2wt7 - Revision history

OCA at 10:16, 9 May 2024

2024-05-09T10:16:48Z

← Older revision		Revision as of 10:16, 9 May 2024
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	<StructureSection load='2wt7' size='340' side='right'caption='[[2wt7]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2wt7' size='340' side='right'caption='[[2wt7]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wt7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WT7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wt7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WT7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt7 OCA], [https://pdbe.org/2wt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wt7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt7 OCA], [https://pdbe.org/2wt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wt7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FOS_MOUSE FOS_MOUSE]] Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.<ref>PMID:12134156</ref> <ref>PMID:12972619</ref> <ref>PMID:15719069</ref> <ref>PMID:21998197</ref> <ref>PMID:22105363</ref> [[https://www.uniprot.org/uniprot/MAFB_MOUSE MAFB_MOUSE]] Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:10790365</ref> <ref>PMID:16443760</ref> <ref>PMID:16847325</ref> <ref>PMID:17901057</ref> <ref>PMID:17548468</ref> <ref>PMID:18199433</ref> <ref>PMID:19143053</ref>		[https://www.uniprot.org/uniprot/FOS_MOUSE FOS_MOUSE] Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.<ref>PMID:12134156</ref> <ref>PMID:12972619</ref> <ref>PMID:15719069</ref> <ref>PMID:21998197</ref> <ref>PMID:22105363</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: ~~Holton, S~~]]		[[Category: Synthetic construct]]
	[[Category: ~~Pogenberg, V~~]]		[[Category: Holton S]]
	[[Category: ~~Wilmanns, M~~]]		[[Category: Pogenberg V]]
	[[Category: ~~Activator]]~~		[[Category: Wilmanns M]]
	~~[[Category: Differentiation]]~~
	~~[[Category: Dna-binding]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Proliferation]]~~
	~~[[Category: Proto-oncogene]]~~
	~~[[Category: Repressor]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Transcription regulation]]~~
	~~[[Category: Tumor suppressor~~]]

OCA at 10:58, 7 July 2021

2021-07-07T10:58:22Z

← Older revision		Revision as of 10:58, 7 July 2021
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	<StructureSection load='2wt7' size='340' side='right'caption='[[2wt7]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2wt7' size='340' side='right'caption='[[2wt7]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wt7]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WT7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wt7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WT7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt7 OCA], [~~http~~://pdbe.org/2wt7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wt7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wt7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt7 OCA], [https://pdbe.org/2wt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wt7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/FOS_MOUSE FOS_MOUSE]] Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.<ref>PMID:12134156</ref> <ref>PMID:12972619</ref> <ref>PMID:15719069</ref> <ref>PMID:21998197</ref> <ref>PMID:22105363</ref> [[~~http~~://www.uniprot.org/uniprot/MAFB_MOUSE MAFB_MOUSE]] Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:10790365</ref> <ref>PMID:16443760</ref> <ref>PMID:16847325</ref> <ref>PMID:17901057</ref> <ref>PMID:17548468</ref> <ref>PMID:18199433</ref> <ref>PMID:19143053</ref>		[[https://www.uniprot.org/uniprot/FOS_MOUSE FOS_MOUSE]] Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.<ref>PMID:12134156</ref> <ref>PMID:12972619</ref> <ref>PMID:15719069</ref> <ref>PMID:21998197</ref> <ref>PMID:22105363</ref> [[https://www.uniprot.org/uniprot/MAFB_MOUSE MAFB_MOUSE]] Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:10790365</ref> <ref>PMID:16443760</ref> <ref>PMID:16847325</ref> <ref>PMID:17901057</ref> <ref>PMID:17548468</ref> <ref>PMID:18199433</ref> <ref>PMID:19143053</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:02, 17 July 2019

2019-07-17T11:02:59Z

← Older revision		Revision as of 11:02, 17 July 2019
Line 1:		Line 1:

	==Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA==		==Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA==
	<StructureSection load='2wt7' size='340' side='right' caption='[[2wt7]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2wt7' size='340' side='right'caption='[[2wt7]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wt7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WT7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wt7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WT7 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Holton, S]]		[[Category: Holton, S]]

OCA at 09:30, 26 September 2018

2018-09-26T09:30:04Z

← Older revision		Revision as of 09:30, 26 September 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/2wt7_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/2wt7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:50, 5 August 2016

2016-08-05T13:50:55Z

← Older revision		Revision as of 13:50, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA==		==Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA==
	<StructureSection load='2wt7' size='340' side='right' caption='[[2wt7]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2wt7' size='340' side='right' caption='[[2wt7]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2wt7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WT7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wt7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WT7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wt7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt7 OCA], [http://pdbe.org/2wt7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wt7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wt7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2wt7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:20, 25 December 2014

