2wdb - Revision history

OCA at 10:11, 9 May 2024

2024-05-09T10:11:32Z

← Older revision		Revision as of 10:11, 9 May 2024
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	<StructureSection load='2wdb' size='340' side='right'caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='2wdb' size='340' side='right'caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus~~ perfringens~~" veillon and zuber 1898~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WDB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA~~-~~D-MANNOSE'>MAN</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [https://pdbe.org/2wdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [https://www.ebi.ac.uk/pdbsum/2wdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [https://pdbe.org/2wdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [https://www.ebi.ac.uk/pdbsum/2wdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdb ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/NAGH_CLOPE NAGH_CLOPE] Putative virulence factor which is likely to act on connective tissue during gas gangrene.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ perfringens ~~veillon and zuber 1898]]~~		[[Category: Clostridium perfringens]]
	~~[[Category: Hydrolase~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Boraston~~, A B~~]]		[[Category: Boraston AB]]
	[[Category: Ficko-Blean, E]]		[[Category: Ficko-Blean E]]
	~~[[Category: Cbm]]~~
	~~[[Category: Clostridium perfringen]]~~
	~~[[Category: Family 32 carbohydrate binding module]]~~
	~~[[Category: Family 84 glycoside hydrolase]]~~
	~~[[Category: Glycosidase]]~~
	~~[[Category: Hexosaminidase]]~~
	~~[[Category: Secreted]]~~
	~~[[Category: Toxin]]~~
	~~[[Category: Virulence~~]]

OCA at 11:04, 6 April 2022

2022-04-06T11:04:49Z

← Older revision		Revision as of 11:04, 6 April 2022
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	<StructureSection load='2wdb' size='340' side='right'caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='2wdb' size='340' side='right'caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WDB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [~~http~~://pdbe.org/2wdb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wdb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [https://pdbe.org/2wdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [https://www.ebi.ac.uk/pdbsum/2wdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:36, 1 July 2020

2020-07-01T08:36:18Z

← Older revision		Revision as of 08:36, 1 July 2020
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	==A family 32 carbohydrate-binding module, from the Mu toxin produced by Clostridium perfringens, in complex with beta-D-glcNAc-beta(1,2) mannose==		==A family 32 carbohydrate-binding module, from the Mu toxin produced by Clostridium perfringens, in complex with beta-D-glcNAc-beta(1,2) mannose==
	<StructureSection load='2wdb' size='340' side='right' caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='2wdb' size='340' side='right'caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WDB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [http://pdbe.org/2wdb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [http://www.ebi.ac.uk/pdbsum/2wdb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [http://pdbe.org/2wdb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [http://www.ebi.ac.uk/pdbsum/2wdb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Hyaluronidase\|Hyaluronidase]]		*[[Hyaluronidase 3D structures\|Hyaluronidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Bacillus perfringens veillon and zuber 1898]]		[[Category: Bacillus perfringens veillon and zuber 1898]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
			[[Category: Large Structures]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]
	[[Category: Ficko-Blean, E]]		[[Category: Ficko-Blean, E]]

OCA at 09:28, 26 September 2018

2018-09-26T09:28:58Z

← Older revision		Revision as of 09:28, 26 September 2018
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	==A ~~FAMILY~~ 32 ~~CARBOHYDRATE~~-~~BINDING MODULE~~, ~~FROM THE MU TOXIN PRODUCED BY CLOSTRIDIUM PERFRINGENS~~, ~~IN COMPLEX WITH BETA~~-D-~~GLCNAC~~-~~BETA~~(1,2)~~MANNOSE~~==
			==A family 32 carbohydrate-binding module, from the Mu toxin produced by Clostridium perfringens, in complex with beta-D-glcNAc-beta(1,2) mannose==
	<StructureSection load='2wdb' size='340' side='right' caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='2wdb' size='340' side='right' caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [http://pdbe.org/2wdb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [http://www.ebi.ac.uk/pdbsum/2wdb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [http://pdbe.org/2wdb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [http://www.ebi.ac.uk/pdbsum/2wdb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wdb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wdb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:29, 10 February 2016

