2vm8 - Revision history

OCA at 15:24, 13 December 2023

2023-12-13T15:24:54Z

← Older revision		Revision as of 15:24, 13 December 2023
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	<StructureSection load='2vm8' size='340' side='right'caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2vm8' size='340' side='right'caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2gse\|2gse]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm8 OCA], [https://pdbe.org/2vm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vm8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vm8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm8 OCA], [https://pdbe.org/2vm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vm8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vm8 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/DPYL2_HUMAN DPYL2_HUMAN] Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.<ref>PMID:11477421</ref> <ref>PMID:15466863</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kursula, P]]		[[Category: Kursula P]]
	~~[[Category: Axonal pathfinding]]~~
	~~[[Category: Crmp]]~~
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Developmental protein]]~~
	~~[[Category: Differentiation]]~~
	~~[[Category: Neurogenesis]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Polymorphism]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Tim barrel~~]]

OCA at 21:01, 20 October 2021

2021-10-20T21:01:08Z

← Older revision		Revision as of 21:01, 20 October 2021
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	<StructureSection load='2vm8' size='340' side='right'caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2vm8' size='340' side='right'caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gse\|2gse]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gse\|2gse]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm8 OCA], [~~http~~://pdbe.org/2vm8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vm8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vm8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vm8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm8 OCA], [https://pdbe.org/2vm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vm8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vm8 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 14:29, 18 December 2019

2019-12-18T14:29:23Z

← Older revision		Revision as of 14:29, 18 December 2019
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	==Human CRMP-2 crystallised in the presence of Mg==		==Human CRMP-2 crystallised in the presence of Mg==
	<StructureSection load='2vm8' size='340' side='right' caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2vm8' size='340' side='right'caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]
	[[Category: Axonal pathfinding]]		[[Category: Axonal pathfinding]]

OCA at 07:28, 17 January 2018

2018-01-17T07:28:42Z

← Older revision		Revision as of 07:28, 17 January 2018
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	==~~HUMAN~~ CRMP-2 ~~CRYSTALLISED IN THE PRESENCE OF MG~~==		==Human CRMP-2 crystallised in the presence of Mg==
	<StructureSection load='2vm8' size='340' side='right' caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2vm8' size='340' side='right' caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vm/2vm8_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vm/2vm8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Axonal pathfinding]]		[[Category: Axonal pathfinding]]
	[[Category: Crmp]]		[[Category: Crmp]]
			[[Category: Cytoplasm]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Differentiation]]		[[Category: Differentiation]]
	[[Category: Neurogenesis]]		[[Category: Neurogenesis]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
			[[Category: Polymorphism]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 11:27, 11 August 2016

2016-08-11T11:27:20Z

← Older revision		Revision as of 11:27, 11 August 2016
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	==HUMAN CRMP-2 CRYSTALLISED IN THE PRESENCE OF MG==		==HUMAN CRMP-2 CRYSTALLISED IN THE PRESENCE OF MG==
	<StructureSection load='2vm8' size='340' side='right' caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2vm8' size='340' side='right' caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gse\|2gse]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gse\|2gse]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vm8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm8 OCA], [http://pdbe.org/2vm8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vm8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vm8 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vm8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2vm8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]
	[[Category: Axonal pathfinding]]		[[Category: Axonal pathfinding]]

OCA at 14:36, 19 January 2015

2015-01-19T14:36:09Z

← Older revision		Revision as of 14:36, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gse\|2gse]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gse\|2gse]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vm8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vm8 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kursula, P.]]		[[Category: Kursula, P]]
	[[Category: Axonal pathfinding]]		[[Category: Axonal pathfinding]]
	[[Category: Crmp]]		[[Category: Crmp]]

