2vfc - Revision history

OCA at 15:18, 13 December 2023

2023-12-13T15:18:27Z

← Older revision		Revision as of 15:18, 13 December 2023
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	<StructureSection load='2vfc' size='340' side='right'caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2vfc' size='340' side='right'caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"mycobacterium_balnei"_linell_and_norden_1952 "mycobacterium balnei" linell and norden 1952~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFC FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2vfb\|2vfb]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [https://pdbe.org/2vfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [https://www.ebi.ac.uk/pdbsum/2vfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [https://pdbe.org/2vfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [https://www.ebi.ac.uk/pdbsum/2vfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfc ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/B2HIZ6_MYCMM B2HIZ6_MYCMM]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Mycobacterium balnei linell and norden 1952]]~~
	~~[[Category: Arylamine N-acetyltransferase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Anderton~~, M C~~]]		[[Category: Mycobacterium marinum]]
	[[Category: Fullam, E]]		[[Category: Anderton MC]]
	[[Category: Lowe~~, E D~~]]		[[Category: Fullam E]]
	[[Category: Noble~~, M E.M~~]]		[[Category: Lowe ED]]
	[[Category: Sim, E]]		[[Category: Noble MEM]]
	[[Category: Westwood~~, I M]]~~		[[Category: Sim E]]
	~~[[Category: Transferase~~]]		[[Category: Westwood IM]]

OCA at 10:44, 7 July 2021

2021-07-07T10:44:53Z

← Older revision		Revision as of 10:44, 7 July 2021
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	<StructureSection load='2vfc' size='340' side='right'caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2vfc' size='340' side='right'caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"mycobacterium_balnei"_linell_and_norden_1952 "mycobacterium balnei" linell and norden 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"mycobacterium_balnei"_linell_and_norden_1952 "mycobacterium balnei" linell and norden 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfb\|2vfb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vfb\|2vfb]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [~~http~~://pdbe.org/2vfc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vfc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [https://pdbe.org/2vfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [https://www.ebi.ac.uk/pdbsum/2vfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:14, 23 May 2019

2019-05-23T07:14:31Z

← Older revision		Revision as of 07:14, 23 May 2019
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	==The structure of Mycobacterium marinum arylamine N-acetyltransferase in complex with CoA==		==The structure of Mycobacterium marinum arylamine N-acetyltransferase in complex with CoA==
	<StructureSection load='2vfc' size='340' side='right' caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2vfc' size='340' side='right'caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"mycobacterium_balnei"_linell_and_norden_1952 "mycobacterium balnei" linell and norden 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"mycobacterium_balnei"_linell_and_norden_1952 "mycobacterium balnei" linell and norden 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFC FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Arylamine N-acetyltransferase\|Arylamine N-acetyltransferase]]		*[[Arylamine N-acetyltransferase 3D structures\|Arylamine N-acetyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Mycobacterium balnei linell and norden 1952]]		[[Category: Mycobacterium balnei linell and norden 1952]]
	[[Category: Arylamine N-acetyltransferase]]		[[Category: Arylamine N-acetyltransferase]]
			[[Category: Large Structures]]
	[[Category: Anderton, M C]]		[[Category: Anderton, M C]]
	[[Category: Fullam, E]]		[[Category: Fullam, E]]

OCA at 20:48, 19 September 2018

2018-09-19T20:48:21Z

← Older revision		Revision as of 20:48, 19 September 2018
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	==~~THE STRUCTURE OF MYCOBACTERIUM MARINUM ARYLAMINE~~ N-~~ACETYLTRANSFERASE IN COMPLEX WITH COA~~==
			==The structure of Mycobacterium marinum arylamine N-acetyltransferase in complex with CoA==
	<StructureSection load='2vfc' size='340' side='right' caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2vfc' size='340' side='right' caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfb\|2vfb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfb\|2vfb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [http://pdbe.org/2vfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [http://www.ebi.ac.uk/pdbsum/2vfc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [http://pdbe.org/2vfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [http://www.ebi.ac.uk/pdbsum/2vfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:40, 8 February 2016

2016-02-08T14:40:42Z

← Older revision		Revision as of 14:40, 8 February 2016
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	<StructureSection load='2vfc' size='340' side='right' caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2vfc' size='340' side='right' caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_marinum Mycobacterium marinum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"mycobacterium_balnei"_linell_and_norden_1952 "mycobacterium balnei" linell and norden 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfb\|2vfb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfb\|2vfb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [http://www.ebi.ac.uk/pdbsum/2vfc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [http://pdbe.org/2vfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [http://www.ebi.ac.uk/pdbsum/2vfc PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vfc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2vfc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Mycobacterium balnei linell and norden 1952]]
	[[Category: Arylamine N-acetyltransferase]]		[[Category: Arylamine N-acetyltransferase]]
	~~[[Category: Mycobacterium marinum]]~~
	[[Category: Anderton, M C]]		[[Category: Anderton, M C]]
	[[Category: Fullam, E]]		[[Category: Fullam, E]]

OCA at 17:33, 19 January 2015

2015-01-19T17:33:00Z

← Older revision		Revision as of 17:33, 19 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfb\|2vfb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfb\|2vfb]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [http://www.ebi.ac.uk/pdbsum/2vfc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [http://www.ebi.ac.uk/pdbsum/2vfc PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Arylamine N-acetyltransferase]]		[[Category: Arylamine N-acetyltransferase]]
	[[Category: Mycobacterium marinum]]		[[Category: Mycobacterium marinum]]
	[[Category: Anderton, M C.]]		[[Category: Anderton, M C]]
	[[Category: Fullam, E.]]		[[Category: Fullam, E]]
	[[Category: Lowe, E D.]]		[[Category: Lowe, E D]]
	[[Category: Noble, M E.M.]]		[[Category: Noble, M E.M]]
	[[Category: Sim, E.]]		[[Category: Sim, E]]
	[[Category: Westwood, I M.]]		[[Category: Westwood, I M]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:47, 29 September 2014