2016-02-10T08:29:52Z

← Older revision		Revision as of 08:29, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2wdb' size='340' side='right' caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='2wdb' size='340' side='right' caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Clostridium_perfringens Clostridium~~ perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WDB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Hyaluronoglucosaminidase Hyaluronoglucosaminidase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [http://www.ebi.ac.uk/pdbsum/2wdb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [http://pdbe.org/2wdb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [http://www.ebi.ac.uk/pdbsum/2wdb PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wdb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2wdb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Clostridium~~ perfringens]]		[[Category: Bacillus perfringens veillon and zuber 1898]]
	[[Category: ~~Hyaluronoglucosaminidase~~]]		[[Category: Hydrolase]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]
	[[Category: Ficko-Blean, E]]		[[Category: Ficko-Blean, E]]
Line 43:		Line 44:
	[[Category: Glycosidase]]		[[Category: Glycosidase]]
	[[Category: Hexosaminidase]]		[[Category: Hexosaminidase]]
	~~[[Category: Hydrolase]]~~
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Virulence]]		[[Category: Virulence]]

OCA at 11:36, 20 January 2015

2015-01-20T11:36:44Z

← Older revision		Revision as of 11:36, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WDB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hyaluronoglucosaminidase Hyaluronoglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hyaluronoglucosaminidase Hyaluronoglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [http://www.ebi.ac.uk/pdbsum/2wdb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [http://www.ebi.ac.uk/pdbsum/2wdb PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Clostridium perfringens]]		[[Category: Clostridium perfringens]]
	[[Category: Hyaluronoglucosaminidase]]		[[Category: Hyaluronoglucosaminidase]]
	[[Category: Boraston, A B.]]		[[Category: Boraston, A B]]
	[[Category: Ficko-Blean, E.]]		[[Category: Ficko-Blean, E]]
	[[Category: Cbm]]		[[Category: Cbm]]
	[[Category: Clostridium perfringen]]		[[Category: Clostridium perfringen]]

OCA at 10:11, 29 September 2014

2014-09-29T10:11:09Z

← Older revision		Revision as of 10:11, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2wdb~~.~~png~~\|~~left~~\|~~200px~~]]		==A FAMILY 32 CARBOHYDRATE-BINDING MODULE, FROM THE MU TOXIN PRODUCED BY CLOSTRIDIUM PERFRINGENS, IN COMPLEX WITH BETA-D-GLCNAC-BETA(1,2)MANNOSE==
			<StructureSection load='2wdb' size='340' side='right' caption='[[2wdb]], [[Resolution\|resolution]] 2.03Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2wdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WDB FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w1q\|2w1q]], [[2w1u\|2w1u]], [[2w1s\|2w1s]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hyaluronoglucosaminidase Hyaluronoglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wdb RCSB], [http://www.ebi.ac.uk/pdbsum/2wdb PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wdb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Many carbohydrate-active enzymes have complex architectures comprising multiple modules that may be involved in catalysis, carbohydrate binding, or protein-protein interactions. Carbohydrate-binding modules (CBMs) are a common ancillary module whose function is to promote the adherence of the complete enzyme to carbohydrate substrates. CBM family 32 has been proposed to be one of the most diverse CBM families classified to date, yet all of the structurally characterized CBM32s thus far recognize galactose-based ligands. Here, we report a unique binding specificity and mode of ligand binding for a family 32 CBM. NagHCBM32-2 is one of four CBM32 modules in NagH, a family 84 glycoside hydrolase secreted by Clostridium perfringens. NagHCBM32-2 has the beta-sandwich scaffold common to members of the family; however, its specificity for N-acetylglucosamine is unusual among CBMs. X-ray crystallographic analysis of the module at resolutions from 1.45 to 2.0 A and in complex with disaccharides reveals that its mode of sugar recognition is quite different from that observed for galactose-specific CBM32s. This study continues to unravel the diversity of CBMs found in family 32 and how these CBMs might impart the carbohydrate-binding specificity to the extracellular glycoside hydrolases in C. perfringens.

