2vff - Revision history

OCA at 15:18, 13 December 2023

2023-12-13T15:18:33Z

← Older revision		Revision as of 15:18, 13 December 2023
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	<StructureSection load='2vff' size='340' side='right'caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2vff' size='340' side='right'caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFF FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]]~~, [[~~2vfg~~\|~~2vfg~~]]~~, [[2vfh\|2vfh]], [[2vfi\|2vfi]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.~~1 5.3.1.1] </span>~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [https://pdbe.org/2vff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [https://www.ebi.ac.uk/pdbsum/2vff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [https://pdbe.org/2vff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [https://www.ebi.ac.uk/pdbsum/2vff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vff ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/TPIS_PLAFA TPIS_PLAFA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Plafa]]~~
	~~[[Category: Triose-phosphate isomerase]]~~
	~~[[Category: Balaram, H]]~~
	~~[[Category: Balaram, P]]~~
	~~[[Category: Banerjee, M]]~~
	~~[[Category: Gayathri, P]]~~
	~~[[Category: Murthy, M R.N]]~~
	~~[[Category: Vijayalakshmi, A]]~~
	~~[[Category: Fatty acid biosynthesis]]~~
	~~[[Category: Gluconeogenesis]]~~
	~~[[Category: Glycolysis]]~~
	~~[[Category: Isomerase]]~~
	~~[[Category: Lipid synthesis]]~~
	~~[[Category: Loop open]]~~
	~~[[Category: Mutant]]~~
	~~[[Category: Pentose shunt]]~~
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: ~~Tim~~]]		[[Category: Balaram H]]
	[[Category: ~~Triosephosphate isomerase~~]]		[[Category: Balaram P]]
			[[Category: Banerjee M]]
			[[Category: Gayathri P]]
			[[Category: Murthy MRN]]
			[[Category: Vijayalakshmi A]]

OCA at 11:35, 30 March 2022

2022-03-30T11:35:54Z

← Older revision		Revision as of 11:35, 30 March 2022
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	<StructureSection load='2vff' size='340' side='right'caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2vff' size='340' side='right'caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [~~http~~://pdbe.org/2vff PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vff PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [https://pdbe.org/2vff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [https://www.ebi.ac.uk/pdbsum/2vff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vff ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:50, 25 June 2020

2020-06-25T07:50:47Z

← Older revision		Revision as of 07:50, 25 June 2020
Line 1:		Line 1:

	==Crystal structure of the F96H mutant of Plasmodium falciparum triosephosphate isomerase==		==Crystal structure of the F96H mutant of Plasmodium falciparum triosephosphate isomerase==
	<StructureSection load='2vff' size='340' side='right' caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2vff' size='340' side='right'caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VFF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [http://pdbe.org/2vff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [http://www.ebi.ac.uk/pdbsum/2vff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [http://pdbe.org/2vff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [http://www.ebi.ac.uk/pdbsum/2vff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vff ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Beta-glucosidase\|Beta-glucosidase]]		*[[Beta-glucosidase 3D structures\|Beta-glucosidase 3D structures]]
	*[[Triose ~~Phosphate Isomerase~~\|Triose ~~Phosphate Isomerase~~]]		*[[Triose phosphate isomerase 3D structures\|Triose phosphate isomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]

OCA at 21:12, 19 September 2018

2018-09-19T21:12:25Z

← Older revision		Revision as of 21:12, 19 September 2018
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	==~~CRYSTAL STRUCTURE OF THE~~ F96H ~~MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE~~==
			==Crystal structure of the F96H mutant of Plasmodium falciparum triosephosphate isomerase==
	<StructureSection load='2vff' size='340' side='right' caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2vff' size='340' side='right' caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [http://pdbe.org/2vff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [http://www.ebi.ac.uk/pdbsum/2vff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [http://pdbe.org/2vff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [http://www.ebi.ac.uk/pdbsum/2vff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vff ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vff_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vff_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:22, 7 February 2016

2016-02-07T19:22:47Z

← Older revision		Revision as of 19:22, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2vff' size='340' side='right' caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2vff' size='340' side='right' caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [http://www.ebi.ac.uk/pdbsum/2vff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [http://pdbe.org/2vff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [http://www.ebi.ac.uk/pdbsum/2vff PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vff ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2vff" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Plasmodium falciparum~~]]		[[Category: Plafa]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Balaram, H]]		[[Category: Balaram, H]]
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	[[Category: Mutant]]		[[Category: Mutant]]
	[[Category: Pentose shunt]]		[[Category: Pentose shunt]]
			[[Category: Plasmodium falciparum]]
	[[Category: Tim]]		[[Category: Tim]]
	[[Category: Triosephosphate isomerase]]		[[Category: Triosephosphate isomerase]]

OCA at 14:07, 19 January 2015

2015-01-19T14:07:44Z

← Older revision		Revision as of 14:07, 19 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [http://www.ebi.ac.uk/pdbsum/2vff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [http://www.ebi.ac.uk/pdbsum/2vff PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Balaram, H.]]		[[Category: Balaram, H]]
	[[Category: Balaram, P.]]		[[Category: Balaram, P]]
	[[Category: Banerjee, M.]]		[[Category: Banerjee, M]]
	[[Category: Gayathri, P.]]		[[Category: Gayathri, P]]
	[[Category: Murthy, M R.N.]]		[[Category: Murthy, M R.N]]
	[[Category: Vijayalakshmi, A.]]		[[Category: Vijayalakshmi, A]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]
	[[Category: Gluconeogenesis]]		[[Category: Gluconeogenesis]]
Line 49:		Line 49:
	[[Category: Mutant]]		[[Category: Mutant]]
	[[Category: Pentose shunt]]		[[Category: Pentose shunt]]
	~~[[Category: Plasmodium falciparum]]~~
	[[Category: Tim]]		[[Category: Tim]]
	[[Category: Triosephosphate isomerase]]		[[Category: Triosephosphate isomerase]]

