2xae - Revision history

OCA at 10:27, 20 December 2023

2023-12-20T10:27:37Z

← Older revision		Revision as of 10:27, 20 December 2023
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	<StructureSection load='2xae' size='340' side='right'caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2xae' size='340' side='right'caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xae]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xae]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XA:(2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC+ACID'>2XA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ii6\|1ii6]], [[2x7e\|2x7e]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[2x7c\|2x7c]], [[1q0b\|1q0b]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2g1q\|2g1q]], [[2uym\|2uym]], [[1yrs\|1yrs]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1x88\|1x88]], [[2x7d\|2x7d]], [[2fl2\|2fl2]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XA:(2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC+ACID'>2XA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xae OCA], [https://pdbe.org/2xae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xae RCSB], [https://www.ebi.ac.uk/pdbsum/2xae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xae ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xae OCA], [https://pdbe.org/2xae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xae RCSB], [https://www.ebi.ac.uk/pdbsum/2xae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xae ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>		[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>		[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Joseph, B]]		[[Category: Joseph B]]
	[[Category: Kaan~~, H Y.K~~]]		[[Category: Kaan HYK]]
	[[Category: Kozielski, F]]		[[Category: Kozielski F]]
	[[Category: Laggner, C]]		[[Category: Laggner C]]
	[[Category: Menger, D]]		[[Category: Menger D]]
	[[Category: Popowycz, F]]		[[Category: Popowycz F]]
	[[Category: Tkocz, K]]		[[Category: Tkocz K]]
	[[Category: Ulaganathan, V]]		[[Category: Ulaganathan V]]
	[[Category: Weiss, J]]		[[Category: Weiss J]]
	~~[[Category: Cell cycle]]~~
	~~[[Category: Ksp]]~~
	~~[[Category: Mitosis~~]]

OCA at 10:48, 13 April 2022

2022-04-13T10:48:35Z

OCA at 15:08, 8 July 2020

2020-07-08T15:08:41Z

← Older revision		Revision as of 15:08, 8 July 2020
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	==Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid==		==Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid==
	<StructureSection load='2xae' size='340' side='right' caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2xae' size='340' side='right'caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xae]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XAE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xae]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XAE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XA:(2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC+ACID'>2XA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XA:(2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC+ACID'>2XA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[2x7e\|2x7e]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[2x7c\|2x7c]], [[1q0b\|1q0b]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2g1q\|2g1q]], [[2uym\|2uym]], [[1yrs\|1yrs]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1x88\|1x88]], [[2x7d\|2x7d]], [[2fl2\|2fl2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[2x7e\|2x7e]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[2x7c\|2x7c]], [[1q0b\|1q0b]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2g1q\|2g1q]], [[2uym\|2uym]], [[1yrs\|1yrs]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1x88\|1x88]], [[2x7d\|2x7d]], [[2fl2\|2fl2]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xae OCA], [http://pdbe.org/2xae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xae RCSB], [http://www.ebi.ac.uk/pdbsum/2xae PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xae ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xae OCA], [http://pdbe.org/2xae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xae RCSB], [http://www.ebi.ac.uk/pdbsum/2xae PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xae ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:

	==See Also==		==See Also==
	*[[Kinesin\|Kinesin]]		*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Joseph, B]]		[[Category: Joseph, B]]
	[[Category: Kaan, H Y.K]]		[[Category: Kaan, H Y.K]]

OCA at 09:15, 3 October 2018

2018-10-03T09:15:41Z

← Older revision		Revision as of 09:15, 3 October 2018
Line 1:		Line 1:

	==~~CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH~~ (R)-2-~~AMINO~~-3-((S)-2-~~METHYL~~-1,1-~~DIPHENYLBUTYLTHIO~~)~~PROPANOIC ACID~~==		==Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid==
	<StructureSection load='2xae' size='340' side='right' caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2xae' size='340' side='right' caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 08:15, 5 August 2016

