2wt8 - Revision history

OCA at 08:03, 23 October 2024

2024-10-23T08:03:32Z

← Older revision		Revision as of 08:03, 23 October 2024
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	<StructureSection load='2wt8' size='340' side='right'caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2wt8' size='340' side='right'caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [https://pdbe.org/2wt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [https://pdbe.org/2wt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt8 ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN] Premature chromosome condensation with microcephaly and intellectual deficit;Autosomal recessive primary microcephaly. Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:[https://omim.org/entry/251200 251200]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:16211557</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN] Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:15220350</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/2wt8_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/2wt8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bayliss, R]]		[[Category: Bayliss R]]
	[[Category: Richards~~, M W~~]]		[[Category: Richards MW]]
	[[Category: Roe~~, S M]]~~		[[Category: Roe SM]]
	~~[[Category: Cell cycle]]~~
	~~[[Category: Chromosome condensation]]~~
	~~[[Category: Dwarfism]]~~
	~~[[Category: Mental retardation]]~~
	~~[[Category: Microcephaly]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Polymorphism]]~~
	~~[[Category: Primary microcephaly~~]]

OCA at 11:15, 6 April 2022

2022-04-06T11:15:25Z

← Older revision		Revision as of 11:15, 6 April 2022
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	<StructureSection load='2wt8' size='340' side='right'caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2wt8' size='340' side='right'caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [~~http~~://pdbe.org/2wt8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wt8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [https://pdbe.org/2wt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt8 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:08, 1 July 2020

2020-07-01T09:08:34Z

← Older revision		Revision as of 09:08, 1 July 2020
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	==Structure of the N-terminal BRCT domain of human microcephalin (Mcph1)==		==Structure of the N-terminal BRCT domain of human microcephalin (Mcph1)==
	<StructureSection load='2wt8' size='340' side='right' caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2wt8' size='340' side='right'caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [http://pdbe.org/2wt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [http://pdbe.org/2wt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt8 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Bayliss, R]]		[[Category: Bayliss, R]]
	[[Category: Richards, M W]]		[[Category: Richards, M W]]

OCA at 09:43, 26 September 2018

2018-09-26T09:43:37Z

← Older revision		Revision as of 09:43, 26 September 2018
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	==~~STRUCTURE OF THE~~ N-~~TERMINAL~~ BRCT ~~DOMAIN OF HUMAN MICROCEPHALIN~~ (~~MCPH1~~)==
			==Structure of the N-terminal BRCT domain of human microcephalin (Mcph1)==
	<StructureSection load='2wt8' size='340' side='right' caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2wt8' size='340' side='right' caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [http://pdbe.org/2wt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [http://pdbe.org/2wt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wt8 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/2wt8_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/2wt8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Microcephaly]]		[[Category: Microcephaly]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
			[[Category: Polymorphism]]
	[[Category: Primary microcephaly]]		[[Category: Primary microcephaly]]

OCA at 15:55, 9 February 2016

2016-02-09T15:55:33Z

← Older revision		Revision as of 15:55, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2wt8' size='340' side='right' caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2wt8' size='340' side='right' caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [http://pdbe.org/2wt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt8 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wt8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2wt8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Bayliss, R]]		[[Category: Bayliss, R]]
	[[Category: Richards, M W]]		[[Category: Richards, M W]]

OCA at 09:48, 20 January 2015

2015-01-20T09:48:57Z

← Older revision		Revision as of 09:48, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt8 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bayliss, R.]]		[[Category: Bayliss, R]]
	[[Category: Richards, M W.]]		[[Category: Richards, M W]]
	[[Category: Roe, S M.]]		[[Category: Roe, S M]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Chromosome condensation]]		[[Category: Chromosome condensation]]