2014-09-29T09:47:08Z

← Older revision		Revision as of 09:47, 29 September 2014
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	[[Image:~~2vfc~~.~~png~~\|~~left~~\|~~200px~~]]		==THE STRUCTURE OF MYCOBACTERIUM MARINUM ARYLAMINE N-ACETYLTRANSFERASE IN COMPLEX WITH COA==
			<StructureSection load='2vfc' size='340' side='right' caption='[[2vfc]], [[Resolution\|resolution]] 2.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2vfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFC FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfb\|2vfb]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfc RCSB], [http://www.ebi.ac.uk/pdbsum/2vfc PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfc_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Arylamine N-acetyltransferase (NAT) enzymes are widespread in nature. They serve to acetylate xenobiotics and/or endogenous substrates using acetyl coenzyme A (CoA) as a cofactor. Conservation of the architecture of the NAT enzyme family from mammals to bacteria has been demonstrated by a series of prokaryotic NAT structures, together with the recently reported structure of human NAT1. We report here the cloning, purification, kinetic characterisation and crystallographic structure determination of NAT from Mycobacterium marinum, a close relative of the pathogenic Mycobacterium tuberculosis. We have also determined the structure of M. marinum NAT in complex with CoA, shedding the first light on cofactor recognition in prokaryotic NATs. Surprisingly, the principal CoA recognition site in M. marinum NAT is located some 30 A from the site of CoA recognition in the recently deposited structure of human NAT2 bound to CoA. The structure explains the Ping-Pong Bi-Bi reaction mechanism of NAT enzymes and suggests mechanisms by which the acetylated enzyme intermediate may be protected. Recognition of CoA in a much wider groove in prokaryotic NATs suggests that this subfamily may accommodate larger substrates than is the case for human NATs and may assist in the identification of potential endogenous substrates. It also suggests the cofactor-binding site as a unique subsite to target in drug design directed against NAT in mycobacteria.

	~~{{STRUCTURE_2vfc\| PDB=2vfc \| SCENE= }}~~		Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase.,Fullam E, Westwood IM, Anderton MC, Lowe ED, Sim E, Noble ME J Mol Biol. 2008 Jan 4;375(1):178-91. Epub 2007 Oct 13. PMID:18005984<ref>PMID:18005984</ref>

	~~===THE STRUCTURE OF MYCOBACTERIUM MARINUM ARYLAMINE N-ACETYLTRANSFERASE IN COMPLEX WITH COA===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18005984}}~~

	~~==About this Structure==~~
	~~[[2vfc]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Mycobacterium_marinum Mycobacterium marinum]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2VFC OCA].~~

	==See Also==		==See Also==
	*[[Arylamine N-acetyltransferase\|Arylamine N-acetyltransferase]]		*[[Arylamine N-acetyltransferase\|Arylamine N-acetyltransferase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018005984<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Arylamine N-acetyltransferase]]		[[Category: Arylamine N-acetyltransferase]]
	[[Category: Mycobacterium marinum]]		[[Category: Mycobacterium marinum]]

OCA at 10:29, 20 October 2012

2012-10-20T10:29:26Z

← Older revision		Revision as of 10:29, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2vfc]] is a 2 chain structure ~~of [[Arylamine N-acetyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA].		[[2vfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA].

	==See Also==		==See Also==

OCA: Protected "2vfc" [edit=sysop:move=sysop]

2012-07-26T02:17:34Z

Protected "2vfc" [edit=sysop:move=sysop]

← Older revision	Revision as of 02:17, 26 July 2012
(No difference)

OCA at 02:17, 26 July 2012

2012-07-26T02:17:32Z

← Older revision		Revision as of 02:17, 26 July 2012
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	~~{{Seed}}~~
	[[Image:2vfc.png\|left\|200px]]		[[Image:2vfc.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2vfc", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2vfc\| PDB=2vfc \| SCENE= }}		{{STRUCTURE_2vfc\| PDB=2vfc \| SCENE= }}

	===THE STRUCTURE OF MYCOBACTERIUM MARINUM ARYLAMINE N-ACETYLTRANSFERASE IN COMPLEX WITH COA===		===THE STRUCTURE OF MYCOBACTERIUM MARINUM ARYLAMINE N-ACETYLTRANSFERASE IN COMPLEX WITH COA===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18005984}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18005984 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18005984}}		{{ABSTRACT_PUBMED_18005984}}

	==About this Structure==		==About this Structure==
	~~2VFC~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA].		[[2vfc]] is a 2 chain structure of [[Arylamine N-acetyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFC OCA].

			==See Also==
			*[[Arylamine N-acetyltransferase\|Arylamine N-acetyltransferase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18005984~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018005984</ref><references group="xtra"/>
	[[Category: Arylamine N-acetyltransferase]]		[[Category: Arylamine N-acetyltransferase]]
	[[Category: Mycobacterium marinum]]		[[Category: Mycobacterium marinum]]
Line 32:		Line 23:
	[[Category: Sim, E.]]		[[Category: Sim, E.]]
	[[Category: Westwood, I M.]]		[[Category: Westwood, I M.]]
	~~[[Category: Acetyl coa]]~~
	~~[[Category: Actyltransferase]]~~
	~~[[Category: Arylamine n-acetyltransferase]]~~
	~~[[Category: Mycobacteria]]~~
	~~[[Category: Nat]]~~
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:43:40 2009''~~