2wf2 - Revision history

OCA at 09:34, 6 November 2024

2024-11-06T09:34:28Z

← Older revision		Revision as of 09:34, 6 November 2024
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	<StructureSection load='2wf2' size='340' side='right'caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2wf2' size='340' side='right'caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZY2:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-8-ETHYL-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-[1,2,5]THIADIAZEPINO[5,4,3-DE]QUINOXALINE-10-CARBOXAMIDE+2,2-DIOXIDE'>ZY2</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[2vnm\|2vnm]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2fdp\|2fdp]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]], [[2wez\|2wez]], [[2wf0\|2wf0]], [[2wf1\|2wf1]], [[2wf3\|2wf3]], [[2wf4\|2wf4]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZY2:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-8-ETHYL-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-[1,2,5]THIADIAZEPINO[5,4,3-DE]QUINOXALINE-10-CARBOXAMIDE+2,2-DIOXIDE'>ZY2</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [https://pdbe.org/2wf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [https://pdbe.org/2wf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>		[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Memapsin 2]]~~		[[Category: Charrier N]]
	~~[[Category: Brien, A O]]~~		[[Category: Clarke B]]
	[[Category: Charrier, N]]		[[Category: Demont E]]
	[[Category: Clarke, B]]		[[Category: Dingwall C]]
	[[Category: Demont, E]]		[[Category: Dunsdon R]]
	[[Category: Dingwall, C]]		[[Category: Hawkins J]]
	[[Category: Dunsdon, R]]		[[Category: Hubbard J]]
	[[Category: Hawkins, J]]		[[Category: Hussain I]]
	[[Category: Hubbard, J]]		[[Category: Maile G]]
	[[Category: Hussain, I]]		[[Category: Matico R]]
	[[Category: Maile, G]]		[[Category: Mosley J]]
	[[Category: Matico, R]]		[[Category: Naylor A]]
	[[Category: Mosley, J]]		[[Category: O'Brien A]]
	[[Category: Naylor, A]]		[[Category: Redshaw S]]
	[[Category: Redshaw, S]]		[[Category: Rowland P]]
	[[Category: Rowland, P]]		[[Category: Smith KJ]]
	[[Category: Smith~~, K J~~]]		[[Category: Soleil V]]
	[[Category: Soleil, V]]		[[Category: Sweitzer S]]
	[[Category: Sweitzer, S]]		[[Category: Theobald P]]
	[[Category: Theobald, P]]		[[Category: Vesey D]]
	[[Category: Vesey, D]]		[[Category: Walter DS]]
	[[Category: Walter~~, D S~~]]		[[Category: Wayne G]]
	[[Category: Wayne, G]]
	~~[[Category: Alternative splicing]]~~
	~~[[Category: Asp-2]]~~
	~~[[Category: Aspartyl protease]]~~
	~~[[Category: Bace-1]]~~
	~~[[Category: Beta-secretase]]~~
	~~[[Category: Beta-site app cleaving enzyme]]~~
	~~[[Category: Disulfide bond]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Memapsin-2]]~~
	~~[[Category: Membrane]]~~
	~~[[Category: Polymorphism]]~~
	~~[[Category: Protease]]~~
	~~[[Category: Transmembrane]]~~
	~~[[Category: Zymogen~~]]

OCA at 10:54, 7 July 2021

2021-07-07T10:54:12Z

← Older revision		Revision as of 10:54, 7 July 2021
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	<StructureSection load='2wf2' size='340' side='right'caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2wf2' size='340' side='right'caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY2:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-8-ETHYL-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-[1,2,5]THIADIAZEPINO[5,4,3-DE]QUINOXALINE-10-CARBOXAMIDE+2,2-DIOXIDE'>ZY2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZY2:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-8-ETHYL-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-[1,2,5]THIADIAZEPINO[5,4,3-DE]QUINOXALINE-10-CARBOXAMIDE+2,2-DIOXIDE'>ZY2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[2vnm\|2vnm]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2fdp\|2fdp]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]], [[2wez\|2wez]], [[2wf0\|2wf0]], [[2wf1\|2wf1]], [[2wf3\|2wf3]], [[2wf4\|2wf4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[2vnm\|2vnm]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2fdp\|2fdp]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]], [[2wez\|2wez]], [[2wf0\|2wf0]], [[2wf1\|2wf1]], [[2wf3\|2wf3]], [[2wf4\|2wf4]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [~~http~~://pdbe.org/2wf2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wf2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [https://pdbe.org/2wf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>		[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:48, 21 May 2019

2019-05-21T07:48:39Z

← Older revision		Revision as of 07:48, 21 May 2019
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	==Human BACE-1 in complex with 8-ethyl-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4,7, 8-tetrahydro-1H,6H-(1,2,5)thiadiazepino(5,4,3-de)quinoxaline-10- carboxamide 2,2-dioxide==		==Human BACE-1 in complex with 8-ethyl-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4,7, 8-tetrahydro-1H,6H-(1,2,5)thiadiazepino(5,4,3-de)quinoxaline-10- carboxamide 2,2-dioxide==
	<StructureSection load='2wf2' size='340' side='right' caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2wf2' size='340' side='right'caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brien, A O]]		[[Category: Brien, A O]]

