2wid - Revision history

OCA at 07:49, 9 October 2024

2024-10-09T07:49:15Z

← Older revision		Revision as of 07:49, 9 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wid_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wid_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 15:58, 13 December 2023

2023-12-13T15:58:11Z

← Older revision		Revision as of 15:58, 13 December 2023
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	<StructureSection load='2wid' size='340' side='right'caption='[[2wid]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2wid' size='340' side='right'caption='[[2wid]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WID FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WID FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN~~</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL~~</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ehq\|1ehq]], [[2j4c\|2j4c]], [[1p0q\|1p0q]], [[1kcj\|1kcj]], [[1xlu\|1xlu]], [[1p0p\|1p0p]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1p0i\|1p0i]], [[1xlw\|1xlw]], [[2wik\|2wik]], [[2wif\|2wif]], [[2wij\|2wij]], [[2wig\|2wig]]</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [https://pdbe.org/2wid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [https://www.ebi.ac.uk/pdbsum/2wid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wid ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [~~http~~://pdbe.org/2wid PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wid PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wid ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[~~http~~://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.		[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>		[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Cholinesterase]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Aurbek, N]]		[[Category: Aurbek N]]
	[[Category: Carletti, E]]		[[Category: Carletti E]]
	[[Category: Fontecilla, J]]		[[Category: Fontecilla J]]
	[[Category: Gillon, E]]		[[Category: Gillon E]]
	[[Category: Loiodice, M]]		[[Category: Loiodice M]]
	[[Category: Masson, P]]		[[Category: Masson P]]
	[[Category: Nachon, F]]		[[Category: Nachon F]]
	[[Category: Nicolet, Y]]		[[Category: Nicolet Y]]
	[[Category: Thiermann, H]]		[[Category: Thiermann H]]
	[[Category: Worek, F]]		[[Category: Worek F]]
	~~[[Category: Aging]]~~
	~~[[Category: Disease mutation]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Inhibition]]~~
	~~[[Category: Polymorphism]]~~
	~~[[Category: Serine esterase~~]]

OCA at 07:59, 4 November 2020

2020-11-04T07:59:39Z

← Older revision		Revision as of 07:59, 4 November 2020
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	==NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1==		==NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1==
	<StructureSection load='2wid' size='340' side='right' caption='[[2wid]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2wid' size='340' side='right'caption='[[2wid]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WID FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WID FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL~~</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL~~</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ehq\|1ehq]], [[2j4c\|2j4c]], [[1p0q\|1p0q]], [[1kcj\|1kcj]], [[1xlu\|1xlu]], [[1p0p\|1p0p]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1p0i\|1p0i]], [[1xlw\|1xlw]], [[2wik\|2wik]], [[2wif\|2wif]], [[2wij\|2wij]], [[2wig\|2wig]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ehq\|1ehq]], [[2j4c\|2j4c]], [[1p0q\|1p0q]], [[1kcj\|1kcj]], [[1xlu\|1xlu]], [[1p0p\|1p0p]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1p0i\|1p0i]], [[1xlw\|1xlw]], [[2wik\|2wik]], [[2wif\|2wif]], [[2wij\|2wij]], [[2wig\|2wig]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [http://pdbe.org/2wid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [http://www.ebi.ac.uk/pdbsum/2wid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wid ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [http://pdbe.org/2wid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [http://www.ebi.ac.uk/pdbsum/2wid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wid ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	==See Also==		==See Also==
	*[[Butyrylcholinesterase\|Butyrylcholinesterase]]		*[[Butyrylcholinesterase 3D structures\|Butyrylcholinesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Aurbek, N]]		[[Category: Aurbek, N]]
	[[Category: Carletti, E]]		[[Category: Carletti, E]]

OCA at 08:55, 30 January 2019

2019-01-30T08:55:15Z

← Older revision		Revision as of 08:55, 30 January 2019
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	</div>		</div>
	<div class="pdbe-citations 2wid" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wid" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Butyrylcholinesterase\|Butyrylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:59, 28 February 2018