	~~{{STRUCTURE_2wdb\| PDB=2wdb \| SCENE= }}~~		N-acetylglucosamine recognition by a family 32 carbohydrate-binding module from Clostridium perfringens NagH.,Ficko-Blean E, Boraston AB J Mol Biol. 2009 Jul 10;390(2):208-20. Epub 2009 May 5. PMID:19422833<ref>PMID:19422833</ref>

	~~===A FAMILY 32 CARBOHYDRATE-BINDING MODULE~~, ~~FROM THE MU TOXIN PRODUCED BY CLOSTRIDIUM PERFRINGENS, IN COMPLEX WITH BETA-D-GLCNAC-BETA(1,2)MANNOSE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19422833}}~~

	~~==About this Structure==~~
	~~[[2wdb]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Clostridium_perfringens Clostridium perfringens]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2WDB OCA].~~

	==See Also==		==See Also==
	*[[Hyaluronidase\|Hyaluronidase]]		*[[Hyaluronidase\|Hyaluronidase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:019422833<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Clostridium perfringens]]		[[Category: Clostridium perfringens]]
	[[Category: Hyaluronoglucosaminidase]]		[[Category: Hyaluronoglucosaminidase]]

OCA at 16:58, 20 October 2012

2012-10-20T16:58:36Z

← Older revision		Revision as of 16:58, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2wdb]] is a 4 chain structure ~~of [[Hyaluronidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA].		[[2wdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA].

	==See Also==		==See Also==

OCA: Protected "2wdb" [edit=sysop:move=sysop]

2012-07-26T23:26:02Z

Protected "2wdb" [edit=sysop:move=sysop]

← Older revision	Revision as of 23:26, 26 July 2012
(No difference)

OCA at 23:26, 26 July 2012

2012-07-26T23:26:01Z

← Older revision		Revision as of 23:26, 26 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2wdb.png\|left\|200px]]		[[Image:2wdb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2wdb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2wdb\| PDB=2wdb \| SCENE= }}		{{STRUCTURE_2wdb\| PDB=2wdb \| SCENE= }}

	===A FAMILY 32 CARBOHYDRATE-BINDING MODULE, FROM THE MU TOXIN PRODUCED BY CLOSTRIDIUM PERFRINGENS, IN COMPLEX WITH BETA-D-GLCNAC-BETA(1,2)MANNOSE===		===A FAMILY 32 CARBOHYDRATE-BINDING MODULE, FROM THE MU TOXIN PRODUCED BY CLOSTRIDIUM PERFRINGENS, IN COMPLEX WITH BETA-D-GLCNAC-BETA(1,2)MANNOSE===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19422833}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19422833 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19422833}}		{{ABSTRACT_PUBMED_19422833}}

	==About this Structure==		==About this Structure==
	~~2WDB~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA].		[[2wdb]] is a 4 chain structure of [[Hyaluronidase]] with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDB OCA].

			==See Also==
			*[[Hyaluronidase\|Hyaluronidase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19422833~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019422833</ref><references group="xtra"/>
	[[Category: Clostridium perfringens]]		[[Category: Clostridium perfringens]]
	[[Category: ~~Hyalurononglucosaminidase~~]]		[[Category: Hyaluronoglucosaminidase]]
	[[Category: Boraston, A B.]]		[[Category: Boraston, A B.]]
	[[Category: Ficko-Blean, E.]]		[[Category: Ficko-Blean, E.]]
Line 38:		Line 29:
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Virulence]]		[[Category: Virulence]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 20 15:45:12 2009''~~