2wbb - Revision history

OCA at 15:50, 13 December 2023

2023-12-13T15:50:27Z

← Older revision		Revision as of 15:50, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2wbb' size='340' side='right'caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2wbb' size='340' side='right'caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=RO3:N~~-{[~~(2Z)-5-BROMO-1,3-THIAZOL-~~2~~(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.22Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>~~[~~https://en.wikipedia.org/wiki/Fructose~~-~~bisphosphatase Fructose~~-~~bisphosphatase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~1.3~~.11 3.1.3.11~~] </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [https://pdbe.org/2wbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [https://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [https://pdbe.org/2wbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [https://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>		[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Fructose-bisphosphatase]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Benz, J]]		[[Category: Alvarez Sanchez R]]
	[[Category: Bernadeau, A]]		[[Category: Benz J]]
	[[Category: Fol, B]]		[[Category: Bernadeau A]]
	[[Category: Gubler, M]]		[[Category: Fol B]]
	[[Category: Haap, W]]		[[Category: Gubler M]]
	[[Category: Hebeisen, P]]		[[Category: Haap W]]
	[[Category: Huber, W]]		[[Category: Hebeisen P]]
	[[Category: Joseph, C]]		[[Category: Huber W]]
	[[Category: Kitas, E]]		[[Category: Joseph C]]
	[[Category: Kuhn, B]]		[[Category: Kitas E]]
	[[Category: Mohr, P]]		[[Category: Kuhn B]]
	[[Category: Paehler, A]]		[[Category: Mohr P]]
	[[Category: Ruf, A]]		[[Category: Paehler A]]
	~~[[Category: Sanchez, R Alvarez~~]]		[[Category: Ruf A]]
	[[Category: Schott, B]]		[[Category: Schott B]]
	[[Category: Tetaz, T]]		[[Category: Tetaz T]]
	[[Category: Tozzo, E]]		[[Category: Tozzo E]]
	[[Category: Wessel~~, H P]]~~		[[Category: Wessel HP]]
	~~[[Category: Allosteric enzyme]]~~
	~~[[Category: Carbohydrate metabolism]]~~
	~~[[Category: Gluconeogenesis]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Phosphoric monoester~~]]

OCA at 11:02, 6 April 2022

2022-04-06T11:02:37Z

← Older revision		Revision as of 11:02, 6 April 2022
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	<StructureSection load='2wbb' size='340' side='right'caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2wbb' size='340' side='right'caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [~~http~~://pdbe.org/2wbb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [https://pdbe.org/2wbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [https://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[~~http~~://omim.org/entry/229700 229700]]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>		[[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:29, 1 July 2020

2020-07-01T08:29:02Z

← Older revision		Revision as of 08:29, 1 July 2020
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	==FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR==		==FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR==
	<StructureSection load='2wbb' size='340' side='right' caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2wbb' size='340' side='right'caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WBB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [http://pdbe.org/2wbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [http://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [http://pdbe.org/2wbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [http://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	==See Also==		==See Also==
	*[[Fructose-1%2C6-bisphosphatase\|Fructose-1%2C6-bisphosphatase]]		*[[Fructose-1%2C6-bisphosphatase 3D structures\|Fructose-1%2C6-bisphosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	[[Category: Fructose-bisphosphatase]]		[[Category: Fructose-bisphosphatase]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Benz, J]]		[[Category: Benz, J]]
	[[Category: Bernadeau, A]]		[[Category: Bernadeau, A]]

OCA at 09:19, 26 September 2018

2018-09-26T09:19:00Z

← Older revision		Revision as of 09:19, 26 September 2018
Line 1:		Line 1:
	==FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR==
			==FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR==
	<StructureSection load='2wbb' size='340' side='right' caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2wbb' size='340' side='right' caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [http://pdbe.org/2wbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [http://www.ebi.ac.uk/pdbsum/2wbb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [http://pdbe.org/2wbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [http://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:53, 7 February 2016

2016-02-07T20:53:29Z

← Older revision		Revision as of 20:53, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2wbb' size='340' side='right' caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2wbb' size='340' side='right' caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WBB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [http://www.ebi.ac.uk/pdbsum/2wbb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [http://pdbe.org/2wbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [http://www.ebi.ac.uk/pdbsum/2wbb PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wbb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2wbb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Fructose-bisphosphatase]]		[[Category: Fructose-bisphosphatase]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Benz, J]]		[[Category: Benz, J]]
	[[Category: Bernadeau, A]]		[[Category: Bernadeau, A]]

OCA at 18:10, 24 December 2014

2014-12-24T18:10:48Z

← Older revision		Revision as of 18:10, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WBB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [http://www.ebi.ac.uk/pdbsum/2wbb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [http://www.ebi.ac.uk/pdbsum/2wbb PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[http://omim.org/entry/229700 229700]]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>		[[http://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[http://omim.org/entry/229700 229700]]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
	~~== Function ==~~

