2wvm - Revision history

OCA at 10:17, 20 December 2023

2023-12-20T10:17:43Z

← Older revision		Revision as of 10:17, 20 December 2023
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	<StructureSection load='2wvm' size='340' side='right'caption='[[2wvm]], [[Resolution\|resolution]] 2.98Å' scene=''>		<StructureSection load='2wvm' size='340' side='right'caption='[[2wvm]], [[Resolution\|resolution]] 2.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thet2 Thet2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WVM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WVM FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GDD:GUANOSINE~~-~~5-DIPHOSPHATE-ALPHA-D-MANNOSE'>GDD</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.977Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2wvl\|2wvl]], [[2wvk\|2wvk]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDD:GUANOSINE-5-DIPHOSPHATE-ALPHA-D-MANNOSE'>GDD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvm OCA], [https://pdbe.org/2wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wvm RCSB], [https://www.ebi.ac.uk/pdbsum/2wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wvm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvm OCA], [https://pdbe.org/2wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wvm RCSB], [https://www.ebi.ac.uk/pdbsum/2wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wvm ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q72K30_THET2 Q72K30_THET2]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Mannosyl-3-phosphoglycerate synthase]]~~		[[Category: Thermus thermophilus HB27]]
	~~[[Category: Thet2~~]]		[[Category: Borges N]]
	[[Category: Borges, N]]		[[Category: Esteves AM]]
	[[Category: Esteves~~, A M~~]]		[[Category: Goncalves S]]
	[[Category: Goncalves, S]]		[[Category: Matias PM]]
	[[Category: Matias~~, P M~~]]		[[Category: Santos H]]
	[[Category: Santos, H]]		[[Category: Soares CM]]
	[[Category: Soares~~, C M~~]]		[[Category: Victor B]]
	[[Category: Victor, B]]
	~~[[Category: Glucosyl transferase]]~~
	~~[[Category: Glycosyltransferase]]~~
	~~[[Category: Gt-a fold]]~~
	~~[[Category: Retaining mechanism]]~~
	~~[[Category: Transferase~~]]

OCA at 10:40, 13 April 2022

2022-04-13T10:40:55Z

← Older revision		Revision as of 10:40, 13 April 2022
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	<StructureSection load='2wvm' size='340' side='right'caption='[[2wvm]], [[Resolution\|resolution]] 2.98Å' scene=''>		<StructureSection load='2wvm' size='340' side='right'caption='[[2wvm]], [[Resolution\|resolution]] 2.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wvm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WVM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WVM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDD:GUANOSINE-5-DIPHOSPHATE-ALPHA-D-MANNOSE'>GDD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDD:GUANOSINE-5-DIPHOSPHATE-ALPHA-D-MANNOSE'>GDD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wvl\|2wvl]], [[2wvk\|2wvk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wvl\|2wvl]], [[2wvk\|2wvk]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvm OCA], [~~http~~://pdbe.org/2wvm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wvm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wvm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wvm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvm OCA], [https://pdbe.org/2wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wvm RCSB], [https://www.ebi.ac.uk/pdbsum/2wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wvm ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 14:58, 8 July 2020

2020-07-08T14:58:23Z

← Older revision		Revision as of 14:58, 8 July 2020
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	==H309A mutant of Mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27 in complex with GDP-alpha-D-Mannose and Mg(II)==		==H309A mutant of Mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27 in complex with GDP-alpha-D-Mannose and Mg(II)==
	<StructureSection load='2wvm' size='340' side='right' caption='[[2wvm]], [[Resolution\|resolution]] 2.98Å' scene=''>		<StructureSection load='2wvm' size='340' side='right'caption='[[2wvm]], [[Resolution\|resolution]] 2.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WVM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WVM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDD:GUANOSINE-5-DIPHOSPHATE-ALPHA-D-MANNOSE'>GDD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDD:GUANOSINE-5-DIPHOSPHATE-ALPHA-D-MANNOSE'>GDD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wvl\|2wvl]], [[2wvk\|2wvk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wvl\|2wvl]], [[2wvk\|2wvk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvm OCA], [http://pdbe.org/2wvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wvm RCSB], [http://www.ebi.ac.uk/pdbsum/2wvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wvm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvm OCA], [http://pdbe.org/2wvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wvm RCSB], [http://www.ebi.ac.uk/pdbsum/2wvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wvm ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Mannosyl-3-phosphoglycerate synthase]]		[[Category: Mannosyl-3-phosphoglycerate synthase]]
	[[Category: Thet2]]		[[Category: Thet2]]