OCA at 01:46, 1 October 2014

2014-10-01T01:46:04Z

← Older revision		Revision as of 01:46, 1 October 2014
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	[[Image:~~2vm8~~.~~png~~\|~~left~~\|~~200px~~]]		==HUMAN CRMP-2 CRYSTALLISED IN THE PRESENCE OF MG==
			<StructureSection load='2vm8' size='340' side='right' caption='[[2vm8]], [[Resolution\|resolution]] 1.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2vm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VM8 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gse\|2gse]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vm8 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vm/2vm8_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The collapsin response mediator protein 2 (CRMP-2) is a central molecule regulating axonal growth cone guidance. It interacts with the cytoskeleton and mediates signals related to myelin-induced axonal growth inhibition. CRMP-2 has also been characterized as a constituent of neurofibrillary tangles in Alzheimer's disease. CD spectroscopy and thermal stability assays using the Thermofluor method indicated that Ca2+ and Mg2+ affect the stability of CRMP-2 and prevent the formation of beta-aggregates upon heating. Gel filtration showed that the presence of Ca2+ or Mg2+ promoted the formation of CRMP-2 homotetramers, and this was further proven by small-angle X-ray scattering experiments, where a 3D solution structure for CRMP-2 was obtained. Previously, we described a crystal structure of human CRMP-2 complexed with calcium. In the present study, we determined the structure of CRMP-2 in the absence of calcium at 1.9 A resolution. When Ca2+ was omitted, crystals could only be grown in the presence of Mg2+ ions. By a proteomic approach, we further identified a number of post-translational modifications in CRMP-2 from rat brain hippocampus and mapped them onto the crystal structure.

	~~{{STRUCTURE_2vm8\| PDB=2vm8 \| SCENE= }}~~		Crystal and solution structure, stability and post-translational modifications of collapsin response mediator protein 2.,Majava V, Loytynoja N, Chen WQ, Lubec G, Kursula P FEBS J. 2008 Sep;275(18):4583-96. Epub 2008 Aug 11. PMID:18699782<ref>PMID:18699782</ref>

	~~===HUMAN CRMP-2 CRYSTALLISED IN THE PRESENCE OF MG===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18699782}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2vm8]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:018699782<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kursula, P.]]		[[Category: Kursula, P.]]

OCA: Protected "2vm8" [edit=sysop:move=sysop]

2013-01-07T21:11:49Z

Protected "2vm8" [edit=sysop:move=sysop]

← Older revision	Revision as of 21:11, 7 January 2013
(No difference)

OCA at 21:11, 7 January 2013

2013-01-07T21:11:46Z

← Older revision		Revision as of 21:11, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2vm8.png\|left\|200px]]		[[Image:2vm8.png\|left\|200px]]

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	{{STRUCTURE_2vm8\| PDB=2vm8 \| SCENE= }}		{{STRUCTURE_2vm8\| PDB=2vm8 \| SCENE= }}

	===HUMAN CRMP-2 CRYSTALLISED IN THE PRESENCE OF MG===		===HUMAN CRMP-2 CRYSTALLISED IN THE PRESENCE OF MG===


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	{{ABSTRACT_PUBMED_18699782}}		{{ABSTRACT_PUBMED_18699782}}

	==About this Structure==		==About this Structure==
	~~2VM8~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA].		[[2vm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18699782~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018699782</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kursula, P.]]		[[Category: Kursula, P.]]
	[[Category: Axonal pathfinding]]		[[Category: Axonal pathfinding]]
	[[Category: Crmp]]		[[Category: Crmp]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Differentiation]]		[[Category: Differentiation]]
	[[Category: Neurogenesis]]		[[Category: Neurogenesis]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	~~[[Category: Polymorphism]]~~
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:19:26 2009''~~

OCA at 22:19, 17 February 2009

2009-02-17T22:19:28Z

← Older revision		Revision as of 22:19, 17 February 2009
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	==About this Structure==		==About this Structure==
	2VM8 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA].		2VM8 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM8 OCA].

	==Reference==		==Reference==
	~~Crystal and solution structure, stability and post-translational modifications of collapsin response mediator protein 2., Majava V, Loytynoja N, Chen WQ, Lubec G, Kursula P, FEBS J. 2008 Aug 11.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18699782 18699782]~~		<ref group="xtra">PMID:18699782</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Kursula, P.]]		[[Category: Kursula, P.]]
	[[Category: Axonal pathfinding]]		[[Category: Axonal pathfinding]]
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	[[Category: Tim barrel]]		[[Category: Tim barrel]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 8 09~~:08:~~30 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:19:26 2009''