OCA at 07:53, 6 March 2019

2019-03-06T07:53:58Z

← Older revision		Revision as of 07:53, 6 March 2019
Line 1:		Line 1:

	==Human BACE-1 in complex with 8-ethyl-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4,7, 8-tetrahydro-1H,6H-(1,2,5)thiadiazepino(5,4,3-de)quinoxaline-10- carboxamide 2,2-dioxide==		==Human BACE-1 in complex with 8-ethyl-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4,7, 8-tetrahydro-1H,6H-(1,2,5)thiadiazepino(5,4,3-de)quinoxaline-10- carboxamide 2,2-dioxide==
	<StructureSection load='2wf2' size='340' side='right' caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2wf2' size='340' side='right' caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>

OCA at 09:08, 26 September 2018

2018-09-26T09:08:39Z

← Older revision		Revision as of 09:08, 26 September 2018
Line 1:		Line 1:
	==~~HUMAN~~ BACE-1 ~~IN COMPLEX WITH~~ 8-~~ETHYL~~-N-((1S,2R)-2-~~HYDROXY~~-3-(((3-(~~METHYLOXY~~)~~PHENYL~~)~~METHYL~~)~~AMINO~~)-1-(~~PHENYLMETHYL~~) ~~PROPYL~~)-1-~~METHYL~~-3,4,7,8-~~TETRAHYDRO~~-1H,6H-(1,2,5) ~~THIADIAZEPINO~~(5,4,3-DE)~~QUINOXALINE~~-10-~~CARBOXAMIDE~~ 2,2-~~DIOXIDE~~==
			==Human BACE-1 in complex with 8-ethyl-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4,7, 8-tetrahydro-1H,6H-(1,2,5)thiadiazepino(5,4,3-de)quinoxaline-10- carboxamide 2,2-dioxide==
	<StructureSection load='2wf2' size='340' side='right' caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2wf2' size='340' side='right' caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[2vnm\|2vnm]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2fdp\|2fdp]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]], [[2wez\|2wez]], [[2wf0\|2wf0]], [[2wf1\|2wf1]], [[2wf3\|2wf3]], [[2wf4\|2wf4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[2vnm\|2vnm]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2fdp\|2fdp]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]], [[2wez\|2wez]], [[2wf0\|2wf0]], [[2wf1\|2wf1]], [[2wf3\|2wf3]], [[2wf4\|2wf4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [http://pdbe.org/2wf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [http://pdbe.org/2wf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 60:		Line 61:
	[[Category: Walter, D S]]		[[Category: Walter, D S]]
	[[Category: Wayne, G]]		[[Category: Wayne, G]]
			[[Category: Alternative splicing]]
	[[Category: Asp-2]]		[[Category: Asp-2]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]
Line 70:		Line 72:
	[[Category: Memapsin-2]]		[[Category: Memapsin-2]]
	[[Category: Membrane]]		[[Category: Membrane]]
			[[Category: Polymorphism]]
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Zymogen]]		[[Category: Zymogen]]

OCA at 04:04, 8 February 2016

2016-02-08T04:04:42Z

← Older revision		Revision as of 04:04, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2wf2' size='340' side='right' caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2wf2' size='340' side='right' caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY2:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-8-ETHYL-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-[1,2,5]THIADIAZEPINO[5,4,3-DE]QUINOXALINE-10-CARBOXAMIDE+2,2-DIOXIDE'>ZY2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY2:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-8-ETHYL-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-[1,2,5]THIADIAZEPINO[5,4,3-DE]QUINOXALINE-10-CARBOXAMIDE+2,2-DIOXIDE'>ZY2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[2vnm\|2vnm]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2fdp\|2fdp]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]], [[2wez\|2wez]], [[2wf0\|2wf0]], [[2wf1\|2wf1]], [[2wf3\|2wf3]], [[2wf4\|2wf4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[2vnm\|2vnm]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2fdp\|2fdp]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]], [[2wez\|2wez]], [[2wf0\|2wf0]], [[2wf1\|2wf1]], [[2wf3\|2wf3]], [[2wf4\|2wf4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [http://pdbe.org/2wf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wf2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2wf2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brien, A O]]		[[Category: Brien, A O]]