OCA at 09:51, 3 October 2018

2018-10-03T09:51:56Z

← Older revision		Revision as of 09:51, 3 October 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wv/2wvm_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wv/2wvm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:47, 4 August 2016

2016-08-04T10:47:59Z

← Older revision		Revision as of 10:47, 4 August 2016
Line 1:		Line 1:

	==H309A mutant of Mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27 in complex with GDP-alpha-D-Mannose and Mg(II)==		==H309A mutant of Mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27 in complex with GDP-alpha-D-Mannose and Mg(II)==
	<StructureSection load='2wvm' size='340' side='right' caption='[[2wvm]], [[Resolution\|resolution]] 2.98Å' scene=''>		<StructureSection load='2wvm' size='340' side='right' caption='[[2wvm]], [[Resolution\|resolution]] 2.98Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wvl\|2wvl]], [[2wvk\|2wvk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wvl\|2wvl]], [[2wvk\|2wvk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wvm RCSB], [http://www.ebi.ac.uk/pdbsum/2wvm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvm OCA], [http://pdbe.org/2wvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wvm RCSB], [http://www.ebi.ac.uk/pdbsum/2wvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wvm ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wvm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2wvm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:35, 21 December 2014

2014-12-21T17:35:20Z

← Older revision		Revision as of 17:35, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2wvm\| PDB=2wvm \| SCENE= }}~~		==H309A mutant of Mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27 in complex with GDP-alpha-D-Mannose and Mg(II)==
	===H309A mutant of Mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27 in complex with GDP-alpha-D-Mannose and Mg(II)===		<StructureSection load='2wvm' size='340' side='right' caption='[[2wvm]], [[Resolution\|resolution]] 2.98Å' scene=''>
	~~{{ABSTRACT_PUBMED_20356840}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2wvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WVM FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDD:GUANOSINE-5-DIPHOSPHATE-ALPHA-D-MANNOSE'>GDD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wvl\|2wvl]], [[2wvk\|2wvk]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wvm RCSB], [http://www.ebi.ac.uk/pdbsum/2wvm PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wv/2wvm_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Mannosyl-3-phosphoglycerate synthase is a glycosyltransferase involved in the two-step synthetic pathway of mannosylglycerate, a compatible solute that accumulates in response to salt and/or heat stresses in many microorganisms thriving in hot environments. The three-dimensional structure of mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27 in its binary complex form, with GDP-alpha-D-mannose and Mg(2+), shows a second metal binding site, about 6 A away from the mannose moiety. Kinetic and mutagenesis studies have shown that this metal site plays a role in catalysis. Additionally, Asp(167) in the DXD motif is found within van der Waals contact distance of the C1' atom in the mannopyranose ring, suggesting its action as a catalytic nucleophile, either in the formation of a glycosyl-enzyme intermediate according to the double-displacement S(N)2 reaction mechanism or in the stabilization of the oxocarbenium ion-like intermediate according to the D(N)*A(Nss) (S(N)i-like) reaction mechanism. We propose that either mechanism may occur in retaining glycosyltransferases with a GT-A fold, and, based on the gathered structural information, we identified an extended structural signature toward a common scaffold between the inverting and retaining glycosyltransferases.