2016-08-05T08:15:15Z

← Older revision		Revision as of 08:15, 5 August 2016
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID==		==CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID==
	<StructureSection load='2xae' size='340' side='right' caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2xae' size='340' side='right' caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xae]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XAE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xae]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XAE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XA:(2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC+ACID'>2XA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XA:(2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC+ACID'>2XA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[2x7e\|2x7e]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[2x7c\|2x7c]], [[1q0b\|1q0b]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2g1q\|2g1q]], [[2uym\|2uym]], [[1yrs\|1yrs]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1x88\|1x88]], [[2x7d\|2x7d]], [[2fl2\|2fl2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[2x7e\|2x7e]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[2x7c\|2x7c]], [[1q0b\|1q0b]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2g1q\|2g1q]], [[2uym\|2uym]], [[1yrs\|1yrs]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1x88\|1x88]], [[2x7d\|2x7d]], [[2fl2\|2fl2]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xae OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xae RCSB], [http://www.ebi.ac.uk/pdbsum/2xae PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xae OCA], [http://pdbe.org/2xae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xae RCSB], [http://www.ebi.ac.uk/pdbsum/2xae PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xae ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2xae" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Joseph, B]]		[[Category: Joseph, B]]
	[[Category: Kaan, H Y.K]]		[[Category: Kaan, H Y.K]]

OCA at 11:51, 18 December 2014

2014-12-18T11:51:28Z

← Older revision		Revision as of 11:51, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2xae\| PDB=2xae \| SCENE= }}~~		==CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID==
	===CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID===		<StructureSection load='2xae' size='340' side='right' caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>
	~~{{ABSTRACT_PUBMED_21344920}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2xae]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XAE FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XA:(2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC+ACID'>2XA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[2x7e\|2x7e]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[2x7c\|2x7c]], [[1q0b\|1q0b]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2g1q\|2g1q]], [[2uym\|2uym]], [[1yrs\|1yrs]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1x88\|1x88]], [[2x7d\|2x7d]], [[2fl2\|2fl2]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xae OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xae RCSB], [http://www.ebi.ac.uk/pdbsum/2xae PDBsum]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The mitotic spindle is a validated target for cancer chemotherapy. Drugs such as taxanes and vinca alkaloids specifically target microtubules and cause the mitotic spindle to collapse. However, toxicity and resistance are problems associated with these drugs. Thus, alternative approaches to inhibiting the mitotic spindle are being pursued. These include targeting Eg5, a human kinesin involved in the formation of the bipolar spindle. We previously identified S-trityl-l-cysteine (STLC) as a potent allosteric inhibitor of Eg5. Here, we report the synthesis of a new series of STLC-like compounds with in vitro inhibition in the low nanomolar range. We also performed a multidrug resistance study in cell lines overexpressing P-glycoprotein and showed that some of these inhibitors may have the potential to overcome susceptibility to this efflux pump. Finally, we performed molecular docking of the compounds and determined the structures of two Eg5-inhibitor complexes to explain the structure-activity relationship of these compounds.

	~~==Disease==~~		Structure-Activity Relationship and Multidrug Resistance Study of New S-trityl-l-Cysteine Derivatives As Inhibitors of Eg5.,Kaan HY, Weiss J, Menger D, Ulaganathan V, Tkocz K, Laggner C, Popowycz F, Joseph B, Kozielski F J Med Chem. 2011 Mar 24;54(6):1576-1586. Epub 2011 Feb 23. PMID:21344920<ref>PMID:21344920</ref>
	~~[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause~~ of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of ~~central nervous system and ocular developmental anomalies~~. ~~Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures~~, ~~broad nose with rounded tip~~, ~~long philtrum with thin upper lip~~, ~~prominent chin~~, ~~and prominent ears. Chorioretinopathy is the most common eye abnormality~~, ~~but retinal folds~~, ~~microphthalmia~~, ~~and myopic and hypermetropic astigmatism have also been reported~~, ~~and some individuals have no overt ocular phenotype~~. ~~Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes~~.<ref>PMID:~~22284827~~</ref>

	~~==Function==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking~~ of ~~KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays~~.<~~ref~~>~~PMID:19001501~~</~~ref~~>		</div>

