2vfa - Revision history

OCA at 05:11, 24 June 2026

2026-06-24T05:11:26Z

← Older revision		Revision as of 05:11, 24 June 2026
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfa_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 15:18, 13 December 2023

2023-12-13T15:18:21Z

← Older revision		Revision as of 15:18, 13 December 2023
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	<StructureSection load='2vfa' size='340' side='right'caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vfa' size='340' side='right'caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafg Plafg~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFA FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=5GP:GUANOSINE-5~~-~~MONOPHOSPHATE'>5GP</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [https://pdbe.org/2vfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [https://www.ebi.ac.uk/pdbsum/2vfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [https://pdbe.org/2vfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [https://www.ebi.ac.uk/pdbsum/2vfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfa ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/HPRT_HUMAN HPRT_HUMAN] Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS) [MIM:[https://omim.org/entry/300322 300322]. LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation.<ref>PMID:6853716</ref> <ref>PMID:3384338</ref> <ref>PMID:3265398</ref> <ref>PMID:2910902</ref> <ref>PMID:2347587</ref> <ref>PMID:2358296</ref> <ref>PMID:2246854</ref> <ref>PMID:2071157</ref> <ref>PMID:7627191</ref> <ref>PMID:9452051</ref> Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT) [MIM:[https://omim.org/entry/300323 300323]; also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia.<ref>PMID:6853490</ref> <ref>PMID:6572373</ref> <ref>PMID:6706936</ref> <ref>PMID:3358423</ref> <ref>PMID:3198771</ref> <ref>PMID:2909537</ref> [:]
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/HGXR_PLAFG HGXR_PLAFG]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.		[https://www.uniprot.org/uniprot/HGXR_PLAFG HGXR_PLAFG] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.[https://www.uniprot.org/uniprot/HPRT_HUMAN HPRT_HUMAN] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Plafg~~]]		[[Category: Plasmodium falciparum]]
	[[Category: Ashok~~, C S~~]]		[[Category: Ashok CS]]
	[[Category: Balaram, H]]		[[Category: Balaram H]]
	[[Category: Gayathri, P]]		[[Category: Gayathri P]]
	[[Category: Murthy~~, M R.N~~]]		[[Category: Murthy MRN]]
	[[Category: Selvi~~, T S~~]]		[[Category: Selvi TS]]
	[[Category: Subbayya~~, I N.S]]~~		[[Category: Subbayya INS]]
	~~[[Category: Chimera]]~~
	~~[[Category: Disease mutation]]~~
	~~[[Category: Glycosyltransferase]]~~
	~~[[Category: Gout]]~~
	~~[[Category: Magnesium]]~~
	~~[[Category: Metal-binding]]~~
	~~[[Category: Purine salvage]]~~
	~~[[Category: Transferase~~]]

OCA at 10:44, 7 July 2021

2021-07-07T10:44:50Z

← Older revision		Revision as of 10:44, 7 July 2021
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	<StructureSection load='2vfa' size='340' side='right'caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vfa' size='340' side='right'caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafg Plafg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VFA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafg Plafg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [~~http~~://pdbe.org/2vfa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vfa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [https://pdbe.org/2vfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [https://www.ebi.ac.uk/pdbsum/2vfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/HGXR_PLAFG HGXR_PLAFG]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.		[[https://www.uniprot.org/uniprot/HGXR_PLAFG HGXR_PLAFG]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 2vfa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2vfa" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:51, 21 August 2019

2019-08-21T07:51:15Z

← Older revision		Revision as of 07:51, 21 August 2019
Line 1:		Line 1:

	==Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases==		==Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases==
	<StructureSection load='2vfa' size='340' side='right' caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vfa' size='340' side='right'caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafg Plafg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafg Plafg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfa_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2vfa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2vfa" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Plafg]]		[[Category: Plafg]]
	[[Category: Ashok, C S]]		[[Category: Ashok, C S]]

OCA at 07:24, 16 November 2017

2017-11-16T07:24:37Z

← Older revision		Revision as of 07:24, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='2vfa' size='340' side='right' caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vfa' size='340' side='right' caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafg Plafg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</td></tr>
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	</div>		</div>
	<div class="pdbe-citations 2vfa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2vfa" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Plafg]]
	[[Category: Ashok, C S]]		[[Category: Ashok, C S]]
	[[Category: Balaram, H]]		[[Category: Balaram, H]]

OCA at 13:43, 15 March 2017

2017-03-15T13:43:03Z

← Older revision		Revision as of 13:43, 15 March 2017
Line 1:		Line 1:

	==Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases==		==Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases==
	<StructureSection load='2vfa' size='340' side='right' caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vfa' size='340' side='right' caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Plafg Plafg]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [http://pdbe.org/2vfa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [http://www.ebi.ac.uk/pdbsum/2vfa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [http://pdbe.org/2vfa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [http://www.ebi.ac.uk/pdbsum/2vfa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Plafg]]~~
	[[Category: Ashok, C S]]		[[Category: Ashok, C S]]
	[[Category: Balaram, H]]		[[Category: Balaram, H]]

OCA at 07:03, 9 February 2016

2016-02-09T07:03:37Z

← Older revision		Revision as of 07:03, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2vfa' size='340' side='right' caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vfa' size='340' side='right' caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafg Plafg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [http://www.ebi.ac.uk/pdbsum/2vfa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [http://pdbe.org/2vfa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [http://www.ebi.ac.uk/pdbsum/2vfa PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vfa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2vfa" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Plasmodium falciparum~~]]		[[Category: Plafg]]
	[[Category: Ashok, C S]]		[[Category: Ashok, C S]]
	[[Category: Balaram, H]]		[[Category: Balaram, H]]