2018-02-28T06:59:21Z

← Older revision		Revision as of 06:59, 28 February 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WID FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WID FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN~~</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL~~</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ehq\|1ehq]], [[2j4c\|2j4c]], [[1p0q\|1p0q]], [[1kcj\|1kcj]], [[1xlu\|1xlu]], [[1p0p\|1p0p]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1p0i\|1p0i]], [[1xlw\|1xlw]], [[2wik\|2wik]], [[2wif\|2wif]], [[2wij\|2wij]], [[2wig\|2wig]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ehq\|1ehq]], [[2j4c\|2j4c]], [[1p0q\|1p0q]], [[1kcj\|1kcj]], [[1xlu\|1xlu]], [[1p0p\|1p0p]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1p0i\|1p0i]], [[1xlw\|1xlw]], [[2wik\|2wik]], [[2wif\|2wif]], [[2wij\|2wij]], [[2wig\|2wig]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wid_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wid_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 2wid" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wid" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Butyrylcholinesterase\|Butyrylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>
Line 56:		Line 53:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Inhibition]]		[[Category: Inhibition]]
			[[Category: Polymorphism]]
	[[Category: Serine esterase]]		[[Category: Serine esterase]]

OCA at 08:25, 11 August 2016

2016-08-11T08:25:21Z

← Older revision		Revision as of 08:25, 11 August 2016
Line 1:		Line 1:

	==NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1==		==NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1==
	<StructureSection load='2wid' size='340' side='right' caption='[[2wid]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2wid' size='340' side='right' caption='[[2wid]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WID FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WID FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ehq\|1ehq]], [[2j4c\|2j4c]], [[1p0q\|1p0q]], [[1kcj\|1kcj]], [[1xlu\|1xlu]], [[1p0p\|1p0p]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1p0i\|1p0i]], [[1xlw\|1xlw]], [[2wik\|2wik]], [[2wif\|2wif]], [[2wij\|2wij]], [[2wig\|2wig]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ehq\|1ehq]], [[2j4c\|2j4c]], [[1p0q\|1p0q]], [[1kcj\|1kcj]], [[1xlu\|1xlu]], [[1p0p\|1p0p]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1p0i\|1p0i]], [[1xlw\|1xlw]], [[2wik\|2wik]], [[2wif\|2wif]], [[2wij\|2wij]], [[2wig\|2wig]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [http://www.ebi.ac.uk/pdbsum/2wid PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [http://pdbe.org/2wid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [http://www.ebi.ac.uk/pdbsum/2wid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wid ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wid ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2wid" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Aurbek, N]]		[[Category: Aurbek, N]]
	[[Category: Carletti, E]]		[[Category: Carletti, E]]

OCA at 09:14, 20 January 2015

2015-01-20T09:14:41Z

← Older revision		Revision as of 09:14, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WID FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WID FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ehq\|1ehq]], [[2j4c\|2j4c]], [[1p0q\|1p0q]], [[1kcj\|1kcj]], [[1xlu\|1xlu]], [[1p0p\|1p0p]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1p0i\|1p0i]], [[1xlw\|1xlw]], [[2wik\|2wik]], [[2wif\|2wif]], [[2wij\|2wij]], [[2wig\|2wig]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ehq\|1ehq]], [[2j4c\|2j4c]], [[1p0q\|1p0q]], [[1kcj\|1kcj]], [[1xlu\|1xlu]], [[1p0p\|1p0p]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1p0i\|1p0i]], [[1xlw\|1xlw]], [[2wik\|2wik]], [[2wif\|2wif]], [[2wij\|2wij]], [[2wig\|2wig]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [http://www.ebi.ac.uk/pdbsum/2wid PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [http://www.ebi.ac.uk/pdbsum/2wid PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.		[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
Line 39:		Line 39:
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aurbek, N.]]		[[Category: Aurbek, N]]
	[[Category: Carletti, E.]]		[[Category: Carletti, E]]
	[[Category: Fontecilla, J.]]		[[Category: Fontecilla, J]]
	[[Category: Gillon, E.]]		[[Category: Gillon, E]]
	[[Category: Loiodice, M.]]		[[Category: Loiodice, M]]
	[[Category: Masson, P.]]		[[Category: Masson, P]]
	[[Category: Nachon, F.]]		[[Category: Nachon, F]]
	[[Category: Nicolet, Y.]]		[[Category: Nicolet, Y]]
	[[Category: Thiermann, H.]]		[[Category: Thiermann, H]]
	[[Category: Worek, F.]]		[[Category: Worek, F]]
	[[Category: Aging]]		[[Category: Aging]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]