OCA at 01:37, 1 October 2014

2014-10-01T01:37:24Z

← Older revision		Revision as of 01:37, 1 October 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2vff\| PDB=2vff \| SCENE= }}~~		==CRYSTAL STRUCTURE OF THE F96H MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE==
	===CRYSTAL STRUCTURE OF THE F96H MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE===		<StructureSection load='2vff' size='340' side='right' caption='[[2vff]], [[Resolution\|resolution]] 1.70Å' scene=''>
	~~{{ABSTRACT_PUBMED_19622869}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2vff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lzo\|1lzo]], [[1m7p\|1m7p]], [[1woa\|1woa]], [[1wob\|1wob]], [[1lyx\|1lyx]], [[1m7o\|1m7o]], [[1o5x\|1o5x]], [[1vga\|1vga]], [[1ydv\|1ydv]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[2vfi\|2vfi]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vff RCSB], [http://www.ebi.ac.uk/pdbsum/2vff PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vff_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Plasmodium falciparum TIM (PfTIM) is unique in possessing a Phe residue at position 96 in place of the conserved Ser that is found in TIMs from the majority of other organisms. In order to probe the role of residue 96, three PfTIM mutants, F96S, F96H and F96W, have been biochemically and structurally characterized. The three mutants exhibited reduced catalytic efficiency and a decrease in substrate-binding affinity, with the most pronounced effects being observed for F96S and F96H. The k(cat) values and K(m) values are (2.54 +/- 0.19) x 10(5) min(-1) and 0.39 +/- 0.049 mM, respectively, for the wild type; (3.72 +/- 0.28) x 10(3) min(-1) and 2.18 +/- 0.028 mM, respectively, for the F96S mutant; (1.11 +/- 0.03) x 10(4) min(-1) and 2.62 +/- 0.042 mM, respectively, for the F96H mutant; and (1.48 +/- 0.05) x 10(5) min(-1) and 1.20 +/- 0.056 mM, respectively, for the F96W mutant. Unliganded and 3-phosphoglycerate (3PG) complexed structures are reported for the wild-type enzyme and the mutants. The ligand binds to the active sites of the wild-type enzyme (wtPfTIM) and the F96W mutant, with a loop-open state in the former and both open and closed states in the latter. In contrast, no density for the ligand could be detected at the active sites of the F96S and F96H mutants under identical conditions. The decrease in ligand affinity could be a consequence of differences in the water network connecting residue 96 to Ser73 in the vicinity of the active site. Soaking of crystals of wtPfTIM and the F96S and F96H mutants resulted in the binding of 3PG at a dimer-interface site. In addition, loop closure at the liganded active site was observed for wtPfTIM. The dimer-interface site in PfTIM shows strong electrostatic anchoring of the phosphate group involving the Arg98 and Lys112 residues of PfTIM.

	~~==About this Structure==~~		Biochemical and structural characterization of residue 96 mutants of Plasmodium falciparum triosephosphate isomerase: active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site.,Gayathri P, Banerjee M, Vijayalakshmi A, Balaram H, Balaram P, Murthy MR Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):847-57. Epub 2009, Jul 17. PMID:19622869<ref>PMID:19622869</ref>
	~~[[2vff]] is~~ a ~~2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=2VFF OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Beta-glucosidase\|Beta-glucosidase]]		*[[Beta-glucosidase\|Beta-glucosidase]]
	*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]		*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:019622869<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]

OCA at 09:28, 11 March 2013

2013-03-11T09:28:45Z

← Older revision		Revision as of 09:28, 11 March 2013
Line 1:		Line 1:
	~~[[Image:2vff.png\|left\|200px]]~~

	{{STRUCTURE_2vff\| PDB=2vff \| SCENE= }}		{{STRUCTURE_2vff\| PDB=2vff \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE F96H MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE===		===CRYSTAL STRUCTURE OF THE F96H MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE===

	{{ABSTRACT_PUBMED_19622869}}		{{ABSTRACT_PUBMED_19622869}}

OCA at 07:37, 20 October 2012

2012-10-20T07:37:46Z

← Older revision		Revision as of 07:37, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2vff]] is a 2 chain structure ~~of [[Beta-glucosidase]] and [[Triose Phosphate Isomerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA].		[[2vff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA].

	==See Also==		==See Also==

OCA at 02:49, 29 August 2012

2012-08-29T02:49:34Z

← Older revision		Revision as of 02:49, 29 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2vff]] is a 2 chain structure of [[Beta-glucosidase~~]], [[TIM test~~]] and [[Triose Phosphate Isomerase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA].		[[2vff]] is a 2 chain structure of [[Beta-glucosidase]] and [[Triose Phosphate Isomerase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFF OCA].

	==See Also==		==See Also==
	*[[Beta-glucosidase\|Beta-glucosidase]]		*[[Beta-glucosidase\|Beta-glucosidase]]
	*[[TIM test\|TIM test]]
	*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]		*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]