	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 37:
	[[Category: Fructose-bisphosphatase]]		[[Category: Fructose-bisphosphatase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Benz, J.]]		[[Category: Benz, J]]
	[[Category: Bernadeau, A.]]		[[Category: Bernadeau, A]]
	[[Category: Fol, B.]]		[[Category: Fol, B]]
	[[Category: Gubler, M.]]		[[Category: Gubler, M]]
	[[Category: Haap, W.]]		[[Category: Haap, W]]
	[[Category: Hebeisen, P.]]		[[Category: Hebeisen, P]]
	[[Category: Huber, W.]]		[[Category: Huber, W]]
	[[Category: Joseph, C.]]		[[Category: Joseph, C]]
	[[Category: Kitas, E.]]		[[Category: Kitas, E]]
	[[Category: Kuhn, B.]]		[[Category: Kuhn, B]]
	[[Category: Mohr, P.]]		[[Category: Mohr, P]]
	[[Category: Paehler, A.]]		[[Category: Paehler, A]]
	[[Category: Ruf, A.]]		[[Category: Ruf, A]]
	[[Category: Sanchez, R Alvarez.]]		[[Category: Sanchez, R Alvarez]]
	[[Category: Schott, B.]]		[[Category: Schott, B]]
	[[Category: Tetaz, T.]]		[[Category: Tetaz, T]]
	[[Category: Tozzo, E.]]		[[Category: Tozzo, E]]
	[[Category: Wessel, H P.]]		[[Category: Wessel, H P]]
	[[Category: Allosteric enzyme]]		[[Category: Allosteric enzyme]]
	[[Category: Carbohydrate metabolism]]		[[Category: Carbohydrate metabolism]]

OCA at 02:02, 1 October 2014

2014-10-01T02:02:02Z

← Older revision		Revision as of 02:02, 1 October 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2wbb\| PDB=2wbb \| SCENE= }}~~		==FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR==
	===FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR===		<StructureSection load='2wbb' size='340' side='right' caption='[[2wbb]], [[Resolution\|resolution]] 2.22Å' scene=''>
	{~~{ABSTRACT_PUBMED_19969452}~~}		== Structural highlights ==
			<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WBB FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjk\|2jjk]], [[1fta\|1fta]], [[2vt5\|2vt5]], [[2fie\|2fie]], [[2fix\|2fix]], [[2fhy\|2fhy]], [[2wbd\|2wbd]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [http://www.ebi.ac.uk/pdbsum/2wbb PDBsum]</span></td></tr>
			<table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[http://omim.org/entry/229700 229700]]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
			== Function ==

	==~~Disease~~==		== Evolutionary Conservation ==
	[[~~http~~://~~www~~.~~uniprot~~.~~org~~/~~uniprot~~/~~F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1~~,~~6-bisphosphatase deficiency (FBPD) [MIM:~~[http://~~omim~~.~~org~~/~~entry/229700 229700]~~]. ~~FBPD is inherited as an autosomal recessive disorder mainly in~~ the ~~liver and causes life-threatening episodes~~ of ~~hypoglycemia~~ and ~~metabolic acidosis (lactacidemia) in newborn infants or young children~~.<~~ref~~>~~PMID:9382095~~</~~ref~~><~~ref~~>~~PMID:12126934<~~/~~ref>~~		[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Sulfonylureido thiazoles were identified from a HTS campaign and optimized through a combination of structure-activity studies, X-ray crystallography and molecular modeling to yield potent inhibitors of fructose-1,6-bisphosphatase. Compound 12 showed favorable ADME properties, for example, F=70%, and a robust 32% glucose reduction in the acute db/db mouse model for Type-2 diabetes.

	~~==About this Structure==~~		Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.,Kitas E, Mohr P, Kuhn B, Hebeisen P, Wessel HP, Haap W, Ruf A, Benz J, Joseph C, Huber W, Sanchez RA, Paehler A, Benardeau A, Gubler M, Schott B, Tozzo E Bioorg Med Chem Lett. 2010 Jan 15;20(2):594-9. Epub 2009 Nov 22. PMID:19969452<ref>PMID:19969452</ref>
	~~[[2wbb]] is a 8 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2WBB OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Fructose-1%2C6-bisphosphatase\|Fructose-1%2C6-bisphosphatase]]		*[[Fructose-1%2C6-bisphosphatase\|Fructose-1%2C6-bisphosphatase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:019969452</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Fructose-bisphosphatase]]		[[Category: Fructose-bisphosphatase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 00:18, 25 March 2013

2013-03-25T00:18:43Z

← Older revision		Revision as of 00:18, 25 March 2013
Line 1:		Line 1:
	~~[[Image:2wbb.png\|left\|200px]]~~

	{{STRUCTURE_2wbb\| PDB=2wbb \| SCENE= }}		{{STRUCTURE_2wbb\| PDB=2wbb \| SCENE= }}

	===FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR===		===FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR===
			{{ABSTRACT_PUBMED_19969452}}

	~~{{ABSTRACT_PUBMED_19969452}}~~		==Disease==
			[[http://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[http://omim.org/entry/229700 229700]]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref><ref>PMID:12126934</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 13:

	==Reference==		==Reference==
	<ref group="xtra">PMID:019969452</ref><references group="xtra"/>		<ref group="xtra">PMID:019969452</ref><references group="xtra"/><references/>
	[[Category: Fructose-bisphosphatase]]		[[Category: Fructose-bisphosphatase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 07:50, 20 October 2012

2012-10-20T07:50:15Z

← Older revision		Revision as of 07:50, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2wbb]] is a 8 chain structure ~~of [[Fructose-1%2C6-bisphosphatase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA].		[[2wbb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA].

	==See Also==		==See Also==

OCA: Protected "2wbb" [edit=sysop:move=sysop]

2012-07-25T17:37:36Z

Protected "2wbb" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:37, 25 July 2012
(No difference)