OCA at 01:58, 1 October 2014

2014-10-01T01:58:38Z

← Older revision		Revision as of 01:58, 1 October 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2wid\| PDB=2wid \| SCENE= }}~~		==NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1==
	===NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1===		<StructureSection load='2wid' size='340' side='right' caption='[[2wid]], [[Resolution\|resolution]] 2.30Å' scene=''>
	~~{{ABSTRACT_PUBMED_19368529}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WID FirstGlance]. <br>
	==Disease==		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ehq\|1ehq]], [[2j4c\|2j4c]], [[1p0q\|1p0q]], [[1kcj\|1kcj]], [[1xlu\|1xlu]], [[1p0p\|1p0p]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1p0i\|1p0i]], [[1xlw\|1xlw]], [[2wik\|2wik]], [[2wif\|2wif]], [[2wij\|2wij]], [[2wig\|2wig]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [http://www.ebi.ac.uk/pdbsum/2wid PDBsum]</span></td></tr>
			<table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.		[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
			== Function ==
			[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wid_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			hBChE [human BChE (butyrylcholinesterase)] naturally scavenges OPs (organophosphates). This bioscavenger is currently in Clinical Phase I for pretreatment of OP intoxication. Phosphylated ChEs (cholinesterases) can undergo a spontaneous time-dependent process called 'aging' during which the conjugate is dealkylated, leading to creation of an enzyme that cannot be reactivated. hBChE inhibited by phosphoramidates such as tabun displays a peculiar resistance to oxime-mediated reactivation. We investigated the basis of oxime resistance of phosphoramidyl-BChE conjugates by determining the kinetics of inhibition, reactivation (obidoxime {1,1'-(oxybis-methylene) bis[4-(hydroxyimino) methyl] pyridinium dichloride}, TMB-4 [1,3-trimethylene-bis(4-hydroxyiminomethylpyridinium) dibromide], HLo 7 {1-[[[4-(aminocarbonyl) pyridinio]methoxy]methyl]-2,4-bis-[(hydroxyimino)methyl] pyridinium dimethanesulfonate)}, HI-6 {1-[[[4-(aminocarbonyl) pyridinio] methoxy] methyl]-2-[(hydroxyimino)methyl]pyridinium dichloride monohydrate} and aging, and the crystal structures of hBChE inhibited by different N-monoalkyl and N,N-dialkyl tabun analogues. The refined structures of aged hBChE conjugates show that aging proceeds through O-dealkylation of the P(R) enantiomer of N,N-diethyl and N-propyl analogues, with subsequent formation of a salt bridge preventing reactivation, similarly to a previous observation made on tabun-ChE conjugates. Interestingly, the N-methyl analogue projects its amino group towards the choline-binding pocket, so that aging proceeds through deamination. This orientation results from a preference of hBChE's acyl-binding pocket for larger than 2-atoms linear substituents. The correlation between the inhibitory potency and the N-monoalkyl chain length is related to increasingly optimized interactions with the acyl-binding pocket as shown by the X-ray structures. These kinetics and X-ray data lead to a structure-activity relationship that highlights steric and electronic effects of the amino substituent of phosphoramidate. This study provides the structural basis to design new oximes capable of reactivating phosphoramidyl-hBChE conjugates after intoxication, notably when hBChE is used as pretreatment, or to design BChE-based catalytic bioscavengers.

	~~==Function==~~		Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.,Carletti E, Aurbek N, Gillon E, Loiodice M, Nicolet Y, Fontecilla-Camps JC, Masson P, Thiermann H, Nachon F, Worek F Biochem J. 2009 Jun 12;421(1):97-106. PMID:19368529<ref>PMID:19368529</ref>
	~~[[http://www~~.~~uniprot~~.~~org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters~~.~~<ref>~~PMID:~~19542320</ref>~~<ref>PMID:~~19452557~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2wid]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA].~~		</div>

	==See Also==		==See Also==
	*[[Butyrylcholinesterase\|Butyrylcholinesterase]]		*[[Butyrylcholinesterase\|Butyrylcholinesterase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:019368529</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 11:02, 24 March 2013

2013-03-24T11:02:33Z

← Older revision		Revision as of 11:02, 24 March 2013
Line 1:		Line 1:
	~~[[Image:2wid.png\|left\|200px]]~~

	{{STRUCTURE_2wid\| PDB=2wid \| SCENE= }}		{{STRUCTURE_2wid\| PDB=2wid \| SCENE= }}
			===NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1===
			{{ABSTRACT_PUBMED_19368529}}

	==~~=NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1=~~==		==Disease==
			[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.

	~~{{ABSTRACT_PUBMED_19368529}}~~		==Function==
			[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref><ref>PMID:19452557</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
	<ref group="xtra">PMID:019368529</ref><references group="xtra"/>		<ref group="xtra">PMID:019368529</ref><references group="xtra"/><references/>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 18:31, 20 October 2012

2012-10-20T18:31:20Z

← Older revision		Revision as of 18:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2wid]] is a 1 chain structure ~~of [[Butyrylcholinesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA].		[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA].

	==See Also==		==See Also==