OCA at 02:19, 1 October 2014

2014-10-01T02:19:06Z

← Older revision		Revision as of 02:19, 1 October 2014
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	[[Image:~~2wt8~~.~~png~~\|~~left~~\|~~200px~~]]		==STRUCTURE OF THE N-TERMINAL BRCT DOMAIN OF HUMAN MICROCEPHALIN (MCPH1)==
			<StructureSection load='2wt8' size='340' side='right' caption='[[2wt8]], [[Resolution\|resolution]] 1.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2wt8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WT8 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
			<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wt8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wt8 RCSB], [http://www.ebi.ac.uk/pdbsum/2wt8 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/2wt8_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Mcph1 is mutated in autosomal recessive primary microcephaly and premature chromosome condensation (PCC) syndrome. Increased chromosome condensation is a common feature of cells isolated from patients afflicted with either disease. Normal cells depleted of Mcph1 also exhibit PCC phenotype. Human Mcph1 contains three BRCA1-carboxyl terminal (BRCT) domains, the first of which (Mcph1N) is necessary for the prevention of PCC. The only known disease-associated missense mutation in Mcph1 resides in this domain (T27R). We have determined the X-ray crystal structure of human Mcph1N to 1.6 A resolution. Compared with other BRCT domain structures, the most striking differences are an elongated, ordered beta1-alpha1 loop and an adjacent hydrophobic pocket. This pocket is in the equivalent structural position to the phosphate binding site of BRCT domains that recognize phospho-proteins, although the phosphate-binding residues are absent in Mcph1N. Mutations in the pocket abrogate the ability of full-length Mcph1 to rescue the PCC phenotype of Mcph1(-/-) mouse embryonic fibroblast cells, suggesting that it forms an essential part of a protein-protein interaction site necessary to prevent PCC.

	~~{{STRUCTURE_2wt8\| PDB=2wt8 \| SCENE= }}~~		A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation.,Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R J Mol Biol. 2010 Feb 5;395(5):908-15. Epub 2009 Nov 17. PMID:19925808<ref>PMID:19925808</ref>

	~~===STRUCTURE OF THE N-TERMINAL BRCT DOMAIN OF HUMAN MICROCEPHALIN (MCPH1)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19925808}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2wt8]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:019925808<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bayliss, R.]]		[[Category: Bayliss, R.]]

OCA: Protected "2wt8" [edit=sysop:move=sysop]

2013-01-07T19:04:48Z

Protected "2wt8" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:04, 7 January 2013
(No difference)

OCA at 19:04, 7 January 2013

2013-01-07T19:04:44Z

← Older revision		Revision as of 19:04, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2wt8.png\|left\|200px]]		[[Image:2wt8.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2wt8", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2wt8\| PDB=2wt8 \| SCENE= }}		{{STRUCTURE_2wt8\| PDB=2wt8 \| SCENE= }}

	===STRUCTURE OF THE N-TERMINAL BRCT DOMAIN OF HUMAN MICROCEPHALIN (MCPH1)===		===STRUCTURE OF THE N-TERMINAL BRCT DOMAIN OF HUMAN MICROCEPHALIN (MCPH1)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19925808}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19925808 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19925808}}		{{ABSTRACT_PUBMED_19925808}}

	==About this Structure==		==About this Structure==
	~~2WT8~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA].		[[2wt8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19925808~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019925808</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bayliss, R.]]		[[Category: Bayliss, R.]]
Line 34:		Line 22:
	[[Category: Microcephaly]]		[[Category: Microcephaly]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	~~[[Category: Polymorphism]]~~
	[[Category: Primary microcephaly]]		[[Category: Primary microcephaly]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 15:54:54 2010''~~

OCA at 13:54, 10 February 2010

2010-02-10T13:54:55Z

← Older revision		Revision as of 13:54, 10 February 2010
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	{{Seed}}		{{Seed}}
	[[Image:2wt8.~~jpg~~\|left\|200px]]		[[Image:2wt8.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
	2WT8 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA].		2WT8 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WT8 OCA].

	==Reference==		==Reference==
Line 37:		Line 37:
	[[Category: Primary microcephaly]]		[[Category: Primary microcephaly]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 2~~ 10:05:~~38 2009~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 15:54:54 2010''