	==~~About this Structure~~==		==See Also==
	[[~~2xae~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAE OCA].		*[[Kinesin\|Kinesin]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:021344920</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Joseph, B.]]		[[Category: Joseph, B]]
	[[Category: Kaan, H Y.K.]]		[[Category: Kaan, H Y.K]]
	[[Category: Kozielski, F.]]		[[Category: Kozielski, F]]
	[[Category: Laggner, C.]]		[[Category: Laggner, C]]
	[[Category: Menger, D.]]		[[Category: Menger, D]]
	[[Category: Popowycz, F.]]		[[Category: Popowycz, F]]
	[[Category: Tkocz, K.]]		[[Category: Tkocz, K]]
	[[Category: Ulaganathan, V.]]		[[Category: Ulaganathan, V]]
	[[Category: Weiss, J.]]		[[Category: Weiss, J]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Ksp]]		[[Category: Ksp]]
	[[Category: Mitosis]]		[[Category: Mitosis]]

OCA at 18:23, 24 March 2013

2013-03-24T18:23:20Z

← Older revision		Revision as of 18:23, 24 March 2013
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	~~[[Image:2xae.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2xae", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2xae\| PDB=2xae \| SCENE= }}		{{STRUCTURE_2xae\| PDB=2xae \| SCENE= }}

	===CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID===		===CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID===
			{{ABSTRACT_PUBMED_21344920}}

			==Disease==
			[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>

	~~<!--~~		==Function==
	~~The line below this paragraph, {{ABSTRACT_PUBMED_21344920}}, adds the Publication Abstract to the page~~		[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21344920 is the PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_21344920}}~~

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
	<ref group="xtra">PMID:021344920</ref><references group="xtra"/>		<ref group="xtra">PMID:021344920</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Joseph, B.]]		[[Category: Joseph, B.]]
Line 33:		Line 24:
	[[Category: Ulaganathan, V.]]		[[Category: Ulaganathan, V.]]
	[[Category: Weiss, J.]]		[[Category: Weiss, J.]]
			[[Category: Cell cycle]]
			[[Category: Ksp]]
			[[Category: Mitosis]]

OCA at 05:56, 25 May 2011

2011-05-25T05:56:03Z

← Older revision		Revision as of 05:56, 25 May 2011
Line 1:		Line 1:
	[[Image:2xae.~~jpg~~\|left\|200px]]		[[Image:2xae.png\|left\|200px]]

	<!--		<!--
Line 22:		Line 22:

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~21344920~~</ref><references group="xtra"/>		<ref group="xtra">PMID:021344920</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Joseph, B.]]		[[Category: Joseph, B.]]

OCA at 08:02, 30 March 2011

2011-03-30T08:02:29Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:2xae.jpg|left|200px]]
-The entry 2xae is ON HOLD  until Paper Publication
+<!--
-Authors: Kaan, H.Y.K., Weiss, J., Menger, D., Ulaganathan, V., Tkocz, K., Laggner, C., Popowycz, F., Joseph, B., Kozielski, F.
+===CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID===
-Description: Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid

OCA: Protected "2xae" [edit=sysop:move=sysop]

2011-01-26T12:35:22Z

Protected "2xae" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:35, 26 January 2011
(No difference)

← Older revision		Revision as of 10:48, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2xae' size='340' side='right'caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2xae' size='340' side='right'caption='[[2xae]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xae]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XAE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xae]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XA:(2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC+ACID'>2XA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XA:(2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC+ACID'>2XA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[2x7e\|2x7e]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[2x7c\|2x7c]], [[1q0b\|1q0b]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2g1q\|2g1q]], [[2uym\|2uym]], [[1yrs\|1yrs]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1x88\|1x88]], [[2x7d\|2x7d]], [[2fl2\|2fl2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ii6\|1ii6]], [[2x7e\|2x7e]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[2x7c\|2x7c]], [[1q0b\|1q0b]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2g1q\|2g1q]], [[2uym\|2uym]], [[1yrs\|1yrs]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1x88\|1x88]], [[2x7d\|2x7d]], [[2fl2\|2fl2]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xae OCA], [~~http~~://pdbe.org/2xae PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xae RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xae PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xae ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xae OCA], [https://pdbe.org/2xae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xae RCSB], [https://www.ebi.ac.uk/pdbsum/2xae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xae ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[~~http~~://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>		[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>		[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==