	~~==About this Structure==~~		Structural analysis of Thermus thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases.,Goncalves S, Borges N, Esteves AM, Victor BL, Soares CM, Santos H, Matias PM J Biol Chem. 2010 Jun 4;285(23):17857-68. Epub 2010 Mar 31. PMID:20356840<ref>PMID:20356840</ref>
	~~[[2wvm]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il/oca-bin~~/~~ocashort?id=2WVM OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:020356840</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Mannosyl-3-phosphoglycerate synthase]]		[[Category: Mannosyl-3-phosphoglycerate synthase]]
	[[Category: Thet2]]		[[Category: Thet2]]
	[[Category: Borges, N.]]		[[Category: Borges, N]]
	[[Category: Esteves, A M.]]		[[Category: Esteves, A M]]
	[[Category: Goncalves, S.]]		[[Category: Goncalves, S]]
	[[Category: Matias, P M.]]		[[Category: Matias, P M]]
	[[Category: Santos, H.]]		[[Category: Santos, H]]
	[[Category: Soares, C M.]]		[[Category: Soares, C M]]
	[[Category: Victor, B.]]		[[Category: Victor, B]]
	[[Category: Glucosyl transferase]]		[[Category: Glucosyl transferase]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]

OCA at 15:14, 19 February 2014

2014-02-19T15:14:07Z

← Older revision		Revision as of 15:14, 19 February 2014
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	~~[[Image:2wvm.png\|left\|200px]]~~

	{{STRUCTURE_2wvm\| PDB=2wvm \| SCENE= }}		{{STRUCTURE_2wvm\| PDB=2wvm \| SCENE= }}
			===H309A mutant of Mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27 in complex with GDP-alpha-D-Mannose and Mg(II)===
	===H309A ~~MUTANT OF MANNOSYL~~-3-~~PHOSPHOGLYCERATE SYNTHASE FROM THERMUS THERMOPHILUS~~ HB27 ~~IN COMPLEX WITH~~ GDP-~~ALPHA~~-D-~~MANNOSE AND MG~~(II)===

	{{ABSTRACT_PUBMED_20356840}}		{{ABSTRACT_PUBMED_20356840}}

	==About this Structure==		==About this Structure==
	[[2wvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA].		[[2wvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:020356840</ref><references group="xtra"/>		<ref group="xtra">PMID:020356840</ref><references group="xtra"/><references/>
	[[Category: Mannosyl-3-phosphoglycerate synthase]]		[[Category: Mannosyl-3-phosphoglycerate synthase]]
	[[Category: ~~Thermus thermophilus~~]]		[[Category: Thet2]]
	[[Category: Borges, N.]]		[[Category: Borges, N.]]
	[[Category: Esteves, A M.]]		[[Category: Esteves, A M.]]

OCA at 13:20, 30 January 2013

2013-01-30T13:20:10Z

← Older revision		Revision as of 13:20, 30 January 2013
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	[[Image:2wvm.png\|left\|200px]]		[[Image:2wvm.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2wvm", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2wvm\| PDB=2wvm \| SCENE= }}		{{STRUCTURE_2wvm\| PDB=2wvm \| SCENE= }}

	===H309A MUTANT OF MANNOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM THERMUS THERMOPHILUS HB27 IN COMPLEX WITH GDP-ALPHA-D-MANNOSE AND MG(II)===		===H309A MUTANT OF MANNOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM THERMUS THERMOPHILUS HB27 IN COMPLEX WITH GDP-ALPHA-D-MANNOSE AND MG(II)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20356840}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20356840 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_20356840}}		{{ABSTRACT_PUBMED_20356840}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20356840</ref><ref group="xtra">PMID:19851010~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020356840</ref><references group="xtra"/>
	[[Category: Mannosyl-3-phosphoglycerate synthase]]		[[Category: Mannosyl-3-phosphoglycerate synthase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]

OCA: Protected "2wvm" [edit=sysop:move=sysop]

2011-03-14T22:56:36Z

Protected "2wvm" [edit=sysop:move=sysop]

← Older revision	Revision as of 22:56, 14 March 2011
(No difference)

OCA at 22:56, 14 March 2011

2011-03-14T22:56:34Z

← Older revision		Revision as of 22:56, 14 March 2011
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	~~{{Seed}}~~
	[[Image:2wvm.png\|left\|200px]]		[[Image:2wvm.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
	~~2WVM~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA].		[[2wvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVM OCA].

	==Reference==		==Reference==
Line 38:		Line 37:
	[[Category: Retaining mechanism]]		[[Category: Retaining mechanism]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:06:57 2010''~~