OCA at 20:28, 24 December 2014

2014-12-24T20:28:29Z

← Older revision		Revision as of 20:28, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY2:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-8-ETHYL-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-[1,2,5]THIADIAZEPINO[5,4,3-DE]QUINOXALINE-10-CARBOXAMIDE+2,2-DIOXIDE'>ZY2</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY2:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-8-ETHYL-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-[1,2,5]THIADIAZEPINO[5,4,3-DE]QUINOXALINE-10-CARBOXAMIDE+2,2-DIOXIDE'>ZY2</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[2vnm\|2vnm]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2fdp\|2fdp]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]], [[2wez\|2wez]], [[2wf0\|2wf0]], [[2wf1\|2wf1]], [[2wf3\|2wf3]], [[2wf4\|2wf4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[2vnm\|2vnm]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2fdp\|2fdp]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]], [[2wez\|2wez]], [[2wf0\|2wf0]], [[2wf1\|2wf1]], [[2wf3\|2wf3]], [[2wf4\|2wf4]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf2 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brien, A O.]]		[[Category: Brien, A O]]
	[[Category: Charrier, N.]]		[[Category: Charrier, N]]
	[[Category: Clarke, B.]]		[[Category: Clarke, B]]
	[[Category: Demont, E.]]		[[Category: Demont, E]]
	[[Category: Dingwall, C.]]		[[Category: Dingwall, C]]
	[[Category: Dunsdon, R.]]		[[Category: Dunsdon, R]]
	[[Category: Hawkins, J.]]		[[Category: Hawkins, J]]
	[[Category: Hubbard, J.]]		[[Category: Hubbard, J]]
	[[Category: Hussain, I.]]		[[Category: Hussain, I]]
	[[Category: Maile, G.]]		[[Category: Maile, G]]
	[[Category: Matico, R.]]		[[Category: Matico, R]]
	[[Category: Mosley, J.]]		[[Category: Mosley, J]]
	[[Category: Naylor, A.]]		[[Category: Naylor, A]]
	[[Category: Redshaw, S.]]		[[Category: Redshaw, S]]
	[[Category: Rowland, P.]]		[[Category: Rowland, P]]
	[[Category: Smith, K J.]]		[[Category: Smith, K J]]
	[[Category: Soleil, V.]]		[[Category: Soleil, V]]
	[[Category: Sweitzer, S.]]		[[Category: Sweitzer, S]]
	[[Category: Theobald, P.]]		[[Category: Theobald, P]]
	[[Category: Vesey, D.]]		[[Category: Vesey, D]]
	[[Category: Walter, D S.]]		[[Category: Walter, D S]]
	[[Category: Wayne, G.]]		[[Category: Wayne, G]]
	[[Category: Asp-2]]		[[Category: Asp-2]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]

OCA at 07:38, 29 September 2014

2014-09-29T07:38:20Z

← Older revision		Revision as of 07:38, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2wf2~~.~~png~~\|~~left~~\|~~200px~~]]		==HUMAN BACE-1 IN COMPLEX WITH 8-ETHYL-N-((1S,2R)-2-HYDROXY-3-(((3-(METHYLOXY)PHENYL)METHYL)AMINO)-1-(PHENYLMETHYL) PROPYL)-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-(1,2,5) THIADIAZEPINO(5,4,3-DE)QUINOXALINE-10-CARBOXAMIDE 2,2-DIOXIDE==
			<StructureSection load='2wf2' size='340' side='right' caption='[[2wf2]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2wf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF2 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY2:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-8-ETHYL-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-[1,2,5]THIADIAZEPINO[5,4,3-DE]QUINOXALINE-10-CARBOXAMIDE+2,2-DIOXIDE'>ZY2</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[2vnm\|2vnm]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2fdp\|2fdp]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]], [[2wez\|2wez]], [[2wf0\|2wf0]], [[2wf1\|2wf1]], [[2wf3\|2wf3]], [[2wf4\|2wf4]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf2 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf2_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Our first generation of hydroxyethylamine transition-state mimetic BACE-1 inhibitors allowed us to validate BACE-1 as a key target for Alzheimer's disease by demonstrating amyloid lowering in an animal model, albeit at rather high doses. Finding a molecule from this series which was active at lower oral doses proved elusive and demonstrated the need to find a novel series of inhibitors with improved pharmacokinetics. This Letter describes the discovery of such inhibitors.

	~~{{STRUCTURE_2wf2\| PDB=2wf2 \| SCENE= }}~~		Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.,Charrier N, Clarke B, Demont E, Dingwall C, Dunsdon R, Hawkins J, Hubbard J, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G Bioorg Med Chem Lett. 2009 Jul 1;19(13):3669-73. Epub 2009 Apr 5. PMID:19477642<ref>PMID:19477642</ref>

	===HUMAN BACE-1 IN COMPLEX WITH 8-ETHYL-N-((1S,2R)-2-HYDROXY-3-(((3-(METHYLOXY)PHENYL)METHYL)AMINO)-1-(PHENYLMETHYL) PROPYL)-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-(1,2,5) THIADIAZEPINO(5,4,3-DE)QUINOXALINE-10-CARBOXAMIDE 2,~~2-DIOXIDE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19477642}}~~

	~~==About this Structure==~~
	~~[[2wf2]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA].~~

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:019477642<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]

OCA at 08:50, 20 October 2012

2012-10-20T08:50:55Z

← Older revision		Revision as of 08:50, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2wf2]] is a 1 chain structure ~~of [[Beta secretase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA].		[[2wf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF2 OCA].

	==See Also==		==See Also==

OCA: Protected "2wf2" [edit=sysop:move=sysop]

2012-07-25T20:58:06Z

Protected "2wf2" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:58, 25 July 2012
(No difference)