2014-12-25T19:20:02Z

← Older revision		Revision as of 19:20, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2wt7\| PDB=2wt7 \| SCENE= }}~~		==Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA==
	===Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA===		<StructureSection load='2wt7' size='340' side='right' caption='[[2wt7]], [[Resolution\|resolution]] 2.30Å' scene=''>
	~~{{ABSTRACT_PUBMED_24530283}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2wt7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WT7 FirstGlance]. <br>
	==Function==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wt7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt7 PDBsum]</span></td></tr>
			</table>
			== Function ==
	[[http://www.uniprot.org/uniprot/FOS_MOUSE FOS_MOUSE]] Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.<ref>PMID:12134156</ref> <ref>PMID:12972619</ref> <ref>PMID:15719069</ref> <ref>PMID:21998197</ref> <ref>PMID:22105363</ref> [[http://www.uniprot.org/uniprot/MAFB_MOUSE MAFB_MOUSE]] Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:10790365</ref> <ref>PMID:16443760</ref> <ref>PMID:16847325</ref> <ref>PMID:17901057</ref> <ref>PMID:17548468</ref> <ref>PMID:18199433</ref> <ref>PMID:19143053</ref>		[[http://www.uniprot.org/uniprot/FOS_MOUSE FOS_MOUSE]] Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.<ref>PMID:12134156</ref> <ref>PMID:12972619</ref> <ref>PMID:15719069</ref> <ref>PMID:21998197</ref> <ref>PMID:22105363</ref> [[http://www.uniprot.org/uniprot/MAFB_MOUSE MAFB_MOUSE]] Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:10790365</ref> <ref>PMID:16443760</ref> <ref>PMID:16847325</ref> <ref>PMID:17901057</ref> <ref>PMID:17548468</ref> <ref>PMID:18199433</ref> <ref>PMID:19143053</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/2wt7_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The ability of basic leucine zipper transcription factors for homo- or heterodimerization provides a paradigm for combinatorial control of eukaryotic gene expression. It has been unclear, however, how facultative dimerization results in alternative DNA-binding repertoires on distinct regulatory elements. To unravel the molecular basis of such coupled preferences, we determined two high-resolution structures of the transcription factor MafB as a homodimer and as a heterodimer with c-Fos bound to variants of the Maf-recognition element. The structures revealed several unexpected and dimer-specific coiled-coil-heptad interactions. Based on these findings, we have engineered two MafB mutants with opposite dimerization preferences. One of them showed a strong preference for MafB/c-Fos heterodimerization and enabled selection of heterodimer-favoring over homodimer-specific Maf-recognition element variants. Our data provide a concept for transcription factor design to selectively activate dimer-specific pathways and binding repertoires.

	~~==About this Structure==~~		Design of a bZip Transcription Factor with Homo/Heterodimer-Induced DNA-Binding Preference.,Pogenberg V, Consani Textor L, Vanhille L, Holton SJ, Sieweke MH, Wilmanns M Structure. 2014 Feb 11. pii: S0969-2126(14)00009-4. doi:, 10.1016/j.str.2013.12.017. PMID:24530283<ref>PMID:24530283</ref>
	~~[[2wt7]] is~~ a ~~4 chain structure~~ with ~~sequence from [http:~~/~~/en~~.~~wikipedia~~.~~org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2WT7 OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:024530283</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Holton, S.]]		[[Category: Holton, S]]
	[[Category: Pogenberg, V.]]		[[Category: Pogenberg, V]]
	[[Category: Wilmanns, M.]]		[[Category: Wilmanns, M]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Differentiation]]		[[Category: Differentiation]]

OCA at 14:55, 3 March 2014

2014-03-03T14:55:16Z

← Older revision		Revision as of 14:55, 3 March 2014
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	{{STRUCTURE_2wt7\| PDB=2wt7 \| SCENE= }}		{{STRUCTURE_2wt7\| PDB=2wt7 \| SCENE= }}
	===Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA===		===Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA===
			{{ABSTRACT_PUBMED_24530283}}

	==Function==		==Function==
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	==Reference==		==Reference==
	<references group="xtra"/><references/>		<ref group="xtra">PMID:024530283</ref><references group="xtra"/><references/>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Holton, S.]]		[[Category: Holton, S.]]

OCA at 08:18, 5 February 2014

2014-02-05T08:18:59Z

← Older revision		Revision as of 08:18, 5 February 2014
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	~~[[Image:2wt7.png\|left\|200px]]~~

	{{STRUCTURE_2wt7\| PDB=2wt7 \| SCENE= }}		{{STRUCTURE_2wt7\| PDB=2wt7 \| SCENE= }}
			===Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA===

	===~~CRYSTAL STRUCTURE OF THE BZIP HETERODIMERIC COMPLEX MAFB~~:~~CFOS BOUND TO DNA===~~		==Function==
			[[http://www.uniprot.org/uniprot/FOS_MOUSE FOS_MOUSE]] Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.<ref>PMID:12134156</ref> <ref>PMID:12972619</ref> <ref>PMID:15719069</ref> <ref>PMID:21998197</ref> <ref>PMID:22105363</ref> [[http://www.uniprot.org/uniprot/MAFB_MOUSE MAFB_MOUSE]] Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:10790365</ref> <ref>PMID:16443760</ref> <ref>PMID:16847325</ref> <ref>PMID:17901057</ref> <ref>PMID:17548468</ref> <ref>PMID:18199433</ref> <ref>PMID:19143053</ref>

			==About this Structure==
			[[2wt7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA].

	==~~About this Structure~~==		==Reference==
	~~[[2wt7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA].~~		<references group="xtra"/><references/>
	[[Category: ~~Mus musculus~~]]		[[Category: Lk3 transgenic mice]]
	[[Category: Holton, S.]]		[[Category: Holton, S.]]
	[[Category: Pogenberg, V.]]		[[Category: Pogenberg, V.]]

OCA: Protected "2wt7" [edit=sysop:move=sysop]

2013-01-07T18:15:14Z

Protected "2wt7" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:15, 7 January 2013
(No difference)

OCA at 18:15, 7 January 2013

2013-01-07T18:15:11Z

← Older revision		Revision as of 18:15, 7 January 2013
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	~~{{Seed}}~~		[[Image:2wt7.png\|left\|200px]]
	[[Image:2wt7.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2wt7", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2wt7\| PDB=2wt7 \| SCENE= }}		{{STRUCTURE_2wt7\| PDB=2wt7 \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2WT7~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA].		[[2wt7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT7 OCA].
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Holton, S.]]		[[Category: Holton, S.]]
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	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Tumor suppressor]]		[[Category: Tumor suppressor]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:09:45 2010''~~