsum/2vda PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vda_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Recognition of signal sequences by cognate receptors controls the entry of virtually all proteins to export pathways. Despite its importance, this process remains poorly understood. Here, we present the solution structure of a signal peptide bound to SecA, the 204 kDa ATPase motor of the Sec translocase. Upon encounter, the signal peptide forms an alpha-helix that inserts into a flexible and elongated groove in SecA. The mode of binding is bimodal, with both hydrophobic and electrostatic interactions mediating recognition. The same groove is used by SecA to recognize a diverse set of signal sequences. Impairment of the signal-peptide binding to SecA results in significant translocation defects. The C-terminal tail of SecA occludes the groove and inhibits signal-peptide binding, but autoinhibition is relieved by the SecB chaperone. Finally, it is shown that SecA interconverts between two conformations in solution, suggesting a simple mechanism for polypeptide translocation.

	~~==About this Structure==~~		Structural basis for signal-sequence recognition by the translocase motor SecA as determined by NMR.,Gelis I, Bonvin AM, Keramisanou D, Koukaki M, Gouridis G, Karamanou S, Economou A, Kalodimos CG Cell. 2007 Nov 16;131(4):756-69. PMID:18022369<ref>PMID:18022369</ref>
	~~[[2vda]] is a 2 chain structure with~~ sequence ~~from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=2VDA OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
			*[[Preprotein translocase\|Preprotein translocase]]
	*[[SecA\|SecA]]		*[[SecA\|SecA]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018022369<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Bonvin, A M.J J.]]		[[Category: Bonvin, A M.J J.]]

OCA at 08:06, 11 March 2013

2013-03-11T08:06:20Z

← Older revision		Revision as of 08:06, 11 March 2013
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	~~[[Image:2vda.png\|left\|200px]]~~		{{Large structure}}

	{{STRUCTURE_2vda\| PDB=2vda \| SCENE= }}		{{STRUCTURE_2vda\| PDB=2vda \| SCENE= }}

	===SOLUTION STRUCTURE OF THE SECA-SIGNAL PEPTIDE COMPLEX===		===SOLUTION STRUCTURE OF THE SECA-SIGNAL PEPTIDE COMPLEX===

	{{ABSTRACT_PUBMED_18022369}}		{{ABSTRACT_PUBMED_18022369}}

OCA at 12:54, 20 October 2012

2012-10-20T12:54:16Z

← Older revision		Revision as of 12:54, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2vda]] is a 2 chain structure ~~of [[SecA]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA].		[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA].

	==See Also==		==See Also==

OCA: Protected "2vda" [edit=sysop:move=sysop]

2012-07-26T10:16:37Z

Protected "2vda" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:16, 26 July 2012
(No difference)

OCA at 10:16, 26 July 2012

2012-07-26T10:16:35Z

← Older revision		Revision as of 10:16, 26 July 2012
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	~~{{Seed}}~~
	[[Image:2vda.png\|left\|200px]]		[[Image:2vda.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2vda", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2vda\| PDB=2vda \| SCENE= }}		{{STRUCTURE_2vda\| PDB=2vda \| SCENE= }}

	===SOLUTION STRUCTURE OF THE SECA-SIGNAL PEPTIDE COMPLEX===		===SOLUTION STRUCTURE OF THE SECA-SIGNAL PEPTIDE COMPLEX===

			{{ABSTRACT_PUBMED_18022369}}

	==About this Structure==		==About this Structure==
	~~2VDA~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA].		[[2vda]] is a 2 chain structure of [[SecA]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA].

			==See Also==
			*[[SecA\|SecA]]

			==Reference==
			<ref group="xtra">PMID:018022369</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Bonvin, A M.J J.]]		[[Category: Bonvin, A M.J J.]]
Line 42:		Line 42:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Transport]]		[[Category: Transport]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:06:07 2009''~~