OCA at 05:13, 25 December 2014

2014-12-25T05:13:39Z

← Older revision		Revision as of 05:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [http://www.ebi.ac.uk/pdbsum/2vfa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [http://www.ebi.ac.uk/pdbsum/2vfa PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/HGXR_PLAFG HGXR_PLAFG]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Ashok, C S.]]		[[Category: Ashok, C S]]
	[[Category: Balaram, H.]]		[[Category: Balaram, H]]
	[[Category: Gayathri, P.]]		[[Category: Gayathri, P]]
	[[Category: Murthy, M R.N.]]		[[Category: Murthy, M R.N]]
	[[Category: Selvi, T S.]]		[[Category: Selvi, T S]]
	[[Category: Subbayya, I N.S.]]		[[Category: Subbayya, I N.S]]
	[[Category: Chimera]]		[[Category: Chimera]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]

OCA at 01:46, 1 October 2014

2014-10-01T01:46:10Z

← Older revision		Revision as of 01:46, 1 October 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2vfa~~\| ~~PDB~~=2vfa \| ~~SCENE~~= }}		==Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases==
	===~~Crystal~~ structure of a chimera of Plasmodium falciparum and human hypoxanthine-~~guanine~~ phosphoribosyl ~~transferases===~~		<StructureSection load='2vfa' size='340' side='right' caption='[[2vfa]], [[Resolution\|resolution]] 2.80Å' scene=''>
	~~{{ABSTRACT_PUBMED_18536021}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFA FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7g\|1z7g]], [[1d6n\|1d6n]], [[1hmp\|1hmp]], [[1cjb\|1cjb]], [[1bzy\|1bzy]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfa RCSB], [http://www.ebi.ac.uk/pdbsum/2vfa PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfa_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The crystal structure of a chimera of Plasmodium falciparum (Pf) and human hypoxanthine guanine phosphoribosyltransferases (HGPRT), which consists of the core of the protein from the human enzyme and the hood region from the Pf enzyme, has been determined as a complex with the product guanosine monophosphate (GMP). The chimera can utilize hypoxanthine, guanine, and xanthine as substrates, similar to the Pf enzyme. It exists as a monomer-dimer mixture in solution, but shifts to a tetramer on addition of phosphoribosyl pyrophosphate (PRPP). The structural studies reveal that the asymmetric unit of the crystal consists of two monomers of the chimeric HGPRT. Surprisingly, the dimer interface of the chimera is the less extensive AC interface of the parent HGPRTs. An analysis of the crystal structures of the various human HGPRTs provides an explanation for the oligomeric characteristics of the chimera. Pro93 and Tyr197 form part of crucial interactions holding together the AB interface in the unliganded or GMP-bound forms of HGPRT, while Pro93 and His26 interact at the interface after binding of PRPP. Replacement of Tyr197 of human HGPRT by Ile207 in the chimera disrupts the interaction at the AB interface in the absence of PRPP. In the presence of PRPP, the interaction between Pro93 and His26 could restore the AB interface, shifting the chimeric enzyme to a tetrameric state. The structure provides valuable insights into the differences in the AB interface between Pf and human HGPRTs, which may be useful for designing selective inhibitors against the parasite enzyme.

	~~==Function==~~		Crystal structure of a chimera of human and Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization.,Gayathri P, Sujay Subbayya IN, Ashok CS, Selvi TS, Balaram H, Murthy MR Proteins. 2008 Dec;73(4):1010-20. PMID:18536021<ref>PMID:18536021</ref>
	~~[[http://www.uniprot.org/uniprot/HGXR_PLAFG HGXR_PLAFG]] Converts guanine to guanosine monophosphate,~~ and hypoxanthine ~~to inosine monophosphate~~. ~~Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine~~, ~~hypoxanthine and xanthine~~. ~~Plays a central role in the generation of purine nucleotides through the purine salvage pathway~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2vfa]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA].~~		</div>

	==See Also==		==See Also==
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]		*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:018536021</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Ashok, C S.]]		[[Category: Ashok, C S.]]

OCA at 04:09, 25 March 2013

2013-03-25T04:09:38Z

← Older revision		Revision as of 04:09, 25 March 2013
Line 1:		Line 1:
	~~[[Image:2vfa.png\|left\|200px]]~~

	{{STRUCTURE_2vfa\| PDB=2vfa \| SCENE= }}		{{STRUCTURE_2vfa\| PDB=2vfa \| SCENE= }}

	===Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases===		===Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases===
			{{ABSTRACT_PUBMED_18536021}}

	~~{{ABSTRACT_PUBMED_18536021}}~~		==Function==
			[[http://www.uniprot.org/uniprot/HGXR_PLAFG HGXR_PLAFG]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

	==About this Structure==		==About this Structure==
	[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum~~,_homo_sapiens~~ Plasmodium falciparum~~, homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA].		[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA].

			==See Also==
			*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:018536021</ref><references group="xtra"/>		<ref group="xtra">PMID:018536021</ref><references group="xtra"/><references/>
	[[Category: Plasmodium falciparum~~, homo sapiens~~]]		[[Category: Plasmodium falciparum]]
	[[Category: Ashok, C S.]]		[[Category: Ashok, C S.]]
	[[Category: Balaram, H.]]		[[Category: Balaram, H.]]